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The map label for this gene is lpxC [H]

Identifier: 15892262

GI number: 15892262

Start: 339846

End: 340721

Strand: Reverse

Name: lpxC [H]

Synonym: RC0339

Alternate gene names: 15892262

Gene position: 340721-339846 (Counterclockwise)

Preceding gene: 15892264

Following gene: 15892260

Centisome position: 26.85

GC content: 32.88

Gene sequence:

>876_bases
ATGCCTAAAATGCAGCAAAGTACATTATTAAAACCGGTTAGTTGTTACGGAATCGGGGTCCACTCAGGAAAACGTACCCA
GTTAACTATAGAGCCCACTAAAGAAAATACCGGAATTATATTCATTAGAACCGATATATCTTCTGAAAATAATTATATTG
AAGCTAGCTATTTCAATGTTTCCGATACCTTGTTATCTACCACTATCAGTAATGATCATAAAGTTCAAATTTCAACAATT
GAACATTTAATGGCAGCACTTTGGGGATGCAGCATTGATAATGCAATTATTAAAATTGACGGTCCTGAAGTACCAATTAT
GGACGGCAGTAGTAAACCTTTTGTGTTTATGATTGAGTGTGCAGGAAAAAAATTACAAAATGCTCCTAAAAAATATCTAA
AAATTTTAAAAGATATAAAAGTAGTTCATAAAGATTGTGAATTATATTGTACTCCTTCCGATCACATGACTGTAGATTTA
ACCATTGATTTTAGTAGTAAAGCTATAGGCAGACAAAATCTAAGTTTTAGGGATCAAGAATCTTTTACTAAAAATATTGC
GGATGCTAGAACTTTTGGCTTTATAAGAGATGTTGATTATTTGAAAAGCAAAGGGCTTGCCCAAGGTGCCTCATTTGAGA
ATGCTATAGGAATAGATGAGCAGGATAAAATCTTAAACCCAAACGGCTTACGTTATGAAGATGAATTTGTTCGCCATAAA
CTATTAGATTTATTCGGTGATTTATATACCAACGGCACTAGCATTGTAAGTGCAATTAAAGGCTACAAAACTAGCCATGC
TCTTAATAATGAACTATTGCATAGAATATTTAGCGATACTACCTCTTACAAATTTGTAACTAGCAGTGAGTTATAA

Upstream 100 bases:

>100_bases
CCAATTTTTGAAGTTCATCGAGTATATGTGTAATATTCTGTAACATAATATAACTTGTATAATTTGGCATTAAATATTAA
TATTTAAATATATTTTTACA

Downstream 100 bases:

>100_bases
TAATCATTTCATATTGTTAAATTTCGCTTTCTTTTTTGCATCCTTTTTAAATTTTCACTTTTTGTCCTTTTTATTTCAGC
ATTATTAACTTTATCTTTAT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MPKMQQSTLLKPVSCYGIGVHSGKRTQLTIEPTKENTGIIFIRTDISSENNYIEASYFNVSDTLLSTTISNDHKVQISTI
EHLMAALWGCSIDNAIIKIDGPEVPIMDGSSKPFVFMIECAGKKLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDL
TIDFSSKAIGRQNLSFRDQESFTKNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHK
LLDLFGDLYTNGTSIVSAIKGYKTSHALNNELLHRIFSDTTSYKFVTSSEL

Sequences:

>Translated_291_residues
MPKMQQSTLLKPVSCYGIGVHSGKRTQLTIEPTKENTGIIFIRTDISSENNYIEASYFNVSDTLLSTTISNDHKVQISTI
EHLMAALWGCSIDNAIIKIDGPEVPIMDGSSKPFVFMIECAGKKLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDL
TIDFSSKAIGRQNLSFRDQESFTKNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHK
LLDLFGDLYTNGTSIVSAIKGYKTSHALNNELLHRIFSDTTSYKFVTSSEL
>Mature_290_residues
PKMQQSTLLKPVSCYGIGVHSGKRTQLTIEPTKENTGIIFIRTDISSENNYIEASYFNVSDTLLSTTISNDHKVQISTIE
HLMAALWGCSIDNAIIKIDGPEVPIMDGSSKPFVFMIECAGKKLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDLT
IDFSSKAIGRQNLSFRDQESFTKNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHKL
LDLFGDLYTNGTSIVSAIKGYKTSHALNNELLHRIFSDTTSYKFVTSSEL

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=287, Percent_Identity=42.8571428571429, Blast_Score=252, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32596; Mature: 32465

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKMQQSTLLKPVSCYGIGVHSGKRTQLTIEPTKENTGIIFIRTDISSENNYIEASYFNV
CCCCCCHHHCCCEEEEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCCEEEEEEECC
SDTLLSTTISNDHKVQISTIEHLMAALWGCSIDNAIIKIDGPEVPIMDGSSKPFVFMIEC
HHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCEEEEEEE
AGKKLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDLTIDFSSKAIGRQNLSFRDQE
CCCHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCHH
SFTKNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LLDLFGDLYTNGTSIVSAIKGYKTSHALNNELLHRIFSDTTSYKFVTSSEL
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCC
>Mature Secondary Structure 
PKMQQSTLLKPVSCYGIGVHSGKRTQLTIEPTKENTGIIFIRTDISSENNYIEASYFNV
CCCCCHHHCCCEEEEEEEECCCCEEEEEEEECCCCCCEEEEEECCCCCCCEEEEEEECC
SDTLLSTTISNDHKVQISTIEHLMAALWGCSIDNAIIKIDGPEVPIMDGSSKPFVFMIEC
HHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCCEEEEEEE
AGKKLQNAPKKYLKILKDIKVVHKDCELYCTPSDHMTVDLTIDFSSKAIGRQNLSFRDQE
CCCHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCHH
SFTKNIADARTFGFIRDVDYLKSKGLAQGASFENAIGIDEQDKILNPNGLRYEDEFVRHK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
LLDLFGDLYTNGTSIVSAIKGYKTSHALNNELLHRIFSDTTSYKFVTSSEL
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA