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The map label for this gene is envZ [H]

Identifier: 158424378

GI number: 158424378

Start: 3129403

End: 3130665

Strand: Direct

Name: envZ [H]

Synonym: AZC_2754

Alternate gene names: 158424378

Gene position: 3129403-3130665 (Clockwise)

Preceding gene: 158424377

Following gene: 158424382

Centisome position: 58.28

GC content: 69.6

Gene sequence:

>1263_bases
ATGAATTCGCTCCGCACCAAGCTCATCGCGCTTCTCGTCACCGCGCTGGTGGTGGTGATCATCATCGCGACGGTCGTCTT
CTTCTACCTGGTCGCGCCCCGCCCGCAGCGGCCGGAGGGGGAGCGGCACATGGCGGAGGCCAGCGTCGTCGCGCTCATTA
TCGGCCTGCTCAAGGATCAGGCGCCGCCCCTGCACCTGCCGGCCATCAGCAATGGGGAGCCGGACGGCATGTATGACCCC
ATGGCGACGCAGGAGCTGGCCCATCTGCTGGCGCAGCTCGGTGTCACGGAACCGGTGCGGGTCTATCGGCGCGAATTCGG
CCGCCATGCAGCCGCCGTTCCGCTACCCGACGGCCGCTACGTGGTGCTGCCCATCCAATTGATGCCTCCCGGGCCGCCCG
GCGACCTGCCCTTCTTCCTCATCGGCTGGCTGGCGCTGGTGGCGCTCGGGACCACCGGCGTCGTCGCCGTCGCCGTCTAT
CGCATGACGAAGCCACTCGAGATCATCGAGCGGGCCGTGGCGGAGATCGGCCCGGACGGTGAGCTGCCGCGCCTTGAGGA
AAAGGGCACCACGGAAGTGCGCGCGGCGGCCGTCGCCATCAACCGCCTCTCGGACCGGCTGCGCAGTTCCATGGAGAGCC
GCATGCGCATCGTCGCGGCCGCCGCCCATGACCTGCGCACCCCCCTCACCCGCATGCGCCTGCGCGCGGAATTTCTGGAG
GAAGAGCGCGAGCAGTGGCTGTCGGACCTGAGCGAGCTTGACCGCATCGCCGACAGCGCCATCCGGCTCGTGCGCGAGGA
AGTGGAGAGCGCCGGAGACGAGCCGGTGGACCTCCACACTCTCGCCCGCGACCTGGAACGGGAGTTGAAGCAGACAGACC
TCAGCATCGAGCTGGTGCGGGCCGAGCCGGTGACGGTGGCCGGCCGTCCCATGGCGCTGAAGCGGGCCATGCGCAATCTC
ATGGTCAATGCCGCCACCCACGGCCGCTCCGCCCGCATGGCGGTCTCCGCCGAGGGCGGCAAGGGTGTGCTGGTGATCGA
GGACGACGGGCCAGGCATTCCCGATGCGCTGATGGCACGGGTGTTCGAACCCTTCTTTCGCGTGGATCCCGCGCGGCAGG
CAATCATTCCCGGCGCCGGGCTCGGACTTGCCATCGCCCACGAGATCGTCACCCGCCACGGCGGCCGCCTCTCCCTCTCG
AACCGCCCGAGCGGCGGCCTGCTCCAGCGCATGGAGCTGCCCGCCGCGACCGAGACGCTCTGA

Upstream 100 bases:

>100_bases
GGCGCAAGCTCGGGGACGCCGGCAGCTTCCAGATCCTGAAGACCCAGCGCAACGGCGGCTATCAGCTCTCCGTGCGCGTC
GAGGCGCTGAAGCCCTCCGC

Downstream 100 bases:

>100_bases
TACAGGTGGTGCCCTTGGGCGACGTCCATAGCCTTTCAAAATCCGCGGCCGGACCGCTGCCAAACCAGTGGGCGTGCGGT
GCAGCGGCGCGCGTGCCGTT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MNSLRTKLIALLVTALVVVIIIATVVFFYLVAPRPQRPEGERHMAEASVVALIIGLLKDQAPPLHLPAISNGEPDGMYDP
MATQELAHLLAQLGVTEPVRVYRREFGRHAAAVPLPDGRYVVLPIQLMPPGPPGDLPFFLIGWLALVALGTTGVVAVAVY
RMTKPLEIIERAVAEIGPDGELPRLEEKGTTEVRAAAVAINRLSDRLRSSMESRMRIVAAAAHDLRTPLTRMRLRAEFLE
EEREQWLSDLSELDRIADSAIRLVREEVESAGDEPVDLHTLARDLERELKQTDLSIELVRAEPVTVAGRPMALKRAMRNL
MVNAATHGRSARMAVSAEGGKGVLVIEDDGPGIPDALMARVFEPFFRVDPARQAIIPGAGLGLAIAHEIVTRHGGRLSLS
NRPSGGLLQRMELPAATETL

Sequences:

>Translated_420_residues
MNSLRTKLIALLVTALVVVIIIATVVFFYLVAPRPQRPEGERHMAEASVVALIIGLLKDQAPPLHLPAISNGEPDGMYDP
MATQELAHLLAQLGVTEPVRVYRREFGRHAAAVPLPDGRYVVLPIQLMPPGPPGDLPFFLIGWLALVALGTTGVVAVAVY
RMTKPLEIIERAVAEIGPDGELPRLEEKGTTEVRAAAVAINRLSDRLRSSMESRMRIVAAAAHDLRTPLTRMRLRAEFLE
EEREQWLSDLSELDRIADSAIRLVREEVESAGDEPVDLHTLARDLERELKQTDLSIELVRAEPVTVAGRPMALKRAMRNL
MVNAATHGRSARMAVSAEGGKGVLVIEDDGPGIPDALMARVFEPFFRVDPARQAIIPGAGLGLAIAHEIVTRHGGRLSLS
NRPSGGLLQRMELPAATETL
>Mature_420_residues
MNSLRTKLIALLVTALVVVIIIATVVFFYLVAPRPQRPEGERHMAEASVVALIIGLLKDQAPPLHLPAISNGEPDGMYDP
MATQELAHLLAQLGVTEPVRVYRREFGRHAAAVPLPDGRYVVLPIQLMPPGPPGDLPFFLIGWLALVALGTTGVVAVAVY
RMTKPLEIIERAVAEIGPDGELPRLEEKGTTEVRAAAVAINRLSDRLRSSMESRMRIVAAAAHDLRTPLTRMRLRAEFLE
EEREQWLSDLSELDRIADSAIRLVREEVESAGDEPVDLHTLARDLERELKQTDLSIELVRAEPVTVAGRPMALKRAMRNL
MVNAATHGRSARMAVSAEGGKGVLVIEDDGPGIPDALMARVFEPFFRVDPARQAIIPGAGLGLAIAHEIVTRHGGRLSLS
NRPSGGLLQRMELPAATETL

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=264, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1787894, Length=279, Percent_Identity=29.3906810035842, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1790346, Length=267, Percent_Identity=28.0898876404494, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082128, Length=308, Percent_Identity=27.5974025974026, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790551, Length=270, Percent_Identity=28.8888888888889, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=321, Percent_Identity=25.5451713395639, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786600, Length=217, Percent_Identity=30.4147465437788, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=32.7659574468085, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788393, Length=240, Percent_Identity=25.4166666666667, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789403, Length=315, Percent_Identity=26.031746031746, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=214, Percent_Identity=27.1028037383178, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45779; Mature: 45779

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLRTKLIALLVTALVVVIIIATVVFFYLVAPRPQRPEGERHMAEASVVALIIGLLKDQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
APPLHLPAISNGEPDGMYDPMATQELAHLLAQLGVTEPVRVYRREFGRHAAAVPLPDGRY
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCE
VVLPIQLMPPGPPGDLPFFLIGWLALVALGTTGVVAVAVYRMTKPLEIIERAVAEIGPDG
EEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
ELPRLEEKGTTEVRAAAVAINRLSDRLRSSMESRMRIVAAAAHDLRTPLTRMRLRAEFLE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEREQWLSDLSELDRIADSAIRLVREEVESAGDEPVDLHTLARDLERELKQTDLSIELVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
AEPVTVAGRPMALKRAMRNLMVNAATHGRSARMAVSAEGGKGVLVIEDDGPGIPDALMAR
CCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHH
VFEPFFRVDPARQAIIPGAGLGLAIAHEIVTRHGGRLSLSNRPSGGLLQRMELPAATETL
HHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHCCCCHHCCC
>Mature Secondary Structure
MNSLRTKLIALLVTALVVVIIIATVVFFYLVAPRPQRPEGERHMAEASVVALIIGLLKDQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
APPLHLPAISNGEPDGMYDPMATQELAHLLAQLGVTEPVRVYRREFGRHAAAVPLPDGRY
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCE
VVLPIQLMPPGPPGDLPFFLIGWLALVALGTTGVVAVAVYRMTKPLEIIERAVAEIGPDG
EEEEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
ELPRLEEKGTTEVRAAAVAINRLSDRLRSSMESRMRIVAAAAHDLRTPLTRMRLRAEFLE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EEREQWLSDLSELDRIADSAIRLVREEVESAGDEPVDLHTLARDLERELKQTDLSIELVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
AEPVTVAGRPMALKRAMRNLMVNAATHGRSARMAVSAEGGKGVLVIEDDGPGIPDALMAR
CCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHH
VFEPFFRVDPARQAIIPGAGLGLAIAHEIVTRHGGRLSLSNRPSGGLLQRMELPAATETL
HHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]