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The map label for this gene is mscS [H]

Identifier: 158424016

GI number: 158424016

Start: 2718278

End: 2720620

Strand: Reverse

Name: mscS [H]

Synonym: AZC_2392

Alternate gene names: 158424016

Gene position: 2720620-2718278 (Counterclockwise)

Preceding gene: 158424017

Following gene: 158424013

Centisome position: 50.67

GC content: 68.33

Gene sequence:

>2343_bases
TTGATGCAGCGATGCGCCATGATCCGGGCCTTGTGCCTGGCGCTTTGCCTCCTGTTCAGCTCTGCCAGTTTCGCCCAGAC
CCCGGCCGCGCCTGCGGGGTCCGTAACGTCTCCCGCCACCGCCGCGCCCAAGAGCGAGGACAGCCTCAAGGTGCTCCTCG
ACACGCTCTCCGACGACAAGGCGCGGGCGGATTTCACCGCCCGGCTGCGCGCTCTGCTCGAAGCGCGCGACGCCACGACC
GGCACGCCGGCCGCCGATGACTGGGTGGCCGGCACCACCCGCTCCCTCTCCGATTTCTCCAGCGGCGTGCTGACCGTGGT
GGGCGAGATCGAGAACTTGCCGACCCAGATGTCCGAGGCCGTGGAAGCGCTGCGCGACCCGGCGGCCCTGCGGCGTATCG
CGTGGGCGGCCGGCACCGTGGTGCTCGCGCTGGCGGCCGCCTTTGCCGCCGAGTGGCTGGCGTCCTTGCTGCTCGCGCGC
CCGCGCCGGGCCATCGAGCGGCGGGCGGGCGATCTTCTCGTCATCCGCCTCTTCCTCATTCTGGTGCGGGCGGTGCTGCT
GGCCTTGCCCATCATCGCTTTTGCCGCCGCCGCTTTCGCGGTGCTGGGCGCGGTGGAGATGAGCTTCGTGGTGCGCCTCG
CCGTGGTCACGCTGGTCAATGCGAGCGTGATGGCGCGGGCGATCATTGCGTTCGGCCATGCGGTGCTCTCGCCCGAGAGC
CGGCGCCTGCGCCTGCCGCCGCTGGACGACGAGAGTGCGGCCTATGGCTTCCTTTGGGTCGGGCGCTTCGCCAACACCGT
CGTCTATGGCTATTTCCTGCTGCGGGCGGCCTGGATCCTCGGCCTCTCGACCAGCGCCTATGCCTTCCTCCTGGATGTGC
TCGGGCTGCTGGTGGCCGGCATGGCCATCGTCTTCCTGCTCCAGATCCGCGCCTCGGTGGCGGGCTGGCTGCGGGCCTCG
GGCGAAGCCGGCACGTCGCTTACGCGCCTGCGCAATCAGGTGGCGGATTTCTGGCACCTGCTCGCCATCGCTTATGTGGT
GGCCGGCTATTTCGTCTGGGTTCTGGATGTGCGGGACGGCTTTGCCTTTCTCGCGCAGGCGACCGCTCTCTCGGTGCTTG
CCATCGTCGCTGCGCGCTTCGCCGCGCGCCTCCTCCAGCGCGGCTTCGGCATGATCTTCCACCTCAGCCCCGAGGTGCGG
CGGCAGTATCCGCTGCTGGAGGCGCGAGCGAACCGCTATCTGCCCATCCTGCGGCAGGTGTTCCAGGGCCTGCTGGCGGT
CCTGACGCTGCTGGTGCTGCTGGAAATCTGGGGCGGAAGTCCCTTCGCGTGGCTCGCCTCCGACAACGGCCAGCGCCTGC
TCAGCCGCTGCATCTCCATTGGCGTCGTGGCGCTCTCGGCGCTCATCGCCTGGGAGGTGGGCACCGCCTTTGCCGAGCGG
CTGATCCGCCGGCATCCGTCGTCAAGCCGGCTAAAGACATTGTTGCCCTTCCTCCAGAATGGCTTTCGCGTGGTGCTTCT
GACGCTGGTGGGGCTGATCCTGCTCTCGGAAATCGGCGTCAACATCGCCCCGCTTCTGGCCGGTGCCGGTGTCTTCGGCC
TCGCCATCGGCTTCGGGGCGCAGACGCTGGTGAAGGATGTCATCACCGGCATCTTCATCCTCATGGAGGACACGCTGTCG
GTGGGTGATGTGGTGGAGGTGGGCGCCCATTCGGGTCTCGTGGAAAAAATCACCATCCGCACGGTGCACATGCGCGATTT
CGACGGCAACGTGCATTCCATCCCCTTCAGCGAGGTGCAGACCATCAAGAACATGTCCAAGGGCTTCGCTTATGCGGTCG
TGGACGTGATGGTCTCCTACCGGGAGAATATCGACGAGGCGCTGAAGACCATGGCCGAGGTGGCGGAGGACATGCGCCGC
GCCGGGCCGCTGGCCGAGACCATCATCGAGCCGTTCGAGGTGGTGGGCGTGGAGGGCCTTCAGGAATCCGCCGTCTGGCT
GCGCGGCCGCTTCAAGACGCGCCCGCTCGGCCAGTGGAACGTGAAGCGCGAATTCTACCGGCGCATCAAGGCAGCGTTCG
ATGCGCGGGGCATCGAGATTCCGCTTCCCCAGCGCCGGCTCTTCTTCGGCACCGACAAGGCCGGCAACGCCCCGCCGCTG
CATATCCTCACCGATGCCAACGCCCTTCAGGTGCAGGAGGACCGGCGCCGCGTGGCGGAGGCCGCCCGCGCCGCCCGTCG
GCCGGGACCGCATATCGAGGAGCATCCGGGCGCGCGGGAGCGCCGGGACGACGAGGCGCAGGAGATCCTGCCCACCGTGG
AGCGCCACCCCGAGCGGGTGTGA

Upstream 100 bases:

>100_bases
CCCCGTCGCGCTGCGCTGCGGAACGATCCCGCCGCCCGACCGTTGCAGGAGAGGCGCCCCTTGCCGCGGGGCGCCTCTGC
CCGCAGCAAAGAGGGATGGC

Downstream 100 bases:

>100_bases
AGCTCAGGGTGCGCTGGCCACCGGCTGGAGGAAGGTCAGTTCGCTGTCGTCATAGCGCCGGCGCTCGATTTCCTCGAAGC
CGTCCGGCACCGTGAAGGCG

Product: mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MMQRCAMIRALCLALCLLFSSASFAQTPAAPAGSVTSPATAAPKSEDSLKVLLDTLSDDKARADFTARLRALLEARDATT
GTPAADDWVAGTTRSLSDFSSGVLTVVGEIENLPTQMSEAVEALRDPAALRRIAWAAGTVVLALAAAFAAEWLASLLLAR
PRRAIERRAGDLLVIRLFLILVRAVLLALPIIAFAAAAFAVLGAVEMSFVVRLAVVTLVNASVMARAIIAFGHAVLSPES
RRLRLPPLDDESAAYGFLWVGRFANTVVYGYFLLRAAWILGLSTSAYAFLLDVLGLLVAGMAIVFLLQIRASVAGWLRAS
GEAGTSLTRLRNQVADFWHLLAIAYVVAGYFVWVLDVRDGFAFLAQATALSVLAIVAARFAARLLQRGFGMIFHLSPEVR
RQYPLLEARANRYLPILRQVFQGLLAVLTLLVLLEIWGGSPFAWLASDNGQRLLSRCISIGVVALSALIAWEVGTAFAER
LIRRHPSSSRLKTLLPFLQNGFRVVLLTLVGLILLSEIGVNIAPLLAGAGVFGLAIGFGAQTLVKDVITGIFILMEDTLS
VGDVVEVGAHSGLVEKITIRTVHMRDFDGNVHSIPFSEVQTIKNMSKGFAYAVVDVMVSYRENIDEALKTMAEVAEDMRR
AGPLAETIIEPFEVVGVEGLQESAVWLRGRFKTRPLGQWNVKREFYRRIKAAFDARGIEIPLPQRRLFFGTDKAGNAPPL
HILTDANALQVQEDRRRVAEAARAARRPGPHIEEHPGARERRDDEAQEILPTVERHPERV

Sequences:

>Translated_780_residues
MMQRCAMIRALCLALCLLFSSASFAQTPAAPAGSVTSPATAAPKSEDSLKVLLDTLSDDKARADFTARLRALLEARDATT
GTPAADDWVAGTTRSLSDFSSGVLTVVGEIENLPTQMSEAVEALRDPAALRRIAWAAGTVVLALAAAFAAEWLASLLLAR
PRRAIERRAGDLLVIRLFLILVRAVLLALPIIAFAAAAFAVLGAVEMSFVVRLAVVTLVNASVMARAIIAFGHAVLSPES
RRLRLPPLDDESAAYGFLWVGRFANTVVYGYFLLRAAWILGLSTSAYAFLLDVLGLLVAGMAIVFLLQIRASVAGWLRAS
GEAGTSLTRLRNQVADFWHLLAIAYVVAGYFVWVLDVRDGFAFLAQATALSVLAIVAARFAARLLQRGFGMIFHLSPEVR
RQYPLLEARANRYLPILRQVFQGLLAVLTLLVLLEIWGGSPFAWLASDNGQRLLSRCISIGVVALSALIAWEVGTAFAER
LIRRHPSSSRLKTLLPFLQNGFRVVLLTLVGLILLSEIGVNIAPLLAGAGVFGLAIGFGAQTLVKDVITGIFILMEDTLS
VGDVVEVGAHSGLVEKITIRTVHMRDFDGNVHSIPFSEVQTIKNMSKGFAYAVVDVMVSYRENIDEALKTMAEVAEDMRR
AGPLAETIIEPFEVVGVEGLQESAVWLRGRFKTRPLGQWNVKREFYRRIKAAFDARGIEIPLPQRRLFFGTDKAGNAPPL
HILTDANALQVQEDRRRVAEAARAARRPGPHIEEHPGARERRDDEAQEILPTVERHPERV
>Mature_780_residues
MMQRCAMIRALCLALCLLFSSASFAQTPAAPAGSVTSPATAAPKSEDSLKVLLDTLSDDKARADFTARLRALLEARDATT
GTPAADDWVAGTTRSLSDFSSGVLTVVGEIENLPTQMSEAVEALRDPAALRRIAWAAGTVVLALAAAFAAEWLASLLLAR
PRRAIERRAGDLLVIRLFLILVRAVLLALPIIAFAAAAFAVLGAVEMSFVVRLAVVTLVNASVMARAIIAFGHAVLSPES
RRLRLPPLDDESAAYGFLWVGRFANTVVYGYFLLRAAWILGLSTSAYAFLLDVLGLLVAGMAIVFLLQIRASVAGWLRAS
GEAGTSLTRLRNQVADFWHLLAIAYVVAGYFVWVLDVRDGFAFLAQATALSVLAIVAARFAARLLQRGFGMIFHLSPEVR
RQYPLLEARANRYLPILRQVFQGLLAVLTLLVLLEIWGGSPFAWLASDNGQRLLSRCISIGVVALSALIAWEVGTAFAER
LIRRHPSSSRLKTLLPFLQNGFRVVLLTLVGLILLSEIGVNIAPLLAGAGVFGLAIGFGAQTLVKDVITGIFILMEDTLS
VGDVVEVGAHSGLVEKITIRTVHMRDFDGNVHSIPFSEVQTIKNMSKGFAYAVVDVMVSYRENIDEALKTMAEVAEDMRR
AGPLAETIIEPFEVVGVEGLQESAVWLRGRFKTRPLGQWNVKREFYRRIKAAFDARGIEIPLPQRRLFFGTDKAGNAPPL
HILTDANALQVQEDRRRVAEAARAARRPGPHIEEHPGARERRDDEAQEILPTVERHPERV

Specific function: Unknown

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI87081787, Length=494, Percent_Identity=32.9959514170041, Blast_Score=203, Evalue=4e-53,
Organism=Escherichia coli, GI2367355, Length=423, Percent_Identity=26.0047281323877, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789291, Length=274, Percent_Identity=24.8175182481752, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR011014 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 84955; Mature: 84955

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQRCAMIRALCLALCLLFSSASFAQTPAAPAGSVTSPATAAPKSEDSLKVLLDTLSDDK
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCH
ARADFTARLRALLEARDATTGTPAADDWVAGTTRSLSDFSSGVLTVVGEIENLPTQMSEA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCHHHHHHH
VEALRDPAALRRIAWAAGTVVLALAAAFAAEWLASLLLARPRRAIERRAGDLLVIRLFLI
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHH
LVRAVLLALPIIAFAAAAFAVLGAVEMSFVVRLAVVTLVNASVMARAIIAFGHAVLSPES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RRLRLPPLDDESAAYGFLWVGRFANTVVYGYFLLRAAWILGLSTSAYAFLLDVLGLLVAG
CCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MAIVFLLQIRASVAGWLRASGEAGTSLTRLRNQVADFWHLLAIAYVVAGYFVWVLDVRDG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
FAFLAQATALSVLAIVAARFAARLLQRGFGMIFHLSPEVRRQYPLLEARANRYLPILRQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCHHHHHHHCCHHHHHHH
FQGLLAVLTLLVLLEIWGGSPFAWLASDNGQRLLSRCISIGVVALSALIAWEVGTAFAER
HHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIRRHPSSSRLKTLLPFLQNGFRVVLLTLVGLILLSEIGVNIAPLLAGAGVFGLAIGFGA
HHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCCH
QTLVKDVITGIFILMEDTLSVGDVVEVGAHSGLVEKITIRTVHMRDFDGNVHSIPFSEVQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHEEEEEEEEEECCCCCCCCCCHHHHH
TIKNMSKGFAYAVVDVMVSYRENIDEALKTMAEVAEDMRRAGPLAETIIEPFEVVGVEGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCH
QESAVWLRGRFKTRPLGQWNVKREFYRRIKAAFDARGIEIPLPQRRLFFGTDKAGNAPPL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCE
HILTDANALQVQEDRRRVAEAARAARRPGPHIEEHPGARERRDDEAQEILPTVERHPERV
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MMQRCAMIRALCLALCLLFSSASFAQTPAAPAGSVTSPATAAPKSEDSLKVLLDTLSDDK
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCH
ARADFTARLRALLEARDATTGTPAADDWVAGTTRSLSDFSSGVLTVVGEIENLPTQMSEA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCHHHHHHH
VEALRDPAALRRIAWAAGTVVLALAAAFAAEWLASLLLARPRRAIERRAGDLLVIRLFLI
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHH
LVRAVLLALPIIAFAAAAFAVLGAVEMSFVVRLAVVTLVNASVMARAIIAFGHAVLSPES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RRLRLPPLDDESAAYGFLWVGRFANTVVYGYFLLRAAWILGLSTSAYAFLLDVLGLLVAG
CCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MAIVFLLQIRASVAGWLRASGEAGTSLTRLRNQVADFWHLLAIAYVVAGYFVWVLDVRDG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
FAFLAQATALSVLAIVAARFAARLLQRGFGMIFHLSPEVRRQYPLLEARANRYLPILRQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCHHHHHHHCCHHHHHHH
FQGLLAVLTLLVLLEIWGGSPFAWLASDNGQRLLSRCISIGVVALSALIAWEVGTAFAER
HHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIRRHPSSSRLKTLLPFLQNGFRVVLLTLVGLILLSEIGVNIAPLLAGAGVFGLAIGFGA
HHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCCH
QTLVKDVITGIFILMEDTLSVGDVVEVGAHSGLVEKITIRTVHMRDFDGNVHSIPFSEVQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHEEEEEEEEEECCCCCCCCCCHHHHH
TIKNMSKGFAYAVVDVMVSYRENIDEALKTMAEVAEDMRRAGPLAETIIEPFEVVGVEGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCH
QESAVWLRGRFKTRPLGQWNVKREFYRRIKAAFDARGIEIPLPQRRLFFGTDKAGNAPPL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCE
HILTDANALQVQEDRRRVAEAARAARRPGPHIEEHPGARERRDDEAQEILPTVERHPERV
EEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]