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The map label for this gene is fabF [H]

Identifier: 158338618

GI number: 158338618

Start: 5569884

End: 5571137

Strand: Reverse

Name: fabF [H]

Synonym: AM1_5522

Alternate gene names: 158338618

Gene position: 5571137-5569884 (Counterclockwise)

Preceding gene: 158338619

Following gene: 158338617

Centisome position: 85.66

GC content: 53.19

Gene sequence:

>1254_bases
ATGACTAACCTAGAGCCTAAGCGCGTTGTAATTACAGGGCTGGGGGCCATCACTCCATTGGGGAATACCCTCTCTGAATA
CTGGGATGGGTTGCTTGCAGGTCGCAGTGGAATTGGCCCCGTCACCCGATTTGATGCAGCGAAACATGCCTGCCGCATTG
CTGGAGAAGTCAAAGGCTTCGATCCCCAAGACTATATGGATCGCAAAGACGCCAAACGCATGGACCGCTTTGCCCAATTT
GCCGTATCTGCCAGCAAACAAGCCCTAGCGGATGCTAACTTCACCATTGACGATTCCAACGCCAACGATATCGGCATTAT
TATCGGTACCGGCATTGGGGGCCTAAAAGTTTTAGAAGATCAGCAGGAAATCTACCTGACCAAAGGGCCAGATCGCTGTA
GTCCCTTTATGATTCCGATGATGATTGCCAACATGGCGGCGGGATTGACGGCCATTCATGTCGGCGCTAAGGGGCCGAAC
TCCTGTTCCGTGACGGCCTGTGCTGCTGGGTCTAACGCCATTGGCGATGCGTTTCGATTTGTCCAACGTGGCTATACCAA
AGCGATGATTTGCGGCGGCACCGAAGCGGCCGTAACACCCTTGTCCATGGCTGGATTCGCGGCCTGTCGGGCCCTTTCTA
CCCGCAATGATGAGCCCACGAAAGCCAGCCGACCTTTTGATAAAGATCGGGATGGTTTTGTCTTGGGAGAAGGCGTTGGC
ATTCTCATCATTGAAGAATTAGAGCATGCCCTAGCCCGAGGGGCCAAAATCTACGCTGAACTGATTGGCTATGGGGTCAC
CTGCGACGCTCACCATATGACCTCCCCCTCTCCGGGCGGCGTGGGTGCTGCGCGAGCCATTGAGCTATGCCTCAAAGACG
CGAACCTCACCCCAGATCAAATCAGCTATATCAACGCCCACGGCACCAGCACGAACGCCAACGATACAACGGAAACGGCT
GCAATTAAGCATGCGATAGGTGATAATGCTTATCGGGTAGCCATTAGTTCCACCAAATCGATGACGGGTCATCTACTCGG
CGGGTCTGGCGGAATTGAAGCAGTGGCGACTGCCATGGCCATTGCCAATGATCAAGTCCCACCGACCATTAACCTGGACA
ATCCTGATGAAGGGTGCGATCTAGACTATATCCCCCATACCAGCCGTGAATTAACGGTGGATGTTGCTCTTTCCAATTCC
TTTGGTTTTGGCGGTCACAATGTCACCCTTGCCTTCCGAAAGTATGTCGATTAA

Upstream 100 bases:

>100_bases
GCAAAGTAAAGGCTTAGCAATCATGCTGCGTGCTAGAGAGCATGCAGCATGATTGCCAACCCCTCAATATTTCATCCTAT
GCTGATCACATGTGACCATC

Downstream 100 bases:

>100_bases
TGTTGGATTCCCTTGCCGAGATGGCATCTGTATTTGAGGCTTGTCTGTACCAAGCCTCTTTTTGACGCCCATAGAGAATA
AAGACAACGCTTTTTCTTGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTNLEPKRVVITGLGAITPLGNTLSEYWDGLLAGRSGIGPVTRFDAAKHACRIAGEVKGFDPQDYMDRKDAKRMDRFAQF
AVSASKQALADANFTIDDSNANDIGIIIGTGIGGLKVLEDQQEIYLTKGPDRCSPFMIPMMIANMAAGLTAIHVGAKGPN
SCSVTACAAGSNAIGDAFRFVQRGYTKAMICGGTEAAVTPLSMAGFAACRALSTRNDEPTKASRPFDKDRDGFVLGEGVG
ILIIEELEHALARGAKIYAELIGYGVTCDAHHMTSPSPGGVGAARAIELCLKDANLTPDQISYINAHGTSTNANDTTETA
AIKHAIGDNAYRVAISSTKSMTGHLLGGSGGIEAVATAMAIANDQVPPTINLDNPDEGCDLDYIPHTSRELTVDVALSNS
FGFGGHNVTLAFRKYVD

Sequences:

>Translated_417_residues
MTNLEPKRVVITGLGAITPLGNTLSEYWDGLLAGRSGIGPVTRFDAAKHACRIAGEVKGFDPQDYMDRKDAKRMDRFAQF
AVSASKQALADANFTIDDSNANDIGIIIGTGIGGLKVLEDQQEIYLTKGPDRCSPFMIPMMIANMAAGLTAIHVGAKGPN
SCSVTACAAGSNAIGDAFRFVQRGYTKAMICGGTEAAVTPLSMAGFAACRALSTRNDEPTKASRPFDKDRDGFVLGEGVG
ILIIEELEHALARGAKIYAELIGYGVTCDAHHMTSPSPGGVGAARAIELCLKDANLTPDQISYINAHGTSTNANDTTETA
AIKHAIGDNAYRVAISSTKSMTGHLLGGSGGIEAVATAMAIANDQVPPTINLDNPDEGCDLDYIPHTSRELTVDVALSNS
FGFGGHNVTLAFRKYVD
>Mature_416_residues
TNLEPKRVVITGLGAITPLGNTLSEYWDGLLAGRSGIGPVTRFDAAKHACRIAGEVKGFDPQDYMDRKDAKRMDRFAQFA
VSASKQALADANFTIDDSNANDIGIIIGTGIGGLKVLEDQQEIYLTKGPDRCSPFMIPMMIANMAAGLTAIHVGAKGPNS
CSVTACAAGSNAIGDAFRFVQRGYTKAMICGGTEAAVTPLSMAGFAACRALSTRNDEPTKASRPFDKDRDGFVLGEGVGI
LIIEELEHALARGAKIYAELIGYGVTCDAHHMTSPSPGGVGAARAIELCLKDANLTPDQISYINAHGTSTNANDTTETAA
IKHAIGDNAYRVAISSTKSMTGHLLGGSGGIEAVATAMAIANDQVPPTINLDNPDEGCDLDYIPHTSRELTVDVALSNSF
GFGGHNVTLAFRKYVD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:
GO:0003824: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0006633: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0008152: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0008610: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0009058: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0016740: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0016746: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0016747: 3-oxoacyl-[acyl-carrier-protein] synthase 2
GO:0033817: 3-oxoacyl-[acyl-carrier-protein] synthase 2

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=43.855421686747, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI223972627, Length=145, Percent_Identity=49.6551724137931, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI41872631, Length=428, Percent_Identity=25.2336448598131, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=50.4854368932039, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=37.9807692307692, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=35.6626506024096, Blast_Score=267, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=39.3939393939394, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=427, Percent_Identity=23.6533957845433, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=418, Percent_Identity=22.0095693779904, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=37.1621621621622, Blast_Score=282, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=41.5492957746479, Blast_Score=318, Evalue=6e-87,
Organism=Drosophila melanogaster, GI221330659, Length=424, Percent_Identity=23.3490566037736, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19920632, Length=424, Percent_Identity=23.3490566037736, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24581345, Length=430, Percent_Identity=21.3953488372093, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43777; Mature: 43646

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLEPKRVVITGLGAITPLGNTLSEYWDGLLAGRSGIGPVTRFDAAKHACRIAGEVKGF
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCC
DPQDYMDRKDAKRMDRFAQFAVSASKQALADANFTIDDSNANDIGIIIGTGIGGLKVLED
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCCEEEECC
QQEIYLTKGPDRCSPFMIPMMIANMAAGLTAIHVGAKGPNSCSVTACAAGSNAIGDAFRF
CCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHH
VQRGYTKAMICGGTEAAVTPLSMAGFAACRALSTRNDEPTKASRPFDKDRDGFVLGEGVG
HHCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
ILIIEELEHALARGAKIYAELIGYGVTCDAHHMTSPSPGGVGAARAIELCLKDANLTPDQ
EEEHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHH
ISYINAHGTSTNANDTTETAAIKHAIGDNAYRVAISSTKSMTGHLLGGSGGIEAVATAMA
EEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHH
IANDQVPPTINLDNPDEGCDLDYIPHTSRELTVDVALSNSFGFGGHNVTLAFRKYVD
HHCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
TNLEPKRVVITGLGAITPLGNTLSEYWDGLLAGRSGIGPVTRFDAAKHACRIAGEVKGF
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCC
DPQDYMDRKDAKRMDRFAQFAVSASKQALADANFTIDDSNANDIGIIIGTGIGGLKVLED
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEECCCCCEEEECC
QQEIYLTKGPDRCSPFMIPMMIANMAAGLTAIHVGAKGPNSCSVTACAAGSNAIGDAFRF
CCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCHHHHHHHH
VQRGYTKAMICGGTEAAVTPLSMAGFAACRALSTRNDEPTKASRPFDKDRDGFVLGEGVG
HHCCCCEEEEECCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCC
ILIIEELEHALARGAKIYAELIGYGVTCDAHHMTSPSPGGVGAARAIELCLKDANLTPDQ
EEEHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHH
ISYINAHGTSTNANDTTETAAIKHAIGDNAYRVAISSTKSMTGHLLGGSGGIEAVATAMA
EEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHH
IANDQVPPTINLDNPDEGCDLDYIPHTSRELTVDVALSNSFGFGGHNVTLAFRKYVD
HHCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]