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The map label for this gene is atoC [H]

Identifier: 158423277

GI number: 158423277

Start: 1891800

End: 1893182

Strand: Direct

Name: atoC [H]

Synonym: AZC_1653

Alternate gene names: 158423277

Gene position: 1891800-1893182 (Clockwise)

Preceding gene: 158423276

Following gene: 158423278

Centisome position: 35.23

GC content: 67.03

Gene sequence:

>1383_bases
ATGGCTCCCGCGATCCTGGTGGTCGATGACGAGAAGCGCCTCGGCGAAGTGCTCGCGGCGGCGCTGACGGAACGCGGATT
CGAGACGACGGCCGTGAGCAGCGCGGCGGCGGCACTCGCCTATTGCGAGGCCAATGCGGTTGATCTCGTGCTCACGGACC
TGCGGATGCCGGACCGCAGCGGGCGGGACCTGCTGCTCGCGCTGAAGGAAGGGCGGCCCGATCTGCCGGTCATCATCATG
ACCGCCTATGCCACGGTGCGCGGGGCCGTTGACCTCATCAAGGACGGCGCCTTCGATTATGTGGCGAAGCCCTTCGAGCT
CGATGACGTGGTCGCCACCATCGAGCGCGCGCTGAAGATCCGGGCGGTCGTCAACGAGAATGCCCGCCTCCGGATGGAGC
TGGAGGGCCGCTACTGCTTCGACAACCTCATCGGCGAGAGCGCGCCCTTCCGCAACGTGCTCCAGCAGGTGGGAGAGGTG
GCCCAGAGCCGGGCCAGCGTGCTGCTGCACGGAGAGAGCGGAACGGGCAAGGAACTGATCGCCCGCGCCATCCACTACAA
CAGCCCGCGCCGGGAGATGCCGTTCATCGCCGTGAACTGCGCGGCCATTCCCGAGACGCTGATCGAAAGCGAACTCTTCG
GTCATGTGAAGGGGGCCTTCACGGGTGCCACCAGCAATCGCGAGGGCCGCTTCAGCGCGGCCGACGGCGGCACGCTGTTC
CTCGACGAGATCGCCGATATGCCGCTCTCGGTGCAGGCCAAGGTGCTGCGGGCGGTTCAGGAGCAGAGCTTCGAGCCGGT
GGGCAGCAGCAAGCCCCTGAAGGTGGACGTGCGCATCATCGCCGCCTCCCACAAGGACCTCCAGAAGGCGATCGCCGACG
GCGCCTTCCGGATGGACCTGTATTACCGCCTCGCGGTCTTCCCCATCACCCTGCCACCGCTGCGCGAACGCCACGATGAT
ATTCCGCTGCTGGCGGCGCACTTTCTGCGCCGTGCGGCACAGGAGATGGGCAAGAAGATCGACGGCATCAGCCTGCCCGC
GCAGGAGGCGCTGGCCCATTATGGCTGGCCCGGCAACATCCGCGAACTCCAGAACTGCATGGAGCGGGCCGCCATCGTCG
CCCGCGGGCCGGTGATCGAGCCCAAGGATCTCATGCTGTTCGGCCCCGAAGCGCCGGGCGCATCGGCGCAGCGCGCGCTG
CCCTCGGACCTTGATGGGGAATTGGAACGCATCGAGCGCGAGTTTCTGCTAGAAGCCCTCAAGGAAAGCGGCGGCGTGCA
GGCGCGCGCGGCCGAGCGGCTCGGCATTACGGAGCGCAGCCTCTGGCATCGGGTCAAGAAGCTGGCGATCAAGGTGTCTC
GGGTGGCAGAGCCCCATGAATAA

Upstream 100 bases:

>100_bases
GGCGGTGCGATCTTCAGCCTGCGTCTGGCGCTGGCAGAGGATCGTACGCTCGTGGCGGCCTCCCAATGAGCCGGCCGGGT
GCGGCAGGCGGAGAATGAAG

Downstream 100 bases:

>100_bases
GATCAACGTCCTTTCGCGCGCGCTTCTGGCGGGACTGCTGCTTGCGGCGGCCGGCGCGCCGGCGCTGGCGGAAGACCCGG
CTTCCGGCGGCTGGATCGTC

Product: Fis-type precursor

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MAPAILVVDDEKRLGEVLAAALTERGFETTAVSSAAAALAYCEANAVDLVLTDLRMPDRSGRDLLLALKEGRPDLPVIIM
TAYATVRGAVDLIKDGAFDYVAKPFELDDVVATIERALKIRAVVNENARLRMELEGRYCFDNLIGESAPFRNVLQQVGEV
AQSRASVLLHGESGTGKELIARAIHYNSPRREMPFIAVNCAAIPETLIESELFGHVKGAFTGATSNREGRFSAADGGTLF
LDEIADMPLSVQAKVLRAVQEQSFEPVGSSKPLKVDVRIIAASHKDLQKAIADGAFRMDLYYRLAVFPITLPPLRERHDD
IPLLAAHFLRRAAQEMGKKIDGISLPAQEALAHYGWPGNIRELQNCMERAAIVARGPVIEPKDLMLFGPEAPGASAQRAL
PSDLDGELERIEREFLLEALKESGGVQARAAERLGITERSLWHRVKKLAIKVSRVAEPHE

Sequences:

>Translated_460_residues
MAPAILVVDDEKRLGEVLAAALTERGFETTAVSSAAAALAYCEANAVDLVLTDLRMPDRSGRDLLLALKEGRPDLPVIIM
TAYATVRGAVDLIKDGAFDYVAKPFELDDVVATIERALKIRAVVNENARLRMELEGRYCFDNLIGESAPFRNVLQQVGEV
AQSRASVLLHGESGTGKELIARAIHYNSPRREMPFIAVNCAAIPETLIESELFGHVKGAFTGATSNREGRFSAADGGTLF
LDEIADMPLSVQAKVLRAVQEQSFEPVGSSKPLKVDVRIIAASHKDLQKAIADGAFRMDLYYRLAVFPITLPPLRERHDD
IPLLAAHFLRRAAQEMGKKIDGISLPAQEALAHYGWPGNIRELQNCMERAAIVARGPVIEPKDLMLFGPEAPGASAQRAL
PSDLDGELERIEREFLLEALKESGGVQARAAERLGITERSLWHRVKKLAIKVSRVAEPHE
>Mature_459_residues
APAILVVDDEKRLGEVLAAALTERGFETTAVSSAAAALAYCEANAVDLVLTDLRMPDRSGRDLLLALKEGRPDLPVIIMT
AYATVRGAVDLIKDGAFDYVAKPFELDDVVATIERALKIRAVVNENARLRMELEGRYCFDNLIGESAPFRNVLQQVGEVA
QSRASVLLHGESGTGKELIARAIHYNSPRREMPFIAVNCAAIPETLIESELFGHVKGAFTGATSNREGRFSAADGGTLFL
DEIADMPLSVQAKVLRAVQEQSFEPVGSSKPLKVDVRIIAASHKDLQKAIADGAFRMDLYYRLAVFPITLPPLRERHDDI
PLLAAHFLRRAAQEMGKKIDGISLPAQEALAHYGWPGNIRELQNCMERAAIVARGPVIEPKDLMLFGPEAPGASAQRALP
SDLDGELERIEREFLLEALKESGGVQARAAERLGITERSLWHRVKKLAIKVSRVAEPHE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=450, Percent_Identity=44.2222222222222, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1790437, Length=444, Percent_Identity=44.5945945945946, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=42.3076923076923, Blast_Score=346, Evalue=1e-96,
Organism=Escherichia coli, GI1788905, Length=375, Percent_Identity=44.8, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1789087, Length=337, Percent_Identity=48.9614243323442, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI87082117, Length=344, Percent_Identity=45.0581395348837, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=46.0815047021944, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI87082152, Length=320, Percent_Identity=41.875, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=44.2367601246106, Blast_Score=241, Evalue=9e-65,
Organism=Escherichia coli, GI1786524, Length=338, Percent_Identity=40.8284023668639, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1787583, Length=319, Percent_Identity=35.423197492163, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1789828, Length=235, Percent_Identity=38.7234042553192, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI87081858, Length=294, Percent_Identity=31.6326530612245, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786784, Length=115, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790552, Length=115, Percent_Identity=33.9130434782609, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50293; Mature: 50162

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPAILVVDDEKRLGEVLAAALTERGFETTAVSSAAAALAYCEANAVDLVLTDLRMPDRS
CCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
GRDLLLALKEGRPDLPVIIMTAYATVRGAVDLIKDGAFDYVAKPFELDDVVATIERALKI
CCEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
RAVVNENARLRMELEGRYCFDNLIGESAPFRNVLQQVGEVAQSRASVLLHGESGTGKELI
HHHCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHH
ARAIHYNSPRREMPFIAVNCAAIPETLIESELFGHVKGAFTGATSNREGRFSAADGGTLF
HHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEECCCCCEEE
LDEIADMPLSVQAKVLRAVQEQSFEPVGSSKPLKVDVRIIAASHKDLQKAIADGAFRMDL
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCEEHHH
YYRLAVFPITLPPLRERHDDIPLLAAHFLRRAAQEMGKKIDGISLPAQEALAHYGWPGNI
EEEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCH
RELQNCMERAAIVARGPVIEPKDLMLFGPEAPGASAQRALPSDLDGELERIEREFLLEAL
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHH
KESGGVQARAAERLGITERSLWHRVKKLAIKVSRVAEPHE
HHCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
APAILVVDDEKRLGEVLAAALTERGFETTAVSSAAAALAYCEANAVDLVLTDLRMPDRS
CCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
GRDLLLALKEGRPDLPVIIMTAYATVRGAVDLIKDGAFDYVAKPFELDDVVATIERALKI
CCEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHH
RAVVNENARLRMELEGRYCFDNLIGESAPFRNVLQQVGEVAQSRASVLLHGESGTGKELI
HHHCCCCCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHH
ARAIHYNSPRREMPFIAVNCAAIPETLIESELFGHVKGAFTGATSNREGRFSAADGGTLF
HHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEECCCCCEEE
LDEIADMPLSVQAKVLRAVQEQSFEPVGSSKPLKVDVRIIAASHKDLQKAIADGAFRMDL
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHCCCEEHHH
YYRLAVFPITLPPLRERHDDIPLLAAHFLRRAAQEMGKKIDGISLPAQEALAHYGWPGNI
EEEEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCH
RELQNCMERAAIVARGPVIEPKDLMLFGPEAPGASAQRALPSDLDGELERIEREFLLEAL
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHH
KESGGVQARAAERLGITERSLWHRVKKLAIKVSRVAEPHE
HHCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]