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The map label for this gene is fgd1 [H]

Identifier: 158318522

GI number: 158318522

Start: 8270846

End: 8271814

Strand: Reverse

Name: fgd1 [H]

Synonym: Franean1_6790

Alternate gene names: 158318522

Gene position: 8271814-8270846 (Counterclockwise)

Preceding gene: 158318524

Following gene: 158318515

Centisome position: 92.09

GC content: 71.41

Gene sequence:

>969_bases
ATGCGGGTCGGCTACAAGCTGGCAACCGAGGCGTTCGGCCCCCGGGAGATCATCCGTCAGGCGGTCGCCGCCGAGGATGC
CGGCTTCGACTTCGTGGAGCTGAGCGATCACTTCCACCCGTGGCTGGACAACCAGGGGCATTCGGCGTTCACGTGGACGA
TGCTCGGCTCGATCGCCGAGCGCACCGGCCGGGTCGGGCTGGTGACCGGCGTGACGTGCCCGACGATCCGGTACCACCCG
GCGGTGGTCGCGCAGGCGGCGGCGACCGTCGCCCTCGTGTCCGACGGGCGTTTCACGCTGGGGCTCGGGTCGGGCGAGCG
CCTCAACGAGCATGTCGTCGGGCGCGGGTTCCCCGCTGTGGCCAGGCGGCACGCGATGCTGCGGGAGGCTGTCGAGATCA
TCCGGCTGTTGTGGCGGGGTGGGTACCAGTCCTACGACGGGCGTTACCTCCAGCTGGAGGACGCGCGGGTGTTCGATCTG
CCCGATCCGCTGCCGGAGATCGCCGTCGCCGCCAGCGGTGGGCCGTCGGTTCGGCTGGCGGCCGAGTGCGGCGATGCCCT
GTTCGCCACCGAGCCCAAGCCCGGGATCGTCGAGGACTACGCGGCCGCGGGTGGAACCGGGGCGCGTTACGCCGAGGTTC
CGCTGGCCTACGCGGCGGACGAGGCTGAGGCGGCCAAGGCTGTACACGCGACCAACCGGTGGGCGCTGACCGGCTGGAAA
GTGATGAGCGAGCTACCCAACCCGGTCAACTTCGCCGCCGCGACGACGACGGTCACCGAGGACGACGTGAGGGGGCAGTT
CGCCTGTGGTCCCGACCCGGCGCGGCATCTGGCGGCCGCCCGCGAGTTCACCGACGCCGGCTTCGACCAGCTGGTCCTGA
TGAACGCCGGCCCTGACCCGGACGGCTTCTTCGACTTCTTCCGCTCGACCTTGGCGGCGCCGCTGCGAGCCCTGGCCCCG
GCCGCCTAA

Upstream 100 bases:

>100_bases
CGGCACCGCCGCGTTCGAGACCCGCCGGGCCCGTCGCGTTGACAGAGCCGATGACATCAGCACCGATCGCCGGCGGCCCG
GACGAGGGAGAGGAGAAGAG

Downstream 100 bases:

>100_bases
CGGCCGGTGTCCCGATTGCCGCGCAGCCGGACGGCCATCGGGACGATCGCCCACAGGACCACCAGCAGCGCGAGAGCCGC
CGCACCGGCGACGATCGCGG

Product: luciferase family protein

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MRVGYKLATEAFGPREIIRQAVAAEDAGFDFVELSDHFHPWLDNQGHSAFTWTMLGSIAERTGRVGLVTGVTCPTIRYHP
AVVAQAAATVALVSDGRFTLGLGSGERLNEHVVGRGFPAVARRHAMLREAVEIIRLLWRGGYQSYDGRYLQLEDARVFDL
PDPLPEIAVAASGGPSVRLAAECGDALFATEPKPGIVEDYAAAGGTGARYAEVPLAYAADEAEAAKAVHATNRWALTGWK
VMSELPNPVNFAAATTTVTEDDVRGQFACGPDPARHLAAAREFTDAGFDQLVLMNAGPDPDGFFDFFRSTLAAPLRALAP
AA

Sequences:

>Translated_322_residues
MRVGYKLATEAFGPREIIRQAVAAEDAGFDFVELSDHFHPWLDNQGHSAFTWTMLGSIAERTGRVGLVTGVTCPTIRYHP
AVVAQAAATVALVSDGRFTLGLGSGERLNEHVVGRGFPAVARRHAMLREAVEIIRLLWRGGYQSYDGRYLQLEDARVFDL
PDPLPEIAVAASGGPSVRLAAECGDALFATEPKPGIVEDYAAAGGTGARYAEVPLAYAADEAEAAKAVHATNRWALTGWK
VMSELPNPVNFAAATTTVTEDDVRGQFACGPDPARHLAAAREFTDAGFDQLVLMNAGPDPDGFFDFFRSTLAAPLRALAP
AA
>Mature_322_residues
MRVGYKLATEAFGPREIIRQAVAAEDAGFDFVELSDHFHPWLDNQGHSAFTWTMLGSIAERTGRVGLVTGVTCPTIRYHP
AVVAQAAATVALVSDGRFTLGLGSGERLNEHVVGRGFPAVARRHAMLREAVEIIRLLWRGGYQSYDGRYLQLEDARVFDL
PDPLPEIAVAASGGPSVRLAAECGDALFATEPKPGIVEDYAAAGGTGARYAEVPLAYAADEAEAAKAVHATNRWALTGWK
VMSELPNPVNFAAATTTVTEDDVRGQFACGPDPARHLAAAREFTDAGFDQLVLMNAGPDPDGFFDFFRSTLAAPLRALAP
AA

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 34411; Mature: 34411

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGYKLATEAFGPREIIRQAVAAEDAGFDFVELSDHFHPWLDNQGHSAFTWTMLGSIAE
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEHHHHHHHHHH
RTGRVGLVTGVTCPTIRYHPAVVAQAAATVALVSDGRFTLGLGSGERLNEHVVGRGFPAV
HCCCEEEEECCCCCCEEECHHHHHHHHHEEEEEECCEEEEECCCCCHHHHHHHCCCCHHH
ARRHAMLREAVEIIRLLWRGGYQSYDGRYLQLEDARVFDLPDPLPEIAVAASGGPSVRLA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEECCCCCCCHHEEEECCCCCEEEH
AECGDALFATEPKPGIVEDYAAAGGTGARYAEVPLAYAADEAEAAKAVHATNRWALTGWK
HHCCCCEEECCCCCCCHHHHHHCCCCCCEEECCCEEEECCHHHHHHHHHCCCCEEEHHHH
VMSELPNPVNFAAATTTVTEDDVRGQFACGPDPARHLAAAREFTDAGFDQLVLMNAGPDP
HHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCC
DGFFDFFRSTLAAPLRALAPAA
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVGYKLATEAFGPREIIRQAVAAEDAGFDFVELSDHFHPWLDNQGHSAFTWTMLGSIAE
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCEEHHHHHHHHHH
RTGRVGLVTGVTCPTIRYHPAVVAQAAATVALVSDGRFTLGLGSGERLNEHVVGRGFPAV
HCCCEEEEECCCCCCEEECHHHHHHHHHEEEEEECCEEEEECCCCCHHHHHHHCCCCHHH
ARRHAMLREAVEIIRLLWRGGYQSYDGRYLQLEDARVFDLPDPLPEIAVAASGGPSVRLA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEECCCCCCCHHEEEECCCCCEEEH
AECGDALFATEPKPGIVEDYAAAGGTGARYAEVPLAYAADEAEAAKAVHATNRWALTGWK
HHCCCCEEECCCCCCCHHHHHHCCCCCCEEECCCEEEECCHHHHHHHHHCCCCEEEHHHH
VMSELPNPVNFAAATTTVTEDDVRGQFACGPDPARHLAAAREFTDAGFDQLVLMNAGPDP
HHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCC
DGFFDFFRSTLAAPLRALAPAA
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]