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The map label for this gene is lysC

Identifier: 15836580

GI number: 15836580

Start: 1198998

End: 1200320

Strand: Direct

Name: lysC

Synonym: CPj1049

Alternate gene names: 15836580

Gene position: 1198998-1200320 (Clockwise)

Preceding gene: 15836579

Following gene: 15836581

Centisome position: 97.75

GC content: 41.04

Gene sequence:

>1323_bases
GTGTCTAAGATAGTTTATAAATTTGGTGGCACTAGCTTAGCAACTGCTGAGAATATCTGTTTGGTTTGTGATATCATTTG
CAAAGATAAGCCTTCTTTTGTTGTTGTAAGCGCAATCGCCGGTGTGACGGACCTCCTTGTAGACTTCTGCTCGTCTTCTT
TAAGAGAACGAGAGGAGGTCTTAAGAAAAATAGAGGGAAAACATGAGGAGATTGTAAAAAACCTAGCGATTCCTTTTCCT
GTCTCTACATGGACGTCTCGACTCCTTCCCTATCTACAACATCTGGAGATCTCAGATCTCGATTTTGCTCGTATTTTGTC
TTTAGGAGAAGATATTTCAGCTTCCCTAGTTCGTGCTGTTTGTAGCACCCGTGGTTGGGATTTAGGATTTCTCGAGGCAC
GTAGTGTCATCTTAACAGACGATAGCTACCGACGTGCCTCTCCAAACCTAGATCTTATGAAAGCACATTGGCATCAGCTC
GAACTAAATCAGCCTTCGTATATTATCCAGGGGTTCATCGGATCTAATGGTTTGGGAGAAACAGTTCTTCTTGGGCGCGG
AGGCAGTGATTATTCAGCAACTTTGATCGCAGAGCTTGCAAGAGCAACAGAAGTGCGTATTTATACCGATGTTAATGGGA
TCTATACCATGGATCCTAAAGTGATTTCCGATGCACAGCGCATTCCTGAGCTCAGTTTCGAAGAGATGCAGAATTTAGCA
AGTTTTGGTGCTAAAGTCCTTTATCCTCCTATGCTCTTTCCTTGTATGCGTGCGGGAATTCCTATTTTTGTGACATCAAC
ATTTGACCCTGAAAAAGGAGGAACATGGGTCTATGCTGTCGATAAGTCTGTGAGTTATGAACCAAGAATAAAAGCTTTAT
CCTTAAGTCAATACCAAAGCTTCTGTTCTGTAGACTATACTGTCCTAGGATGTGGGGGATTAGAAGAGATTTTAGGCATT
TTAGAATCCCATGGGATAGATCCTGAATTGATGATAGCACAAAACAACGTCGTTGGATTTGTAATGGATGATGATATCAT
TTCTCAAGAAGCTCAAGAGCACCTTGTAGATGTTTTATCGCTATCTAGTGTCACACGCTTGCATCATAGTGTTGCATTGA
TTACCATGATCGGAGATAATCTTTCTTCTCCAAAAGTTGTCTCAACAATTACGGAGAAACTCAGAGGTTTTCAAGGACCT
GTATTTTGTTTTTGCCAAAGTTCAATGGCATTAAGCTTTGTTGTTGCCTCAGAGTTGGCAGAGGGTATTATAGAAGAATT
ACATAATGATTATGTAAAACAAAAAGCTATAGTCGCCACGTAG

Upstream 100 bases:

>100_bases
TAAAGATGAATGTTTTAATACATAATTTGGTGCGAGGTGCTGCAGGGACTTTACTCGCAAGTATGGAGAATTATTTTTTC
GACTATCTTAAGAGGGAAAT

Downstream 100 bases:

>100_bases
GGAGAATCATGCATTTACTTACAGCAACTGTTACACCTTTTTTCCCTAATGGCACTATAGATTTTGCTAGCTTAGAACGT
CTTTTATCTTTTCAAGATGC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSKIVYKFGGTSLATAENICLVCDIICKDKPSFVVVSAIAGVTDLLVDFCSSSLREREEVLRKIEGKHEEIVKNLAIPFP
VSTWTSRLLPYLQHLEISDLDFARILSLGEDISASLVRAVCSTRGWDLGFLEARSVILTDDSYRRASPNLDLMKAHWHQL
ELNQPSYIIQGFIGSNGLGETVLLGRGGSDYSATLIAELARATEVRIYTDVNGIYTMDPKVISDAQRIPELSFEEMQNLA
SFGAKVLYPPMLFPCMRAGIPIFVTSTFDPEKGGTWVYAVDKSVSYEPRIKALSLSQYQSFCSVDYTVLGCGGLEEILGI
LESHGIDPELMIAQNNVVGFVMDDDIISQEAQEHLVDVLSLSSVTRLHHSVALITMIGDNLSSPKVVSTITEKLRGFQGP
VFCFCQSSMALSFVVASELAEGIIEELHNDYVKQKAIVAT

Sequences:

>Translated_440_residues
MSKIVYKFGGTSLATAENICLVCDIICKDKPSFVVVSAIAGVTDLLVDFCSSSLREREEVLRKIEGKHEEIVKNLAIPFP
VSTWTSRLLPYLQHLEISDLDFARILSLGEDISASLVRAVCSTRGWDLGFLEARSVILTDDSYRRASPNLDLMKAHWHQL
ELNQPSYIIQGFIGSNGLGETVLLGRGGSDYSATLIAELARATEVRIYTDVNGIYTMDPKVISDAQRIPELSFEEMQNLA
SFGAKVLYPPMLFPCMRAGIPIFVTSTFDPEKGGTWVYAVDKSVSYEPRIKALSLSQYQSFCSVDYTVLGCGGLEEILGI
LESHGIDPELMIAQNNVVGFVMDDDIISQEAQEHLVDVLSLSSVTRLHHSVALITMIGDNLSSPKVVSTITEKLRGFQGP
VFCFCQSSMALSFVVASELAEGIIEELHNDYVKQKAIVAT
>Mature_439_residues
SKIVYKFGGTSLATAENICLVCDIICKDKPSFVVVSAIAGVTDLLVDFCSSSLREREEVLRKIEGKHEEIVKNLAIPFPV
STWTSRLLPYLQHLEISDLDFARILSLGEDISASLVRAVCSTRGWDLGFLEARSVILTDDSYRRASPNLDLMKAHWHQLE
LNQPSYIIQGFIGSNGLGETVLLGRGGSDYSATLIAELARATEVRIYTDVNGIYTMDPKVISDAQRIPELSFEEMQNLAS
FGAKVLYPPMLFPCMRAGIPIFVTSTFDPEKGGTWVYAVDKSVSYEPRIKALSLSQYQSFCSVDYTVLGCGGLEEILGIL
ESHGIDPELMIAQNNVVGFVMDDDIISQEAQEHLVDVLSLSSVTRLHHSVALITMIGDNLSSPKVVSTITEKLRGFQGPV
FCFCQSSMALSFVVASELAEGIIEELHNDYVKQKAIVAT

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartokinase family

Homologues:

Organism=Escherichia coli, GI1790455, Length=449, Percent_Identity=34.7438752783964, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1790376, Length=454, Percent_Identity=27.5330396475771, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1786183, Length=297, Percent_Identity=28.956228956229, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320893, Length=313, Percent_Identity=27.1565495207668, Blast_Score=87, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AK_CHLPN (Q9Z6L0)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   F86621
- PIR:   G81537
- PIR:   H72002
- RefSeq:   NP_225243.1
- RefSeq:   NP_301104.1
- RefSeq:   NP_445342.1
- RefSeq:   NP_877362.1
- ProteinModelPortal:   Q9Z6L0
- GeneID:   1467769
- GeneID:   895115
- GeneID:   919815
- GeneID:   962716
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0803
- KEGG:   cpn:CPn1049
- KEGG:   cpt:CpB1090
- TIGR:   CP_0803
- HOGENOM:   HBG724395
- OMA:   IRVMTFS
- PhylomeDB:   Q9Z6L0
- ProtClustDB:   PRK05925
- BioCyc:   CPNE115711:CP_0803-MONOMER
- BioCyc:   CPNE115713:CPN1049-MONOMER
- BioCyc:   CPNE138677:CPJ1049-MONOMER
- BioCyc:   CPNE182082:CPB1090-MONOMER
- BRENDA:   2.7.2.4
- InterPro:   IPR001048
- InterPro:   IPR001341
- InterPro:   IPR018042
- Gene3D:   G3DSA:3.40.1160.10
- TIGRFAMs:   TIGR00657

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.4

Molecular weight: Translated: 48382; Mature: 48251

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIVYKFGGTSLATAENICLVCDIICKDKPSFVVVSAIAGVTDLLVDFCSSSLREREEV
CCCEEEEECCCEEHHHCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
LRKIEGKHEEIVKNLAIPFPVSTWTSRLLPYLQHLEISDLDFARILSLGEDISASLVRAV
HHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHH
CSTRGWDLGFLEARSVILTDDSYRRASPNLDLMKAHWHQLELNQPSYIIQGFIGSNGLGE
HHCCCCCEEHHHHCEEEEECCCCCCCCCCCHHHHHHHHEECCCCCCEEEEEECCCCCCCC
TVLLGRGGSDYSATLIAELARATEVRIYTDVNGIYTMDPKVISDAQRIPELSFEEMQNLA
EEEEECCCCCHHHHHHHHHHHHCEEEEEEECCCEEECCCHHHHHHHHCCCCCHHHHHHHH
SFGAKVLYPPMLFPCMRAGIPIFVTSTFDPEKGGTWVYAVDKSVSYEPRIKALSLSQYQS
HCCCHHHCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCEEEEHHHHHH
FCSVDYTVLGCGGLEEILGILESHGIDPELMIAQNNVVGFVMDDDIISQEAQEHLVDVLS
HHCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECCEEEEEECCHHHHHHHHHHHHHHHH
LSSVTRLHHSVALITMIGDNLSSPKVVSTITEKLRGFQGPVFCFCQSSMALSFVVASELA
HHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHH
EGIIEELHNDYVKQKAIVAT
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKIVYKFGGTSLATAENICLVCDIICKDKPSFVVVSAIAGVTDLLVDFCSSSLREREEV
CCEEEEECCCEEHHHCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
LRKIEGKHEEIVKNLAIPFPVSTWTSRLLPYLQHLEISDLDFARILSLGEDISASLVRAV
HHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHH
CSTRGWDLGFLEARSVILTDDSYRRASPNLDLMKAHWHQLELNQPSYIIQGFIGSNGLGE
HHCCCCCEEHHHHCEEEEECCCCCCCCCCCHHHHHHHHEECCCCCCEEEEEECCCCCCCC
TVLLGRGGSDYSATLIAELARATEVRIYTDVNGIYTMDPKVISDAQRIPELSFEEMQNLA
EEEEECCCCCHHHHHHHHHHHHCEEEEEEECCCEEECCCHHHHHHHHCCCCCHHHHHHHH
SFGAKVLYPPMLFPCMRAGIPIFVTSTFDPEKGGTWVYAVDKSVSYEPRIKALSLSQYQS
HCCCHHHCCHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCEEEEHHHHHH
FCSVDYTVLGCGGLEEILGILESHGIDPELMIAQNNVVGFVMDDDIISQEAQEHLVDVLS
HHCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECCEEEEEECCHHHHHHHHHHHHHHHH
LSSVTRLHHSVALITMIGDNLSSPKVVSTITEKLRGFQGPVFCFCQSSMALSFVVASELA
HHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHH
EGIIEELHNDYVKQKAIVAT
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362