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The map label for this gene is mutL

Identifier: 158424017

GI number: 158424017

Start: 2720723

End: 2722600

Strand: Reverse

Name: mutL

Synonym: AZC_2393

Alternate gene names: 158424017

Gene position: 2722600-2720723 (Counterclockwise)

Preceding gene: 158424018

Following gene: 158424016

Centisome position: 50.7

GC content: 70.71

Gene sequence:

>1878_bases
ATGACCATCCGTCGCCTTCCGCCCGTTCTCATTGATCGCATCGCCGCGGGCGAAGTGGTCGAGCGTCCTGCGGCGGCCGT
GAAGGAACTGGTCGAGAATGCGATCGATGCCGGCGCCACGGAGATCGAGGTGCTGGTGGTCGGTGGCGGACGGGAGATGA
TCCGCATCTCCGACAATGGCTCCGGCATGAGTGCGGACGAACTGTCCCTCGCCGTCGAGCGTCACGCCACCTCCAAGCTC
CCCACCGAAGACCTTCTCGCCATTTCGACGCTGGGCTTCCGGGGTGAGGCGCTGCCCTCAATTGGCGCCGTGGCGCGCCT
CTCCATCGCCAGCCGCCCCAAGTCCGCGCCCCATGCCTTCGAGATTCGCGTCGAGGGCGGGGTCGTCACCCCGCCCCGTC
CGGCGGCGCTCAATGGCGGCACGCGGGTGGAGGTGCGCGATCTCTTCTTCGCGACGCCCGCGCGCCTGAAATTCCTGAAA
TCCGACCGGGCCGAAGCCGCCGCCGCCGCGGACGTGGTGCGCCGCCTCGCGCTGGCCCGGCCCGATGTCGCCTTCACCTT
GATGACTGATGACCGCCAGCCCCTCACCTGGGTGGCGAGGTCCATGGATGAGGCCGGTCGCGCAGCCCGTGTCGCCGATG
TCCTCGGCGCGGAGGCGGGGCGCAACCTCATTCCGGTGGTGGGCGAGCGGGGCGGGGTGCGGCTGGTGGGGCTCGCGGGA
CTGCCCACCTATTCCAAGGCCAATTCGCTCTCCCAATTCCTGTTCGTGAACGGCCGGCCGGTACGGGACAAACTGCTGAT
GGGCGCGCTTCGAGCCGCCTATTCCGACCTGCTGCCTTCCGACCGCTATCCGGTGCTCGCCCTCTTCCTCAGCCTCGATC
CGCGCGAGGTGGACGTGAACGTTCATCCCGCCAAGACCGAGGTGCGCTTTCGCGACGGGGGGAACGTGCGCGCCCTTCTG
GTGCGCACGCTGACCGATGCGCTCGCCGCCCGCGTGCCGAGCACCGCCGGCACCATCGCCGACCGGCTGGTGGAACTCGC
CCGCACGCCGGAACTGGAGCCGGCGCGCCCCGCCGCCGCCATCCCGGAGTTCCGGCCCTATCGGGCCGAGCCCATGCCGG
CCGGGGGCTACGATTGGCGCGCCTCCCCCGCGCGCCCGCTGAACGTGGCGGAGCCGGACGGGGCGCTCGAGGCCGAGATG
GAAAGCTTCGCCGAAGCGGTGCAGGCTTCCTTCGACGTCGGGATGCCCGCCGCGGACGCCCGCGCCGATGCGGCCGTGCC
CGAGACGGGCGATCTCGACCGGCCGCTGGGCGCGGCGCGCGCGCAACTGCACGAGACCTACATCGTCGCGCAAACCCGCG
AGGGCATGGTGCTGGTGGATCAGCACGCCGCCCATGAGCGCCTCGTCTATGAGAAGCTGAAGGCCGCGCTGGAGCGGGAC
GGGGTGGCACGGCAGGGCCTGCTGGTGCCTGCGGTGGTCGATCTCGATCCGGCCGAGGCGGACCGGCTGGCGGAGCGGGC
TGGGGATCTGGCGGCGCTCGGGCTCGTCATCGAGCCCTTCGGCATCGGCGCGGTTCTGGTGCGCGAGGTGCCGGCGCTGC
TCGCCAAGGCGGACGTGACGAAACTCGTGCGGGACGTGGCTGAGCATTCCGCGGAATGGGATGACGCGCTCCCGCTGGAG
CGGCGCCTGCTGCACGTGGCCGCCACCATGGCTTGCCACGGCTCCGTGCGGGCCGGCCGGCGCCTTAGGGTGGAGGAGAT
GAACGCCCTCCTGCGGGAGATGGAGGAGACGCCGAACGCCGGCGAGTGCAATCACGGACGGCCGACCTTCATCACTTTGT
CCCTGAAGGACGTGGAAAAACTGTTCGCCCGCCGCTGA

Upstream 100 bases:

>100_bases
TTTGCGTGGACGACGCAGCAGCCTCCGGGCCCTCGATTAGGGAGGAGGGGCCCGCTGCTCTAGGATCGGGCCGTTCCCAG
TCATCGGCCGAATCATCCTC

Downstream 100 bases:

>100_bases
GGCCCCGTCGCGCTGCGCTGCGGAACGATCCCGCCGCCCGACCGTTGCAGGAGAGGCGCCCCTTGCCGCGGGGCGCCTCT
GCCCGCAGCAAAGAGGGATG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MTIRRLPPVLIDRIAAGEVVERPAAAVKELVENAIDAGATEIEVLVVGGGREMIRISDNGSGMSADELSLAVERHATSKL
PTEDLLAISTLGFRGEALPSIGAVARLSIASRPKSAPHAFEIRVEGGVVTPPRPAALNGGTRVEVRDLFFATPARLKFLK
SDRAEAAAAADVVRRLALARPDVAFTLMTDDRQPLTWVARSMDEAGRAARVADVLGAEAGRNLIPVVGERGGVRLVGLAG
LPTYSKANSLSQFLFVNGRPVRDKLLMGALRAAYSDLLPSDRYPVLALFLSLDPREVDVNVHPAKTEVRFRDGGNVRALL
VRTLTDALAARVPSTAGTIADRLVELARTPELEPARPAAAIPEFRPYRAEPMPAGGYDWRASPARPLNVAEPDGALEAEM
ESFAEAVQASFDVGMPAADARADAAVPETGDLDRPLGAARAQLHETYIVAQTREGMVLVDQHAAHERLVYEKLKAALERD
GVARQGLLVPAVVDLDPAEADRLAERAGDLAALGLVIEPFGIGAVLVREVPALLAKADVTKLVRDVAEHSAEWDDALPLE
RRLLHVAATMACHGSVRAGRRLRVEEMNALLREMEETPNAGECNHGRPTFITLSLKDVEKLFARR

Sequences:

>Translated_625_residues
MTIRRLPPVLIDRIAAGEVVERPAAAVKELVENAIDAGATEIEVLVVGGGREMIRISDNGSGMSADELSLAVERHATSKL
PTEDLLAISTLGFRGEALPSIGAVARLSIASRPKSAPHAFEIRVEGGVVTPPRPAALNGGTRVEVRDLFFATPARLKFLK
SDRAEAAAAADVVRRLALARPDVAFTLMTDDRQPLTWVARSMDEAGRAARVADVLGAEAGRNLIPVVGERGGVRLVGLAG
LPTYSKANSLSQFLFVNGRPVRDKLLMGALRAAYSDLLPSDRYPVLALFLSLDPREVDVNVHPAKTEVRFRDGGNVRALL
VRTLTDALAARVPSTAGTIADRLVELARTPELEPARPAAAIPEFRPYRAEPMPAGGYDWRASPARPLNVAEPDGALEAEM
ESFAEAVQASFDVGMPAADARADAAVPETGDLDRPLGAARAQLHETYIVAQTREGMVLVDQHAAHERLVYEKLKAALERD
GVARQGLLVPAVVDLDPAEADRLAERAGDLAALGLVIEPFGIGAVLVREVPALLAKADVTKLVRDVAEHSAEWDDALPLE
RRLLHVAATMACHGSVRAGRRLRVEEMNALLREMEETPNAGECNHGRPTFITLSLKDVEKLFARR
>Mature_624_residues
TIRRLPPVLIDRIAAGEVVERPAAAVKELVENAIDAGATEIEVLVVGGGREMIRISDNGSGMSADELSLAVERHATSKLP
TEDLLAISTLGFRGEALPSIGAVARLSIASRPKSAPHAFEIRVEGGVVTPPRPAALNGGTRVEVRDLFFATPARLKFLKS
DRAEAAAAADVVRRLALARPDVAFTLMTDDRQPLTWVARSMDEAGRAARVADVLGAEAGRNLIPVVGERGGVRLVGLAGL
PTYSKANSLSQFLFVNGRPVRDKLLMGALRAAYSDLLPSDRYPVLALFLSLDPREVDVNVHPAKTEVRFRDGGNVRALLV
RTLTDALAARVPSTAGTIADRLVELARTPELEPARPAAAIPEFRPYRAEPMPAGGYDWRASPARPLNVAEPDGALEAEME
SFAEAVQASFDVGMPAADARADAAVPETGDLDRPLGAARAQLHETYIVAQTREGMVLVDQHAAHERLVYEKLKAALERDG
VARQGLLVPAVVDLDPAEADRLAERAGDLAALGLVIEPFGIGAVLVREVPALLAKADVTKLVRDVAEHSAEWDDALPLER
RLLHVAATMACHGSVRAGRRLRVEEMNALLREMEETPNAGECNHGRPTFITLSLKDVEKLFARR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=313, Percent_Identity=37.6996805111821, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI4505911, Length=350, Percent_Identity=28, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI189458898, Length=350, Percent_Identity=28, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI4505913, Length=345, Percent_Identity=28.9855072463768, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI310128478, Length=345, Percent_Identity=28.9855072463768, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI189458896, Length=348, Percent_Identity=26.4367816091954, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI263191589, Length=219, Percent_Identity=31.0502283105023, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI310128480, Length=306, Percent_Identity=26.797385620915, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI91992160, Length=332, Percent_Identity=26.5060240963855, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI91992162, Length=332, Percent_Identity=26.5060240963855, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790612, Length=560, Percent_Identity=34.4642857142857, Blast_Score=251, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71991825, Length=330, Percent_Identity=36.0606060606061, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17562796, Length=341, Percent_Identity=26.6862170087977, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=319, Percent_Identity=38.871473354232, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324247, Length=353, Percent_Identity=27.4787535410765, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=731, Percent_Identity=20.656634746922, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=397, Percent_Identity=26.1964735516373, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17136968, Length=314, Percent_Identity=37.8980891719745, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI17136970, Length=344, Percent_Identity=26.453488372093, Blast_Score=106, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_AZOC5 (A8I6D2)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001525309.1
- ProteinModelPortal:   A8I6D2
- SMR:   A8I6D2
- GeneID:   5691771
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_2393
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   ACAU438753:AZC_2393-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 67053; Mature: 66921

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRRLPPVLIDRIAAGEVVERPAAAVKELVENAIDAGATEIEVLVVGGGREMIRISDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCC
SGMSADELSLAVERHATSKLPTEDLLAISTLGFRGEALPSIGAVARLSIASRPKSAPHAF
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
EIRVEGGVVTPPRPAALNGGTRVEVRDLFFATPARLKFLKSDRAEAAAAADVVRRLALAR
EEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDVAFTLMTDDRQPLTWVARSMDEAGRAARVADVLGAEAGRNLIPVVGERGGVRLVGLAG
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEC
LPTYSKANSLSQFLFVNGRPVRDKLLMGALRAAYSDLLPSDRYPVLALFLSLDPREVDVN
CCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEE
VHPAKTEVRFRDGGNVRALLVRTLTDALAARVPSTAGTIADRLVELARTPELEPARPAAA
ECCCCEEEEECCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
IPEFRPYRAEPMPAGGYDWRASPARPLNVAEPDGALEAEMESFAEAVQASFDVGMPAADA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
RADAAVPETGDLDRPLGAARAQLHETYIVAQTREGMVLVDQHAAHERLVYEKLKAALERD
CCCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHC
GVARQGLLVPAVVDLDPAEADRLAERAGDLAALGLVIEPFGIGAVLVREVPALLAKADVT
CCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
KLVRDVAEHSAEWDDALPLERRLLHVAATMACHGSVRAGRRLRVEEMNALLREMEETPNA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCEECHHHHHHHHHHHHHCCCC
GECNHGRPTFITLSLKDVEKLFARR
CCCCCCCCEEEEEEHHHHHHHHHCC
>Mature Secondary Structure 
TIRRLPPVLIDRIAAGEVVERPAAAVKELVENAIDAGATEIEVLVVGGGREMIRISDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCC
SGMSADELSLAVERHATSKLPTEDLLAISTLGFRGEALPSIGAVARLSIASRPKSAPHAF
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
EIRVEGGVVTPPRPAALNGGTRVEVRDLFFATPARLKFLKSDRAEAAAAADVVRRLALAR
EEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDVAFTLMTDDRQPLTWVARSMDEAGRAARVADVLGAEAGRNLIPVVGERGGVRLVGLAG
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEC
LPTYSKANSLSQFLFVNGRPVRDKLLMGALRAAYSDLLPSDRYPVLALFLSLDPREVDVN
CCCCHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEE
VHPAKTEVRFRDGGNVRALLVRTLTDALAARVPSTAGTIADRLVELARTPELEPARPAAA
ECCCCEEEEECCCCCEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
IPEFRPYRAEPMPAGGYDWRASPARPLNVAEPDGALEAEMESFAEAVQASFDVGMPAADA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
RADAAVPETGDLDRPLGAARAQLHETYIVAQTREGMVLVDQHAAHERLVYEKLKAALERD
CCCCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHC
GVARQGLLVPAVVDLDPAEADRLAERAGDLAALGLVIEPFGIGAVLVREVPALLAKADVT
CCCCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
KLVRDVAEHSAEWDDALPLERRLLHVAATMACHGSVRAGRRLRVEEMNALLREMEETPNA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCEECHHHHHHHHHHHHHCCCC
GECNHGRPTFITLSLKDVEKLFARR
CCCCCCCCEEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA