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The map label for this gene is rnc

Identifier: 15835590

GI number: 15835590

Start: 68986

End: 69699

Strand: Reverse

Name: rnc

Synonym: CPj0054

Alternate gene names: 15835590

Gene position: 69699-68986 (Counterclockwise)

Preceding gene: 15835604

Following gene: 15835589

Centisome position: 5.68

GC content: 43.0

Gene sequence:

>714_bases
ATGCATCCCCCTATAGACATCACGGCTATTGAAGCTAAGTTAAATTTTACATTTACACAACCTAAGCTCTTAGAAATAGC
GCTGACTCACCCCTCATATAAAAACGAGTCGGCGGTGCAAATTGAAGATAGTGAGCGTTTAGAATTTTTAGGAGATGCTG
TCCTTGGTCTCATTGTTACTGAGCATCTTTTTCTTCTCTTTCCTTCGATGGATGAGGGAACTCTATCCACGGCACGGGCT
TCTTTAGTGAATGCAAAAGCGTGCTGTCGTTATACAACCATGCTAGGGATTGGGGATTATCTTCTTATAGGAAAAGGGGA
AAAAATCCAGAGTGAGCGAGGACGTCTTTCTGCCTATGCCAATCTATTTGAATCTATTTTAGGTGCTGTGTATTTGGATG
GGGGTCTTTCTCCAGCTAGGAAACTTACGGTTCCCCTCCTTCCTCCTAGAGAAGAAATTCTTCCTTTAATGTCTGGCAAT
CCTAAGAACCTTCTTCAGCAGTTCACACAAAAGCAGTTTCGCGTTCTTCCGGTATATCAATCCACGGCAGTTACGGATGC
TCAAGGAAATGTCAGTTACCAGATCCAGGTTCTTGTGAATCAAGAGGTTTGGGGAGAGGGAAATGCGTCATCCAAAAAGG
AAGCAGAAAAAATTGCAGCACAACAGGCACTAGATACGTATGGCAACAAAAACCAAAACACAATGGACGTGTAA

Upstream 100 bases:

>100_bases
TCCGAATAAGATAACAAATCCAAAAGCACTATAGACTTTAAGCTTTTTTCCGCCTATAAAAATTCCCAACTCTAAGTTTA
AGGACGGCGCCCTCCTATCT

Downstream 100 bases:

>100_bases
TCAATGTGGAGCTACTGCTCCTAAATGGTTAGGGCAATGTCCAGGCTGCCACAACTGGAACTCTTTGGTTGAAGAATATG
TCCCCCAGGCTCGATCTGGG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MHPPIDITAIEAKLNFTFTQPKLLEIALTHPSYKNESAVQIEDSERLEFLGDAVLGLIVTEHLFLLFPSMDEGTLSTARA
SLVNAKACCRYTTMLGIGDYLLIGKGEKIQSERGRLSAYANLFESILGAVYLDGGLSPARKLTVPLLPPREEILPLMSGN
PKNLLQQFTQKQFRVLPVYQSTAVTDAQGNVSYQIQVLVNQEVWGEGNASSKKEAEKIAAQQALDTYGNKNQNTMDV

Sequences:

>Translated_237_residues
MHPPIDITAIEAKLNFTFTQPKLLEIALTHPSYKNESAVQIEDSERLEFLGDAVLGLIVTEHLFLLFPSMDEGTLSTARA
SLVNAKACCRYTTMLGIGDYLLIGKGEKIQSERGRLSAYANLFESILGAVYLDGGLSPARKLTVPLLPPREEILPLMSGN
PKNLLQQFTQKQFRVLPVYQSTAVTDAQGNVSYQIQVLVNQEVWGEGNASSKKEAEKIAAQQALDTYGNKNQNTMDV
>Mature_237_residues
MHPPIDITAIEAKLNFTFTQPKLLEIALTHPSYKNESAVQIEDSERLEFLGDAVLGLIVTEHLFLLFPSMDEGTLSTARA
SLVNAKACCRYTTMLGIGDYLLIGKGEKIQSERGRLSAYANLFESILGAVYLDGGLSPARKLTVPLLPPREEILPLMSGN
PKNLLQQFTQKQFRVLPVYQSTAVTDAQGNVSYQIQVLVNQEVWGEGNASSKKEAEKIAAQQALDTYGNKNQNTMDV

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=229, Percent_Identity=29.6943231441048, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI155030234, Length=229, Percent_Identity=29.6943231441048, Blast_Score=88, Evalue=7e-18,
Organism=Escherichia coli, GI1788920, Length=214, Percent_Identity=31.7757009345794, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17506883, Length=96, Percent_Identity=38.5416666666667, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193202651, Length=96, Percent_Identity=38.5416666666667, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=29.5652173913043, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CHLPN (Q9Z9C7)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D72126
- PIR:   G86497
- RefSeq:   NP_224262.1
- RefSeq:   NP_300114.1
- RefSeq:   NP_445263.1
- RefSeq:   NP_876331.1
- ProteinModelPortal:   Q9Z9C7
- SMR:   Q9Z9C7
- PHCI-2DPAGE:   Q9Z9C7
- GeneID:   1466738
- GeneID:   895023
- GeneID:   918843
- GeneID:   963180
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0721
- KEGG:   cpn:CPn0054
- KEGG:   cpt:CpB0055
- TIGR:   CP_0721
- HOGENOM:   HBG744556
- OMA:   VECRIDD
- ProtClustDB:   PRK00102
- BioCyc:   CPNE115711:CP_0721-MONOMER
- BioCyc:   CPNE115713:CPN0054-MONOMER
- BioCyc:   CPNE138677:CPJ0054-MONOMER
- BioCyc:   CPNE182082:CPB0055-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26088; Mature: 26088

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPPIDITAIEAKLNFTFTQPKLLEIALTHPSYKNESAVQIEDSERLEFLGDAVLGLIVT
CCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
EHLFLLFPSMDEGTLSTARASLVNAKACCRYTTMLGIGDYLLIGKGEKIQSERGRLSAYA
HHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
NLFESILGAVYLDGGLSPARKLTVPLLPPREEILPLMSGNPKNLLQQFTQKQFRVLPVYQ
HHHHHHHHHEEECCCCCCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHEEEEEEEC
STAVTDAQGNVSYQIQVLVNQEVWGEGNASSKKEAEKIAAQQALDTYGNKNQNTMDV
CCEEECCCCCEEEEEEEEEECEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHPPIDITAIEAKLNFTFTQPKLLEIALTHPSYKNESAVQIEDSERLEFLGDAVLGLIVT
CCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHH
EHLFLLFPSMDEGTLSTARASLVNAKACCRYTTMLGIGDYLLIGKGEKIQSERGRLSAYA
HHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
NLFESILGAVYLDGGLSPARKLTVPLLPPREEILPLMSGNPKNLLQQFTQKQFRVLPVYQ
HHHHHHHHHEEECCCCCCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHHEEEEEEEC
STAVTDAQGNVSYQIQVLVNQEVWGEGNASSKKEAEKIAAQQALDTYGNKNQNTMDV
CCEEECCCCCEEEEEEEEEECEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362