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The map label for this gene is cusR [H]

Identifier: 158422761

GI number: 158422761

Start: 1264805

End: 1265521

Strand: Direct

Name: cusR [H]

Synonym: AZC_1137

Alternate gene names: 158422761

Gene position: 1264805-1265521 (Clockwise)

Preceding gene: 158422760

Following gene: 158422763

Centisome position: 23.55

GC content: 67.78

Gene sequence:

>717_bases
ATGGACGCGAATCTCGAAACGGACTTCAGCCTTTCCATGCGACTGCTCCTCGTCGAGGACGACCAAGACGCGGCCGACTA
CCTGCGCAAGGCCTTCCGCGAGGCGGGCCATGTGGTGGACCATGCGGCCGACGGCGAGGACGGCCTCGCCTATGCGCTCG
ACGGCAAATATGACGTGCTGGTGGTGGACCGCATGCTGCCCCGCCGCGACGGCCTCTCGCTGGTCGCCGAACTGCGTGGG
CGCGGCGATGCCACGCCTGTGCTCATCCTCTCGGCGCTGGGACAGGTGGACGACCGCGTGGTCGGACTGCGGGCCGGCGG
CGACGATTATCTGCCCAAGCCCTATGCCTTCACCGAACTGCTTGCCCGCGTCGAGGCGCTGTCGCGCCGGGGGGCGCCGC
AGGCAGCCGAGACCGTCTATCGGGTGGGCGACCTTGAACTCGATCGCCTCGCCCATCGCGTCGCGCGCGGCGGCAAGGAG
ATCCCGCTCCAGCCGCGCGAATTCCGCCTGCTCGAATATCTCATGCGGCACGCGGGGCAGGTGGTGACGCGCACCATGCT
GCTGGAAAACGTCTGGGACTATCACTTCGACCCCCAGACCAACGTCATCGACGTCCACGTCTCCCGCCTGCGCTCCAAGA
TCGACAAGGGCTTCGACGTGCCGCTGATCCACACCGTGCGCGGCGCCGGCTACATGGTCCGCGTGGGCTTGCGCTAA

Upstream 100 bases:

>100_bases
CCTTGCTTCCCGCGCCGTCATCGTTTGGGGGCCTCGCGATTTCGCGGACCCGAGAGCTGCAACCGTGCTGCGCCAGCCCG
CAATGGTGATCTAGACTGAC

Downstream 100 bases:

>100_bases
GGGGCGTCCGGCATGGCTGAGGCGGCATTACCCCCCTCCCAACCCTCCCCCGCAAGGGGGGAGGGCTTTGTCGCGCATTG
TCTCGGGCGATCCATCTCTC

Product: response regulator receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MDANLETDFSLSMRLLLVEDDQDAADYLRKAFREAGHVVDHAADGEDGLAYALDGKYDVLVVDRMLPRRDGLSLVAELRG
RGDATPVLILSALGQVDDRVVGLRAGGDDYLPKPYAFTELLARVEALSRRGAPQAAETVYRVGDLELDRLAHRVARGGKE
IPLQPREFRLLEYLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRVGLR

Sequences:

>Translated_238_residues
MDANLETDFSLSMRLLLVEDDQDAADYLRKAFREAGHVVDHAADGEDGLAYALDGKYDVLVVDRMLPRRDGLSLVAELRG
RGDATPVLILSALGQVDDRVVGLRAGGDDYLPKPYAFTELLARVEALSRRGAPQAAETVYRVGDLELDRLAHRVARGGKE
IPLQPREFRLLEYLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRVGLR
>Mature_238_residues
MDANLETDFSLSMRLLLVEDDQDAADYLRKAFREAGHVVDHAADGEDGLAYALDGKYDVLVVDRMLPRRDGLSLVAELRG
RGDATPVLILSALGQVDDRVVGLRAGGDDYLPKPYAFTELLARVEALSRRGAPQAAETVYRVGDLELDRLAHRVARGGKE
IPLQPREFRLLEYLMRHAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRVGLR

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=48.4304932735426, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=41.5525114155251, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.9140271493213, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=38.4615384615385, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=34.375, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=34.0909090909091, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=203, Percent_Identity=35.9605911330049, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=33.1858407079646, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=34.5454545454545, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.8421052631579, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=33.1818181818182, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=28.3185840707965, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=27.1929824561404, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=28.2608695652174, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=38.6138613861386, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26647; Mature: 26647

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDANLETDFSLSMRLLLVEDDQDAADYLRKAFREAGHVVDHAADGEDGLAYALDGKYDVL
CCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCHHHHCCCCCCCCEEEEECCCEEEE
VVDRMLPRRDGLSLVAELRGRGDATPVLILSALGQVDDRVVGLRAGGDDYLPKPYAFTEL
EECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHH
LARVEALSRRGAPQAAETVYRVGDLELDRLAHRVARGGKEIPLQPREFRLLEYLMRHAGQ
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
VVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRVGLR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHEEECCCCEEEEECCC
>Mature Secondary Structure
MDANLETDFSLSMRLLLVEDDQDAADYLRKAFREAGHVVDHAADGEDGLAYALDGKYDVL
CCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCHHHHCCCCCCCCEEEEECCCEEEE
VVDRMLPRRDGLSLVAELRGRGDATPVLILSALGQVDDRVVGLRAGGDDYLPKPYAFTEL
EECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHH
LARVEALSRRGAPQAAETVYRVGDLELDRLAHRVARGGKEIPLQPREFRLLEYLMRHAGQ
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
VVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIDKGFDVPLIHTVRGAGYMVRVGLR
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]