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The map label for this gene is tktA [H]

Identifier: 158338617

GI number: 158338617

Start: 5567731

End: 5569737

Strand: Reverse

Name: tktA [H]

Synonym: AM1_5521

Alternate gene names: 158338617

Gene position: 5569737-5567731 (Counterclockwise)

Preceding gene: 158338618

Following gene: 158338616

Centisome position: 85.64

GC content: 50.42

Gene sequence:

>2007_bases
ATGGTTGTTGCGACCCAATCCCTAGACGAACTTTGTATTAATGCCATTCGTTTTCTGGCTATTGATGCCGTCGAAAAAGC
CAAATCGGGACACCCAGGTTTACCCATGGGTGCTGCCCCAATGGCCTATGTCCTTTGGGACCGCATCATGCGGTTTAACC
CTAAAAATCCCTATTGGTTTAACCGCGATCGATTTGTGCTGTCTGCAGGGCATGGCTGCATGCTGCAATATGCCCTTCTC
CATCTGACTGGGTTTAACAGCGTTTCCCTTGAAGAAATTAAGAATTTCCGTCAGTGGGGCTCAAAAACTCCGGGACACCC
TGAGAACTTTGAAACGCCTGGGGTTGAAGTCACGACTGGGCCTTTGGGCCAAGGCATTTGTAATGCCGTCGGTTTGGCCA
TGGCCGAAGCCCATTTGGCAGCCAAGTTCAACAAGCCAGAGCATACCCTTGTAGACCATTACTCCTATGTCATCTTGGGT
GATGGTTGCAATATGGAAGGGGTGTCCGGCGAAGCCTGCTCCTTGGCAGGGCACTTGGGCTTGGGTAAATTGATTGCCCT
TTACGATGACAACCATATTTCCATTGATGGTTCTACAGATATTTCCTTCACAGAAGATGTGGGCAAGCGGTTTGAAGCCT
ATGGTTGGCATGTCCAGCATGTTGAGAATGGCAACACCGATCTTGACGGGATCCAGAAAGCGATTGAAGCCGCGAAAGTT
GTAACCGATAAGCCTTCCTTGATTAAGGTCACTACTACCATTGGCTACGGGTCTCCGAATAAGGCCGATACCGCTGGTGT
TCATGGCGCTGCCCTTGGAGATGCAGAGATTAAAGCCACCCGAGAAAATCTGGGCTGGAGCCATGAACCCTTTGATATTC
CCGACGATGTTCTATCCCACTTCCGGCAAGCAGTGGATCGGGGTGCTACGGCTGAATCCGAGTGGGATGCAGTTCTGGCC
TCCTATCGGTCTCAATACCCTGCTGAAGCAGCTGAATTTGAGCGGATGTTGAAAGGAGAACTCCCCGCAGATTGGGATAA
GGCTCTTCCCAGATACACCCCTGCAGATAAAGGTCTAGCCACTCGGAAGCACTCCGAAATCACCATCAATGCCTTGGCAG
GTGCCATTCCTGAGATGATTGGTGGATCCGCTGACCTGACCCACTCCAACCTGACGGAAATTAAAGGCTCAGGGAATTTC
CAAAAGGGAGATTACAATAACCGCAACCTTCGGTTTGGGGTTCGTGAGCATGGCATGGGGGCTATCTGTAACGGTATTGC
CCTGCATAATTCCGGTTTAATTCCCTACTGCGCCACTTTCTTGGTGTTCGCAGATTATATGAGAGCAGCCATCCGTCTAT
CTGCCCTAGCTGAAGCGGGTGTTATTTACGTCATGACCCATGACTCTATTGGTTTGGGTGAAGATGGTCCAACTCACCAA
CCCGTGGAAACAATTGCTTCCTTGCGAGCCATTCCCAACCTAACGGTGATTCGACCTGCAGACGGAAACGAGGTTTCTGG
GGCGTATAAAGTTGCGATCGCAAGTCGTAAATATCCCACACTGATCGCCTTTACGCGTCAGGCCCTCCCTAACTTAGCCG
GTAGCTCCATTGATGCCGTGGCCAAGGGCGCTTACATTATGTCCGACAGCGATGGCACACCCGACATGATCATGATTGCG
ACAGGCAGTGAAGTACACCTTTGTGAACAAGCTGCTGAGCAGTTACGGTCTGAAGGCAAGAAGGTTCGCGTAGTCTCCAT
GCCCTCCTGGGAATTGTTTGAAGCTCAAACGCCGGAGTACAAAGAGTCTGTTTTACCCAAGGCTATTACTAAGCGTTTAG
CCGTAGAGGCTGCAGCCGATTTCGGTTGGCATCGGTATATTGGTTTTGAAGGTCAATCTATCAGCATCAATCGCTTTGGT
GCCTCTGCACCTGGAAACACTTGCCTAGAACAGTTTGGCTTTACCGTTGAGAACGTTCTCGCCAAAGCCAAGGATCTAAT
GAGCTAA

Upstream 100 bases:

>100_bases
GTACCAAGCCTCTTTTTGACGCCCATAGAGAATAAAGACAACGCTTTTTCTTGCCGCTTATCCCTTCTTGCAGTTCAGTA
AATACTAAAAATTCAAGCTT

Downstream 100 bases:

>100_bases
GGTCTTTCAAGAATCATTTGGTTCGCAGTCCTCCTATTGCTAGGGGGACTGTTTTTTTATGAGGGTCAGCACACCCGCTA
GTCCGAATGATTCATGAGGG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MVVATQSLDELCINAIRFLAIDAVEKAKSGHPGLPMGAAPMAYVLWDRIMRFNPKNPYWFNRDRFVLSAGHGCMLQYALL
HLTGFNSVSLEEIKNFRQWGSKTPGHPENFETPGVEVTTGPLGQGICNAVGLAMAEAHLAAKFNKPEHTLVDHYSYVILG
DGCNMEGVSGEACSLAGHLGLGKLIALYDDNHISIDGSTDISFTEDVGKRFEAYGWHVQHVENGNTDLDGIQKAIEAAKV
VTDKPSLIKVTTTIGYGSPNKADTAGVHGAALGDAEIKATRENLGWSHEPFDIPDDVLSHFRQAVDRGATAESEWDAVLA
SYRSQYPAEAAEFERMLKGELPADWDKALPRYTPADKGLATRKHSEITINALAGAIPEMIGGSADLTHSNLTEIKGSGNF
QKGDYNNRNLRFGVREHGMGAICNGIALHNSGLIPYCATFLVFADYMRAAIRLSALAEAGVIYVMTHDSIGLGEDGPTHQ
PVETIASLRAIPNLTVIRPADGNEVSGAYKVAIASRKYPTLIAFTRQALPNLAGSSIDAVAKGAYIMSDSDGTPDMIMIA
TGSEVHLCEQAAEQLRSEGKKVRVVSMPSWELFEAQTPEYKESVLPKAITKRLAVEAAADFGWHRYIGFEGQSISINRFG
ASAPGNTCLEQFGFTVENVLAKAKDLMS

Sequences:

>Translated_668_residues
MVVATQSLDELCINAIRFLAIDAVEKAKSGHPGLPMGAAPMAYVLWDRIMRFNPKNPYWFNRDRFVLSAGHGCMLQYALL
HLTGFNSVSLEEIKNFRQWGSKTPGHPENFETPGVEVTTGPLGQGICNAVGLAMAEAHLAAKFNKPEHTLVDHYSYVILG
DGCNMEGVSGEACSLAGHLGLGKLIALYDDNHISIDGSTDISFTEDVGKRFEAYGWHVQHVENGNTDLDGIQKAIEAAKV
VTDKPSLIKVTTTIGYGSPNKADTAGVHGAALGDAEIKATRENLGWSHEPFDIPDDVLSHFRQAVDRGATAESEWDAVLA
SYRSQYPAEAAEFERMLKGELPADWDKALPRYTPADKGLATRKHSEITINALAGAIPEMIGGSADLTHSNLTEIKGSGNF
QKGDYNNRNLRFGVREHGMGAICNGIALHNSGLIPYCATFLVFADYMRAAIRLSALAEAGVIYVMTHDSIGLGEDGPTHQ
PVETIASLRAIPNLTVIRPADGNEVSGAYKVAIASRKYPTLIAFTRQALPNLAGSSIDAVAKGAYIMSDSDGTPDMIMIA
TGSEVHLCEQAAEQLRSEGKKVRVVSMPSWELFEAQTPEYKESVLPKAITKRLAVEAAADFGWHRYIGFEGQSISINRFG
ASAPGNTCLEQFGFTVENVLAKAKDLMS
>Mature_668_residues
MVVATQSLDELCINAIRFLAIDAVEKAKSGHPGLPMGAAPMAYVLWDRIMRFNPKNPYWFNRDRFVLSAGHGCMLQYALL
HLTGFNSVSLEEIKNFRQWGSKTPGHPENFETPGVEVTTGPLGQGICNAVGLAMAEAHLAAKFNKPEHTLVDHYSYVILG
DGCNMEGVSGEACSLAGHLGLGKLIALYDDNHISIDGSTDISFTEDVGKRFEAYGWHVQHVENGNTDLDGIQKAIEAAKV
VTDKPSLIKVTTTIGYGSPNKADTAGVHGAALGDAEIKATRENLGWSHEPFDIPDDVLSHFRQAVDRGATAESEWDAVLA
SYRSQYPAEAAEFERMLKGELPADWDKALPRYTPADKGLATRKHSEITINALAGAIPEMIGGSADLTHSNLTEIKGSGNF
QKGDYNNRNLRFGVREHGMGAICNGIALHNSGLIPYCATFLVFADYMRAAIRLSALAEAGVIYVMTHDSIGLGEDGPTHQ
PVETIASLRAIPNLTVIRPADGNEVSGAYKVAIASRKYPTLIAFTRQALPNLAGSSIDAVAKGAYIMSDSDGTPDMIMIA
TGSEVHLCEQAAEQLRSEGKKVRVVSMPSWELFEAQTPEYKESVLPKAITKRLAVEAAADFGWHRYIGFEGQSISINRFG
ASAPGNTCLEQFGFTVENVLAKAKDLMS

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=577, Percent_Identity=27.5563258232236, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI4507521, Length=577, Percent_Identity=27.5563258232236, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI133778974, Length=597, Percent_Identity=24.9581239530988, Blast_Score=130, Evalue=4e-30,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=53.0211480362538, Blast_Score=686, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=662, Percent_Identity=51.8126888217523, Blast_Score=674, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=686, Percent_Identity=25.6559766763848, Blast_Score=153, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6325331, Length=668, Percent_Identity=52.6946107784431, Blast_Score=694, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=48.1315396113602, Blast_Score=638, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=591, Percent_Identity=26.3959390862944, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI45550715, Length=591, Percent_Identity=26.3959390862944, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24645119, Length=552, Percent_Identity=26.0869565217391, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24666278, Length=585, Percent_Identity=25.8119658119658, Blast_Score=143, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72171; Mature: 72171

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVATQSLDELCINAIRFLAIDAVEKAKSGHPGLPMGAAPMAYVLWDRIMRFNPKNPYWF
CEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
NRDRFVLSAGHGCMLQYALLHLTGFNSVSLEEIKNFRQWGSKTPGHPENFETPGVEVTTG
CCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGQGICNAVGLAMAEAHLAAKFNKPEHTLVDHYSYVILGDGCNMEGVSGEACSLAGHLG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEEEEEECCCCCCCCCCCHHHHHHCCC
LGKLIALYDDNHISIDGSTDISFTEDVGKRFEAYGWHVQHVENGNTDLDGIQKAIEAAKV
CCCEEEEEECCEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
VTDKPSLIKVTTTIGYGSPNKADTAGVHGAALGDAEIKATRENLGWSHEPFDIPDDVLSH
HCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
FRQAVDRGATAESEWDAVLASYRSQYPAEAAEFERMLKGELPADWDKALPRYTPADKGLA
HHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCC
TRKHSEITINALAGAIPEMIGGSADLTHSNLTEIKGSGNFQKGDYNNRNLRFGVREHGMG
CCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEECHHHCCCC
AICNGIALHNSGLIPYCATFLVFADYMRAAIRLSALAEAGVIYVMTHDSIGLGEDGPTHQ
HHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCC
PVETIASLRAIPNLTVIRPADGNEVSGAYKVAIASRKYPTLIAFTRQALPNLAGSSIDAV
HHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHH
AKGAYIMSDSDGTPDMIMIATGSEVHLCEQAAEQLRSEGKKVRVVSMPSWELFEAQTPEY
HCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHCCCCCHH
KESVLPKAITKRLAVEAAADFGWHRYIGFEGQSISINRFGASAPGNTCLEQFGFTVENVL
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHH
AKAKDLMS
HHHHHHCC
>Mature Secondary Structure
MVVATQSLDELCINAIRFLAIDAVEKAKSGHPGLPMGAAPMAYVLWDRIMRFNPKNPYWF
CEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEE
NRDRFVLSAGHGCMLQYALLHLTGFNSVSLEEIKNFRQWGSKTPGHPENFETPGVEVTTG
CCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
PLGQGICNAVGLAMAEAHLAAKFNKPEHTLVDHYSYVILGDGCNMEGVSGEACSLAGHLG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEEEEEEECCCCCCCCCCCHHHHHHCCC
LGKLIALYDDNHISIDGSTDISFTEDVGKRFEAYGWHVQHVENGNTDLDGIQKAIEAAKV
CCCEEEEEECCEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
VTDKPSLIKVTTTIGYGSPNKADTAGVHGAALGDAEIKATRENLGWSHEPFDIPDDVLSH
HCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
FRQAVDRGATAESEWDAVLASYRSQYPAEAAEFERMLKGELPADWDKALPRYTPADKGLA
HHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCC
TRKHSEITINALAGAIPEMIGGSADLTHSNLTEIKGSGNFQKGDYNNRNLRFGVREHGMG
CCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEEECHHHCCCC
AICNGIALHNSGLIPYCATFLVFADYMRAAIRLSALAEAGVIYVMTHDSIGLGEDGPTHQ
HHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCC
PVETIASLRAIPNLTVIRPADGNEVSGAYKVAIASRKYPTLIAFTRQALPNLAGSSIDAV
HHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHH
AKGAYIMSDSDGTPDMIMIATGSEVHLCEQAAEQLRSEGKKVRVVSMPSWELFEAQTPEY
HCCCEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHCCCCCHH
KESVLPKAITKRLAVEAAADFGWHRYIGFEGQSISINRFGASAPGNTCLEQFGFTVENVL
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHH
AKAKDLMS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]