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The map label for this gene is lpxC [H]

Identifier: 158333778

GI number: 158333778

Start: 572855

End: 573628

Strand: Reverse

Name: lpxC [H]

Synonym: AM1_0586

Alternate gene names: 158333778

Gene position: 573628-572855 (Counterclockwise)

Preceding gene: 158333779

Following gene: 158333777

Centisome position: 8.82

GC content: 52.97

Gene sequence:

>774_bases
ATGGGCTTGCATACGGGGGCTACTGCCACCGTCACCGTTTATCCAGCGCCGCCCCATCAAGGGCGATATTTTGGTTACCA
AGATCAGCCAGATATTCCTGCTCACCTCTCATCGGTACACCAAACCCAGTTCTGCACCACCTTGAAGCAGGCAGATACCA
CTATTGCAACGGTGGAACATCTGTTGGCGGCTTTAGCAGGAATGGGCATTGATAATGCCCGTATTGATCTAGACGGACCC
GAAGTTCCGATTTTAGATGGATCTGCCCAGAGGTGGACCGAGGCCATTCTGAAGGCAGGCTATCAGGTTCAGTCAGAACT
TCGCCTCAGACCGACCCTGCATCATCCAGTTTTGGTGCAGGATGCAGACGCCTTTGTGATGGCCCTGCCAGAGCCCCACC
TCTCCTTTAGCTACGGCATTGAGTTTCCTGAACCCGCCATTGGTAAACAGTGGTACCGATTGAGTCCTAACGCGTTTCTC
TCTGATATTGCCCCCGCCCGCACCTTTGGCCGGGCCAAGGATGTCGAATCCCTGCAAGCTAAGGGGTTCATCAAAGGTGG
TAGTCTAGACAATGCTTTGGTTTGTCGTCAGGACGAATGGCTGAATCCGCCGTTGCGATTTGCAAACGAGCCGGTTCGCC
ACAAACTGTTGGACTTGATTGGCGATTTAAGTTTATTGGGGTATTTCCCCCCCGCCCATTACGTTGCATATAAAGCCAGT
CACTCCCTCCACATTCGCTTTGCCAAACGCCTTCAGCAAGCCTTACTCGGCTGA

Upstream 100 bases:

>100_bases
AAGCGTGGATGCCAGTAAGACCGAGGGGTTAAAGGGTTTTGAAGATGCGATCGCATCTCCTTATCAACACACCCTAAACC
ACAGCTTTACCCTTACTGGC

Downstream 100 bases:

>100_bases
CTGCATTTTTTGTTGAATCGTGATTGCTTATTATGTCAAATCCCTCTGATGGCTCTACCGATCCCAAAACCACCTTTATG
ATTGAGGAGATTCAAGAGCT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MGLHTGATATVTVYPAPPHQGRYFGYQDQPDIPAHLSSVHQTQFCTTLKQADTTIATVEHLLAALAGMGIDNARIDLDGP
EVPILDGSAQRWTEAILKAGYQVQSELRLRPTLHHPVLVQDADAFVMALPEPHLSFSYGIEFPEPAIGKQWYRLSPNAFL
SDIAPARTFGRAKDVESLQAKGFIKGGSLDNALVCRQDEWLNPPLRFANEPVRHKLLDLIGDLSLLGYFPPAHYVAYKAS
HSLHIRFAKRLQQALLG

Sequences:

>Translated_257_residues
MGLHTGATATVTVYPAPPHQGRYFGYQDQPDIPAHLSSVHQTQFCTTLKQADTTIATVEHLLAALAGMGIDNARIDLDGP
EVPILDGSAQRWTEAILKAGYQVQSELRLRPTLHHPVLVQDADAFVMALPEPHLSFSYGIEFPEPAIGKQWYRLSPNAFL
SDIAPARTFGRAKDVESLQAKGFIKGGSLDNALVCRQDEWLNPPLRFANEPVRHKLLDLIGDLSLLGYFPPAHYVAYKAS
HSLHIRFAKRLQQALLG
>Mature_256_residues
GLHTGATATVTVYPAPPHQGRYFGYQDQPDIPAHLSSVHQTQFCTTLKQADTTIATVEHLLAALAGMGIDNARIDLDGPE
VPILDGSAQRWTEAILKAGYQVQSELRLRPTLHHPVLVQDADAFVMALPEPHLSFSYGIEFPEPAIGKQWYRLSPNAFLS
DIAPARTFGRAKDVESLQAKGFIKGGSLDNALVCRQDEWLNPPLRFANEPVRHKLLDLIGDLSLLGYFPPAHYVAYKASH
SLHIRFAKRLQQALLG

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:
GO:0008610: UDP-3-0-acyl N-acetylglucosamine deacetylase
GO:0008759: UDP-3-0-acyl N-acetylglucosamine deacetylase
GO:0009245: UDP-3-0-acyl N-acetylglucosamine deacetylase
GO:0016787: UDP-3-0-acyl N-acetylglucosamine deacetylase

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=266, Percent_Identity=40.2255639097744, Blast_Score=176, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 28349; Mature: 28217

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLHTGATATVTVYPAPPHQGRYFGYQDQPDIPAHLSSVHQTQFCTTLKQADTTIATVEH
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHH
LLAALAGMGIDNARIDLDGPEVPILDGSAQRWTEAILKAGYQVQSELRLRPTLHHPVLVQ
HHHHHHHCCCCCCEEECCCCCCEEECCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEE
DADAFVMALPEPHLSFSYGIEFPEPAIGKQWYRLSPNAFLSDIAPARTFGRAKDVESLQA
CCCEEEEECCCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHH
KGFIKGGSLDNALVCRQDEWLNPPLRFANEPVRHKLLDLIGDLSLLGYFPPAHYVAYKAS
CCEEECCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEECC
HSLHIRFAKRLQQALLG
CCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GLHTGATATVTVYPAPPHQGRYFGYQDQPDIPAHLSSVHQTQFCTTLKQADTTIATVEH
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHH
LLAALAGMGIDNARIDLDGPEVPILDGSAQRWTEAILKAGYQVQSELRLRPTLHHPVLVQ
HHHHHHHCCCCCCEEECCCCCCEEECCCHHHHHHHHHHCCCCCHHHHCCCCCCCCCEEEE
DADAFVMALPEPHLSFSYGIEFPEPAIGKQWYRLSPNAFLSDIAPARTFGRAKDVESLQA
CCCEEEEECCCCCCEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCHHHHHHHHH
KGFIKGGSLDNALVCRQDEWLNPPLRFANEPVRHKLLDLIGDLSLLGYFPPAHYVAYKAS
CCEEECCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEECC
HSLHIRFAKRLQQALLG
CCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA