Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 158422841

GI number: 158422841

Start: 1362950

End: 1363429

Strand: Reverse

Name: folK [H]

Synonym: AZC_1217

Alternate gene names: 158422841

Gene position: 1363429-1362950 (Counterclockwise)

Preceding gene: 158422842

Following gene: 158422836

Centisome position: 25.39

GC content: 74.17

Gene sequence:

>480_bases
ATGACCACCGCCTATCTCTGCCTCGGCGGCAATGTGGGCGACGTGGCCGCGACCCTTGCCGAAGCCGGCCGGCTGCTGGA
GGCGGGCGGGCTGGTCATCCGCGCGCGCTCGCCCCTCTACCGCACGCCGCCCTGGGGGCCGGTGCCGCAGCCGCCCTATC
TCAACCAGGTGCTCGCCGTCGCCGGCGCCCCCTCCCCGCGCGCCCTGCTGACGCTGGCGCTGGATGTGGAACGTCAGCTC
GGACGGGACCGCGCGCGGGAGGCGCGCTTCGGCCCCCGCACCGCGGACATCGACATCCTCGCCTATGGCGACGAGACGGT
GCGCGAGCCGGATCTGGAACTGCCCCATCCGCGCCTGCTGGAGCGCGCCTTCGCGCTGGTGCCGCTGCTGGACATCGCGC
CCGACATCATCATCTCCGGCACACGGGCGCGGGACGCGCTGGCGCGGCTTGACCGGAGCGGCATCGAGCGGGTGGACTGA

Upstream 100 bases:

>100_bases
ACGTCATCGGCATCATGGCGGGGGTGGAGATCATCCGCGTGCATGACGTCGCCGAGCACGTGCAGGCGGCCCGCGTGGCC
GAAGCCATCCGCCGGGCGCG

Downstream 100 bases:

>100_bases
CTACTCCGCCGTGCCCTGATCTTCGGCGACAAGCGCCTGCGCCTGCGCCACCCAGCCCTCGCGCTCGATGCGGCCCGGAA
AGGCCAGCGCTGCGCCCACC

Product: 8-dihydro-6-hydroxymethylpterin- pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MTTAYLCLGGNVGDVAATLAEAGRLLEAGGLVIRARSPLYRTPPWGPVPQPPYLNQVLAVAGAPSPRALLTLALDVERQL
GRDRAREARFGPRTADIDILAYGDETVREPDLELPHPRLLERAFALVPLLDIAPDIIISGTRARDALARLDRSGIERVD

Sequences:

>Translated_159_residues
MTTAYLCLGGNVGDVAATLAEAGRLLEAGGLVIRARSPLYRTPPWGPVPQPPYLNQVLAVAGAPSPRALLTLALDVERQL
GRDRAREARFGPRTADIDILAYGDETVREPDLELPHPRLLERAFALVPLLDIAPDIIISGTRARDALARLDRSGIERVD
>Mature_158_residues
TTAYLCLGGNVGDVAATLAEAGRLLEAGGLVIRARSPLYRTPPWGPVPQPPYLNQVLAVAGAPSPRALLTLALDVERQLG
RDRAREARFGPRTADIDILAYGDETVREPDLELPHPRLLERAFALVPLLDIAPDIIISGTRARDALARLDRSGIERVD

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=162, Percent_Identity=38.2716049382716, Blast_Score=100, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6324073, Length=135, Percent_Identity=34.8148148148148, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17178; Mature: 17047

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAYLCLGGNVGDVAATLAEAGRLLEAGGLVIRARSPLYRTPPWGPVPQPPYLNQVLAV
CCEEEEEECCCHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
AGAPSPRALLTLALDVERQLGRDRAREARFGPRTADIDILAYGDETVREPDLELPHPRLL
CCCCCCCEEEEHHHHHHHHHCHHHHHHHCCCCCCCCEEEEEECCHHCCCCCCCCCCHHHH
ERAFALVPLLDIAPDIIISGTRARDALARLDRSGIERVD
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTAYLCLGGNVGDVAATLAEAGRLLEAGGLVIRARSPLYRTPPWGPVPQPPYLNQVLAV
CEEEEEECCCHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHH
AGAPSPRALLTLALDVERQLGRDRAREARFGPRTADIDILAYGDETVREPDLELPHPRLL
CCCCCCCEEEEHHHHHHHHHCHHHHHHHCCCCCCCCEEEEEECCHHCCCCCCCCCCHHHH
ERAFALVPLLDIAPDIIISGTRARDALARLDRSGIERVD
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]