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The map label for this gene is birA [H]

Identifier: 158423306

GI number: 158423306

Start: 1924561

End: 1925130

Strand: Direct

Name: birA [H]

Synonym: AZC_1682

Alternate gene names: 158423306

Gene position: 1924561-1925130 (Clockwise)

Preceding gene: 158423305

Following gene: 158423307

Centisome position: 35.84

GC content: 67.72

Gene sequence:

>570_bases
GTGCTCCCCAATCCTGCGCCGGTGGCCAACCTGGCGCAGCTCTGTTTTGTGGCCGGGCTCGCCCTACGCGACGCCGTGGT
GGCAGCCGCGCCCCTGATCTCCATCGACGGCCTGCGGCTCAAGTGGCCCAACGACCTGATGCTGGATGGCGGCAAGCTCG
CCGGCATCCTGGTCGAGGGGGCCAATGACCGCTACGGCCGGCCGGCCGCGGTCATCGGCTTCGGCGTCAACTGCCTGCAC
CATCCCGAGGGCCTGCCCTATCGGGCGACCAGCCTGGAGGAAGCGGGGGCGCCCACGGCGCCCGACCGGCTGCTGGAAGC
GCTCGATCTTGCCATGACCGTCCGCCTCAACCAGTGGAACGGCGGCAACGGCTTTGCTTCCATCCGCACCGAATGGATGC
GCTACGCCCTCGCCATCGGCGACACCATCACGGTGAAGATCGGCGAGCGGGAAGTGACCGGCCGGTTCGAGAGTATCGAT
AATCGCGGCGCGATGATGTTGCGCCGCCGGGATGGCATCGCCGAAATCGTTACGGCGGGCGAGGTCTCCCTCACACCGAA
AGTGGATTGA

Upstream 100 bases:

>100_bases
GCGAGGCCATGCCCGCCTGGCTGGTCGCGGACATCCAGACCGCGGGACGGGGGCGGCGCGGCCCTGGACCAGCGAACTGG
GCAACCTCTTCGCGACCCTC

Downstream 100 bases:

>100_bases
ACCATCTGATGGCTGACAACAACGAGCTCGTCTTCGCGCCTCTCGGGGGGGTGGGCGAGATCGGCATGAATCTCGGCCTC
TACGGGATCGGACCGCGCAA

Product: biotin--acetyl-CoA-carboxylase ligase

Products: NA

Alternate protein names: Biotin--protein ligase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MLPNPAPVANLAQLCFVAGLALRDAVVAAAPLISIDGLRLKWPNDLMLDGGKLAGILVEGANDRYGRPAAVIGFGVNCLH
HPEGLPYRATSLEEAGAPTAPDRLLEALDLAMTVRLNQWNGGNGFASIRTEWMRYALAIGDTITVKIGEREVTGRFESID
NRGAMMLRRRDGIAEIVTAGEVSLTPKVD

Sequences:

>Translated_189_residues
MLPNPAPVANLAQLCFVAGLALRDAVVAAAPLISIDGLRLKWPNDLMLDGGKLAGILVEGANDRYGRPAAVIGFGVNCLH
HPEGLPYRATSLEEAGAPTAPDRLLEALDLAMTVRLNQWNGGNGFASIRTEWMRYALAIGDTITVKIGEREVTGRFESID
NRGAMMLRRRDGIAEIVTAGEVSLTPKVD
>Mature_189_residues
MLPNPAPVANLAQLCFVAGLALRDAVVAAAPLISIDGLRLKWPNDLMLDGGKLAGILVEGANDRYGRPAAVIGFGVNCLH
HPEGLPYRATSLEEAGAPTAPDRLLEALDLAMTVRLNQWNGGNGFASIRTEWMRYALAIGDTITVKIGEREVTGRFESID
NRGAMMLRRRDGIAEIVTAGEVSLTPKVD

Specific function: Activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins [H]

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Escherichia coli, GI1790408, Length=171, Percent_Identity=32.7485380116959, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004408
- InterPro:   IPR003142
- InterPro:   IPR004143 [H]

Pfam domain/function: PF02237 BPL_C; PF03099 BPL_LipA_LipB [H]

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 20216; Mature: 20216

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPNPAPVANLAQLCFVAGLALRDAVVAAAPLISIDGLRLKWPNDLMLDGGKLAGILVEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCEEECCCEEEEEEEEC
ANDRYGRPAAVIGFGVNCLHHPEGLPYRATSLEEAGAPTAPDRLLEALDLAMTVRLNQWN
CCCCCCCCEEEEEECCEEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHEEEEEEECCC
GGNGFASIRTEWMRYALAIGDTITVKIGEREVTGRFESIDNRGAMMLRRRDGIAEIVTAG
CCCCCHHHHHHHHHHHHHCCCEEEEEECCEEECCHHHCCCCCCEEEEEECCCHHHEEECC
EVSLTPKVD
CEEECCCCC
>Mature Secondary Structure
MLPNPAPVANLAQLCFVAGLALRDAVVAAAPLISIDGLRLKWPNDLMLDGGKLAGILVEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCEEECCCEEEEEEEEC
ANDRYGRPAAVIGFGVNCLHHPEGLPYRATSLEEAGAPTAPDRLLEALDLAMTVRLNQWN
CCCCCCCCEEEEEECCEEEECCCCCCCCCCCHHHCCCCCCHHHHHHHHHHEEEEEEECCC
GGNGFASIRTEWMRYALAIGDTITVKIGEREVTGRFESIDNRGAMMLRRRDGIAEIVTAG
CCCCCHHHHHHHHHHHHHCCCEEEEEECCEEECCHHHCCCCCCEEEEEECCCHHHEEECC
EVSLTPKVD
CEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]