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The map label for this gene is sucD

Identifier: 15892521

GI number: 15892521

Start: 584745

End: 585623

Strand: Reverse

Name: sucD

Synonym: RC0598

Alternate gene names: 15892521

Gene position: 585623-584745 (Counterclockwise)

Preceding gene: 15892522

Following gene: 15892516

Centisome position: 46.16

GC content: 40.05

Gene sequence:

>879_bases
ATGGCAATATTAATAAATAAAAAAACACAAGTTATCTGTCAGGGTTTTACTGGTTTACAAGGAACTTTTCACTCTGAACA
AGCGATAGCGTACGGCACTAACATGGTTGGCGGTGTTACACCCGGCAAAGGCGGTCATACTCACCTTGATTTACCTGTAT
ATAATACCGTACATGAAGCAAAAGCAAAAACCGGTGCAAATGCAAGCGTTATATATGTTCCGCCCGGCTTTGCCGCTGAT
TCGATATTAGAAGCAATCGATGCTGAAATTGAAGTAGTAGTATGTATAACGGAAGGAATTCCGGTGCTTGATATGGTGAA
AGTAAAACGTGCTTTAGTCGGTTCTAAAACTAGATTAATTGGTCCTAACTGCCCTGGAGTTATCACACCGGGTGAATGTA
AAATCGGTATTATGCCTGGACATATTCATAAAAGAGGAACAATAGGTATTGTTTCAAGATCAGGTACTCTAACTTATGAA
GCAGTAGCACAGACAACAGCAGTAGGACTTGGACAATCTACGTGTATCGGTATAGGCGGCGATCCTGTTAACGGCACTAA
TTTTGTTGATTGTATTGAGATGTTTTTGAAAGATGATGAAACAAAAGCAATTATTATGATCGGTGAAATTGGCGGTAATG
CAGAAGAAGATGCAGCTGAGTTTATCAAGCAGTCAAAAATCAAGAAACCTATAGTAAGCTTTATTGCAGGTATTACAGCA
CCTCCAGGTAAAAGAATGGGACATGCCGGAGCCATTATTGTCGGAAGAACAGGAAGTGCCGAAGATAAGCTTGAAGCTCT
ACAAAGTGCCGGCGTAATTATCACTAGATCCCCTGCCGATATCGGTAAAACTATGTTAGATTTACTAAATAAAGGCTAA

Upstream 100 bases:

>100_bases
TGACCACAGTATCCATAAAAAAATTAAAAAAGGACTGGATCACGCGATCAAGTCGCGGGATGATATCAAAGTAAAATAAA
AACAATAAACATTATTTAAC

Downstream 100 bases:

>100_bases
AGTTATTCAAGAGCAATTGCTGTCATTCCTACTAGGCCTTGTTGCGTGAAGACTGAAGGTCCTCATTGCGAGGAAATTAC
GTAACTAATTGACGAAGCAA

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MAILINKKTQVICQGFTGLQGTFHSEQAIAYGTNMVGGVTPGKGGHTHLDLPVYNTVHEAKAKTGANASVIYVPPGFAAD
SILEAIDAEIEVVVCITEGIPVLDMVKVKRALVGSKTRLIGPNCPGVITPGECKIGIMPGHIHKRGTIGIVSRSGTLTYE
AVAQTTAVGLGQSTCIGIGGDPVNGTNFVDCIEMFLKDDETKAIIMIGEIGGNAEEDAAEFIKQSKIKKPIVSFIAGITA
PPGKRMGHAGAIIVGRTGSAEDKLEALQSAGVIITRSPADIGKTMLDLLNKG

Sequences:

>Translated_292_residues
MAILINKKTQVICQGFTGLQGTFHSEQAIAYGTNMVGGVTPGKGGHTHLDLPVYNTVHEAKAKTGANASVIYVPPGFAAD
SILEAIDAEIEVVVCITEGIPVLDMVKVKRALVGSKTRLIGPNCPGVITPGECKIGIMPGHIHKRGTIGIVSRSGTLTYE
AVAQTTAVGLGQSTCIGIGGDPVNGTNFVDCIEMFLKDDETKAIIMIGEIGGNAEEDAAEFIKQSKIKKPIVSFIAGITA
PPGKRMGHAGAIIVGRTGSAEDKLEALQSAGVIITRSPADIGKTMLDLLNKG
>Mature_291_residues
AILINKKTQVICQGFTGLQGTFHSEQAIAYGTNMVGGVTPGKGGHTHLDLPVYNTVHEAKAKTGANASVIYVPPGFAADS
ILEAIDAEIEVVVCITEGIPVLDMVKVKRALVGSKTRLIGPNCPGVITPGECKIGIMPGHIHKRGTIGIVSRSGTLTYEA
VAQTTAVGLGQSTCIGIGGDPVNGTNFVDCIEMFLKDDETKAIIMIGEIGGNAEEDAAEFIKQSKIKKPIVSFIAGITAP
PGKRMGHAGAIIVGRTGSAEDKLEALQSAGVIITRSPADIGKTMLDLLNKG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family

Homologues:

Organism=Homo sapiens, GI109452591, Length=293, Percent_Identity=69.9658703071672, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI38569421, Length=252, Percent_Identity=29.7619047619048, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38569423, Length=252, Percent_Identity=29.7619047619048, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1786949, Length=290, Percent_Identity=69.3103448275862, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17553126, Length=291, Percent_Identity=66.3230240549828, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17550194, Length=287, Percent_Identity=65.1567944250871, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17557344, Length=257, Percent_Identity=30.3501945525292, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17551266, Length=258, Percent_Identity=30.2325581395349, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324716, Length=297, Percent_Identity=52.1885521885522, Blast_Score=293, Evalue=2e-80,
Organism=Drosophila melanogaster, GI21356559, Length=287, Percent_Identity=59.9303135888502, Blast_Score=352, Evalue=1e-97,
Organism=Drosophila melanogaster, GI28574296, Length=291, Percent_Identity=65.2920962199313, Blast_Score=349, Evalue=1e-96,
Organism=Drosophila melanogaster, GI281363477, Length=256, Percent_Identity=30.078125, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281363475, Length=256, Percent_Identity=30.078125, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281363473, Length=256, Percent_Identity=30.078125, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SUCD_RICCN (Q92I22)

Other databases:

- EMBL:   AE006914
- PIR:   F97774
- RefSeq:   NP_360235.1
- HSSP:   O19069
- ProteinModelPortal:   Q92I22
- SMR:   Q92I22
- GeneID:   928794
- GenomeReviews:   AE006914_GR
- KEGG:   rco:RC0598
- NMPDR:   fig|272944.1.peg.598
- OMA:   ADAICEA
- ProtClustDB:   PRK05678
- BioCyc:   RCON272944:RC0598-MONOMER
- BRENDA:   6.2.1.5
- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:3.40.50.261
- PIRSF:   PIRSF001553
- PRINTS:   PR01798
- SMART:   SM00881
- TIGRFAMs:   TIGR01019

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 30298; Mature: 30166

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS01216 SUCCINYL_COA_LIG_1; PS00399 SUCCINYL_COA_LIG_2

Important sites: ACT_SITE 248-248

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILINKKTQVICQGFTGLQGTFHSEQAIAYGTNMVGGVTPGKGGHTHLDLPVYNTVHEA
CEEEEECCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEECCHHHHHHHH
KAKTGANASVIYVPPGFAADSILEAIDAEIEVVVCITEGIPVLDMVKVKRALVGSKTRLI
HHCCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEE
GPNCPGVITPGECKIGIMPGHIHKRGTIGIVSRSGTLTYEAVAQTTAVGLGQSTCIGIGG
CCCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCCEEHHHHHHHHHHCCCCCEEEECCC
DPVNGTNFVDCIEMFLKDDETKAIIMIGEIGGNAEEDAAEFIKQSKIKKPIVSFIAGITA
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PPGKRMGHAGAIIVGRTGSAEDKLEALQSAGVIITRSPADIGKTMLDLLNKG
CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AILINKKTQVICQGFTGLQGTFHSEQAIAYGTNMVGGVTPGKGGHTHLDLPVYNTVHEA
EEEEECCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEECCHHHHHHHH
KAKTGANASVIYVPPGFAADSILEAIDAEIEVVVCITEGIPVLDMVKVKRALVGSKTRLI
HHCCCCCCEEEEECCCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEE
GPNCPGVITPGECKIGIMPGHIHKRGTIGIVSRSGTLTYEAVAQTTAVGLGQSTCIGIGG
CCCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCCEEHHHHHHHHHHCCCCCEEEECCC
DPVNGTNFVDCIEMFLKDDETKAIIMIGEIGGNAEEDAAEFIKQSKIKKPIVSFIAGITA
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PPGKRMGHAGAIIVGRTGSAEDKLEALQSAGVIITRSPADIGKTMLDLLNKG
CCCCCCCCCCEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893