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The map label for this gene is phoQ [H]

Identifier: 158422754

GI number: 158422754

Start: 1256345

End: 1257739

Strand: Direct

Name: phoQ [H]

Synonym: AZC_1130

Alternate gene names: 158422754

Gene position: 1256345-1257739 (Clockwise)

Preceding gene: 158422753

Following gene: 158422755

Centisome position: 23.4

GC content: 68.46

Gene sequence:

>1395_bases
ATGATCCTGCCGCGCACGCCCGGCTCGCTTGCCTTCCGCCTGTTCCTCTCGGCGGTGGTGGTCACGGCGCTGATCCTGCT
CGTGGTGGGCGTCGTGCTGTCCTCGCTCTATCGCGACGGCGCCGAGCGCGCCTTCGACCGGCGCCTCGACGTCTATCTGA
AGACCATCGTGGGTGGCCTTGCGACCGGCGACATGCCCGACACCGGCGAACTGCCGGAGCCGCAGGGCCTCACGGACCCG
CTGTTCCTTTTCCCCTTTTCCGGCTGGTACTGGCAGATGAGCCGGCTCGATGGTCCCGAGCCAGCCTCCCGCCGTTCGCG
CTCACTGCCCGAGGGCGGCCTGCCGAGCCTCGAAGCTCTGGGGGTCGTAGAGCGGCCGGGCGGCGTGCGCGAGGGCTATG
CGCCGGGTCCCGAAAAGCAGATGCTGCGCCTCGTGGAGCGCACCCTCGACCTGGGGCAGGACGGACGCTACCGCATCACG
GTGGCGGGCGATGCCTCCGAGATCGAGGACGAGATCACCAATTTCAATCTCGCCCTGGTCGGCACCTTCGGCGTGTTGGG
CCTCGCCTTCCTGCTCACCGTGCTGTTCCAGGTCCGCTTCGGTCTGCGGCCGCTGGTGCGTATCCGCGAGGCGCTGTCCG
CCGTGCGGTCCGGCAAGGCGGAACGGCTCGAGGGAGAATATCCGGAGGAGGTCGCCCCGCTGGTGGCGGAGGTGAACGCC
CTCATCGACGCGAACAAGGAGATCGTGGACCGCGCCCGCACCCATGTGGGCAATCTCGCCCATGCGCTGAAGACGCCCCT
CTCCGTCCTGCTCAACGAGGCCGGCAATCGCGACGATCCGCTGGCGGTGCGCGTGCGCGACCAGGCGACGCTCATGCGCG
ACCAGGTGGGGCACCATCTGGAACGCGCCCGCATGGCCGCCCGCGTCTCGGTGGTGGTGAGCGTGTGCGATGTCATCCCC
ATCGTCACCGGCCTTTCGCGCACCATGGAGAAGATCCACCGGACGCGCGATCTCTCCATCGAGGTGGAAGTGGTGGGCGA
GGACATCCGTTTCCGGGGCGAGCGGCACGATCTGGAGGAGATGATCGGCAATCTCATCGACAATGCCTGCAAATGGGCGG
CGGGACGGGTGTTCGTGCGGGTGGCGATGGAGCCGCGCGGCGCCAGCGACCGGGCCTATTTCCGGGTGGTGATCGATGAT
GACGGCCCTGGCCTCAGCCCCGGCAAGCGGGCCGAGGTGCGCCGGCGCGGGCGTCGGCTCGACGAATCCAAGCCGGGTTC
CGGCCTCGGCCTGTCCATCGTCCATGAACTCGCCTCGCTCTACGGGGGACGGTTCGACATGAACACCGCGCCTCTTGGCG
GATTGCGTACGGAACTGGTATTGCCCGCAGCCTGA

Upstream 100 bases:

>100_bases
ATCGACTGTGATGTGATCCAGACCGTCCGTGGCCTGGGCTATCTTCTGGCAGCGCCGGAGACCGCGCGCTGAGCATGCCC
GCCTTCCGGCAGACCGTCCC

Downstream 100 bases:

>100_bases
CCCGAAGGTGGGGCGGTCCGCCGCAGGCAGGCCCCTCCGCTTTCTCGTAAATTTTGTATCCTGTGCGTGCTCCGGTCCGT
CCGCCGGAGACCCGAGCGAA

Product: sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MILPRTPGSLAFRLFLSAVVVTALILLVVGVVLSSLYRDGAERAFDRRLDVYLKTIVGGLATGDMPDTGELPEPQGLTDP
LFLFPFSGWYWQMSRLDGPEPASRRSRSLPEGGLPSLEALGVVERPGGVREGYAPGPEKQMLRLVERTLDLGQDGRYRIT
VAGDASEIEDEITNFNLALVGTFGVLGLAFLLTVLFQVRFGLRPLVRIREALSAVRSGKAERLEGEYPEEVAPLVAEVNA
LIDANKEIVDRARTHVGNLAHALKTPLSVLLNEAGNRDDPLAVRVRDQATLMRDQVGHHLERARMAARVSVVVSVCDVIP
IVTGLSRTMEKIHRTRDLSIEVEVVGEDIRFRGERHDLEEMIGNLIDNACKWAAGRVFVRVAMEPRGASDRAYFRVVIDD
DGPGLSPGKRAEVRRRGRRLDESKPGSGLGLSIVHELASLYGGRFDMNTAPLGGLRTELVLPAA

Sequences:

>Translated_464_residues
MILPRTPGSLAFRLFLSAVVVTALILLVVGVVLSSLYRDGAERAFDRRLDVYLKTIVGGLATGDMPDTGELPEPQGLTDP
LFLFPFSGWYWQMSRLDGPEPASRRSRSLPEGGLPSLEALGVVERPGGVREGYAPGPEKQMLRLVERTLDLGQDGRYRIT
VAGDASEIEDEITNFNLALVGTFGVLGLAFLLTVLFQVRFGLRPLVRIREALSAVRSGKAERLEGEYPEEVAPLVAEVNA
LIDANKEIVDRARTHVGNLAHALKTPLSVLLNEAGNRDDPLAVRVRDQATLMRDQVGHHLERARMAARVSVVVSVCDVIP
IVTGLSRTMEKIHRTRDLSIEVEVVGEDIRFRGERHDLEEMIGNLIDNACKWAAGRVFVRVAMEPRGASDRAYFRVVIDD
DGPGLSPGKRAEVRRRGRRLDESKPGSGLGLSIVHELASLYGGRFDMNTAPLGGLRTELVLPAA
>Mature_464_residues
MILPRTPGSLAFRLFLSAVVVTALILLVVGVVLSSLYRDGAERAFDRRLDVYLKTIVGGLATGDMPDTGELPEPQGLTDP
LFLFPFSGWYWQMSRLDGPEPASRRSRSLPEGGLPSLEALGVVERPGGVREGYAPGPEKQMLRLVERTLDLGQDGRYRIT
VAGDASEIEDEITNFNLALVGTFGVLGLAFLLTVLFQVRFGLRPLVRIREALSAVRSGKAERLEGEYPEEVAPLVAEVNA
LIDANKEIVDRARTHVGNLAHALKTPLSVLLNEAGNRDDPLAVRVRDQATLMRDQVGHHLERARMAARVSVVVSVCDVIP
IVTGLSRTMEKIHRTRDLSIEVEVVGEDIRFRGERHDLEEMIGNLIDNACKWAAGRVFVRVAMEPRGASDRAYFRVVIDD
DGPGLSPGKRAEVRRRGRRLDESKPGSGLGLSIVHELASLYGGRFDMNTAPLGGLRTELVLPAA

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=268, Percent_Identity=29.8507462686567, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789403, Length=352, Percent_Identity=27.8409090909091, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=27.1255060728745, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790346, Length=259, Percent_Identity=22.7799227799228, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=302, Percent_Identity=24.5033112582781, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=279, Percent_Identity=26.8817204301075, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50800; Mature: 50800

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILPRTPGSLAFRLFLSAVVVTALILLVVGVVLSSLYRDGAERAFDRRLDVYLKTIVGGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATGDMPDTGELPEPQGLTDPLFLFPFSGWYWQMSRLDGPEPASRRSRSLPEGGLPSLEAL
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCHHHHHCCCCCCCCCCHHHC
GVVERPGGVREGYAPGPEKQMLRLVERTLDLGQDGRYRITVAGDASEIEDEITNFNLALV
CCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCHHHH
GTFGVLGLAFLLTVLFQVRFGLRPLVRIREALSAVRSGKAERLEGEYPEEVAPLVAEVNA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
LIDANKEIVDRARTHVGNLAHALKTPLSVLLNEAGNRDDPLAVRVRDQATLMRDQVGHHL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHH
ERARMAARVSVVVSVCDVIPIVTGLSRTMEKIHRTRDLSIEVEVVGEDIRFRGERHDLEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHCCCCCHHHH
MIGNLIDNACKWAAGRVFVRVAMEPRGASDRAYFRVVIDDDGPGLSPGKRAEVRRRGRRL
HHHHHHHHHHHHHHCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCC
DESKPGSGLGLSIVHELASLYGGRFDMNTAPLGGLRTELVLPAA
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCC
>Mature Secondary Structure
MILPRTPGSLAFRLFLSAVVVTALILLVVGVVLSSLYRDGAERAFDRRLDVYLKTIVGGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATGDMPDTGELPEPQGLTDPLFLFPFSGWYWQMSRLDGPEPASRRSRSLPEGGLPSLEAL
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCCCCCCCHHHHHCCCCCCCCCCHHHC
GVVERPGGVREGYAPGPEKQMLRLVERTLDLGQDGRYRITVAGDASEIEDEITNFNLALV
CCEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCHHHH
GTFGVLGLAFLLTVLFQVRFGLRPLVRIREALSAVRSGKAERLEGEYPEEVAPLVAEVNA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHH
LIDANKEIVDRARTHVGNLAHALKTPLSVLLNEAGNRDDPLAVRVRDQATLMRDQVGHHL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHH
ERARMAARVSVVVSVCDVIPIVTGLSRTMEKIHRTRDLSIEVEVVGEDIRFRGERHDLEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHCCCCCHHHH
MIGNLIDNACKWAAGRVFVRVAMEPRGASDRAYFRVVIDDDGPGLSPGKRAEVRRRGRRL
HHHHHHHHHHHHHHCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCC
DESKPGSGLGLSIVHELASLYGGRFDMNTAPLGGLRTELVLPAA
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]