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The map label for this gene is glxR [H]

Identifier: 158425114

GI number: 158425114

Start: 4007222

End: 4008100

Strand: Direct

Name: glxR [H]

Synonym: AZC_3490

Alternate gene names: 158425114

Gene position: 4007222-4008100 (Clockwise)

Preceding gene: 158425113

Following gene: 158425115

Centisome position: 74.63

GC content: 66.78

Gene sequence:

>879_bases
ATGAACGTGGGTTTCATCGGTCTCGGCATCATGGGCACCCCCATGGCCGGCCACCTCATCGACGCCGGGCACACCCTCTT
CCTCTATGACGTGGTGAAGGTGCCCGCCGAATTGACCGACAAGGGCGCCACGGCGGTCGCCTCCTCCGCCGAGGTGGCGA
AGAATGCGGACGTCATCATCCTCATGGTGCCGGACACCCCGCACGTGGACGAGGCGCTGTTCGGCGCCGGCGGCGTTGCG
GAAGGCCTCAGCGCCGGCAAGATCGTGGTGGACATGAGCTCCATCTCGCCGGTGGAGACGAAGAAGTTCGCCGAGAAGAT
CAACGCGCTCGGTTGCGATTATCTCGACGCCCCGGTCTCCGGCGGCGACGTGGGCGCCAAGGCCGCCTCCCTCACCATCA
TGGTCGGCGGCCCGGAAAAGGCCTTCGAGACGGTGAAGCCGCTGTTCGAGAAGATGGGCAAGAACATCACCCTCGTCGGC
GGCAATGGCGACGGCCAGACCACCAAGGTCGCCAACCAGATCATCGTCGCCCTCACCATCGAGGCGGTGGGCGAGGCGCT
GCTCTTCGCATCCAAGGCGGGCGCCGACCCGGCCAAGGTGCGCCAGGCGCTGATGGGCGGCTTTGCCTCCTCGCGCATCC
TGGAGGTGCACGGCGAGCGCATGGTGAAGCGCAACTTCAACCCCGGCTTCCGCATCGAGCTGCACCAGAAGGACCTGAAC
CTCGCGCTGTCCTCCGCGCGGGCGCTCAAGGTGGCGCTGCCAAACACCGCGACGGCGCAGGAGCTGTTCAACGCCGTGGC
CGCCCGCGGCGGCTCCAAGCTCGATCACTCCGCCATGGTGAATGCGCTGGAACTGCTGGCGAACCACGACATCGCCTGA

Upstream 100 bases:

>100_bases
CCCCTACAAGGGCTGAGCTGCCAGAACCATTCCGCCAAGGACACCGCCCGCCGCCCGGCCTGCCGGGCGTGCGCGGCGCA
CATGCACGGGAGCACGCACA

Downstream 100 bases:

>100_bases
CCGTTTGCCCGCCATGGCCCGGCGACGGGCCATGGCGGTGACGCACCTGCGTCACCGCGCCTTTGTATCAAGTGCGATCA
GGACAAAGGCGGCACGGCAG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MNVGFIGLGIMGTPMAGHLIDAGHTLFLYDVVKVPAELTDKGATAVASSAEVAKNADVIILMVPDTPHVDEALFGAGGVA
EGLSAGKIVVDMSSISPVETKKFAEKINALGCDYLDAPVSGGDVGAKAASLTIMVGGPEKAFETVKPLFEKMGKNITLVG
GNGDGQTTKVANQIIVALTIEAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMVKRNFNPGFRIELHQKDLN
LALSSARALKVALPNTATAQELFNAVAARGGSKLDHSAMVNALELLANHDIA

Sequences:

>Translated_292_residues
MNVGFIGLGIMGTPMAGHLIDAGHTLFLYDVVKVPAELTDKGATAVASSAEVAKNADVIILMVPDTPHVDEALFGAGGVA
EGLSAGKIVVDMSSISPVETKKFAEKINALGCDYLDAPVSGGDVGAKAASLTIMVGGPEKAFETVKPLFEKMGKNITLVG
GNGDGQTTKVANQIIVALTIEAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMVKRNFNPGFRIELHQKDLN
LALSSARALKVALPNTATAQELFNAVAARGGSKLDHSAMVNALELLANHDIA
>Mature_292_residues
MNVGFIGLGIMGTPMAGHLIDAGHTLFLYDVVKVPAELTDKGATAVASSAEVAKNADVIILMVPDTPHVDEALFGAGGVA
EGLSAGKIVVDMSSISPVETKKFAEKINALGCDYLDAPVSGGDVGAKAASLTIMVGGPEKAFETVKPLFEKMGKNITLVG
GNGDGQTTKVANQIIVALTIEAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMVKRNFNPGFRIELHQKDLN
LALSSARALKVALPNTATAQELFNAVAARGGSKLDHSAMVNALELLANHDIA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=34.5890410958904, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=27.6595744680851, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786719, Length=292, Percent_Identity=68.8356164383562, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI145693186, Length=294, Percent_Identity=42.5170068027211, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1789092, Length=283, Percent_Identity=30.0353356890459, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17557316, Length=277, Percent_Identity=31.7689530685921, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24655230, Length=291, Percent_Identity=36.426116838488, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19922568, Length=291, Percent_Identity=36.426116838488, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28574115, Length=278, Percent_Identity=28.0575539568345, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24655240, Length=65, Percent_Identity=49.2307692307692, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30167; Mature: 30167

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVGFIGLGIMGTPMAGHLIDAGHTLFLYDVVKVPAELTDKGATAVASSAEVAKNADVII
CCCEEEEECEECCCCCCCEECCCCEEEEHHHHHCCHHHCCCCCHHHHCCHHHHCCCCEEE
LMVPDTPHVDEALFGAGGVAEGLSAGKIVVDMSSISPVETKKFAEKINALGCDYLDAPVS
EECCCCCCHHHHHHCCCCHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCC
GGDVGAKAASLTIMVGGPEKAFETVKPLFEKMGKNITLVGGNGDGQTTKVANQIIVALTI
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHEEEEEEH
EAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMVKRNFNPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCHHHHHHHHHHHHCCCCCCEEEEEECCCHH
LALSSARALKVALPNTATAQELFNAVAARGGSKLDHSAMVNALELLANHDIA
HHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNVGFIGLGIMGTPMAGHLIDAGHTLFLYDVVKVPAELTDKGATAVASSAEVAKNADVII
CCCEEEEECEECCCCCCCEECCCCEEEEHHHHHCCHHHCCCCCHHHHCCHHHHCCCCEEE
LMVPDTPHVDEALFGAGGVAEGLSAGKIVVDMSSISPVETKKFAEKINALGCDYLDAPVS
EECCCCCCHHHHHHCCCCHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCC
GGDVGAKAASLTIMVGGPEKAFETVKPLFEKMGKNITLVGGNGDGQTTKVANQIIVALTI
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHEEEEEEH
EAVGEALLFASKAGADPAKVRQALMGGFASSRILEVHGERMVKRNFNPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHCHHHHHHHHHHHHCCCCCCEEEEEECCCHH
LALSSARALKVALPNTATAQELFNAVAARGGSKLDHSAMVNALELLANHDIA
HHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]