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The map label for this gene is hhoA [H]

Identifier: 158337474

GI number: 158337474

Start: 4381891

End: 4383111

Strand: Direct

Name: hhoA [H]

Synonym: AM1_4353

Alternate gene names: 158337474

Gene position: 4381891-4383111 (Clockwise)

Preceding gene: 158337472

Following gene: 158337475

Centisome position: 67.38

GC content: 51.76

Gene sequence:

>1221_bases
ATGCTTTTCTCAAAGTTCTTTCCAGAATTATGCTCTTTTCCCAGGCCAATACAGCGGCCTGAATGGCTCAAGAGAGTTCT
CTCGGCGGTGTTGGTTATGGGCCTGACCCTGGGATTGATGTTGCCTGCCCAGGCAGAAGTCGCTCCTGCTAGCCCTGCTG
CTAAGATCCTCACCAGTGCAACCACTGGAGCCCCCCATAACTTTATTTCAGATGTGGTGCAAAAGGTGGGAGATACCGTC
GTTAGGATTGATACGGAACGGACCGTGGTTCGTCCTGCTGCCGATCCCTTTTTCGATGATCCCTTTTTACGCGATTTCTT
TGGTCCCGAAGGGTATCCCCGCAGTCCCCGAGAAGATCGGCTTCGAGGGCAAGGATCCGGGTTCATTATTGAGAGTTCCG
GCATTATTCTTACCAATGCCCATGTGGTCAGCAAAGCCGATACCGTTTCCGTTACCCTCAAGGACGGCCGAATTTTTGAA
GGTGATGTCCGCGGAGTCGATGAAGTCTCCGATTTAGCCGTCGTCAAGCTGAAAGGAGTCAAAGATTCGCTGCCCGTTGC
CGCCTTAGGTAATTCGGATCAAGCCCAGGTGGGGGATTGGGCCATTGCTGTGGGTAACCCCGTTGGCTTAGACAACACCG
TGACGTTGGGGATTATCAGTACCCTGCACCGTACCAGTGCTGAGGTGGGCATCCCCGGCAAGCGACTGGACTTTATTCAG
ACGGATGCTGCAATTAATCCCGGTAACTCCGGCGGTCCCCTATTAAGTGATGTAGGTGAAGTGATTGGGATCAATACCGC
TATTCGCGCCGATGCCATGGGCATTGGGTTTGCCATTCCCATTAATAAAGCTAAAAGTCTCAAAGACCAGCTTGTTCGGG
GTGAGAAAATTGCTTATCCCTACGTCGGTGTCCAAATGACGACCCTTACCCCAGAGCAGGCTCAGGAAAACAATAAAGAT
CCCAACTCTCCCTTTATCTTGCCTGAAATTGATGGTGCTCTAGTGATGAAAGTTTTCCCCGATACACCGGCAGCTAAGGC
TGGTATCCGTTGGGGGGATGTGATTGTGTCGGTGGACGGTCAACCGATTAAGAGTGCCAATGACATGCAGATGTTTGTCG
AAAATACTCAAGTCGGCCAAAATCTACAGCTTGTCCTCAAGCGTGGTGAACGCACTCAGCAGATTGCTGTGCGGACAGCA
GCCCTGGAAAATGCGGCCTAG

Upstream 100 bases:

>100_bases
TGTGGGTCACCCCACTGCTATTTAAGAAGGTTACAGTTAGAAACGACTAAACTTGTTATAGCGTAGACGGTGGCAGCAAA
GCAGCAAGAAACCCATGAAA

Downstream 100 bases:

>100_bases
ATGAGCGTATCTTTATCTCGCCCTCCCCTGTGGTTTTGGATAGGAATCAGTTGCGTTTGGATCTTTGCCTTAGCCTTCCG
TTTTTGGGGATTAGAACGGT

Product: trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLFSKFFPELCSFPRPIQRPEWLKRVLSAVLVMGLTLGLMLPAQAEVAPASPAAKILTSATTGAPHNFISDVVQKVGDTV
VRIDTERTVVRPAADPFFDDPFLRDFFGPEGYPRSPREDRLRGQGSGFIIESSGIILTNAHVVSKADTVSVTLKDGRIFE
GDVRGVDEVSDLAVVKLKGVKDSLPVAALGNSDQAQVGDWAIAVGNPVGLDNTVTLGIISTLHRTSAEVGIPGKRLDFIQ
TDAAINPGNSGGPLLSDVGEVIGINTAIRADAMGIGFAIPINKAKSLKDQLVRGEKIAYPYVGVQMTTLTPEQAQENNKD
PNSPFILPEIDGALVMKVFPDTPAAKAGIRWGDVIVSVDGQPIKSANDMQMFVENTQVGQNLQLVLKRGERTQQIAVRTA
ALENAA

Sequences:

>Translated_406_residues
MLFSKFFPELCSFPRPIQRPEWLKRVLSAVLVMGLTLGLMLPAQAEVAPASPAAKILTSATTGAPHNFISDVVQKVGDTV
VRIDTERTVVRPAADPFFDDPFLRDFFGPEGYPRSPREDRLRGQGSGFIIESSGIILTNAHVVSKADTVSVTLKDGRIFE
GDVRGVDEVSDLAVVKLKGVKDSLPVAALGNSDQAQVGDWAIAVGNPVGLDNTVTLGIISTLHRTSAEVGIPGKRLDFIQ
TDAAINPGNSGGPLLSDVGEVIGINTAIRADAMGIGFAIPINKAKSLKDQLVRGEKIAYPYVGVQMTTLTPEQAQENNKD
PNSPFILPEIDGALVMKVFPDTPAAKAGIRWGDVIVSVDGQPIKSANDMQMFVENTQVGQNLQLVLKRGERTQQIAVRTA
ALENAA
>Mature_406_residues
MLFSKFFPELCSFPRPIQRPEWLKRVLSAVLVMGLTLGLMLPAQAEVAPASPAAKILTSATTGAPHNFISDVVQKVGDTV
VRIDTERTVVRPAADPFFDDPFLRDFFGPEGYPRSPREDRLRGQGSGFIIESSGIILTNAHVVSKADTVSVTLKDGRIFE
GDVRGVDEVSDLAVVKLKGVKDSLPVAALGNSDQAQVGDWAIAVGNPVGLDNTVTLGIISTLHRTSAEVGIPGKRLDFIQ
TDAAINPGNSGGPLLSDVGEVIGINTAIRADAMGIGFAIPINKAKSLKDQLVRGEKIAYPYVGVQMTTLTPEQAQENNKD
PNSPFILPEIDGALVMKVFPDTPAAKAGIRWGDVIVSVDGQPIKSANDMQMFVENTQVGQNLQLVLKRGERTQQIAVRTA
ALENAA

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoB and HtrA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=397, Percent_Identity=37.0277078085642, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI22129776, Length=334, Percent_Identity=37.125748502994, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI7019477, Length=342, Percent_Identity=36.8421052631579, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI24308541, Length=310, Percent_Identity=34.8387096774194, Blast_Score=162, Evalue=5e-40,
Organism=Escherichia coli, GI1789629, Length=379, Percent_Identity=35.6200527704486, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI1786356, Length=362, Percent_Identity=38.6740331491713, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1789630, Length=293, Percent_Identity=36.8600682593857, Blast_Score=167, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24646839, Length=344, Percent_Identity=36.9186046511628, Blast_Score=185, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43367; Mature: 43367

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSKFFPELCSFPRPIQRPEWLKRVLSAVLVMGLTLGLMLPAQAEVAPASPAAKILTSA
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHC
TTGAPHNFISDVVQKVGDTVVRIDTERTVVRPAADPFFDDPFLRDFFGPEGYPRSPREDR
CCCCCHHHHHHHHHHHCCEEEEEECCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCHHHH
LRGQGSGFIIESSGIILTNAHVVSKADTVSVTLKDGRIFEGDVRGVDEVSDLAVVKLKGV
HCCCCCEEEEECCCEEEECCEEEECCCEEEEEEECCEEEECCCCCCHHHHCEEEEEEECC
KDSLPVAALGNSDQAQVGDWAIAVGNPVGLDNTVTLGIISTLHRTSAEVGIPGKRLDFIQ
CCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEE
TDAAINPGNSGGPLLSDVGEVIGINTAIRADAMGIGFAIPINKAKSLKDQLVRGEKIAYP
CCCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCEEEEECCHHHHHHHHHHCCCEEECC
YVGVQMTTLTPEQAQENNKDPNSPFILPEIDGALVMKVFPDTPAAKAGIRWGDVIVSVDG
EECEEEEECCHHHHHHCCCCCCCCEEEECCCCEEEEEECCCCCCHHCCCEECEEEEEECC
QPIKSANDMQMFVENTQVGQNLQLVLKRGERTQQIAVRTAALENAA
CCCCCCCHHHHEEHHHCCCCCHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLFSKFFPELCSFPRPIQRPEWLKRVLSAVLVMGLTLGLMLPAQAEVAPASPAAKILTSA
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHC
TTGAPHNFISDVVQKVGDTVVRIDTERTVVRPAADPFFDDPFLRDFFGPEGYPRSPREDR
CCCCCHHHHHHHHHHHCCEEEEEECCCEEECCCCCCCCCCCHHHHHCCCCCCCCCCHHHH
LRGQGSGFIIESSGIILTNAHVVSKADTVSVTLKDGRIFEGDVRGVDEVSDLAVVKLKGV
HCCCCCEEEEECCCEEEECCEEEECCCEEEEEEECCEEEECCCCCCHHHHCEEEEEEECC
KDSLPVAALGNSDQAQVGDWAIAVGNPVGLDNTVTLGIISTLHRTSAEVGIPGKRLDFIQ
CCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEE
TDAAINPGNSGGPLLSDVGEVIGINTAIRADAMGIGFAIPINKAKSLKDQLVRGEKIAYP
CCCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCEEEEECCHHHHHHHHHHCCCEEECC
YVGVQMTTLTPEQAQENNKDPNSPFILPEIDGALVMKVFPDTPAAKAGIRWGDVIVSVDG
EECEEEEECCHHHHHHCCCCCCCCEEEECCCCEEEEEECCCCCCHHCCCEECEEEEEECC
QPIKSANDMQMFVENTQVGQNLQLVLKRGERTQQIAVRTAALENAA
CCCCCCCHHHHEEHHHCCCCCHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]