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The map label for this gene is gcvT [H]

Identifier: 158423001

GI number: 158423001

Start: 1559219

End: 1560352

Strand: Direct

Name: gcvT [H]

Synonym: AZC_1377

Alternate gene names: 158423001

Gene position: 1559219-1560352 (Clockwise)

Preceding gene: 158423000

Following gene: 158423002

Centisome position: 29.04

GC content: 62.96

Gene sequence:

>1134_bases
ATGACGGTCAGCTGGCGTACTGCGGTCCTTGCGGATCGCCACCGGGCTCTCGGCTCGAAGCTCGAAGACTGGAGCGGCAT
GCCTACCGCCTGGACCTATGACAAGGACATGGCGGCCGAGCACGTGGCCATCCGCACCAAGGCGGGCCTCATGGACGTGT
CGGGTCTCAAGAAGATCCATATGGTCGGCCCGCACGCTTTGGCCGTGCTGGATTACATCACCACCCGCGATGTCTCGAAG
ATTACGCCCGGCCGCTCGGTCTATGCCTGCATGCTGAATGATCGCGGCCTCTTTACCGATGACTGCATCATCTACCGCAC
CGGCCCCAATGCCTGGATGCTGGTCCATGGCTCGGGTTCGGGCCATGAGGAGGTGGTGAAGCAGTCCATGGGGCGCAATT
GCGCCGTGCTGTTCGACGACGATCTGCAGGATCTTTCCCTGCAAGGCCCGCTCGCGGTGGACTTCCTCGCCAAATATGTC
CCCGGCATCCGCGACCTGAAGTATTTCCATCACATGCAGACCACGCTGTTCGGCGTGCCGGTGATGATCTCGCGCACCGG
CTATACGGGCGAGCGCGGCTATGAGCTGTTCGTGCGGGGGCAGGATGCGGCGAAGGTGTGGGACACCATCGTCGCGGAAG
GGGCGGAGATGGGCATCATCCCCTGCTGCTTCAGCGTGCTCGATATGCTGCGCGTGGAAAGCTACCTGCTGTTCTACCCT
TATGACAATTCGCAGATGTATCCCTTCGCGGACCAGCCGCCCGGCGACACGCTTTGGGAACTCGGCCTCGATTTCACCGT
CAGCCCCGGCAAGACCGGCTTTCGCGGAGCCGAGGAGCATTATCGGCTGAAGGGCAAGGAACGCTTCAGGATCTTCGGGA
TGCTGATCGAGGCTGACGGCCCGGCCGATCTCGGCGATGAGGTGTGGGCGGACAGCAAGAAGGTCGGCGTCATCACCTGT
CCCTGCTATTCGACGCTCACCGGCAAATCCATGGCCATCGCCCGCCTCGACGTGGACAAGGCGGTGCAGGGCACGCCGCT
GGAGGTGCGGGGCAAGTCGCTCTCCGCCAAGGCCATCGCCCACACGCTGCCCTTTGACGATCCGGAAAAGAAGAAGCGCA
CCGCCCTCGGCTGA

Upstream 100 bases:

>100_bases
GGACACGCCACCTCCAAGTCATGCCCGGGCTTGTCCCGGCCATGACAGTCCAAACGCCATTTCACACGCCACAAACCTTT
GACAGAACAGGGGAACAACG

Downstream 100 bases:

>100_bases
GCGGCCCATTCCCCTGGTTCGGCAGCCCCCGCGGCCGTGTTCAGCTGCCCATTCTCACAACGAAAGCCTTCCTTCCCAGA
GCCGGGGAGGAAGGCTTCTG

Product: aminomethyltransferase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTVSWRTAVLADRHRALGSKLEDWSGMPTAWTYDKDMAAEHVAIRTKAGLMDVSGLKKIHMVGPHALAVLDYITTRDVSK
ITPGRSVYACMLNDRGLFTDDCIIYRTGPNAWMLVHGSGSGHEEVVKQSMGRNCAVLFDDDLQDLSLQGPLAVDFLAKYV
PGIRDLKYFHHMQTTLFGVPVMISRTGYTGERGYELFVRGQDAAKVWDTIVAEGAEMGIIPCCFSVLDMLRVESYLLFYP
YDNSQMYPFADQPPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFRIFGMLIEADGPADLGDEVWADSKKVGVITC
PCYSTLTGKSMAIARLDVDKAVQGTPLEVRGKSLSAKAIAHTLPFDDPEKKKRTALG

Sequences:

>Translated_377_residues
MTVSWRTAVLADRHRALGSKLEDWSGMPTAWTYDKDMAAEHVAIRTKAGLMDVSGLKKIHMVGPHALAVLDYITTRDVSK
ITPGRSVYACMLNDRGLFTDDCIIYRTGPNAWMLVHGSGSGHEEVVKQSMGRNCAVLFDDDLQDLSLQGPLAVDFLAKYV
PGIRDLKYFHHMQTTLFGVPVMISRTGYTGERGYELFVRGQDAAKVWDTIVAEGAEMGIIPCCFSVLDMLRVESYLLFYP
YDNSQMYPFADQPPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFRIFGMLIEADGPADLGDEVWADSKKVGVITC
PCYSTLTGKSMAIARLDVDKAVQGTPLEVRGKSLSAKAIAHTLPFDDPEKKKRTALG
>Mature_376_residues
TVSWRTAVLADRHRALGSKLEDWSGMPTAWTYDKDMAAEHVAIRTKAGLMDVSGLKKIHMVGPHALAVLDYITTRDVSKI
TPGRSVYACMLNDRGLFTDDCIIYRTGPNAWMLVHGSGSGHEEVVKQSMGRNCAVLFDDDLQDLSLQGPLAVDFLAKYVP
GIRDLKYFHHMQTTLFGVPVMISRTGYTGERGYELFVRGQDAAKVWDTIVAEGAEMGIIPCCFSVLDMLRVESYLLFYPY
DNSQMYPFADQPPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFRIFGMLIEADGPADLGDEVWADSKKVGVITCP
CYSTLTGKSMAIARLDVDKAVQGTPLEVRGKSLSAKAIAHTLPFDDPEKKKRTALG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=352, Percent_Identity=25.5681818181818, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI44662838, Length=373, Percent_Identity=24.3967828418231, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI257796258, Length=357, Percent_Identity=24.6498599439776, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI257796256, Length=321, Percent_Identity=23.6760124610592, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI194306651, Length=228, Percent_Identity=25.4385964912281, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789272, Length=369, Percent_Identity=27.3712737127371, Blast_Score=108, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17560118, Length=386, Percent_Identity=26.1658031088083, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=256, Percent_Identity=28.515625, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129441, Length=384, Percent_Identity=26.3020833333333, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 41735; Mature: 41604

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSWRTAVLADRHRALGSKLEDWSGMPTAWTYDKDMAAEHVAIRTKAGLMDVSGLKKIH
CCCCCHHHHHHHHHHHHCCCCHHCCCCCCEEECCHHHHHHHEEEEECCCCEECCCCCEEE
MVGPHALAVLDYITTRDVSKITPGRSVYACMLNDRGLFTDDCIIYRTGPNAWMLVHGSGS
EECCHHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCEECCEEEEEECCCEEEEEECCCC
GHEEVVKQSMGRNCAVLFDDDLQDLSLQGPLAVDFLAKYVPGIRDLKYFHHMQTTLFGVP
CHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
VMISRTGYTGERGYELFVRGQDAAKVWDTIVAEGAEMGIIPCCFSVLDMLRVESYLLFYP
EEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCEEEEEEE
YDNSQMYPFADQPPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFRIFGMLIEADG
CCCCEECCCCCCCCCCCHHHCCCCEEECCCCCCCCCCHHHHCCCCCCEEEEEEEEEECCC
PADLGDEVWADSKKVGVITCPCYSTLTGKSMAIARLDVDKAVQGTPLEVRGKSLSAKAIA
CCCCCHHHHCCCCCEEEEECCCCCCCCCCCEEEEEECHHHCCCCCCEEECCCCCCHHHHH
HTLPFDDPEKKKRTALG
HCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
TVSWRTAVLADRHRALGSKLEDWSGMPTAWTYDKDMAAEHVAIRTKAGLMDVSGLKKIH
CCCCHHHHHHHHHHHHCCCCHHCCCCCCEEECCHHHHHHHEEEEECCCCEECCCCCEEE
MVGPHALAVLDYITTRDVSKITPGRSVYACMLNDRGLFTDDCIIYRTGPNAWMLVHGSGS
EECCHHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCEECCEEEEEECCCEEEEEECCCC
GHEEVVKQSMGRNCAVLFDDDLQDLSLQGPLAVDFLAKYVPGIRDLKYFHHMQTTLFGVP
CHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
VMISRTGYTGERGYELFVRGQDAAKVWDTIVAEGAEMGIIPCCFSVLDMLRVESYLLFYP
EEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCEEEEEEE
YDNSQMYPFADQPPGDTLWELGLDFTVSPGKTGFRGAEEHYRLKGKERFRIFGMLIEADG
CCCCEECCCCCCCCCCCHHHCCCCEEECCCCCCCCCCHHHHCCCCCCEEEEEEEEEECCC
PADLGDEVWADSKKVGVITCPCYSTLTGKSMAIARLDVDKAVQGTPLEVRGKSLSAKAIA
CCCCCHHHHCCCCCEEEEECCCCCCCCCCCEEEEEECHHHCCCCCCEEECCCCCCHHHHH
HTLPFDDPEKKKRTALG
HCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]