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The map label for this gene is htpX [H]

Identifier: 158333752

GI number: 158333752

Start: 546581

End: 548644

Strand: Direct

Name: htpX [H]

Synonym: AM1_0560

Alternate gene names: 158333752

Gene position: 546581-548644 (Clockwise)

Preceding gene: 158333751

Following gene: 158333753

Centisome position: 8.4

GC content: 49.52

Gene sequence:

>2064_bases
ATGGCCTCACTACAGGAAGACTTAAAAGCTGGAATTGCCGCACACCAAAAAGGACAACAGTCCCAGGCTATCCAGATTTT
AGAGCGCGTGTGGCAAGCTGCCACTCCAGGAAGTTCTGTCCATGTGCAGGCCCAAATGTATCTGATCATGGCTCATCAGA
GCTGTGGTCAACTCGAACAAGCTTTGATGCTCTGCCAGCCTCTAGCTGCCAGTCCCATTGCCCAAGTTCAGGAATGGGCT
AATCAGGTCTTGCCTCAGTTACAGCAAGACCAGGAGAATCAAATTCCAACCGCTACGGCATCCGCTACGGCAGAGACTTC
TGCTCCCAGTCCAGAACCTAGTCAACCTAGTCCGGAATTTAGCCAAAAGTCCCGGTCTTTCGGTGGGATGAAACTGGCAA
TGGTTGGTATTGGTGGCAATCTCAGTTTGGCTTCTGGAATTACCATAAGCCTGCTGTTTGGGATGGTACTTGTCCTCGTC
TTGGGCGTCTTTTTGATCACGGAAAGTGATAATCCAGGCTTGGGACTTGGAGCTGCCGTTATTTTTACTCTTGTTATTAA
TGCAGCGGTTTTCTTCTTTTCACCCTTTCTCATGGATTGGACCCAGCGGTGGCTTTATGGCACCCATTGGATCACCCTGG
GAGAGCTAGAACATCTCAGTCCCGAAACCAGCCAAATTTTGCAGAGAATTTGTACTGAGAAGAATCTGAAGATGCCTCGT
TTAGGCATTATTGAAGATCAAAATCCAACCGCCTTTACCTACGGTTCCCTGCCTAACAGTGCACGGCTCGTCGTAAGTCG
AGGATTATTCACCTACCTAGATGAAGACGAAGTGGCGACGGTCTATGCCCATGAGTTAGGCCACATCGTCCACTGGGATT
TTGCGGTCATGACCTTAGCCTCTACTTTGGTGCAGATTACTTATTTGATTTACACCTTTGCCAGCCGAGCAGGACGTAGA
GGGGGAAGTAGCAAAGGAAAAGATGCTTTGCAAGCCGCTGCGATCTCAGCCTATATCTTCTACATCATTGGCACCTACCT
GGTCTTATACCTATCCCGAACTCGGGAGTATTTTGCCGATCACTTTGCGGCAGAAGTAACAGGCAACCCCAATGCCTTAT
CCCGAGCTTTAGTCAAAATTGCCTACGGAATTGTCGAAGAAGGTCAACGCTCCAAAGAGCCTAGCCGTTTACTGGAAGGA
ACCCGAGCTTTGGGGATCTACGATGCCAAAGCGGCGACCTCCTCCGGCACGGCCTATCGAGTCGCTTCTGATACCAGCAA
AATTGGTCGTGTCTTTTTGTGGGATCTATTCAACCCCTGGGCGTTTTGGATGGAGCTGCAATCCACCCACCCCCTCACGG
GTAAACGTGTTCGGGCCTTGAGTACCTACGCGGAGCAACTAGGTTTGGACATTGAATTTGATATGGGCCGAGTCGTGGGA
GAAGGTCGCCATTTAAATAAGCAACGCCTCTATAGCCACTTCTTCCTAGATTTGTTGCTCTATGGGGCCGAATTTATTGG
CTTAGGGGTGGGTCTGATTCTAGGACTTGCCGTCGGAACAAATCCCATCTCGTTAATGCTGATCGGTTTAGGGATCGGTA
TTCTCGCTAAAACCTTCATCATGTATCCCAACTTTGGTCAGGCTCCTGAACGGGATATCTTAACCCTGATGTCGGATCCT
TATGCCAGTCCCCTGCGTGGGCAACCTGTGCAGCTTGAAGGTCAACTGATTGGGCGTGGAGATGCGGGCTATAAGTTTGG
TTCAGATTTGAAACTGCAAGATAAAAGCGGCATGTTATTTCTCCGCTATTCCTCTCGCTTTGGGCCGATCGGCAACTTCC
TATTTGGTATGTCTCAAGTCAAGGACTTGATTGGAACCCAGGTGGGCACAACGGGATGGTTCCGTCGCAGTATTGCCCCC
TGGATGGATCTTATCCAACTCAGAACAGATGGCGGGCGTGTGATCAATAGTTATCATCGGTTTTGGTCTTTCGGGTTTGG
CGGATTTTTCATTGTTCTGGGGCTGGTCTTCAACTTTTTATTGCTTCCCGGCTTGGTCGGTTAG

Upstream 100 bases:

>100_bases
GGGGTTAAGTCACTACACACCTCTAAAAATACTGGTAAGCTGAATTTCGTTTAACTGCTCTCGGTTTATCTATAGCCGTT
TACAAAGCAAGGAGCTGTTT

Downstream 100 bases:

>100_bases
TTCTGAAAAAGATTCCTTGCTTAAATGCCGCTTCTAAGGGCTCACACCCTTAGATTAATGGGGCCTGATCATCTCCTCAC
TCCTCACTAATTGCTTGAAG

Product: M48B family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MASLQEDLKAGIAAHQKGQQSQAIQILERVWQAATPGSSVHVQAQMYLIMAHQSCGQLEQALMLCQPLAASPIAQVQEWA
NQVLPQLQQDQENQIPTATASATAETSAPSPEPSQPSPEFSQKSRSFGGMKLAMVGIGGNLSLASGITISLLFGMVLVLV
LGVFLITESDNPGLGLGAAVIFTLVINAAVFFFSPFLMDWTQRWLYGTHWITLGELEHLSPETSQILQRICTEKNLKMPR
LGIIEDQNPTAFTYGSLPNSARLVVSRGLFTYLDEDEVATVYAHELGHIVHWDFAVMTLASTLVQITYLIYTFASRAGRR
GGSSKGKDALQAAAISAYIFYIIGTYLVLYLSRTREYFADHFAAEVTGNPNALSRALVKIAYGIVEEGQRSKEPSRLLEG
TRALGIYDAKAATSSGTAYRVASDTSKIGRVFLWDLFNPWAFWMELQSTHPLTGKRVRALSTYAEQLGLDIEFDMGRVVG
EGRHLNKQRLYSHFFLDLLLYGAEFIGLGVGLILGLAVGTNPISLMLIGLGIGILAKTFIMYPNFGQAPERDILTLMSDP
YASPLRGQPVQLEGQLIGRGDAGYKFGSDLKLQDKSGMLFLRYSSRFGPIGNFLFGMSQVKDLIGTQVGTTGWFRRSIAP
WMDLIQLRTDGGRVINSYHRFWSFGFGGFFIVLGLVFNFLLLPGLVG

Sequences:

>Translated_687_residues
MASLQEDLKAGIAAHQKGQQSQAIQILERVWQAATPGSSVHVQAQMYLIMAHQSCGQLEQALMLCQPLAASPIAQVQEWA
NQVLPQLQQDQENQIPTATASATAETSAPSPEPSQPSPEFSQKSRSFGGMKLAMVGIGGNLSLASGITISLLFGMVLVLV
LGVFLITESDNPGLGLGAAVIFTLVINAAVFFFSPFLMDWTQRWLYGTHWITLGELEHLSPETSQILQRICTEKNLKMPR
LGIIEDQNPTAFTYGSLPNSARLVVSRGLFTYLDEDEVATVYAHELGHIVHWDFAVMTLASTLVQITYLIYTFASRAGRR
GGSSKGKDALQAAAISAYIFYIIGTYLVLYLSRTREYFADHFAAEVTGNPNALSRALVKIAYGIVEEGQRSKEPSRLLEG
TRALGIYDAKAATSSGTAYRVASDTSKIGRVFLWDLFNPWAFWMELQSTHPLTGKRVRALSTYAEQLGLDIEFDMGRVVG
EGRHLNKQRLYSHFFLDLLLYGAEFIGLGVGLILGLAVGTNPISLMLIGLGIGILAKTFIMYPNFGQAPERDILTLMSDP
YASPLRGQPVQLEGQLIGRGDAGYKFGSDLKLQDKSGMLFLRYSSRFGPIGNFLFGMSQVKDLIGTQVGTTGWFRRSIAP
WMDLIQLRTDGGRVINSYHRFWSFGFGGFFIVLGLVFNFLLLPGLVG
>Mature_686_residues
ASLQEDLKAGIAAHQKGQQSQAIQILERVWQAATPGSSVHVQAQMYLIMAHQSCGQLEQALMLCQPLAASPIAQVQEWAN
QVLPQLQQDQENQIPTATASATAETSAPSPEPSQPSPEFSQKSRSFGGMKLAMVGIGGNLSLASGITISLLFGMVLVLVL
GVFLITESDNPGLGLGAAVIFTLVINAAVFFFSPFLMDWTQRWLYGTHWITLGELEHLSPETSQILQRICTEKNLKMPRL
GIIEDQNPTAFTYGSLPNSARLVVSRGLFTYLDEDEVATVYAHELGHIVHWDFAVMTLASTLVQITYLIYTFASRAGRRG
GSSKGKDALQAAAISAYIFYIIGTYLVLYLSRTREYFADHFAAEVTGNPNALSRALVKIAYGIVEEGQRSKEPSRLLEGT
RALGIYDAKAATSSGTAYRVASDTSKIGRVFLWDLFNPWAFWMELQSTHPLTGKRVRALSTYAEQLGLDIEFDMGRVVGE
GRHLNKQRLYSHFFLDLLLYGAEFIGLGVGLILGLAVGTNPISLMLIGLGIGILAKTFIMYPNFGQAPERDILTLMSDPY
ASPLRGQPVQLEGQLIGRGDAGYKFGSDLKLQDKSGMLFLRYSSRFGPIGNFLFGMSQVKDLIGTQVGTTGWFRRSIAPW
MDLIQLRTDGGRVINSYHRFWSFGFGGFFIVLGLVFNFLLLPGLVG

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=156, Percent_Identity=28.2051282051282, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 75363; Mature: 75232

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLQEDLKAGIAAHQKGQQSQAIQILERVWQAATPGSSVHVQAQMYLIMAHQSCGQLEQ
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHHHHHHHHH
ALMLCQPLAASPIAQVQEWANQVLPQLQQDQENQIPTATASATAETSAPSPEPSQPSPEF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
SQKSRSFGGMKLAMVGIGGNLSLASGITISLLFGMVLVLVLGVFLITESDNPGLGLGAAV
HHHHCCCCCEEEEEEEECCCEEHHCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHH
IFTLVINAAVFFFSPFLMDWTQRWLYGTHWITLGELEHLSPETSQILQRICTEKNLKMPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHHHCCCCCCCCC
LGIIEDQNPTAFTYGSLPNSARLVVSRGLFTYLDEDEVATVYAHELGHIVHWDFAVMTLA
CCEEECCCCCEEEECCCCCCCHHHEECCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
STLVQITYLIYTFASRAGRRGGSSKGKDALQAAAISAYIFYIIGTYLVLYLSRTREYFAD
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFAAEVTGNPNALSRALVKIAYGIVEEGQRSKEPSRLLEGTRALGIYDAKAATSSGTAYR
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHEEEEECCCCCCCCCEEE
VASDTSKIGRVFLWDLFNPWAFWMELQSTHPLTGKRVRALSTYAEQLGLDIEFDMGRVVG
EECCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEECCHHHHC
EGRHLNKQRLYSHFFLDLLLYGAEFIGLGVGLILGLAVGTNPISLMLIGLGIGILAKTFI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MYPNFGQAPERDILTLMSDPYASPLRGQPVQLEGQLIGRGDAGYKFGSDLKLQDKSGMLF
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEECCEEEECCCCCCCCCCCCEEECCCCEEE
LRYSSRFGPIGNFLFGMSQVKDLIGTQVGTTGWFRRSIAPWMDLIQLRTDGGRVINSYHR
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FWSFGFGGFFIVLGLVFNFLLLPGLVG
HHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ASLQEDLKAGIAAHQKGQQSQAIQILERVWQAATPGSSVHVQAQMYLIMAHQSCGQLEQ
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEHHHHHHHHH
ALMLCQPLAASPIAQVQEWANQVLPQLQQDQENQIPTATASATAETSAPSPEPSQPSPEF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
SQKSRSFGGMKLAMVGIGGNLSLASGITISLLFGMVLVLVLGVFLITESDNPGLGLGAAV
HHHHCCCCCEEEEEEEECCCEEHHCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHH
IFTLVINAAVFFFSPFLMDWTQRWLYGTHWITLGELEHLSPETSQILQRICTEKNLKMPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHHHCCCCCCCCC
LGIIEDQNPTAFTYGSLPNSARLVVSRGLFTYLDEDEVATVYAHELGHIVHWDFAVMTLA
CCEEECCCCCEEEECCCCCCCHHHEECCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
STLVQITYLIYTFASRAGRRGGSSKGKDALQAAAISAYIFYIIGTYLVLYLSRTREYFAD
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFAAEVTGNPNALSRALVKIAYGIVEEGQRSKEPSRLLEGTRALGIYDAKAATSSGTAYR
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHEEEEECCCCCCCCCEEE
VASDTSKIGRVFLWDLFNPWAFWMELQSTHPLTGKRVRALSTYAEQLGLDIEFDMGRVVG
EECCHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEECCHHHHC
EGRHLNKQRLYSHFFLDLLLYGAEFIGLGVGLILGLAVGTNPISLMLIGLGIGILAKTFI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
MYPNFGQAPERDILTLMSDPYASPLRGQPVQLEGQLIGRGDAGYKFGSDLKLQDKSGMLF
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEECCEEEECCCCCCCCCCCCEEECCCCEEE
LRYSSRFGPIGNFLFGMSQVKDLIGTQVGTTGWFRRSIAPWMDLIQLRTDGGRVINSYHR
EEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FWSFGFGGFFIVLGLVFNFLLLPGLVG
HHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA