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The map label for this gene is degP [H]

Identifier: 158422760

GI number: 158422760

Start: 1262747

End: 1264324

Strand: Direct

Name: degP [H]

Synonym: AZC_1136

Alternate gene names: 158422760

Gene position: 1262747-1264324 (Clockwise)

Preceding gene: 158422759

Following gene: 158422761

Centisome position: 23.52

GC content: 69.71

Gene sequence:

>1578_bases
ATGGCGGGGATGACCAGAGAGAGACGCATGACCCGCTCCACCAACTCCTCCTTCCTGACGAAGCGCCGCACCGCCCTGAT
GGCGGGTGTCGTCGGTCTCGCGGTTGCCGGCGTCGCGGTCGGCCAGTTCGGCTACGGGAGCACGCCGGCGCTCGCGCAGG
CCACCACCGCCGCCCCCGTCACCGCCCAGAGCTTCTCCTTCGCCGACGTGGTGCAGAAGGTGACCCCGGCCGTGGTGTCG
GTGAAGATCAAGAAGGACGTGTCCGCCCAGCAGATGGCCATGGGCGGCGATGACGAATTCGGCGGTGCCGACGTGCCGCC
CCAGATCGAGCGCTTCCTGAAGCGCTTCGGGTTCGAAAACGGCCAGGGCGGTCCCGGCGGCATGCAGCGCATGCCCCGCG
GCGGCGGCGCCGGCGAGCGCCGGGTCGTGGGCCAGGGCTCCGGCTTCATCATCTCGCCCGACGGCTATGTGGTGACCAAC
AACCACGTGGTGGATGGCGCGTCCGAGGTGGACGTGACCATGACCGATGGCAAGGAATACACCGCCAAGGTGATCGGCAC
CGATCCGCGCACGGACGTCGCCCTCATCAAGATCGACGGCAAGAACGACCTGCCCTTCGTGAAGCTCGCGGACGGCGCGC
CGCGCGTCGGCGACTGGGTGATCGCGGTGGGCAATCCCTTCGGCCTCGGCGGCACGGTCACGGCGGGCATCGTCTCGGCC
CGCGGCCGCGACATCGGCTCCGGCCCCTATGACGACTTCGTGCAGATCGATGCGCCGATCAACCGGGGCAACTCGGGCGG
CCCGACCTTCGATCTCAACGGCAACGTCATCGGCATGAACACCGCCATCGTGTCGCCCTCCGGCGGCAACGTGGGCATCG
CCTTCGCCATCCCGTCCGAGACGGTGAAGACGGTGGTGGACCAGCTCCGCCAGGACGGCAAGGTGGCGCGCGGCTATATC
GGCGTGCAGATCCAGCCCGTGACGGATGATCTCGCCTCCGGTCTCGGCCTCAATGCCGCCGAAGGCGCCCTCGTGGCCCA
GGTGCAGCCGGACACCCCGGCGGCCAAGGCGGGCCTCAAGAGCGGTGACGTGGTGACCAAGGTCAATGGCGATGCCGTGA
AGGACGCCCGCGACCTCAGCCGCAAGATCGGCATGATGAAGCCCGGCGCCTCCGTTGCCCTCACTGTGGTGCGGGACGGC
AAGACGCAGGCCTTCAACGTGAAGCTCGAGCAGCTGCCCACCGATCAGCAGATGGCGAGCGCCGACGGCAACGGGCCGGC
CACGCATGACGTGCCGCGCCTCGGCCTCCAGCTCGCCCCGGCCAAGAGCGTCCAGGGCGCCGGCGCCCAGGGCGTGGTGG
TGACGGAAGTGGACCCGAACGGCCCTGCGGCCGCCCGCGGCATCCGCTCCGGCGACGTGATCCTCGACGTGGGCGGCAAG
ACGGTCTCCAACCCGTCCGATGTCCGCGAGGGGCTCGCCGCTGCCAAGGCCGAGAACCGCAAGGCGGTCCTCATGCGGGT
GAAGGGCGAGCAGGGCGTGCGCTTCGTCGCCATCACCCTCGACAAGTCCAAGGGCTGA

Upstream 100 bases:

>100_bases
GCGCCCTCACGGAGCCGTGACGCGTCTTACAGAACCGTAATCTTTCAGCCAGCGGACCGTAAGGCGCGCGGGCCTAGGTT
CTCTCTCACGCCCGCCGGAC

Downstream 100 bases:

>100_bases
TCCTCCGCCACCCGGAGGCTGAGGCCTCCGGGACCGGCGACAACCGGCACCGGGTGGCCTCGGAAGGTTAAGGCAGGTGG
CACGGGTGCGGGGAACCCCG

Product: peptidase S1C protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MAGMTRERRMTRSTNSSFLTKRRTALMAGVVGLAVAGVAVGQFGYGSTPALAQATTAAPVTAQSFSFADVVQKVTPAVVS
VKIKKDVSAQQMAMGGDDEFGGADVPPQIERFLKRFGFENGQGGPGGMQRMPRGGGAGERRVVGQGSGFIISPDGYVVTN
NHVVDGASEVDVTMTDGKEYTAKVIGTDPRTDVALIKIDGKNDLPFVKLADGAPRVGDWVIAVGNPFGLGGTVTAGIVSA
RGRDIGSGPYDDFVQIDAPINRGNSGGPTFDLNGNVIGMNTAIVSPSGGNVGIAFAIPSETVKTVVDQLRQDGKVARGYI
GVQIQPVTDDLASGLGLNAAEGALVAQVQPDTPAAKAGLKSGDVVTKVNGDAVKDARDLSRKIGMMKPGASVALTVVRDG
KTQAFNVKLEQLPTDQQMASADGNGPATHDVPRLGLQLAPAKSVQGAGAQGVVVTEVDPNGPAAARGIRSGDVILDVGGK
TVSNPSDVREGLAAAKAENRKAVLMRVKGEQGVRFVAITLDKSKG

Sequences:

>Translated_525_residues
MAGMTRERRMTRSTNSSFLTKRRTALMAGVVGLAVAGVAVGQFGYGSTPALAQATTAAPVTAQSFSFADVVQKVTPAVVS
VKIKKDVSAQQMAMGGDDEFGGADVPPQIERFLKRFGFENGQGGPGGMQRMPRGGGAGERRVVGQGSGFIISPDGYVVTN
NHVVDGASEVDVTMTDGKEYTAKVIGTDPRTDVALIKIDGKNDLPFVKLADGAPRVGDWVIAVGNPFGLGGTVTAGIVSA
RGRDIGSGPYDDFVQIDAPINRGNSGGPTFDLNGNVIGMNTAIVSPSGGNVGIAFAIPSETVKTVVDQLRQDGKVARGYI
GVQIQPVTDDLASGLGLNAAEGALVAQVQPDTPAAKAGLKSGDVVTKVNGDAVKDARDLSRKIGMMKPGASVALTVVRDG
KTQAFNVKLEQLPTDQQMASADGNGPATHDVPRLGLQLAPAKSVQGAGAQGVVVTEVDPNGPAAARGIRSGDVILDVGGK
TVSNPSDVREGLAAAKAENRKAVLMRVKGEQGVRFVAITLDKSKG
>Mature_524_residues
AGMTRERRMTRSTNSSFLTKRRTALMAGVVGLAVAGVAVGQFGYGSTPALAQATTAAPVTAQSFSFADVVQKVTPAVVSV
KIKKDVSAQQMAMGGDDEFGGADVPPQIERFLKRFGFENGQGGPGGMQRMPRGGGAGERRVVGQGSGFIISPDGYVVTNN
HVVDGASEVDVTMTDGKEYTAKVIGTDPRTDVALIKIDGKNDLPFVKLADGAPRVGDWVIAVGNPFGLGGTVTAGIVSAR
GRDIGSGPYDDFVQIDAPINRGNSGGPTFDLNGNVIGMNTAIVSPSGGNVGIAFAIPSETVKTVVDQLRQDGKVARGYIG
VQIQPVTDDLASGLGLNAAEGALVAQVQPDTPAAKAGLKSGDVVTKVNGDAVKDARDLSRKIGMMKPGASVALTVVRDGK
TQAFNVKLEQLPTDQQMASADGNGPATHDVPRLGLQLAPAKSVQGAGAQGVVVTEVDPNGPAAARGIRSGDVILDVGGKT
VSNPSDVREGLAAAKAENRKAVLMRVKGEQGVRFVAITLDKSKG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=335, Percent_Identity=34.9253731343284, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI22129776, Length=399, Percent_Identity=31.5789473684211, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI24308541, Length=263, Percent_Identity=36.8821292775665, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI7019477, Length=285, Percent_Identity=33.6842105263158, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1786356, Length=449, Percent_Identity=40.0890868596882, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI1789629, Length=454, Percent_Identity=36.784140969163, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1789630, Length=274, Percent_Identity=37.2262773722628, Blast_Score=182, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24646839, Length=272, Percent_Identity=32.7205882352941, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 53839; Mature: 53708

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGMTRERRMTRSTNSSFLTKRRTALMAGVVGLAVAGVAVGQFGYGSTPALAQATTAAPV
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCC
TAQSFSFADVVQKVTPAVVSVKIKKDVSAQQMAMGGDDEFGGADVPPQIERFLKRFGFEN
EECCCCHHHHHHHHCCEEEEEEEECCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC
GQGGPGGMQRMPRGGGAGERRVVGQGSGFIISPDGYVVTNNHVVDGASEVDVTMTDGKEY
CCCCCCHHHHCCCCCCCCCCEEEECCCCEEECCCCEEEECCEEECCCCEEEEEEECCCEE
TAKVIGTDPRTDVALIKIDGKNDLPFVKLADGAPRVGDWVIAVGNPFGLGGTVTAGIVSA
EEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHCC
RGRDIGSGPYDDFVQIDAPINRGNSGGPTFDLNGNVIGMNTAIVSPSGGNVGIAFAIPSE
CCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCHH
TVKTVVDQLRQDGKVARGYIGVQIQPVTDDLASGLGLNAAEGALVAQVQPDTPAAKAGLK
HHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHCCCCCCCCCCEEEEEECCCCCHHHCCCC
SGDVVTKVNGDAVKDARDLSRKIGMMKPGASVALTVVRDGKTQAFNVKLEQLPTDQQMAS
CCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEHHHCCCCHHHHC
ADGNGPATHDVPRLGLQLAPAKSVQGAGAQGVVVTEVDPNGPAAARGIRSGDVILDVGGK
CCCCCCCCCCHHHCCEEECCCCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCC
TVSNPSDVREGLAAAKAENRKAVLMRVKGEQGVRFVAITLDKSKG
CCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEECCCC
>Mature Secondary Structure 
AGMTRERRMTRSTNSSFLTKRRTALMAGVVGLAVAGVAVGQFGYGSTPALAQATTAAPV
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCC
TAQSFSFADVVQKVTPAVVSVKIKKDVSAQQMAMGGDDEFGGADVPPQIERFLKRFGFEN
EECCCCHHHHHHHHCCEEEEEEEECCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCC
GQGGPGGMQRMPRGGGAGERRVVGQGSGFIISPDGYVVTNNHVVDGASEVDVTMTDGKEY
CCCCCCHHHHCCCCCCCCCCEEEECCCCEEECCCCEEEECCEEECCCCEEEEEEECCCEE
TAKVIGTDPRTDVALIKIDGKNDLPFVKLADGAPRVGDWVIAVGNPFGLGGTVTAGIVSA
EEEEECCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHCC
RGRDIGSGPYDDFVQIDAPINRGNSGGPTFDLNGNVIGMNTAIVSPSGGNVGIAFAIPSE
CCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCHH
TVKTVVDQLRQDGKVARGYIGVQIQPVTDDLASGLGLNAAEGALVAQVQPDTPAAKAGLK
HHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHCCCCCCCCCCEEEEEECCCCCHHHCCCC
SGDVVTKVNGDAVKDARDLSRKIGMMKPGASVALTVVRDGKTQAFNVKLEQLPTDQQMAS
CCCEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEHHHCCCCHHHHC
ADGNGPATHDVPRLGLQLAPAKSVQGAGAQGVVVTEVDPNGPAAARGIRSGDVILDVGGK
CCCCCCCCCCHHHCCEEECCCCCCCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCC
TVSNPSDVREGLAAAKAENRKAVLMRVKGEQGVRFVAITLDKSKG
CCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]