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The map label for this gene is dxr [H]

Identifier: 158423323

GI number: 158423323

Start: 1945154

End: 1946323

Strand: Direct

Name: dxr [H]

Synonym: AZC_1699

Alternate gene names: 158423323

Gene position: 1945154-1946323 (Clockwise)

Preceding gene: 158423322

Following gene: 158423324

Centisome position: 36.22

GC content: 70.77

Gene sequence:

>1170_bases
ATGACTTCGGTTTCCATCCTCGGCGCCACGGGTTCGGTCGGCCGCAGCACCGTCAGGGTGCTGGAGGGGGAACGGGAGCG
GTTCCGGGTGGAGGCGGTGGCGGGTGGTCGTGATGCGGCCGGGCTCGCCGAGCTTGCCATCCACCTCGGGGCCAAGTTCG
CCGCCGTGGCCGATGATGCGGCCGGTGCCGAGCTGAAGGCCCGGCTCGCCGGCACGGGGATCGCCTGCGGCGCCGGCCGG
ACGGCGGTGCTTGAGGCGGCGGCGCGGGATGCGGATATCGTGGTGGCGGGCATTTCCGGCATTGCGGGCCTTGAGCCGAC
CGTCGCGGCGTTCCGCGCCGGCCGGCGGATCGGCGTCGCCAACAAGGAATGCCTCGTGGCCGCCGGTGCCTTCTTCACGG
CCGAGGCGGAGCGGGTCGGGGCGGAGATCTTCCCCGTCGATTCCGAGCACAATGCCATCTTCCAGGCCCTGTCCGCGGGG
CCGCGCGCGGCCGTGGAGAAGGTGCAGATCACCGCGTCGGGCGGACCGTTCCGCACCGCCCCGCGCGAGGCGATCGCCAA
GGCCGGGCCGGCGGCGGCGCTGAAGCACCCCAACTGGTCCATGGGGGCCAAGATCACCATCGATTCGGCCACGCTCATGA
ACAAGGGGCTGGAACTGATCGAGGCGCACCACCTCTTCGGCGTGCCGCCGGAGCAGCTCGAGGTGATCGTCCATCCCGAA
TCCATCGTCCACGGTCTGGTGGCGTTCGAGGACGGGTCGGTGGTGGCGGTGCTCGCCATGCCCGACATGGCCCTGCCCAT
CGCCCATTGCCTCAGCCATCCCGGCCGTCTGCCCACCACGTGCCGGAAGCTCGACCTTGCCGCTCTCGGCCGCCTCACCT
TCGAGGCGCCGGATCTCGACCGCTTCCCGTGCCTGAGCCTCGCGCTGTCCGCGCTGGGGGAGGGGGGGGCGGCACCGACG
ATCCTCAACGGCGCCAATGAGGTGGCGGTCGCCGCCTTCCTCGAAGGCCGCATCGGCTTCTACGGAATCAGTGCCATCGT
CGAGGAAACGCTGGCGCTGGCGACGCGCGGTGCGGCACCCGCATCGGTTGCCGAGGCGCTGCAACTCGACGCCGAGGCGC
GGCGCATTGCCCTTTCCCTCTTGCCTAAGTTTGCCGCAAAGGCATCCTAA

Upstream 100 bases:

>100_bases
CGATGGCTTTGCCGCCGCCGCGCTGGCGGCGCTCGTGATCGCCGTGCTTCACGGCGGCCCGACGCCCGCCGCCGGTCTGC
TTCTCTGGTAGGACATTGCC

Downstream 100 bases:

>100_bases
AGGCAGGGTCAGGCATGCCTCGGCGGTTATGACGGGGTGTGCCTGGATGCGGATCGGCGGCCGACGGCGGGCGCGGGACG
CGTTCGGCGCCGCAGGCCGC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTSVSILGATGSVGRSTVRVLEGERERFRVEAVAGGRDAAGLAELAIHLGAKFAAVADDAAGAELKARLAGTGIACGAGR
TAVLEAAARDADIVVAGISGIAGLEPTVAAFRAGRRIGVANKECLVAAGAFFTAEAERVGAEIFPVDSEHNAIFQALSAG
PRAAVEKVQITASGGPFRTAPREAIAKAGPAAALKHPNWSMGAKITIDSATLMNKGLELIEAHHLFGVPPEQLEVIVHPE
SIVHGLVAFEDGSVVAVLAMPDMALPIAHCLSHPGRLPTTCRKLDLAALGRLTFEAPDLDRFPCLSLALSALGEGGAAPT
ILNGANEVAVAAFLEGRIGFYGISAIVEETLALATRGAAPASVAEALQLDAEARRIALSLLPKFAAKAS

Sequences:

