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The map label for this gene is garR [H]

Identifier: 158317638

GI number: 158317638

Start: 7160562

End: 7161389

Strand: Reverse

Name: garR [H]

Synonym: Franean1_5896

Alternate gene names: 158317638

Gene position: 7161389-7160562 (Counterclockwise)

Preceding gene: 158317639

Following gene: 158317632

Centisome position: 79.73

GC content: 76.93

Gene sequence:

>828_bases
ATGGGCGTCCGGATGGCCCACCACATCCTGGCCGCCGGGCACGAGCTGGCCGTCTGGAACAGGACACCCGGGCGCGCCGG
CGAGCTGACGGCCCGCGGCGCCAGCGAGGCGGCCGACCCGGCGGGTGCGGTGCGCGGCGCGGACGCCTGCGTGCTGATGC
TGTTCGACCCGGCGTCGGCGGCGGATGTCCTCGCCGCGGTGATCCCCGCCGCGCCGCCCGGCCTGCTTGTGATCAACTGC
ACCACGGTCGGCCCCGCGGCCGCCCGCGAGCAGGGCAGCGTCGCCCTGGCAGCGGGCCTGCGCTACCTGGACGCGCCGGT
GATCGGCACGATCGGGCCGGCCGAGGCGGGCACCCTGCGCGTCCTGGTGGGCGCCGCCGACGCCGATCTCGCCGCGGCCC
GCGGGATCCTCGAGACCTTCGGCGACCCGGGGCGCATCGACCATGTCGGGCCGGTCGGTGCCGCCAGCGCGCTCAAGACG
GTGTTCAACCTCGGCCTGGCCGAGGCGACGGCCGCCGCCGCCGAGGTGCTCCGCTACGGCACCGAGCTCGGCGTCGACCG
GAGCCTGCTGCTGTCCGAGCTCGCCGCCGGGCCGCTGGGATTCATCGTCGAGTACAAGCGGGCGATGCTGGAGTCGGGCG
ACTACTCCACGCCGGCCTTCACCGTGGCCGGGCTCGCCAAGGACGTCCGGCTGGCCACCGAGTCGGTCGCGGGACGGCTG
CCGATCGCCGAGGCGACCCTGGCCCTCACCGCCGCCGCCACCCGGGCCGGCCACGCCGAGCACGACTTCGCCGCGCTGGC
CGCCGCGGATGTGCCCGACCCGGCCTGA

Upstream 100 bases:

>100_bases
CCGGGCTGGCACGGGTGCTTCGACCGCGGCCGGTCGGCCGCGGCGGGAGCGTCAACGAGGGAGGTATCGCGTGAAGGTCG
CGTTTCTCGGCCTGGGCCGG

Downstream 100 bases:

>100_bases
GCCCGCCCCACCCGGAGCCGGCCCGGGCGGGCGCCGCTCGGGCTGGTTCCGGGTGGACCCGCGGCGGCGCTGGCTGGTGC
TCGGTGTGGCCGGCGCGGGC

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MGVRMAHHILAAGHELAVWNRTPGRAGELTARGASEAADPAGAVRGADACVLMLFDPASAADVLAAVIPAAPPGLLVINC
TTVGPAAAREQGSVALAAGLRYLDAPVIGTIGPAEAGTLRVLVGAADADLAAARGILETFGDPGRIDHVGPVGAASALKT
VFNLGLAEATAAAAEVLRYGTELGVDRSLLLSELAAGPLGFIVEYKRAMLESGDYSTPAFTVAGLAKDVRLATESVAGRL
PIAEATLALTAAATRAGHAEHDFAALAAADVPDPA

Sequences:

>Translated_275_residues
MGVRMAHHILAAGHELAVWNRTPGRAGELTARGASEAADPAGAVRGADACVLMLFDPASAADVLAAVIPAAPPGLLVINC
TTVGPAAAREQGSVALAAGLRYLDAPVIGTIGPAEAGTLRVLVGAADADLAAARGILETFGDPGRIDHVGPVGAASALKT
VFNLGLAEATAAAAEVLRYGTELGVDRSLLLSELAAGPLGFIVEYKRAMLESGDYSTPAFTVAGLAKDVRLATESVAGRL
PIAEATLALTAAATRAGHAEHDFAALAAADVPDPA
>Mature_274_residues
GVRMAHHILAAGHELAVWNRTPGRAGELTARGASEAADPAGAVRGADACVLMLFDPASAADVLAAVIPAAPPGLLVINCT
TVGPAAAREQGSVALAAGLRYLDAPVIGTIGPAEAGTLRVLVGAADADLAAARGILETFGDPGRIDHVGPVGAASALKTV
FNLGLAEATAAAAEVLRYGTELGVDRSLLLSELAAGPLGFIVEYKRAMLESGDYSTPAFTVAGLAKDVRLATESVAGRLP
IAEATLALTAAATRAGHAEHDFAALAAADVPDPA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=279, Percent_Identity=26.1648745519713, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=27.208480565371, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI145693186, Length=273, Percent_Identity=28.2051282051282, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790315, Length=276, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24655230, Length=193, Percent_Identity=27.979274611399, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922568, Length=193, Percent_Identity=27.979274611399, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 27432; Mature: 27301

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVRMAHHILAAGHELAVWNRTPGRAGELTARGASEAADPAGAVRGADACVLMLFDPASA
CCCHHHHHHHHCCCEEEEEECCCCCCCCEECCCCCCCCCCHHHCCCCCEEEEEEECCCCH
ADVLAAVIPAAPPGLLVINCTTVGPAAAREQGSVALAAGLRYLDAPVIGTIGPAEAGTLR
HHHHHHHHCCCCCCEEEEEECCCCCHHHHCCCCEEHHHHHHHHCCCCCCCCCCCCCCEEE
VLVGAADADLAAARGILETFGDPGRIDHVGPVGAASALKTVFNLGLAEATAAAAEVLRYG
EEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
TELGVDRSLLLSELAAGPLGFIVEYKRAMLESGDYSTPAFTVAGLAKDVRLATESVAGRL
HHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PIAEATLALTAAATRAGHAEHDFAALAAADVPDPA
CHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
GVRMAHHILAAGHELAVWNRTPGRAGELTARGASEAADPAGAVRGADACVLMLFDPASA
CCHHHHHHHHCCCEEEEEECCCCCCCCEECCCCCCCCCCHHHCCCCCEEEEEEECCCCH
ADVLAAVIPAAPPGLLVINCTTVGPAAAREQGSVALAAGLRYLDAPVIGTIGPAEAGTLR
HHHHHHHHCCCCCCEEEEEECCCCCHHHHCCCCEEHHHHHHHHCCCCCCCCCCCCCCEEE
VLVGAADADLAAARGILETFGDPGRIDHVGPVGAASALKTVFNLGLAEATAAAAEVLRYG
EEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
TELGVDRSLLLSELAAGPLGFIVEYKRAMLESGDYSTPAFTVAGLAKDVRLATESVAGRL
HHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PIAEATLALTAAATRAGHAEHDFAALAAADVPDPA
CHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]