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The map label for this gene is sul [H]

Identifier: 158422842

GI number: 158422842

Start: 1363426

End: 1364355

Strand: Reverse

Name: sul [H]

Synonym: AZC_1218

Alternate gene names: 158422842

Gene position: 1364355-1363426 (Counterclockwise)

Preceding gene: 158422847

Following gene: 158422841

Centisome position: 25.41

GC content: 68.92

Gene sequence:

>930_bases
ATGCCTTCCCAGCCGCCCGCTCCCCGCTTGCGCCGGCCGCCCAAGGGAGGCATTCGTTGCGATACCTTCCGCGCCTGCCC
ACGGAGCCGGCCCTTGACCGCCCTTCCCGCCCACATCCTCGACGCCCGCGGCCGACCGGTACCGCTCTCCGAGCGCACGC
TGATCATGGGCATCCTCAATGTGACGCCCGATTCCTTCTCGGACGGAGGACTCAGCGCTGCGCCCGAGACCGCGCGCGAG
ACCGCCCGCCGCCTTGTGCGCGAAGGCGCGGACATTCTCGACGTGGGCGGCGAGAGCACGCGGCCCGGCCACACCCGCAT
TTCGGATGACGAGGAATGGGACCGCATCGCCCCGGTGCTGGACGGGCTGGCGGACGAACTGGGCGTGCTCGTCTCCGTGG
ACACTTATAAAGCCGAGGTGGCCCGCCGGGCGCTGAAGACGGGCGTCGCCATCATCAACGACATCTGGGGCTTTGCCTTC
GATCCCAACATGCCGGCAGTGGTGGCGGATAGCGCGGCCGCCGCCGTGCTGATGCACAATCGCGAGGCCATTGATCCGGC
CATCGACATCATGGCGGACATGATCACCTTCTTCGAGCGGGCGCTGGAGAAAGCCGACAAGGCCGGCATCCCGCTCAACC
GGCTCGTGCTCGATCCCGGCATCGGCTTCGGCAAGACGTTCGAGCAGAATCTGGCGGCCTGCGCCCGCCTCTCCGAGCTG
CGCGTGCTCGGCCTGCCGCTGCTGCTCGGCACCTCGCGCAAGTCCATGATCGGCAAGGTCATCGAGACGCAGCCCACGGA
GCGCCTGCCGGGCACCATCGCCTCGAACGTCATCGGCATCATGGCGGGGGTGGAGATCATCCGCGTGCATGACGTCGCCG
AGCACGTGCAGGCGGCCCGCGTGGCCGAAGCCATCCGCCGGGCGCGATGA

Upstream 100 bases:

>100_bases
ACCAGGATGCGCATGGCCCCGTCCCTTCCCAACCGCAAGCGCCCGAACGCGGCGCAGGCGGTGCTTAACCCCAGACCGGA
CGGACTGCAACGAAGGTCGC

Downstream 100 bases:

>100_bases
CCACCGCCTATCTCTGCCTCGGCGGCAATGTGGGCGACGTGGCCGCGACCCTTGCCGAAGCCGGCCGGCTGCTGGAGGCG
GGCGGGCTGGTCATCCGCGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPSQPPAPRLRRPPKGGIRCDTFRACPRSRPLTALPAHILDARGRPVPLSERTLIMGILNVTPDSFSDGGLSAAPETARE
TARRLVREGADILDVGGESTRPGHTRISDDEEWDRIAPVLDGLADELGVLVSVDTYKAEVARRALKTGVAIINDIWGFAF
DPNMPAVVADSAAAAVLMHNREAIDPAIDIMADMITFFERALEKADKAGIPLNRLVLDPGIGFGKTFEQNLAACARLSEL
RVLGLPLLLGTSRKSMIGKVIETQPTERLPGTIASNVIGIMAGVEIIRVHDVAEHVQAARVAEAIRRAR

Sequences:

>Translated_309_residues
MPSQPPAPRLRRPPKGGIRCDTFRACPRSRPLTALPAHILDARGRPVPLSERTLIMGILNVTPDSFSDGGLSAAPETARE
TARRLVREGADILDVGGESTRPGHTRISDDEEWDRIAPVLDGLADELGVLVSVDTYKAEVARRALKTGVAIINDIWGFAF
DPNMPAVVADSAAAAVLMHNREAIDPAIDIMADMITFFERALEKADKAGIPLNRLVLDPGIGFGKTFEQNLAACARLSEL
RVLGLPLLLGTSRKSMIGKVIETQPTERLPGTIASNVIGIMAGVEIIRVHDVAEHVQAARVAEAIRRAR
>Mature_308_residues
PSQPPAPRLRRPPKGGIRCDTFRACPRSRPLTALPAHILDARGRPVPLSERTLIMGILNVTPDSFSDGGLSAAPETARET
ARRLVREGADILDVGGESTRPGHTRISDDEEWDRIAPVLDGLADELGVLVSVDTYKAEVARRALKTGVAIINDIWGFAFD
PNMPAVVADSAAAAVLMHNREAIDPAIDIMADMITFFERALEKADKAGIPLNRLVLDPGIGFGKTFEQNLAACARLSELR
VLGLPLLLGTSRKSMIGKVIETQPTERLPGTIASNVIGIMAGVEIIRVHDVAEHVQAARVAEAIRRAR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=276, Percent_Identity=44.2028985507246, Blast_Score=214, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6324073, Length=321, Percent_Identity=30.8411214953271, Blast_Score=129, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 33286; Mature: 33155

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSQPPAPRLRRPPKGGIRCDTFRACPRSRPLTALPAHILDARGRPVPLSERTLIMGILN
CCCCCCCCCCCCCCCCCCEECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEHH
VTPDSFSDGGLSAAPETARETARRLVREGADILDVGGESTRPGHTRISDDEEWDRIAPVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHH
DGLADELGVLVSVDTYKAEVARRALKTGVAIINDIWGFAFDPNMPAVVADSAAAAVLMHN
HHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEECHHHHHHHHHC
REAIDPAIDIMADMITFFERALEKADKAGIPLNRLVLDPGIGFGKTFEQNLAACARLSEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHH
RVLGLPLLLGTSRKSMIGKVIETQPTERLPGTIASNVIGIMAGVEIIRVHDVAEHVQAAR
HHHHHHHHHCCCHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAEAIRRAR
HHHHHHHCC
>Mature Secondary Structure 
PSQPPAPRLRRPPKGGIRCDTFRACPRSRPLTALPAHILDARGRPVPLSERTLIMGILN
CCCCCCCCCCCCCCCCCEECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEHH
VTPDSFSDGGLSAAPETARETARRLVREGADILDVGGESTRPGHTRISDDEEWDRIAPVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHH
DGLADELGVLVSVDTYKAEVARRALKTGVAIINDIWGFAFDPNMPAVVADSAAAAVLMHN
HHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEECHHHHHHHHHC
REAIDPAIDIMADMITFFERALEKADKAGIPLNRLVLDPGIGFGKTFEQNLAACARLSEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCHHHHHHHHHHHHHHHH
RVLGLPLLLGTSRKSMIGKVIETQPTERLPGTIASNVIGIMAGVEIIRVHDVAEHVQAAR
HHHHHHHHHCCCHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAEAIRRAR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]