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The map label for this gene is zwf

Identifier: 15835773

GI number: 15835773

Start: 273925

End: 275463

Strand: Direct

Name: zwf

Synonym: CPj0238

Alternate gene names: 15835773

Gene position: 273925-275463 (Clockwise)

Preceding gene: 15835772

Following gene: 15835774

Centisome position: 22.33

GC content: 39.64

Gene sequence:

>1539_bases
ATGACGAATGTTGTTCAGGAAACTATAGGTGGATTGAATTCCCCACGAACGTGCCCTCCTTGTATTTTAGTTATCTTTGG
AGCGACTGGAGATCTGACGGCAAGGAAACTTTTACCCGCTCTATATCACCTCACTAAAGAAGGACGCCTTTCAGACCAGT
TTGTTTGCGTAGGATTTGCACGTCGAGAGAAATCGAATGAACTGTTCCGCCAAGAGATGAAACAAGCTGTCATACAATTT
TCTCCTTCCGAATTAGATATTAAGGTATGGGAAGATTTCCAACAGCGCCTCTTTTATCATCGCTCAGAATTCGATAACAA
TATGGGATATACATCTCTCAAGGACTCCTTAGAAGATTTAGATAAAACGTACGGAACACGTGGAAATCGTCTTTTTTATC
TTTCTACTCCCCCCCAATATTTTTCTAGAATCATTGAAAATTTAAATAAACATAAGCTTTTCTATAAAAATCAAGACCAA
GGGAAACCCTGGTCCCGTGTCATTATAGAAAAACCTTTTGGAAGAGACTTAGATAGTGCTAAGCAACTTCAGCAATGTAT
CAATGAGAATCTTAATGAAAATTCGGTCTATCATATAGATCACTATTTAGGGAAGGAAACGGTTCAAAACATCTTAACAA
CACGTTTCGCCAATACGATTTTCGAATCGTGTTGGAATTCACAATATATCGATCATGTCCAAATCAGTTTGAGTGAAACG
ATTGGCATAGGATCTCGCGGCAATTTCTTTGAGAAATCTGGGATGCTTCGGGATATGGTACAGAACCATATGATGCAGCT
ACTCTGTTTACTCACTATGGAGCCTCCTACAACTTTTGATGCTGATGAAATCAGAAAAGAAAAAATCAAAATTCTTCAAC
GTATCTCACCATTTTCAGAAGGTTCTTCGATTGTCCGAGGACAATATGGTCCAGGAACGGTTCAAGGAGTCTCGGTCCTT
GGCTATCGTGAAGAAGAGAATGTTGACAAAGATTCCCGAGTAGAGACCTACGTAGCTTTAAAAACAGTCATTAATAATCC
CCGTTGGCTTGGAGTTCCTTTCTATTTACGTGCAGGAAAACGACTCGCCAAAAAATCTACAGACATTTCTATTATTTTTA
AAAAATCACCCTACAATTTATTTGCAGCCGAAGAATGTTCACGTTGTCCGATAGAAAATGATTTGCTAATCATCAGAATT
CAACCGGACGAAGGTGTCGCTTTGAAATTCAACTGTAAGGTTCCAGGAACTAATAATATTGTCCGTCCTGTTAAGATGGA
CTTCCGTTACGACAGCTATTTCCAAACTACAACTCCAGAAGCATACGAGCGTTTATTATGTGATTGCATTATAGGGGATC
GTACGTTATTTACTGGTGGAGATGAAGTTATGGCTTCTTGGAAGCTTTTTACTCCTGTATTAGAGGAGTGGGACCAAGAT
TCCTCACCCTCGTTTCCAAACTATCCTGCAGGATCTTCAGGTCCTAAAGAAGCTGATGCTCTCATTGAAAGAGACGGAAG
AAGCTGGAGACCTTTATAG

Upstream 100 bases:

>100_bases
AAACTAACCTTGTAATCATCAAAAACTACGGGATTTTAATTTTAGAAACTTTTTACTTTTTGTTATTTTCGCAAGTGCGG
GGACAAAAAAGGAGATAAAA

Downstream 100 bases:

>100_bases
ACAATCTTATACAGCATCTAGAAATCGATAAGCATGACAAACATAGGGATTGAGACTATGGCAACACTGATAAATTTCAA
TGATACGAACAAACTTTTGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MTNVVQETIGGLNSPRTCPPCILVIFGATGDLTARKLLPALYHLTKEGRLSDQFVCVGFARREKSNELFRQEMKQAVIQF
SPSELDIKVWEDFQQRLFYHRSEFDNNMGYTSLKDSLEDLDKTYGTRGNRLFYLSTPPQYFSRIIENLNKHKLFYKNQDQ
GKPWSRVIIEKPFGRDLDSAKQLQQCINENLNENSVYHIDHYLGKETVQNILTTRFANTIFESCWNSQYIDHVQISLSET
IGIGSRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPTTFDADEIRKEKIKILQRISPFSEGSSIVRGQYGPGTVQGVSVL
GYREEENVDKDSRVETYVALKTVINNPRWLGVPFYLRAGKRLAKKSTDISIIFKKSPYNLFAAEECSRCPIENDLLIIRI
QPDEGVALKFNCKVPGTNNIVRPVKMDFRYDSYFQTTTPEAYERLLCDCIIGDRTLFTGGDEVMASWKLFTPVLEEWDQD
SSPSFPNYPAGSSGPKEADALIERDGRSWRPL

Sequences:

>Translated_512_residues
MTNVVQETIGGLNSPRTCPPCILVIFGATGDLTARKLLPALYHLTKEGRLSDQFVCVGFARREKSNELFRQEMKQAVIQF
SPSELDIKVWEDFQQRLFYHRSEFDNNMGYTSLKDSLEDLDKTYGTRGNRLFYLSTPPQYFSRIIENLNKHKLFYKNQDQ
GKPWSRVIIEKPFGRDLDSAKQLQQCINENLNENSVYHIDHYLGKETVQNILTTRFANTIFESCWNSQYIDHVQISLSET
IGIGSRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPTTFDADEIRKEKIKILQRISPFSEGSSIVRGQYGPGTVQGVSVL
GYREEENVDKDSRVETYVALKTVINNPRWLGVPFYLRAGKRLAKKSTDISIIFKKSPYNLFAAEECSRCPIENDLLIIRI
QPDEGVALKFNCKVPGTNNIVRPVKMDFRYDSYFQTTTPEAYERLLCDCIIGDRTLFTGGDEVMASWKLFTPVLEEWDQD
SSPSFPNYPAGSSGPKEADALIERDGRSWRPL
>Mature_511_residues
TNVVQETIGGLNSPRTCPPCILVIFGATGDLTARKLLPALYHLTKEGRLSDQFVCVGFARREKSNELFRQEMKQAVIQFS
PSELDIKVWEDFQQRLFYHRSEFDNNMGYTSLKDSLEDLDKTYGTRGNRLFYLSTPPQYFSRIIENLNKHKLFYKNQDQG
KPWSRVIIEKPFGRDLDSAKQLQQCINENLNENSVYHIDHYLGKETVQNILTTRFANTIFESCWNSQYIDHVQISLSETI
GIGSRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPTTFDADEIRKEKIKILQRISPFSEGSSIVRGQYGPGTVQGVSVLG
YREEENVDKDSRVETYVALKTVINNPRWLGVPFYLRAGKRLAKKSTDISIIFKKSPYNLFAAEECSRCPIENDLLIIRIQ
PDEGVALKFNCKVPGTNNIVRPVKMDFRYDSYFQTTTPEAYERLLCDCIIGDRTLFTGGDEVMASWKLFTPVLEEWDQDS
SPSFPNYPAGSSGPKEADALIERDGRSWRPL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI109389365, Length=487, Percent_Identity=35.3182751540041, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI108773793, Length=487, Percent_Identity=35.3182751540041, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI52145310, Length=491, Percent_Identity=27.9022403258656, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1788158, Length=500, Percent_Identity=39.6, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17538218, Length=491, Percent_Identity=35.6415478615071, Blast_Score=321, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6324088, Length=481, Percent_Identity=37.2141372141372, Blast_Score=322, Evalue=6e-89,
Organism=Drosophila melanogaster, GI24643352, Length=490, Percent_Identity=34.8979591836735, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24643350, Length=489, Percent_Identity=34.560327198364, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI221513548, Length=495, Percent_Identity=29.8989898989899, Blast_Score=222, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PD_CHLPN (Q9Z8U6)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   C72103
- PIR:   F86520
- RefSeq:   NP_224447.1
- RefSeq:   NP_300297.1
- RefSeq:   NP_445068.1
- RefSeq:   NP_876520.1
- ProteinModelPortal:   Q9Z8U6
- GeneID:   1466927
- GeneID:   895162
- GeneID:   918927
- GeneID:   962733
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0524
- KEGG:   cpj:CPj0238
- KEGG:   cpn:CPn0238
- KEGG:   cpt:CpB0244
- TIGR:   CP_0524
- HOGENOM:   HBG322449
- OMA:   SRRWAGV
- PhylomeDB:   Q9Z8U6
- ProtClustDB:   PRK05722
- BioCyc:   CPNE115711:CP_0524-MONOMER
- BioCyc:   CPNE115713:CPN0238-MONOMER
- BioCyc:   CPNE138677:CPJ0238-MONOMER
- BioCyc:   CPNE182082:CPB0244-MONOMER
- BRENDA:   1.1.1.49
- GO:   GO:0005488
- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR23429
- PIRSF:   PIRSF000110
- PRINTS:   PR00079
- TIGRFAMs:   TIGR00871

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N

EC number: =1.1.1.49

Molecular weight: Translated: 58740; Mature: 58609

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: ACT_SITE 263-263 BINDING 29-29 BINDING 61-61 BINDING 201-201 BINDING 205-205 BINDING 365-365

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNVVQETIGGLNSPRTCPPCILVIFGATGDLTARKLLPALYHLTKEGRLSDQFVCVGFA
CCCHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHH
RREKSNELFRQEMKQAVIQFSPSELDIKVWEDFQQRLFYHRSEFDNNMGYTSLKDSLEDL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DKTYGTRGNRLFYLSTPPQYFSRIIENLNKHKLFYKNQDQGKPWSRVIIEKPFGRDLDSA
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHCEEEECCCCCCCCHHHEEEECCCCCCHHHH
KQLQQCINENLNENSVYHIDHYLGKETVQNILTTRFANTIFESCWNSQYIDHVQISLSET
HHHHHHHHCCCCCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHH
IGIGSRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPTTFDADEIRKEKIKILQRISPFSE
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GSSIVRGQYGPGTVQGVSVLGYREEENVDKDSRVETYVALKTVINNPRWLGVPFYLRAGK
CCCEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEECCHHHHHHHH
RLAKKSTDISIIFKKSPYNLFAAEECSRCPIENDLLIIRIQPDEGVALKFNCKVPGTNNI
HHHHCCCCEEEEEECCCCCEEEHHHHHCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCC
VRPVKMDFRYDSYFQTTTPEAYERLLCDCIIGDRTLFTGGDEVMASWKLFTPVLEEWDQD
CCCEEECCEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCC
SSPSFPNYPAGSSGPKEADALIERDGRSWRPL
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TNVVQETIGGLNSPRTCPPCILVIFGATGDLTARKLLPALYHLTKEGRLSDQFVCVGFA
CCHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEHH
RREKSNELFRQEMKQAVIQFSPSELDIKVWEDFQQRLFYHRSEFDNNMGYTSLKDSLEDL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
DKTYGTRGNRLFYLSTPPQYFSRIIENLNKHKLFYKNQDQGKPWSRVIIEKPFGRDLDSA
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHCEEEECCCCCCCCHHHEEEECCCCCCHHHH
KQLQQCINENLNENSVYHIDHYLGKETVQNILTTRFANTIFESCWNSQYIDHVQISLSET
HHHHHHHHCCCCCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHH
IGIGSRGNFFEKSGMLRDMVQNHMMQLLCLLTMEPPTTFDADEIRKEKIKILQRISPFSE
CCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GSSIVRGQYGPGTVQGVSVLGYREEENVDKDSRVETYVALKTVINNPRWLGVPFYLRAGK
CCCEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEECCHHHHHHHH
RLAKKSTDISIIFKKSPYNLFAAEECSRCPIENDLLIIRIQPDEGVALKFNCKVPGTNNI
HHHHCCCCEEEEEECCCCCEEEHHHHHCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCC
VRPVKMDFRYDSYFQTTTPEAYERLLCDCIIGDRTLFTGGDEVMASWKLFTPVLEEWDQD
CCCEEECCEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCC
SSPSFPNYPAGSSGPKEADALIERDGRSWRPL
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362