>Translated_389_residues
MTSVSILGATGSVGRSTVRVLEGERERFRVEAVAGGRDAAGLAELAIHLGAKFAAVADDAAGAELKARLAGTGIACGAGR
TAVLEAAARDADIVVAGISGIAGLEPTVAAFRAGRRIGVANKECLVAAGAFFTAEAERVGAEIFPVDSEHNAIFQALSAG
PRAAVEKVQITASGGPFRTAPREAIAKAGPAAALKHPNWSMGAKITIDSATLMNKGLELIEAHHLFGVPPEQLEVIVHPE
SIVHGLVAFEDGSVVAVLAMPDMALPIAHCLSHPGRLPTTCRKLDLAALGRLTFEAPDLDRFPCLSLALSALGEGGAAPT
ILNGANEVAVAAFLEGRIGFYGISAIVEETLALATRGAAPASVAEALQLDAEARRIALSLLPKFAAKAS
>Mature_388_residues
TSVSILGATGSVGRSTVRVLEGERERFRVEAVAGGRDAAGLAELAIHLGAKFAAVADDAAGAELKARLAGTGIACGAGRT
AVLEAAARDADIVVAGISGIAGLEPTVAAFRAGRRIGVANKECLVAAGAFFTAEAERVGAEIFPVDSEHNAIFQALSAGP
RAAVEKVQITASGGPFRTAPREAIAKAGPAAALKHPNWSMGAKITIDSATLMNKGLELIEAHHLFGVPPEQLEVIVHPES
IVHGLVAFEDGSVVAVLAMPDMALPIAHCLSHPGRLPTTCRKLDLAALGRLTFEAPDLDRFPCLSLALSALGEGGAAPTI
LNGANEVAVAAFLEGRIGFYGISAIVEETLALATRGAAPASVAEALQLDAEARRIALSLLPKFAAKAS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=43.6868686868687, Blast_Score=303, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 39669; Mature: 39538

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVSILGATGSVGRSTVRVLEGERERFRVEAVAGGRDAAGLAELAIHLGAKFAAVADDA
CCCEEEEECCCCCCHHHHHHHCCCCHHEEEEEECCCCCHHHHHHHHHHHCCHHEEECCCC
AGAELKARLAGTGIACGAGRTAVLEAAARDADIVVAGISGIAGLEPTVAAFRAGRRIGVA
CCCHHHHHHCCCCEECCCCCHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCEECCC
NKECLVAAGAFFTAEAERVGAEIFPVDSEHNAIFQALSAGPRAAVEKVQITASGGPFRTA
CCCEEEEECCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCHHEEEEEEEEECCCCCCCC
PREAIAKAGPAAALKHPNWSMGAKITIDSATLMNKGLELIEAHHLFGVPPEQLEVIVHPE
CHHHHHHCCCCHHCCCCCCCCCCEEEECHHHHHHHCHHHHHHHHHCCCCHHHEEEEECCH
SIVHGLVAFEDGSVVAVLAMPDMALPIAHCLSHPGRLPTTCRKLDLAALGRLTFEAPDLD
HHHHHHEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEECCCCCC
RFPCLSLALSALGEGGAAPTILNGANEVAVAAFLEGRIGFYGISAIVEETLALATRGAAP
CCHHHHHHHHHHCCCCCCCEEECCCCHHEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCH
ASVAEALQLDAEARRIALSLLPKFAAKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSVSILGATGSVGRSTVRVLEGERERFRVEAVAGGRDAAGLAELAIHLGAKFAAVADDA
CCEEEEECCCCCCHHHHHHHCCCCHHEEEEEECCCCCHHHHHHHHHHHCCHHEEECCCC
AGAELKARLAGTGIACGAGRTAVLEAAARDADIVVAGISGIAGLEPTVAAFRAGRRIGVA
CCCHHHHHHCCCCEECCCCCHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCEECCC
NKECLVAAGAFFTAEAERVGAEIFPVDSEHNAIFQALSAGPRAAVEKVQITASGGPFRTA
CCCEEEEECCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCHHEEEEEEEEECCCCCCCC
PREAIAKAGPAAALKHPNWSMGAKITIDSATLMNKGLELIEAHHLFGVPPEQLEVIVHPE
CHHHHHHCCCCHHCCCCCCCCCCEEEECHHHHHHHCHHHHHHHHHCCCCHHHEEEEECCH
SIVHGLVAFEDGSVVAVLAMPDMALPIAHCLSHPGRLPTTCRKLDLAALGRLTFEAPDLD
HHHHHHEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEECCCCCC
RFPCLSLALSALGEGGAAPTILNGANEVAVAAFLEGRIGFYGISAIVEETLALATRGAAP
CCHHHHHHHHHHCCCCCCCEEECCCCHHEEEEHHHCCCCHHHHHHHHHHHHHHHHCCCCH
ASVAEALQLDAEARRIALSLLPKFAAKAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA