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The map label for this gene is qor [C]

Identifier: 158421832

GI number: 158421832

Start: 249289

End: 250308

Strand: Direct

Name: qor [C]

Synonym: AZC_0208

Alternate gene names: 158421832

Gene position: 249289-250308 (Clockwise)

Preceding gene: 158421830

Following gene: 158421833

Centisome position: 4.64

GC content: 69.12

Gene sequence:

>1020_bases
TTGAGCATGAAGGCGATCGGATACCGGCAGTCCGGCCCCATCGACCGGGACGACGCTTTGGTGGACATCGAGATCGACCG
CCCGGCGGCACGCGGGCGCGATCTCCTGGTCGAGGTGGCGGCCATCTCCGTCAATCCCGTGGACACCAAGGTGCGCAAGC
GGGCGGCACCGCCCGAGGGGGAGTGGAAGATCCTCGGCTGGGATGCGGTGGGACGTGTCGTCGAGGTGGGCGAGGGCGTC
ACCCGCTTCCGGCCGGGTGATGAGGTCTATTATGCCGGCTCCCTCACCCGTCCCGGCGCCAACAGCGCCTTCCATCTGGT
GGACGAGCGCATCGTGGGGCGCAAGCCTGCGACCCTGTCCAACCCGGAGGCGGCAGCCCTGCCGCTGACTGCCATCACCG
CCTGGGAGATGCTGTTCGACCGGCTCGACATCGTGAAGAGCGTGCCGGGCGCGGCCAACGCCATCCTCATCGTCGGCGGT
GCCGGCGGGGTGGGCTCCATCGCCATCCAGCTGGTGCGGGCGCTCACCGACCTCACTGTCATCGCCACCGCCTCGCGCCC
GGAGACGCAGGACTGGGTGAGGGCGCTCGGCGCCCATCACGTGGTGGACCACAGCGCGCCCATCGCGGCGCAGGTGGCGG
CCCTCGGGCTCGGCGCACCGGCCTTCGTCTTCTCGACCACAGAAACCCACCGGCATCTGGCGGAAATCGCCGAGTTGATC
GCCCCGCAGGGCCGCTTCGGGCTGATCGATGATCCGGACGGGCTCGATGTCTCGGTCTTCAAGCGCAAGTCGGTCTCGAC
CCATTGGGAGTTCATGTTCACCCGCTCCATGTTCGAGACGGCGGACATGGACGCACAGGGCCGGCTGCTGGATGAGGTGG
CGCGGCTCGTGGAGGCCGGCAAGGTGCGCACCACGCTCACGCAGACGCTGCGCCCCATCAGCGCCGCCACGCTGAAGACC
GCCCACGCCATCCTCGAGAGCGGCAAGGCGCGGGGCAAGATCGTGGTGGAAGGCTTCTGA

Upstream 100 bases:

>100_bases
GCTCACAGTATCAAAAAGGATACTATGTGCTTTCCTTGTACGTATTGCCTTTGAAGGAGCGTAGGGCAACATCCCCGCCA
TATCAACGTGGCTATGGAGC

Downstream 100 bases:

>100_bases
AGCTCCATTCCGCCGCATACGGACGTATGGCGGGGTAGCGCTCCCGCATAATGGTCCGCCGGCCGTCCGCTGCCCACACT
GCCACCGGCTCGGAGGGTCT

Product: zinc-dependent alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSMKAIGYRQSGPIDRDDALVDIEIDRPAARGRDLLVEVAAISVNPVDTKVRKRAAPPEGEWKILGWDAVGRVVEVGEGV
TRFRPGDEVYYAGSLTRPGANSAFHLVDERIVGRKPATLSNPEAAALPLTAITAWEMLFDRLDIVKSVPGAANAILIVGG
AGGVGSIAIQLVRALTDLTVIATASRPETQDWVRALGAHHVVDHSAPIAAQVAALGLGAPAFVFSTTETHRHLAEIAELI
APQGRFGLIDDPDGLDVSVFKRKSVSTHWEFMFTRSMFETADMDAQGRLLDEVARLVEAGKVRTTLTQTLRPISAATLKT
AHAILESGKARGKIVVEGF

Sequences:

>Translated_339_residues
MSMKAIGYRQSGPIDRDDALVDIEIDRPAARGRDLLVEVAAISVNPVDTKVRKRAAPPEGEWKILGWDAVGRVVEVGEGV
TRFRPGDEVYYAGSLTRPGANSAFHLVDERIVGRKPATLSNPEAAALPLTAITAWEMLFDRLDIVKSVPGAANAILIVGG
AGGVGSIAIQLVRALTDLTVIATASRPETQDWVRALGAHHVVDHSAPIAAQVAALGLGAPAFVFSTTETHRHLAEIAELI
APQGRFGLIDDPDGLDVSVFKRKSVSTHWEFMFTRSMFETADMDAQGRLLDEVARLVEAGKVRTTLTQTLRPISAATLKT
AHAILESGKARGKIVVEGF
>Mature_338_residues
SMKAIGYRQSGPIDRDDALVDIEIDRPAARGRDLLVEVAAISVNPVDTKVRKRAAPPEGEWKILGWDAVGRVVEVGEGVT
RFRPGDEVYYAGSLTRPGANSAFHLVDERIVGRKPATLSNPEAAALPLTAITAWEMLFDRLDIVKSVPGAANAILIVGGA
GGVGSIAIQLVRALTDLTVIATASRPETQDWVRALGAHHVVDHSAPIAAQVAALGLGAPAFVFSTTETHRHLAEIAELIA
PQGRFGLIDDPDGLDVSVFKRKSVSTHWEFMFTRSMFETADMDAQGRLLDEVARLVEAGKVRTTLTQTLRPISAATLKTA
HAILESGKARGKIVVEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=335, Percent_Identity=30.4477611940298, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI194239676, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI194239674, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI13236495, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI22538446, Length=329, Percent_Identity=26.1398176291793, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI22538444, Length=329, Percent_Identity=26.1398176291793, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790485, Length=172, Percent_Identity=31.9767441860465, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71987554, Length=362, Percent_Identity=26.5193370165746, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17507255, Length=347, Percent_Identity=27.0893371757925, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36289; Mature: 36158

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMKAIGYRQSGPIDRDDALVDIEIDRPAARGRDLLVEVAAISVNPVDTKVRKRAAPPEG
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCCHHHHHHHCCCCCC
EWKILGWDAVGRVVEVGEGVTRFRPGDEVYYAGSLTRPGANSAFHLVDERIVGRKPATLS
CEEEEEHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCC
NPEAAALPLTAITAWEMLFDRLDIVKSVPGAANAILIVGGAGGVGSIAIQLVRALTDLTV
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEE
IATASRPETQDWVRALGAHHVVDHSAPIAAQVAALGLGAPAFVFSTTETHRHLAEIAELI
EEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
APQGRFGLIDDPDGLDVSVFKRKSVSTHWEFMFTRSMFETADMDAQGRLLDEVARLVEAG
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
KVRTTLTQTLRPISAATLKTAHAILESGKARGKIVVEGF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure 
SMKAIGYRQSGPIDRDDALVDIEIDRPAARGRDLLVEVAAISVNPVDTKVRKRAAPPEG
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCCHHHHHHHCCCCCC
EWKILGWDAVGRVVEVGEGVTRFRPGDEVYYAGSLTRPGANSAFHLVDERIVGRKPATLS
CEEEEEHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCC
NPEAAALPLTAITAWEMLFDRLDIVKSVPGAANAILIVGGAGGVGSIAIQLVRALTDLTV
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEE
IATASRPETQDWVRALGAHHVVDHSAPIAAQVAALGLGAPAFVFSTTETHRHLAEIAELI
EEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
APQGRFGLIDDPDGLDVSVFKRKSVSTHWEFMFTRSMFETADMDAQGRLLDEVARLVEAG
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
KVRTTLTQTLRPISAATLKTAHAILESGKARGKIVVEGF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA