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The map label for this gene is gcvT [H]

Identifier: 158422999

GI number: 158422999

Start: 1555776

End: 1558145

Strand: Direct

Name: gcvT [H]

Synonym: AZC_1375

Alternate gene names: 158422999

Gene position: 1555776-1558145 (Clockwise)

Preceding gene: 158422998

Following gene: 158423000

Centisome position: 28.97

GC content: 67.51

Gene sequence:

>2370_bases
ATGAACAGCGCGGGTCTGTCCATAGCCCAAGCGGCGGCACCGGTCTTCATGGCCGGCGCTCCGCCCCGGAGCCGGCCCGC
GCTGGCGCCGGGCGTGGAACGCTATGTGGTGGCAGGCGGTGGGGCGCAGGTCTTCACCCTTGAGCCGGGCGACCGTATCG
AGATCGCCCAGCTGGAAGGCGGACAGCCGGTGGAACTGCTCGCCTTCGATACCGCCGGCCGGCCCGCCACTGAGGCTCTG
GGGCTGGCCGGGCAGGGGCGGGCGGAGGGGCTGCTGCGCATCCTCGCCTCCGGCGCGCCGGACGCCGAGCGCGTGCGCTT
CGGCCTGTTCCGTCGGCAGATCGACCCGGCGGCGGGCCATGCGGCCCGCCTGTTCGGGCCGGACGCGGTTGCGGGGCAGT
CCGTGCTGCTGGTTGCCGAACGGATGCTCCACGTCATCGTGGCGGCGCCGGCGGAAGCCATGCTGGTGTGGGAGCAGAAC
CCGGCCACCGATCTCCTCGTCTTCCTCGCCCGCGCCGTGCTGCGCCGCGGGGCCGAGGCCCGCCTGCCGGATCCGCTGGC
GGAACCGCGCCTTGATCTGCGGATCAATGTCGCCTCCGCCATCAGCTTTGAGGTCTTCGAGGGCGAGACGATCCAGATCA
TCGACATCGAGGGCCGACAATGCTCCGACTTCATCGCCTTCGGTCGCAAGGCTCTGGACAAGGGCCGCATACTCGGCCTC
GACGCCACCACCACCCGCACCCTGAATGGGGCCGCCTATCCGCGGCCCGGCCTCTATTCCAAATTCTTCGATCAGGACCG
CAATGCGCTGGTGGAAGTCGTGCAGGACACGGTGGGGCGGCACGATACGTTCAACCTCGCCTGCACCGCCCGCTATTATG
AAGACATGGGCTATTTCGGGCATGTGAACTGTTCGGACAATTTCAATGGCGCCATGCGGGATTATGGCGTCGGGCAATAC
CGTGGCTGGCCGGCCATCAACTTCTTCTACAACACCAATGTCGCTGCCAATAACATCATCTGGTCCGACGAGCCCTGGTC
CCGGCCGGGCGATTATGTGCTGCTGCGGGCGCTGAGCGATCTCGTCTGCGGCGCCTCCGCCTGCCCCTCTGACATCGATG
CCTCCAACGGCTGGCAACTCTCCGAAATCCAGGTGCGCGTCTATCCCAAGGACGTGCCCTTCAAGCGTGCGATCGGCACC
CGCATGACCCCCGACACACCGACCCGCTTCACCCGGGAGTCCGGGTTCCACCCGCGCACCTCGGAACTGACCCGCGCCTT
CACGGACTATCGCGGCTTCTGGGTGCCCCAGCATTTCGCCTCGACTGGCGCCATCGCCGAATATTGGGCCTGCCGCGAGG
CCGTGGTGCTCATGGACCTCTCGGCCCTGCGCAAGCTGGAGATCGTGGGGCCGGATGCTGAGACCTTCCTGCAAGGCCTC
TTGCCCCGCGACATCCGCAAGCTTTCCGTCGGACAGATCTTCTACACGCCGCTCTGCTACGCGCACGGCGGCATGGTGGA
CGACGGCACGCTCTTCCGCCTCGGCGACAACAATTTCCGCTGGATCGGCGGGGATGATGCGAGCCTGCTCTGGATCGAGG
AACAGGCCGCGAAATTCGGCGGCCGCGTGAGCCTCAAGACCGCGAGCGGCGAGATCCACAACGTGGCTCTCCAAGGCCCG
CGCTCGCGCGAGACCTTGCGCAAGATCCTCTGGACGGCACCCGGCCGCCCGACGCTCGACGAACTCGGGCTCTTCCGCCT
CACCATCGGACGCATCGGCGGCTATGACGGCATCCCCGTCCTGGTCTCCCGCACCGGCTATACGGGCGAGCTCGGCTACG
AGGTCTTCTGCCATCCCAAGGATGCACCGCAGGTGTGGGATGCGCTGATGGAGGCGGGCGCGGAATTCGGCATCCGCCCC
TTCGGCTTCGAGGCGCTGGACATGGTGCGCATCGAGGCGGGCCTCGTCTTCGGCGGGCATGATTTCGATAGCACCACGGA
TCCGTTCGAAGCGGGCATCGGCTTCACCGTGCCGACGAAAAAGGAAGAGGATTATATCGGCAAGGCCGCGCTCCAGCGCC
GCCGGGAGCATCCCGCGCACAAGCTGGTGGGCCTTGAGGTGCAGGGAGGGGAAATCCCCGCACATGGCGATCCCCTCTTC
ATCGGCCGGGCGCAGGTCGGCCTCGTCACCAGCGCCACCCGCTCGCCGCTGCTGGCCCGAACCATCGCGCTCGCGCGCGT
CGATGTCGCCCATGCGCTGCCCGGCTTGACGCTGGAGATCGGCCGCCTCGACGGCCACCAGAAGCGCCTCGCCGCAACCG
TCGTGCCCTTCCCCTTCTACGACCCCGAAAAGAAGCGCGTGCGCGCCTGA

Upstream 100 bases:

>100_bases
TCACCGGCACGCTGGCGCCCAAGCACCATACGCCATGGATGCAGGCACTGGACGACAGCCTGGAAGCCTTCCTCGCCACC
ATGCCCAGCCAGGCCGCGGA

Downstream 100 bases:

>100_bases
GCGCGCCACAGATCGAAGGAAACAGCCATGCTCCAGGAAACCACCTTCAAAGCCGCCGGCAGGCTTGAGGACCACGGTGC
CGCCGATGCGGCCAGCTACG

Product: aminomethyltransferase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 789; Mature: 789

Protein sequence:

>789_residues
MNSAGLSIAQAAAPVFMAGAPPRSRPALAPGVERYVVAGGGAQVFTLEPGDRIEIAQLEGGQPVELLAFDTAGRPATEAL
GLAGQGRAEGLLRILASGAPDAERVRFGLFRRQIDPAAGHAARLFGPDAVAGQSVLLVAERMLHVIVAAPAEAMLVWEQN
PATDLLVFLARAVLRRGAEARLPDPLAEPRLDLRINVASAISFEVFEGETIQIIDIEGRQCSDFIAFGRKALDKGRILGL
DATTTRTLNGAAYPRPGLYSKFFDQDRNALVEVVQDTVGRHDTFNLACTARYYEDMGYFGHVNCSDNFNGAMRDYGVGQY
RGWPAINFFYNTNVAANNIIWSDEPWSRPGDYVLLRALSDLVCGASACPSDIDASNGWQLSEIQVRVYPKDVPFKRAIGT
RMTPDTPTRFTRESGFHPRTSELTRAFTDYRGFWVPQHFASTGAIAEYWACREAVVLMDLSALRKLEIVGPDAETFLQGL
LPRDIRKLSVGQIFYTPLCYAHGGMVDDGTLFRLGDNNFRWIGGDDASLLWIEEQAAKFGGRVSLKTASGEIHNVALQGP
RSRETLRKILWTAPGRPTLDELGLFRLTIGRIGGYDGIPVLVSRTGYTGELGYEVFCHPKDAPQVWDALMEAGAEFGIRP
FGFEALDMVRIEAGLVFGGHDFDSTTDPFEAGIGFTVPTKKEEDYIGKAALQRRREHPAHKLVGLEVQGGEIPAHGDPLF
IGRAQVGLVTSATRSPLLARTIALARVDVAHALPGLTLEIGRLDGHQKRLAATVVPFPFYDPEKKRVRA

Sequences:

>Translated_789_residues
MNSAGLSIAQAAAPVFMAGAPPRSRPALAPGVERYVVAGGGAQVFTLEPGDRIEIAQLEGGQPVELLAFDTAGRPATEAL
GLAGQGRAEGLLRILASGAPDAERVRFGLFRRQIDPAAGHAARLFGPDAVAGQSVLLVAERMLHVIVAAPAEAMLVWEQN
PATDLLVFLARAVLRRGAEARLPDPLAEPRLDLRINVASAISFEVFEGETIQIIDIEGRQCSDFIAFGRKALDKGRILGL
DATTTRTLNGAAYPRPGLYSKFFDQDRNALVEVVQDTVGRHDTFNLACTARYYEDMGYFGHVNCSDNFNGAMRDYGVGQY
RGWPAINFFYNTNVAANNIIWSDEPWSRPGDYVLLRALSDLVCGASACPSDIDASNGWQLSEIQVRVYPKDVPFKRAIGT
RMTPDTPTRFTRESGFHPRTSELTRAFTDYRGFWVPQHFASTGAIAEYWACREAVVLMDLSALRKLEIVGPDAETFLQGL
LPRDIRKLSVGQIFYTPLCYAHGGMVDDGTLFRLGDNNFRWIGGDDASLLWIEEQAAKFGGRVSLKTASGEIHNVALQGP
RSRETLRKILWTAPGRPTLDELGLFRLTIGRIGGYDGIPVLVSRTGYTGELGYEVFCHPKDAPQVWDALMEAGAEFGIRP
FGFEALDMVRIEAGLVFGGHDFDSTTDPFEAGIGFTVPTKKEEDYIGKAALQRRREHPAHKLVGLEVQGGEIPAHGDPLF
IGRAQVGLVTSATRSPLLARTIALARVDVAHALPGLTLEIGRLDGHQKRLAATVVPFPFYDPEKKRVRA
>Mature_789_residues
MNSAGLSIAQAAAPVFMAGAPPRSRPALAPGVERYVVAGGGAQVFTLEPGDRIEIAQLEGGQPVELLAFDTAGRPATEAL
GLAGQGRAEGLLRILASGAPDAERVRFGLFRRQIDPAAGHAARLFGPDAVAGQSVLLVAERMLHVIVAAPAEAMLVWEQN
PATDLLVFLARAVLRRGAEARLPDPLAEPRLDLRINVASAISFEVFEGETIQIIDIEGRQCSDFIAFGRKALDKGRILGL
DATTTRTLNGAAYPRPGLYSKFFDQDRNALVEVVQDTVGRHDTFNLACTARYYEDMGYFGHVNCSDNFNGAMRDYGVGQY
RGWPAINFFYNTNVAANNIIWSDEPWSRPGDYVLLRALSDLVCGASACPSDIDASNGWQLSEIQVRVYPKDVPFKRAIGT
RMTPDTPTRFTRESGFHPRTSELTRAFTDYRGFWVPQHFASTGAIAEYWACREAVVLMDLSALRKLEIVGPDAETFLQGL
LPRDIRKLSVGQIFYTPLCYAHGGMVDDGTLFRLGDNNFRWIGGDDASLLWIEEQAAKFGGRVSLKTASGEIHNVALQGP
RSRETLRKILWTAPGRPTLDELGLFRLTIGRIGGYDGIPVLVSRTGYTGELGYEVFCHPKDAPQVWDALMEAGAEFGIRP
FGFEALDMVRIEAGLVFGGHDFDSTTDPFEAGIGFTVPTKKEEDYIGKAALQRRREHPAHKLVGLEVQGGEIPAHGDPLF
IGRAQVGLVTSATRSPLLARTIALARVDVAHALPGLTLEIGRLDGHQKRLAATVVPFPFYDPEKKRVRA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=352, Percent_Identity=28.125, Blast_Score=123, Evalue=8e-28,
Organism=Homo sapiens, GI194306651, Length=349, Percent_Identity=27.7936962750716, Blast_Score=112, Evalue=2e-24,
Organism=Homo sapiens, GI44662838, Length=344, Percent_Identity=26.1627906976744, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI197927446, Length=390, Percent_Identity=25.1282051282051, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI21361378, Length=390, Percent_Identity=25.1282051282051, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI257796258, Length=325, Percent_Identity=26.1538461538462, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI257796256, Length=331, Percent_Identity=25.9818731117825, Blast_Score=84, Evalue=7e-16,
Organism=Homo sapiens, GI257796254, Length=235, Percent_Identity=28.936170212766, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789272, Length=330, Percent_Identity=30.9090909090909, Blast_Score=147, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32563613, Length=312, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17560118, Length=366, Percent_Identity=28.1420765027322, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71994045, Length=356, Percent_Identity=28.0898876404494, Blast_Score=102, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71994052, Length=356, Percent_Identity=28.0898876404494, Blast_Score=102, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320222, Length=347, Percent_Identity=26.8011527377522, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20129441, Length=366, Percent_Identity=27.8688524590164, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI28571104, Length=295, Percent_Identity=28.8135593220339, Blast_Score=103, Evalue=6e-22,
Organism=Drosophila melanogaster, GI20130091, Length=328, Percent_Identity=27.4390243902439, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 86058; Mature: 86058

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAGLSIAQAAAPVFMAGAPPRSRPALAPGVERYVVAGGGAQVFTLEPGDRIEIAQLEG
CCCCCCCHHHHHCCEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEEECCC
GQPVELLAFDTAGRPATEALGLAGQGRAEGLLRILASGAPDAERVRFGLFRRQIDPAAGH
CCCEEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
AARLFGPDAVAGQSVLLVAERMLHVIVAAPAEAMLVWEQNPATDLLVFLARAVLRRGAEA
EEEECCCCHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
RLPDPLAEPRLDLRINVASAISFEVFEGETIQIIDIEGRQCSDFIAFGRKALDKGRILGL
CCCCCCCCCCCEEEEEEEHEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEE
DATTTRTLNGAAYPRPGLYSKFFDQDRNALVEVVQDTVGRHDTFNLACTARYYEDMGYFG
CCCCCEEECCCCCCCCCCHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEEEEHHHCCCCEE
HVNCSDNFNGAMRDYGVGQYRGWPAINFFYNTNVAANNIIWSDEPWSRPGDYVLLRALSD
EEECCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHH
LVCGASACPSDIDASNGWQLSEIQVRVYPKDVPFKRAIGTRMTPDTPTRFTRESGFHPRT
HHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHCCCCCCCCCCCHHHCCCCCCCH
SELTRAFTDYRGFWVPQHFASTGAIAEYWACREAVVLMDLSALRKLEIVGPDAETFLQGL
HHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHC
LPRDIRKLSVGQIFYTPLCYAHGGMVDDGTLFRLGDNNFRWIGGDDASLLWIEEQAAKFG
CHHHHHHHHCCEEEECHHHHHCCCCCCCCCEEEECCCCEEEECCCCCEEEEEEHHHHHCC
GRVSLKTASGEIHNVALQGPRSRETLRKILWTAPGRPTLDELGLFRLTIGRIGGYDGIPV
CEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHCCEEEEEEHHCCCCCCCEE
LVSRTGYTGELGYEVFCHPKDAPQVWDALMEAGAEFGIRPFGFEALDMVRIEAGLVFGGH
EEECCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHCCCCCCCCHHHEEEEEEEEEEECCC
DFDSTTDPFEAGIGFTVPTKKEEDYIGKAALQRRREHPAHKLVGLEVQGGEIPAHGDPLF
CCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCEEE
IGRAQVGLVTSATRSPLLARTIALARVDVAHALPGLTLEIGRLDGHQKRLAATVVPFPFY
EECCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHEEEEEEECCCCC
DPEKKRVRA
CCCHHHCCC
>Mature Secondary Structure
MNSAGLSIAQAAAPVFMAGAPPRSRPALAPGVERYVVAGGGAQVFTLEPGDRIEIAQLEG
CCCCCCCHHHHHCCEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEEECCC
GQPVELLAFDTAGRPATEALGLAGQGRAEGLLRILASGAPDAERVRFGLFRRQIDPAAGH
CCCEEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
AARLFGPDAVAGQSVLLVAERMLHVIVAAPAEAMLVWEQNPATDLLVFLARAVLRRGAEA
EEEECCCCHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
RLPDPLAEPRLDLRINVASAISFEVFEGETIQIIDIEGRQCSDFIAFGRKALDKGRILGL
CCCCCCCCCCCEEEEEEEHEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEE
DATTTRTLNGAAYPRPGLYSKFFDQDRNALVEVVQDTVGRHDTFNLACTARYYEDMGYFG
CCCCCEEECCCCCCCCCCHHHHHHCHHHHHHHHHHHHCCCCCCEEEEEEEEHHHCCCCEE
HVNCSDNFNGAMRDYGVGQYRGWPAINFFYNTNVAANNIIWSDEPWSRPGDYVLLRALSD
EEECCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHH
LVCGASACPSDIDASNGWQLSEIQVRVYPKDVPFKRAIGTRMTPDTPTRFTRESGFHPRT
HHCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHCCCCCCCCCCCHHHCCCCCCCH
SELTRAFTDYRGFWVPQHFASTGAIAEYWACREAVVLMDLSALRKLEIVGPDAETFLQGL
HHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHC
LPRDIRKLSVGQIFYTPLCYAHGGMVDDGTLFRLGDNNFRWIGGDDASLLWIEEQAAKFG
CHHHHHHHHCCEEEECHHHHHCCCCCCCCCEEEECCCCEEEECCCCCEEEEEEHHHHHCC
GRVSLKTASGEIHNVALQGPRSRETLRKILWTAPGRPTLDELGLFRLTIGRIGGYDGIPV
CEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHCCEEEEEEHHCCCCCCCEE
LVSRTGYTGELGYEVFCHPKDAPQVWDALMEAGAEFGIRPFGFEALDMVRIEAGLVFGGH
EEECCCCCCCCCCEEEECCCCCHHHHHHHHHCCHHCCCCCCCCHHHEEEEEEEEEEECCC
DFDSTTDPFEAGIGFTVPTKKEEDYIGKAALQRRREHPAHKLVGLEVQGGEIPAHGDPLF
CCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCCCEEE
IGRAQVGLVTSATRSPLLARTIALARVDVAHALPGLTLEIGRLDGHQKRLAATVVPFPFY
EECCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHEEEEEEECCCCC
DPEKKRVRA
CCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA