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The map label for this gene is echA8 [H]

Identifier: 158317998

GI number: 158317998

Start: 7600429

End: 7601226

Strand: Direct

Name: echA8 [H]

Synonym: Franean1_6258

Alternate gene names: 158317998

Gene position: 7600429-7601226 (Clockwise)

Preceding gene: 158317997

Following gene: 158317999

Centisome position: 84.62

GC content: 71.43

Gene sequence:

>798_bases
ATGACCGATGACCTGGGAGCGGCGGGCCTGCGTTTCGAGCGCGACGGAGCCATCGGCTGGTGTGTGATCGACCGGCCGGC
CGCCCGGAACGCCCTGACACCAGCGATGTACTTCGGCATCAAGCGGGCCGTGCAACTGGTCAACACCTCGCCCGACCTGG
CCGCACTGATCATCACCGGCACCGGTGACGTGTTCGCCCCCGGCGGCGACCTCGGCAGCAGGTCCGAGCCCGGCGACAAC
CTGCCGCCCGACCTGCGCGGCGAGGACGTCCTGCCGTTCCTCACCATCCGGGACAGCCGGGCGCCGGTGGTGGCCGCCGT
CAACGGCATCTGCCAGGCCGGTGGCCTGCTGATCGCCATGATGGCGGACATCGCGGTCGCCAGCGACCAGGCGACGTTCC
GGGTCCCCGAGCTGCTGCGGGGCATCCCCGACGCCACCTATGCGGCCGTTCTGCCCGCCCACGTCGGCATCGCGGTGGCC
CGTGACCTGCTGTTGTCGGCGCGCCGCTTCGACGCCGCCGAGGCCCAGCGGCTGGGCGTGATCAGCCGAGTCGTGCCGCA
CGACCAGCTCCGCGAGGCCGCCGTCCAGGCCGCCGGGGAGATTCTGCAGACCGCCCCGGCGGCCCGCATGCATGTCAAGC
GCATGCTGAACGAGCGCTATGGGCTCATCGACTACCAGACCATGTTCTGGGCGATGCAGCAGTCGCCCGAGCCACGTGAG
GGCATGCGCGCGTTCATGGAGAAGCGGGCGCCTGAATGGGTCCCCGAGCAGTTCGCCGGCGACGGCGGGCGGCGCTGA

Upstream 100 bases:

>100_bases
CGCGAACAGTGGCGCCGAATCGCCGCCGCCGTGTGATCGCACCGCCGGGCGACGCCCTGGCATGCCATCATCGCGAGCGG
CGGCACGAGGGAGGAGCAGC

Downstream 100 bases:

>100_bases
CCTCACACCCGTTCCGCCAGCTGAGAGGTTTGCGGCCCGGGACTTCCAGTGCGCGATACCTGGGCTGCCCCAGATGCCGG
GCAGCCCAGGATGCCGCGCG

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTDDLGAAGLRFERDGAIGWCVIDRPAARNALTPAMYFGIKRAVQLVNTSPDLAALIITGTGDVFAPGGDLGSRSEPGDN
LPPDLRGEDVLPFLTIRDSRAPVVAAVNGICQAGGLLIAMMADIAVASDQATFRVPELLRGIPDATYAAVLPAHVGIAVA
RDLLLSARRFDAAEAQRLGVISRVVPHDQLREAAVQAAGEILQTAPAARMHVKRMLNERYGLIDYQTMFWAMQQSPEPRE
GMRAFMEKRAPEWVPEQFAGDGGRR

Sequences:

>Translated_265_residues
MTDDLGAAGLRFERDGAIGWCVIDRPAARNALTPAMYFGIKRAVQLVNTSPDLAALIITGTGDVFAPGGDLGSRSEPGDN
LPPDLRGEDVLPFLTIRDSRAPVVAAVNGICQAGGLLIAMMADIAVASDQATFRVPELLRGIPDATYAAVLPAHVGIAVA
RDLLLSARRFDAAEAQRLGVISRVVPHDQLREAAVQAAGEILQTAPAARMHVKRMLNERYGLIDYQTMFWAMQQSPEPRE
GMRAFMEKRAPEWVPEQFAGDGGRR
>Mature_264_residues
TDDLGAAGLRFERDGAIGWCVIDRPAARNALTPAMYFGIKRAVQLVNTSPDLAALIITGTGDVFAPGGDLGSRSEPGDNL
PPDLRGEDVLPFLTIRDSRAPVVAAVNGICQAGGLLIAMMADIAVASDQATFRVPELLRGIPDATYAAVLPAHVGIAVAR
DLLLSARRFDAAEAQRLGVISRVVPHDQLREAAVQAAGEILQTAPAARMHVKRMLNERYGLIDYQTMFWAMQQSPEPREG
MRAFMEKRAPEWVPEQFAGDGGRR

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=268, Percent_Identity=29.1044776119403, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI31542718, Length=245, Percent_Identity=30.2040816326531, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI68989263, Length=168, Percent_Identity=32.1428571428571, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4502327, Length=254, Percent_Identity=27.5590551181102, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI70995211, Length=209, Percent_Identity=29.1866028708134, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787659, Length=253, Percent_Identity=30.4347826086957, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI221142681, Length=256, Percent_Identity=32.03125, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788597, Length=261, Percent_Identity=32.183908045977, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082183, Length=241, Percent_Identity=26.5560165975104, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=258, Percent_Identity=32.9457364341085, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17554946, Length=238, Percent_Identity=30.672268907563, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17535521, Length=264, Percent_Identity=24.6212121212121, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=248, Percent_Identity=25.8064516129032, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=254, Percent_Identity=28.3464566929134, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=210, Percent_Identity=29.5238095238095, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=210, Percent_Identity=28.0952380952381, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17540306, Length=193, Percent_Identity=28.4974093264249, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=214, Percent_Identity=28.0373831775701, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI25144276, Length=210, Percent_Identity=27.1428571428571, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508953, Length=210, Percent_Identity=27.1428571428571, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508951, Length=210, Percent_Identity=27.1428571428571, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=31.3008130081301, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=31.3008130081301, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653139, Length=261, Percent_Identity=28.3524904214559, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19920382, Length=209, Percent_Identity=29.6650717703349, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357171, Length=182, Percent_Identity=31.8681318681319, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650670, Length=203, Percent_Identity=29.5566502463054, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28541; Mature: 28410

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDLGAAGLRFERDGAIGWCVIDRPAARNALTPAMYFGIKRAVQLVNTSPDLAALIITG
CCCCCCCCCCEEECCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEC
TGDVFAPGGDLGSRSEPGDNLPPDLRGEDVLPFLTIRDSRAPVVAAVNGICQAGGLLIAM
CCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
MADIAVASDQATFRVPELLRGIPDATYAAVLPAHVGIAVARDLLLSARRFDAAEAQRLGV
HHHHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ISRVVPHDQLREAAVQAAGEILQTAPAARMHVKRMLNERYGLIDYQTMFWAMQQSPEPRE
HHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHH
GMRAFMEKRAPEWVPEQFAGDGGRR
HHHHHHHHCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
TDDLGAAGLRFERDGAIGWCVIDRPAARNALTPAMYFGIKRAVQLVNTSPDLAALIITG
CCCCCCCCCEEECCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEC
TGDVFAPGGDLGSRSEPGDNLPPDLRGEDVLPFLTIRDSRAPVVAAVNGICQAGGLLIAM
CCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
MADIAVASDQATFRVPELLRGIPDATYAAVLPAHVGIAVARDLLLSARRFDAAEAQRLGV
HHHHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ISRVVPHDQLREAAVQAAGEILQTAPAARMHVKRMLNERYGLIDYQTMFWAMQQSPEPRE
HHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHH
GMRAFMEKRAPEWVPEQFAGDGGRR
HHHHHHHHCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]