Click here to switch to the map view.

The map label for this gene is ppx [H]

Identifier: 158333751

GI number: 158333751

Start: 544724

End: 546322

Strand: Direct

Name: ppx [H]

Synonym: AM1_0559

Alternate gene names: 158333751

Gene position: 544724-546322 (Clockwise)

Preceding gene: 158333748

Following gene: 158333752

Centisome position: 8.38

GC content: 48.97

Gene sequence:

>1599_bases
ATGCAAACCATTGCTGCTATTGATGTGGGAACCAATTCAATCCACATGGTCGTGGTGAAAGTTAACCCTGAAATTCCAGC
ATTTAATATTATTGATACCGAAAAAAGTACCGTTCGCTTAGGGGAAGGAAGCAAAGATACTGGGAAGCTGCATCCCGATG
CGATCGCAAGAGCAATTGCCGCCCTTCGTCGCTGCCAAGAAGTGGCCGCAGCCTGTAAAGTCGAGCAAATTCAGGCGGTT
GCCACCAGTGCTGTCCGGGAAGCCCTCAATGGTCGGACCTTTATTCGCGCCGTTGAATCTGAACTCGGCCTCAAAATCAA
TGTCATCTCAGGTCCGGAAGAAGCTCGTCGAATTTATCTTGGGGTTTTATCGGGCATCGAATTTAATAAAAAACCCCACG
TCATTGTTGATATTGGGGGCGGATCAACCGAGCTTATTTTAGGGGATGGCCAAGATCCTCGCTCCCTTAGTAGTACCAAA
GTAGGTGCGGTTCGGCTAACCGAGGAATATATCACCACCGATCCGGTCAGTACCCGTGAATTTGAACGATTACAGGCTTA
CGTCAGAGGGATGTTGGAATGGCCTGTTGAAGAGTTGCGTTCCCATCTTTCCCCTGGTGAGATTCCAACCCTTATTGGGA
CTTCCGGCACAATTGAAAGTATTCTCAAACTCCATGCCTGCGAAGTGATGGGAGCCTGCCCCACCTCACTTCATGGCCAT
GTCCTCACCCTGGATGACCTAAACGAACTGATTCGCAAGTTACGCAAGCTCAATTACGAAGAGCGCTGCAAAATGCCTGG
CATGACCGAGCGGCGCGCAGAAATTATTTTAGCCGGAGCCGTGATTTTGGCTGAAACAATGACCCTGCTGAAATTAGACT
CCATTACCACCTGTGAACGAGCCCTACGGGAAGGCATTGTGGTGGACTGGATGATGAAGCAAGGCTTAATCGAAGATCGT
CTCCGCTACCAGGGGTCCGTGCGAGAGCGTAGCGTTATGAATTTGGCCCATCAGTACCATGTGGAACTGGCGACAGCTGA
ACGAATCGCTGATTTCGCTGTTGCTTTATTTGATCAGACCCACGGTGCACTCCATGATTGGGGGATAGACGAACGCCATT
CACTGTGGGCAGCCGCTATTTTGCATAATTGTGGGCATTACATCAGCCATTCCGCCCACCATAAGCATTCCTATTACTTA
ATTCGCCATGGTGGTTTGTTGGGCTATACGGATGCCGAAGTAGAAATTATTGCTAACCTAGCTCGGTATCACCGCAAAGG
CCCCCCCAAGAAAAAGCATGAGAATTATCAGAACCTAGTGAATAAAACCCAACGTCGGATAGTCGATCAGCTCAGCGCTA
TCCTGAAGTTAGCGGTCGCATTAGATCGACGACAAATCGGTGCCATTGAATCCCTACATTGTGAAATGGAAGAAGATACC
ATCACCCTCCATCTTCAAGCCAGTCAAGCCGACGATGACTGTGCTTTAGAACTATGGAGCTTAGATATGAAAAAGGCTTG
TTTTGAAGCCGAATTTGATGTCACCTTGGTCGCTCAACTTGCTGAATCTGCTCCTAGCCCCGATTTGCAGCCAGCCTGA

Upstream 100 bases:

>100_bases
AGATAGATGCCAATCTATTGCAGAGATTCAAACCACGTTGACCACTGTCCCCAAATCCGCATACAGTTTTGAACAGAATC
ATCCAGGGGCTAAACGAGCC

Downstream 100 bases:

>100_bases
TTAATCCTAGTCCTCACTGTTAAACCCAAGGATTTGGACATTCCACCTCATCTAGAGTTAACTTGTTAGCTTAGGAATGG
AAAGAGAATCATTTAAGGAG

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MQTIAAIDVGTNSIHMVVVKVNPEIPAFNIIDTEKSTVRLGEGSKDTGKLHPDAIARAIAALRRCQEVAAACKVEQIQAV
ATSAVREALNGRTFIRAVESELGLKINVISGPEEARRIYLGVLSGIEFNKKPHVIVDIGGGSTELILGDGQDPRSLSSTK
VGAVRLTEEYITTDPVSTREFERLQAYVRGMLEWPVEELRSHLSPGEIPTLIGTSGTIESILKLHACEVMGACPTSLHGH
VLTLDDLNELIRKLRKLNYEERCKMPGMTERRAEIILAGAVILAETMTLLKLDSITTCERALREGIVVDWMMKQGLIEDR
LRYQGSVRERSVMNLAHQYHVELATAERIADFAVALFDQTHGALHDWGIDERHSLWAAAILHNCGHYISHSAHHKHSYYL
IRHGGLLGYTDAEVEIIANLARYHRKGPPKKKHENYQNLVNKTQRRIVDQLSAILKLAVALDRRQIGAIESLHCEMEEDT
ITLHLQASQADDDCALELWSLDMKKACFEAEFDVTLVAQLAESAPSPDLQPA

Sequences:

>Translated_532_residues
MQTIAAIDVGTNSIHMVVVKVNPEIPAFNIIDTEKSTVRLGEGSKDTGKLHPDAIARAIAALRRCQEVAAACKVEQIQAV
ATSAVREALNGRTFIRAVESELGLKINVISGPEEARRIYLGVLSGIEFNKKPHVIVDIGGGSTELILGDGQDPRSLSSTK
VGAVRLTEEYITTDPVSTREFERLQAYVRGMLEWPVEELRSHLSPGEIPTLIGTSGTIESILKLHACEVMGACPTSLHGH
VLTLDDLNELIRKLRKLNYEERCKMPGMTERRAEIILAGAVILAETMTLLKLDSITTCERALREGIVVDWMMKQGLIEDR
LRYQGSVRERSVMNLAHQYHVELATAERIADFAVALFDQTHGALHDWGIDERHSLWAAAILHNCGHYISHSAHHKHSYYL
IRHGGLLGYTDAEVEIIANLARYHRKGPPKKKHENYQNLVNKTQRRIVDQLSAILKLAVALDRRQIGAIESLHCEMEEDT
ITLHLQASQADDDCALELWSLDMKKACFEAEFDVTLVAQLAESAPSPDLQPA
>Mature_532_residues
MQTIAAIDVGTNSIHMVVVKVNPEIPAFNIIDTEKSTVRLGEGSKDTGKLHPDAIARAIAALRRCQEVAAACKVEQIQAV
ATSAVREALNGRTFIRAVESELGLKINVISGPEEARRIYLGVLSGIEFNKKPHVIVDIGGGSTELILGDGQDPRSLSSTK
VGAVRLTEEYITTDPVSTREFERLQAYVRGMLEWPVEELRSHLSPGEIPTLIGTSGTIESILKLHACEVMGACPTSLHGH
VLTLDDLNELIRKLRKLNYEERCKMPGMTERRAEIILAGAVILAETMTLLKLDSITTCERALREGIVVDWMMKQGLIEDR
LRYQGSVRERSVMNLAHQYHVELATAERIADFAVALFDQTHGALHDWGIDERHSLWAAAILHNCGHYISHSAHHKHSYYL
IRHGGLLGYTDAEVEIIANLARYHRKGPPKKKHENYQNLVNKTQRRIVDQLSAILKLAVALDRRQIGAIESLHCEMEEDT
ITLHLQASQADDDCALELWSLDMKKACFEAEFDVTLVAQLAESAPSPDLQPA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:
GO:0008081: Exopolyphosphatase
GO:0046872: Exopolyphosphatase

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=428, Percent_Identity=30.1401869158879, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI48994966, Length=483, Percent_Identity=29.8136645962733, Blast_Score=175, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 59014; Mature: 59014

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIAAIDVGTNSIHMVVVKVNPEIPAFNIIDTEKSTVRLGEGSKDTGKLHPDAIARAIA
CCEEEEEEECCCCEEEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHH
ALRRCQEVAAACKVEQIQAVATSAVREALNGRTFIRAVESELGLKINVISGPEEARRIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEECCHHHHHHHHH
GVLSGIEFNKKPHVIVDIGGGSTELILGDGQDPRSLSSTKVGAVRLTEEYITTDPVSTRE
HHHCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHCCCCCCHHH
FERLQAYVRGMLEWPVEELRSHLSPGEIPTLIGTSGTIESILKLHACEVMGACPTSLHGH
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
VLTLDDLNELIRKLRKLNYEERCKMPGMTERRAEIILAGAVILAETMTLLKLDSITTCER
EEEHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALREGIVVDWMMKQGLIEDRLRYQGSVRERSVMNLAHQYHVELATAERIADFAVALFDQT
HHHCCCEEHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGALHDWGIDERHSLWAAAILHNCGHYISHSAHHKHSYYLIRHGGLLGYTDAEVEIIANL
CCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEECCCCHHHHHHHH
ARYHRKGPPKKKHENYQNLVNKTQRRIVDQLSAILKLAVALDRRQIGAIESLHCEMEEDT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCEECCCE
ITLHLQASQADDDCALELWSLDMKKACFEAEFDVTLVAQLAESAPSPDLQPA
EEEEEEECCCCCCHHHHHHHCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQTIAAIDVGTNSIHMVVVKVNPEIPAFNIIDTEKSTVRLGEGSKDTGKLHPDAIARAIA
CCEEEEEEECCCCEEEEEEEECCCCCEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHH
ALRRCQEVAAACKVEQIQAVATSAVREALNGRTFIRAVESELGLKINVISGPEEARRIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEECCHHHHHHHHH
GVLSGIEFNKKPHVIVDIGGGSTELILGDGQDPRSLSSTKVGAVRLTEEYITTDPVSTRE
HHHCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHHCCCCCCHHH
FERLQAYVRGMLEWPVEELRSHLSPGEIPTLIGTSGTIESILKLHACEVMGACPTSLHGH
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
VLTLDDLNELIRKLRKLNYEERCKMPGMTERRAEIILAGAVILAETMTLLKLDSITTCER
EEEHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALREGIVVDWMMKQGLIEDRLRYQGSVRERSVMNLAHQYHVELATAERIADFAVALFDQT
HHHCCCEEHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGALHDWGIDERHSLWAAAILHNCGHYISHSAHHKHSYYLIRHGGLLGYTDAEVEIIANL
CCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCEEECCCCHHHHHHHH
ARYHRKGPPKKKHENYQNLVNKTQRRIVDQLSAILKLAVALDRRQIGAIESLHCEMEEDT
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCEECCCE
ITLHLQASQADDDCALELWSLDMKKACFEAEFDVTLVAQLAESAPSPDLQPA
EEEEEEECCCCCCHHHHHHHCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]