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The map label for this gene is phoP [H]

Identifier: 158422753

GI number: 158422753

Start: 1255645

End: 1256316

Strand: Direct

Name: phoP [H]

Synonym: AZC_1129

Alternate gene names: 158422753

Gene position: 1255645-1256316 (Clockwise)

Preceding gene: 158422752

Following gene: 158422754

Centisome position: 23.38

GC content: 65.92

Gene sequence:

>672_bases
GTGCGTCTGCTGGTGATAGAAGACGATCCGGATCTGAACCGGCAATTGGTGAATGCGCTGGGTGAAGCGGGATACGCGGT
CGATACGGCCTTCGACGGGGAGGAGGGGCACTTCCTCGGCGACAGCGAGCCGTATGACGCGGTGGTGCTAGACATCGGCC
TGCCCAAGCTCGACGGCATCTCCGTCCTGGAGCATTGGCGCCGGGCCGGCCGCCGCATGCCGGTACTGATCCTCACTGCC
CGCGACCGCTGGAGCGACAAGGTGCAGGGCTTCGATGCTGGCGCCGACGACTATGTGGCCAAGCCCTTCCACATGGAGGA
GGTGCTCGCCCGCCTGCGGGCGCTGCTGCGCCGCGCCAGCGGCCATGCCTCCAGCGAGCTGACCTGCGGCCCCGTACGTC
TCGATACACGTTCCGGCCGCGTCTCGGTGGGTGGCTCGCCGGTGAAGCTCACCAGCCATGAATATCGCCTGCTCTCCTAT
CTCATGCACCATGCCGGCCGCGTCGTCTCCCGCGCCGAACTGGTGGAGCATCTCTACGAGCAGGATTTCGACCGCGACTC
GAACACCATCGAGGTGTTCGTCGGCCGCCTGCGCAAGAAGATCGACTGTGATGTGATCCAGACCGTCCGTGGCCTGGGCT
ATCTTCTGGCAGCGCCGGAGACCGCGCGCTGA

Upstream 100 bases:

>100_bases
CGCGGGGAGCGTCCCGAGATGTACACAGCAGACCTGACAGAAGCCGCGCGCTCTGGCATTCTCCCGCCCGGCCTGAGGTG
TGGTCGGCGAGGACGAAGAC

Downstream 100 bases:

>100_bases
GCATGCCCGCCTTCCGGCAGACCGTCCCATGATCCTGCCGCGCACGCCCGGCTCGCTTGCCTTCCGCCTGTTCCTCTCGG
CGGTGGTGGTCACGGCGCTG

Product: response regulator receiver

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRLLVIEDDPDLNRQLVNALGEAGYAVDTAFDGEEGHFLGDSEPYDAVVLDIGLPKLDGISVLEHWRRAGRRMPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRASGHASSELTCGPVRLDTRSGRVSVGGSPVKLTSHEYRLLSY
LMHHAGRVVSRAELVEHLYEQDFDRDSNTIEVFVGRLRKKIDCDVIQTVRGLGYLLAAPETAR

Sequences:

>Translated_223_residues
MRLLVIEDDPDLNRQLVNALGEAGYAVDTAFDGEEGHFLGDSEPYDAVVLDIGLPKLDGISVLEHWRRAGRRMPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRASGHASSELTCGPVRLDTRSGRVSVGGSPVKLTSHEYRLLSY
LMHHAGRVVSRAELVEHLYEQDFDRDSNTIEVFVGRLRKKIDCDVIQTVRGLGYLLAAPETAR
>Mature_223_residues
MRLLVIEDDPDLNRQLVNALGEAGYAVDTAFDGEEGHFLGDSEPYDAVVLDIGLPKLDGISVLEHWRRAGRRMPVLILTA
RDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRASGHASSELTCGPVRLDTRSGRVSVGGSPVKLTSHEYRLLSY
LMHHAGRVVSRAELVEHLYEQDFDRDSNTIEVFVGRLRKKIDCDVIQTVRGLGYLLAAPETAR

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=46.5437788018433, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=43.6363636363636, Blast_Score=186, Evalue=8e-49,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=40.4444444444444, Blast_Score=174, Evalue=5e-45,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=43.6363636363636, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=39.4618834080717, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=34.6666666666667, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=34.2465753424658, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=32.2727272727273, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.0434782608696, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=29.0178571428571, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.8245614035088, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=34.2592592592593, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=25.8620689655172, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790299, Length=143, Percent_Identity=29.3706293706294, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24894; Mature: 24894

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVIEDDPDLNRQLVNALGEAGYAVDTAFDGEEGHFLGDSEPYDAVVLDIGLPKLDGI
CEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVLEHWRRAGRRMPVLILTARDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRAS
HHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHC
GHASSELTCGPVRLDTRSGRVSVGGSPVKLTSHEYRLLSYLMHHAGRVVSRAELVEHLYE
CCCCCCCCCCCEEEECCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKIDCDVIQTVRGLGYLLAAPETAR
HCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MRLLVIEDDPDLNRQLVNALGEAGYAVDTAFDGEEGHFLGDSEPYDAVVLDIGLPKLDGI
CEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
SVLEHWRRAGRRMPVLILTARDRWSDKVQGFDAGADDYVAKPFHMEEVLARLRALLRRAS
HHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHC
GHASSELTCGPVRLDTRSGRVSVGGSPVKLTSHEYRLLSYLMHHAGRVVSRAELVEHLYE
CCCCCCCCCCCEEEECCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKIDCDVIQTVRGLGYLLAAPETAR
HCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA