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The map label for this gene is ubiB [C]

Identifier: 158334576

GI number: 158334576

Start: 1385128

End: 1386843

Strand: Direct

Name: ubiB [C]

Synonym: AM1_1403

Alternate gene names: 158334576

Gene position: 1385128-1386843 (Clockwise)

Preceding gene: 158334571

Following gene: 158334581

Centisome position: 21.3

GC content: 48.83

Gene sequence:

>1716_bases
ATGCAGCAACAGCTCATGTCATCCCCCCCGCCTGCTAACAGCGCACTGCAGCGATATGACGCCCGTAAGATCGCTTCTTA
CTACCGCTGGCGTCCTTGGAAAGCGCTCTGGCGTCTTATCTACATTATTAGTCTTTTTAATGGATTTATTTGGGGGCTGT
TGTGGGATCGATGGACCCATACCAGCACAGCCCATTATCCTCAACGCGCCATTCAGATTCGGAAAATTCTGACCCAATTA
GGGCCAACCTTTATTAAGGTGGGTCAAGCTTTATCGACTCGCCCTGATCTGATTCCCAAGGACTTCCTGACAGAGCTGAT
GTTGCTCCAGGATCAGTTGCCTCCATTCCCTAATGAGCAAGCATTTGCGCAAATTGAAGCTGAGTTACGCCAGCCAGTCC
GGGAGATTTATCAAGAGATTTCAGCTCAGCCCGTTGCGGCTGCTAGCTTAGGCCAAGTTTATCGAGGCCGATTGTTTACG
GGTGAAGAAGTCGCCATTAAGGTTCAGCGCCCTAATCTGAGGCCGAAGCTGACATTAGATCTGTATCTAATGCGATGGAT
GGCGGCTCGGTTTGGACGATTTCTCCCCCTCAATTTAGGTCATGATTTAACCCTGATTGTGGATGAGTTTGGTACCAAGC
TATTTGAAGAGATTGACTACATCAATGAAGGTCAGAATGCCGAGCGGTTTGCAGAGAACTTCAAAGAGTATCCTGCTGTT
GAAGTTCCCCGGATTCACTGGGCCTATAGTGGCAGAAAGGTCTTAACTCTCCAATGGATTAATGGTTTTAAGCTAACGGA
TAGTCAATGCGCAGTTGAAGCCAATATGGACCCGGATCGCCTGGTACAGATTGGTGTGATTTCAAGCTTGCGTCAGCTGC
TAGAGTTTGGTTTTTTCCATGCCGATCCCCATCCTGGCAATCTGTTTGCCACCTCCGAAGGCAGCATGGCCTATGTAGAC
TTTGGCATGATGGACCAGCTCGATCAAACCACAAAGAATACCTTAGTGGATGCGGTCGTTCACCTCGTTAATAAAGACTA
TGAGTTGCTGGCAACTGATTTTGTCAAGCTGGGTTTTCTCACTCCTGAAACAGATATCCGCCCCATTATTCCCGCTCTAG
AAGATGTATTCGATGACATCATTGGCGCTAAAGTGGGTGATTTCAACTTCAAAACCATTACTGATCGGTTCTCGGAGTTG
ATGTATGACTATCCCTTCCGAGTACCGGCAAAGTTTGCGCTGATCATTCGGTCTTTGGTGACTCAAGAAGGGGTCGCCCT
ATGCCTTAATCCTGACTTCAAGATTCTGGAAGTGAGTTATCCCTACGTGGCTCAGCGCCTGTTGGCTGGAGAAACCCCAG
ACTTTCAGCGTCGTCTCTTGGAAGTGCTGTTTAAGGATGGTAAATTCCAATGGCAGCGCCTGGAGAACCTGATTGCGATC
GCACAAACGGATCAGAGTTTCGATCTCATCCCCACTGCCCGCTTAGGCATGCAGTTCTTGATGTCTGATGAGGGAGATTA
TTTGCGGCGTCAGGTGGTATTGGCCTTGATCGAGGATGATCGGCTCCATACCGAAGAAGTCGAACGACTGTGGAACTTAA
TTAAGGGCGATTTGAAGCCCGAGAAGCTCTTTAGTGTTGCCCTAGGCGCTTTGGCTGAATTCTCTGACTCCAATCTTCCT
GAATGGCTGCCTCGGCCGCCTCTGCCTGTCTCATAA

Upstream 100 bases:

>100_bases
TGATTTGGGAAGTGCTAAAAACTTCAATAAGAAGCTAGATTTGCAATGGTTTAAGGGTATTGAGAACGCAGTTTTGGAGT
TGTGAGGACAACGCAACGTG

Downstream 100 bases:

>100_bases
ACGTTTCAAGCAGGAAAAGTCCTAACCATAGCGCTGAGCTAGAGCGGCTTGGGCTTCTTCGCGATCGTCGAAATGGATTT
TTTCGGTGCCTAGGATTTGG

Product: ABC-1 family protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MQQQLMSSPPPANSALQRYDARKIASYYRWRPWKALWRLIYIISLFNGFIWGLLWDRWTHTSTAHYPQRAIQIRKILTQL
GPTFIKVGQALSTRPDLIPKDFLTELMLLQDQLPPFPNEQAFAQIEAELRQPVREIYQEISAQPVAAASLGQVYRGRLFT
GEEVAIKVQRPNLRPKLTLDLYLMRWMAARFGRFLPLNLGHDLTLIVDEFGTKLFEEIDYINEGQNAERFAENFKEYPAV
EVPRIHWAYSGRKVLTLQWINGFKLTDSQCAVEANMDPDRLVQIGVISSLRQLLEFGFFHADPHPGNLFATSEGSMAYVD
FGMMDQLDQTTKNTLVDAVVHLVNKDYELLATDFVKLGFLTPETDIRPIIPALEDVFDDIIGAKVGDFNFKTITDRFSEL
MYDYPFRVPAKFALIIRSLVTQEGVALCLNPDFKILEVSYPYVAQRLLAGETPDFQRRLLEVLFKDGKFQWQRLENLIAI
AQTDQSFDLIPTARLGMQFLMSDEGDYLRRQVVLALIEDDRLHTEEVERLWNLIKGDLKPEKLFSVALGALAEFSDSNLP
EWLPRPPLPVS

Sequences:

>Translated_571_residues
MQQQLMSSPPPANSALQRYDARKIASYYRWRPWKALWRLIYIISLFNGFIWGLLWDRWTHTSTAHYPQRAIQIRKILTQL
GPTFIKVGQALSTRPDLIPKDFLTELMLLQDQLPPFPNEQAFAQIEAELRQPVREIYQEISAQPVAAASLGQVYRGRLFT
GEEVAIKVQRPNLRPKLTLDLYLMRWMAARFGRFLPLNLGHDLTLIVDEFGTKLFEEIDYINEGQNAERFAENFKEYPAV
EVPRIHWAYSGRKVLTLQWINGFKLTDSQCAVEANMDPDRLVQIGVISSLRQLLEFGFFHADPHPGNLFATSEGSMAYVD
FGMMDQLDQTTKNTLVDAVVHLVNKDYELLATDFVKLGFLTPETDIRPIIPALEDVFDDIIGAKVGDFNFKTITDRFSEL
MYDYPFRVPAKFALIIRSLVTQEGVALCLNPDFKILEVSYPYVAQRLLAGETPDFQRRLLEVLFKDGKFQWQRLENLIAI
AQTDQSFDLIPTARLGMQFLMSDEGDYLRRQVVLALIEDDRLHTEEVERLWNLIKGDLKPEKLFSVALGALAEFSDSNLP
EWLPRPPLPVS
>Mature_571_residues
MQQQLMSSPPPANSALQRYDARKIASYYRWRPWKALWRLIYIISLFNGFIWGLLWDRWTHTSTAHYPQRAIQIRKILTQL
GPTFIKVGQALSTRPDLIPKDFLTELMLLQDQLPPFPNEQAFAQIEAELRQPVREIYQEISAQPVAAASLGQVYRGRLFT
GEEVAIKVQRPNLRPKLTLDLYLMRWMAARFGRFLPLNLGHDLTLIVDEFGTKLFEEIDYINEGQNAERFAENFKEYPAV
EVPRIHWAYSGRKVLTLQWINGFKLTDSQCAVEANMDPDRLVQIGVISSLRQLLEFGFFHADPHPGNLFATSEGSMAYVD
FGMMDQLDQTTKNTLVDAVVHLVNKDYELLATDFVKLGFLTPETDIRPIIPALEDVFDDIIGAKVGDFNFKTITDRFSEL
MYDYPFRVPAKFALIIRSLVTQEGVALCLNPDFKILEVSYPYVAQRLLAGETPDFQRRLLEVLFKDGKFQWQRLENLIAI
AQTDQSFDLIPTARLGMQFLMSDEGDYLRRQVVLALIEDDRLHTEEVERLWNLIKGDLKPEKLFSVALGALAEFSDSNLP
EWLPRPPLPVS

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=253, Percent_Identity=29.6442687747036, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI41393593, Length=260, Percent_Identity=28.0769230769231, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI217035081, Length=251, Percent_Identity=28.6852589641434, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI34147522, Length=343, Percent_Identity=25.6559766763848, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI27363457, Length=298, Percent_Identity=26.1744966442953, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI217416386, Length=251, Percent_Identity=26.2948207171315, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI2367309, Length=378, Percent_Identity=29.3650793650794, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17559152, Length=240, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32565180, Length=302, Percent_Identity=24.5033112582781, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323282, Length=241, Percent_Identity=26.9709543568465, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6325148, Length=255, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321319, Length=254, Percent_Identity=24.8031496062992, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24662575, Length=263, Percent_Identity=32.6996197718631, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI22024280, Length=286, Percent_Identity=32.5174825174825, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI18859849, Length=263, Percent_Identity=26.9961977186312, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 65725; Mature: 65725

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQLMSSPPPANSALQRYDARKIASYYRWRPWKALWRLIYIISLFNGFIWGLLWDRWTH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TSTAHYPQRAIQIRKILTQLGPTFIKVGQALSTRPDLIPKDFLTELMLLQDQLPPFPNEQ
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHH
AFAQIEAELRQPVREIYQEISAQPVAAASLGQVYRGRLFTGEEVAIKVQRPNLRPKLTLD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHH
LYLMRWMAARFGRFLPLNLGHDLTLIVDEFGTKLFEEIDYINEGQNAERFAENFKEYPAV
HHHHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
EVPRIHWAYSGRKVLTLQWINGFKLTDSQCAVEANMDPDRLVQIGVISSLRQLLEFGFFH
CCCCEEEEECCCEEEEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
ADPHPGNLFATSEGSMAYVDFGMMDQLDQTTKNTLVDAVVHLVNKDYELLATDFVKLGFL
CCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
TPETDIRPIIPALEDVFDDIIGAKVGDFNFKTITDRFSELMYDYPFRVPAKFALIIRSLV
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TQEGVALCLNPDFKILEVSYPYVAQRLLAGETPDFQRRLLEVLFKDGKFQWQRLENLIAI
HHCCCEEEECCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
AQTDQSFDLIPTARLGMQFLMSDEGDYLRRQVVLALIEDDRLHTEEVERLWNLIKGDLKP
HCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCH
EKLFSVALGALAEFSDSNLPEWLPRPPLPVS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQQQLMSSPPPANSALQRYDARKIASYYRWRPWKALWRLIYIISLFNGFIWGLLWDRWTH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TSTAHYPQRAIQIRKILTQLGPTFIKVGQALSTRPDLIPKDFLTELMLLQDQLPPFPNEQ
CCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHH
AFAQIEAELRQPVREIYQEISAQPVAAASLGQVYRGRLFTGEEVAIKVQRPNLRPKLTLD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHH
LYLMRWMAARFGRFLPLNLGHDLTLIVDEFGTKLFEEIDYINEGQNAERFAENFKEYPAV
HHHHHHHHHHHCCEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
EVPRIHWAYSGRKVLTLQWINGFKLTDSQCAVEANMDPDRLVQIGVISSLRQLLEFGFFH
CCCCEEEEECCCEEEEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCC
ADPHPGNLFATSEGSMAYVDFGMMDQLDQTTKNTLVDAVVHLVNKDYELLATDFVKLGFL
CCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
TPETDIRPIIPALEDVFDDIIGAKVGDFNFKTITDRFSELMYDYPFRVPAKFALIIRSLV
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TQEGVALCLNPDFKILEVSYPYVAQRLLAGETPDFQRRLLEVLFKDGKFQWQRLENLIAI
HHCCCEEEECCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
AQTDQSFDLIPTARLGMQFLMSDEGDYLRRQVVLALIEDDRLHTEEVERLWNLIKGDLKP
HCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCH
EKLFSVALGALAEFSDSNLPEWLPRPPLPVS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]