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The map label for this gene is copR [H]

Identifier: 158317452

GI number: 158317452

Start: 6922036

End: 6922698

Strand: Reverse

Name: copR [H]

Synonym: Franean1_5704

Alternate gene names: 158317452

Gene position: 6922698-6922036 (Counterclockwise)

Preceding gene: 158317453

Following gene: 158317451

Centisome position: 77.07

GC content: 70.89

Gene sequence:

>663_bases
ATGGCCAACCGGGTGCTGATCGCCGAGGACGAGTACCGGATCGCCTCGTTCATCGAGAAGGGCCTGCGCGCGAACGGGTT
CCTGCCGGTCTGCGTCGGCGACGGCGCGTCCGCGCTCGAGGTCGCCCTGCGGGGCGAGGTCGACCTGATCGTCCTCGACC
TCGGCCTGCCCGACATGGACGGCTTCTCCGTCCTGCGGCGGCTGCGCGGAGCCGGGGTGGACGTGCCGGTGGTCGTCCTG
ACGGCGCGCGACGGCGTGCGTGACACCGTGGCCGCCCTCGAGGGCGGTGCCGACGACTACATGTCCAAGCCGTTCCGGTT
CGAGGAGCTGCTGGCGCGCATCCGGCTGCGGCTGCGGGCGGACCGGGCGCCCGAGGCGACCGTCCTGCGGGTCCGGGGGG
TCAGCCTCGACCTGCGTACCCGCCGGGCCCAGGTGGGCGGCCGGACGGTCGACCTGACAGCCCGGGAGTTCGTGCTCGCG
GAGACGTTCCTGCGCCACCCCGGCCAGGTACTGGCCCGCGAACAGCTGCTCTCTGCGGTCTGGGGTTACGACTACGACCC
GGGCAGTAACGTCGTGGACGTCTACGTCGGATATCTACGCCGCAAGATCGGCGCGGACTGTATAACCACCGTACGTGGGA
TGGGATATCGGCTGGAAGCCTGA

Upstream 100 bases:

>100_bases
GAGGGCGCGACCTTCGAGCTGGCGGTGCCCCGCCGTGGCCCCTCCGGCACGGGACGGCCCGGTGCCGTGGTCGGTGTCGT
GGTCGGAGGGCGGGACTGAG

Downstream 100 bases:

>100_bases
CGGACCCGGCTCACCGCATCCTGCCACATTAGTCGGACGGGTGCCCCTCGATTCTTTCTTCGGATACCGGCGGCGCCGGC
TGTGTGGCATCCTCCCTGGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MANRVLIAEDEYRIASFIEKGLRANGFLPVCVGDGASALEVALRGEVDLIVLDLGLPDMDGFSVLRRLRGAGVDVPVVVL
TARDGVRDTVAALEGGADDYMSKPFRFEELLARIRLRLRADRAPEATVLRVRGVSLDLRTRRAQVGGRTVDLTAREFVLA
ETFLRHPGQVLAREQLLSAVWGYDYDPGSNVVDVYVGYLRRKIGADCITTVRGMGYRLEA

Sequences:

>Translated_220_residues
MANRVLIAEDEYRIASFIEKGLRANGFLPVCVGDGASALEVALRGEVDLIVLDLGLPDMDGFSVLRRLRGAGVDVPVVVL
TARDGVRDTVAALEGGADDYMSKPFRFEELLARIRLRLRADRAPEATVLRVRGVSLDLRTRRAQVGGRTVDLTAREFVLA
ETFLRHPGQVLAREQLLSAVWGYDYDPGSNVVDVYVGYLRRKIGADCITTVRGMGYRLEA
>Mature_219_residues
ANRVLIAEDEYRIASFIEKGLRANGFLPVCVGDGASALEVALRGEVDLIVLDLGLPDMDGFSVLRRLRGAGVDVPVVVLT
ARDGVRDTVAALEGGADDYMSKPFRFEELLARIRLRLRADRAPEATVLRVRGVSLDLRTRRAQVGGRTVDLTAREFVLAE
TFLRHPGQVLAREQLLSAVWGYDYDPGSNVVDVYVGYLRRKIGADCITTVRGMGYRLEA

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=41.6289592760181, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.0090497737557, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1789402, Length=215, Percent_Identity=38.6046511627907, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=39.8230088495575, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790552, Length=217, Percent_Identity=36.8663594470046, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=42.3580786026201, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=34.841628959276, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=34.2222222222222, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=36.1990950226244, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.9557522123894, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=33.4801762114537, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.0175438596491, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.695652173913, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.1385281385281, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=34.2592592592593, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790299, Length=159, Percent_Identity=25.1572327044025, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=30, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=32.0388349514563, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788521, Length=83, Percent_Identity=42.1686746987952, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24206; Mature: 24075

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRVLIAEDEYRIASFIEKGLRANGFLPVCVGDGASALEVALRGEVDLIVLDLGLPDMD
CCCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHEEECCCEEEEEEECCCCCCC
GFSVLRRLRGAGVDVPVVVLTARDGVRDTVAALEGGADDYMSKPFRFEELLARIRLRLRA
HHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHC
DRAPEATVLRVRGVSLDLRTRRAQVGGRTVDLTAREFVLAETFLRHPGQVLAREQLLSAV
CCCCCEEEEEEECCEEEHHHHHHHHCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WGYDYDPGSNVVDVYVGYLRRKIGADCITTVRGMGYRLEA
HCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECC
>Mature Secondary Structure 
ANRVLIAEDEYRIASFIEKGLRANGFLPVCVGDGASALEVALRGEVDLIVLDLGLPDMD
CCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHEEECCCEEEEEEECCCCCCC
GFSVLRRLRGAGVDVPVVVLTARDGVRDTVAALEGGADDYMSKPFRFEELLARIRLRLRA
HHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHC
DRAPEATVLRVRGVSLDLRTRRAQVGGRTVDLTAREFVLAETFLRHPGQVLAREQLLSAV
CCCCCEEEEEEECCEEEHHHHHHHHCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WGYDYDPGSNVVDVYVGYLRRKIGADCITTVRGMGYRLEA
HCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]