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The map label for this gene is hyi [H]

Identifier: 158425113

GI number: 158425113

Start: 4006358

End: 4007137

Strand: Direct

Name: hyi [H]

Synonym: AZC_3489

Alternate gene names: 158425113

Gene position: 4006358-4007137 (Clockwise)

Preceding gene: 158425112

Following gene: 158425114

Centisome position: 74.61

GC content: 64.1

Gene sequence:

>780_bases
ATGCCCAAGTTTGCTGCCAATCTGACCATGCTCTGGAACGAGATCGACTTCCTGGACCGCTTCGCCAAGGCGGCGGAGGC
CGGTTTCAAGGGCGTGGAGTATCTCTTCCCCTACGCCTATCCCAAGGAGGAGCTGGCCGAGCGCCTTGAGAAGCACGGGC
TCACCCAGGCGCTGCACAATCTGCCGGCCGGCGAGTGGGCGAAGGGCGAACGCGGCATCGCCGTCCTGCCCGACCGCGTC
GGCGAGTTCCAGGACAGCGTCGGCACCGCACTCGAATATGCCAAGGTGCTGAAGACGCAGACGCTGAACGTGCTGGCGGG
CATCGCCCCCAAGGACGTGCCGGCGGAGAAGATCTACGAGACGCTGGTCTCGAACCTGAAATTCGCCGCCGCCGAGGCCA
AGAAGGCGGGCATCCCGCTGGTGGTCGAGGCCATCAACACCCGCGACATTCCCGGCTTCTATCTCAACACCACCAAGCAG
ACGCTCAGCTTGCTGGATGACGTGGGGCCGCAGGACGTCTTCTTCCAGTACGACATCTACCACATGCAGATCATGGAGGG
CGATCTCGTCCCCACACTGCGCGCCAACATGGCCCGCATCAAGCACATCCAGCTCGCGGACAATCCGGGCCGCGGCGAGC
CGGGCACGGGCGAGATCAACTACCCGTTCATCTTCAAGGCCATCGACGATGCCGGTTACACCGGCTGGATCGGTGCCGAA
TACAAGCCCGCGACGACCACCGACGCCGGCATCGGCTGGTTCGCCCCCTACAAGGGCTGA

Upstream 100 bases:

>100_bases
CCGCCCGTCCGCCCTATCCCTTTCACACGGAACGTTTTACGGCTTGGATTGCCAAACAATCGAAGCCTGACTTGCCCAGG
CTCAGCCAGCGGAGAGGTGA

Downstream 100 bases:

>100_bases
GCTGCCAGAACCATTCCGCCAAGGACACCGCCCGCCGCCCGGCCTGCCGGGCGTGCGCGGCGCACATGCACGGGAGCACG
CACAATGAACGTGGGTTTCA

Product: hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MPKFAANLTMLWNEIDFLDRFAKAAEAGFKGVEYLFPYAYPKEELAERLEKHGLTQALHNLPAGEWAKGERGIAVLPDRV
GEFQDSVGTALEYAKVLKTQTLNVLAGIAPKDVPAEKIYETLVSNLKFAAAEAKKAGIPLVVEAINTRDIPGFYLNTTKQ
TLSLLDDVGPQDVFFQYDIYHMQIMEGDLVPTLRANMARIKHIQLADNPGRGEPGTGEINYPFIFKAIDDAGYTGWIGAE
YKPATTTDAGIGWFAPYKG

Sequences:

>Translated_259_residues
MPKFAANLTMLWNEIDFLDRFAKAAEAGFKGVEYLFPYAYPKEELAERLEKHGLTQALHNLPAGEWAKGERGIAVLPDRV
GEFQDSVGTALEYAKVLKTQTLNVLAGIAPKDVPAEKIYETLVSNLKFAAAEAKKAGIPLVVEAINTRDIPGFYLNTTKQ
TLSLLDDVGPQDVFFQYDIYHMQIMEGDLVPTLRANMARIKHIQLADNPGRGEPGTGEINYPFIFKAIDDAGYTGWIGAE
YKPATTTDAGIGWFAPYKG
>Mature_258_residues
PKFAANLTMLWNEIDFLDRFAKAAEAGFKGVEYLFPYAYPKEELAERLEKHGLTQALHNLPAGEWAKGERGIAVLPDRVG
EFQDSVGTALEYAKVLKTQTLNVLAGIAPKDVPAEKIYETLVSNLKFAAAEAKKAGIPLVVEAINTRDIPGFYLNTTKQT
LSLLDDVGPQDVFFQYDIYHMQIMEGDLVPTLRANMARIKHIQLADNPGRGEPGTGEINYPFIFKAIDDAGYTGWIGAEY
KPATTTDAGIGWFAPYKG

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=263, Percent_Identity=36.1216730038023, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI300068964, Length=244, Percent_Identity=36.0655737704918, Blast_Score=146, Evalue=2e-35,
Organism=Escherichia coli, GI1786718, Length=258, Percent_Identity=53.4883720930233, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI1789095, Length=258, Percent_Identity=39.1472868217054, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17552022, Length=240, Percent_Identity=37.9166666666667, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI17530883, Length=257, Percent_Identity=32.295719844358, Blast_Score=137, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 28576; Mature: 28445

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFAANLTMLWNEIDFLDRFAKAAEAGFKGVEYLFPYAYPKEELAERLEKHGLTQALHN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCHHHHHHH
LPAGEWAKGERGIAVLPDRVGEFQDSVGTALEYAKVLKTQTLNVLAGIAPKDVPAEKIYE
CCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
TLVSNLKFAAAEAKKAGIPLVVEAINTRDIPGFYLNTTKQTLSLLDDVGPQDVFFQYDIY
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEEEE
HMQIMEGDLVPTLRANMARIKHIQLADNPGRGEPGTGEINYPFIFKAIDDAGYTGWIGAE
EEEEECCCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
YKPATTTDAGIGWFAPYKG
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKFAANLTMLWNEIDFLDRFAKAAEAGFKGVEYLFPYAYPKEELAERLEKHGLTQALHN
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCHHHHHHH
LPAGEWAKGERGIAVLPDRVGEFQDSVGTALEYAKVLKTQTLNVLAGIAPKDVPAEKIYE
CCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
TLVSNLKFAAAEAKKAGIPLVVEAINTRDIPGFYLNTTKQTLSLLDDVGPQDVFFQYDIY
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCHHHHHHHHHCCCCCCEEEEEEEE
HMQIMEGDLVPTLRANMARIKHIQLADNPGRGEPGTGEINYPFIFKAIDDAGYTGWIGAE
EEEEECCCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
YKPATTTDAGIGWFAPYKG
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]