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The map label for this gene is arlS [H]

Identifier: 158317453

GI number: 158317453

Start: 6922700

End: 6924184

Strand: Reverse

Name: arlS [H]

Synonym: Franean1_5705

Alternate gene names: 158317453

Gene position: 6924184-6922700 (Counterclockwise)

Preceding gene: 158317454

Following gene: 158317452

Centisome position: 77.09

GC content: 74.88

Gene sequence:

>1485_bases
GTGAGGCTGTCCCGGACGCGCCGCGTCGTGCGCCATGTCGCGACCTCCGCACGCCTGCACATCCTCGGATGGCAGGTGCT
GCTGGTGGGGGTCGCGCTTGCCGGGTCGGTGCTGGTCTCGCGCGAGGTGCTCCTGGCCAGGGTGGACGAGCGCGTCGACC
GGGGCCTGGCCCGCCAGGTCGCCGAGCTGCGCCGCCTCGCGACCGCCAGCGTCGACCCGCGGACGTCCCGGCCGTTCACC
GACGTGCGCGAGCTGCTCGAGGCGCATCTGGAGCGCACCATCCCGGGGTCCAACGAGACCATGCTCGCGCTCGTCGACGG
CCGGCCGTTCCGGCGCAGCGCCGAGGAGCCGGTCTACCGGCTGGACAACGATCCACGGGCGGTCGCGGCTTTCGTCGTGG
GCCCGCAGCCGCGGTACGGGACAATCACGACGCCGGCGGGGGAGGTGCGGTTCGCCACCGTCCCGGTCCAGGTGGCGGGG
GCACCGGAGCGGGGCGTGTTCGCCGCCGCTGTCTTCGCGGACCGGGAGCGGGCCGAGGTACAGGAGGTGGTCCGGGTGCT
GGCGATCGCCGGGTTCGCGGCCCTGGCTCTGGCCGGTGCAGGCGGATGGCTGGTGGCCGGCCGCGTGCTCGCGCCGGTGC
GGGAGCTGCGCCGCACCGCCCAGGCCATCAGCGACACGGACTTCTCCCGGCGCATCCCCGTGGCGGGCCGCGACGAGATC
GCCGAGCTGGCGCGCACCTTCAACAGCATGCTGGACCGCCTGGAGGACGCCTTCGCGACCCAGCGCGCGTTCGTCGACGA
CGCCGGCCACGAGCTGCGCACGCCCATCACGATCATCAGCGGGCACCTTGAGCTGCTCTCCGACGATCCGGCGGAGCGGA
CCGAGACCGTGGCCCTGGTCACCGACGAGCTGGACCGGATGAGCCGGATGGTCGACGACCTGCTGACCCTGGCGAAGGCC
CGGCAGCCCGACTTCCTCCGGGTCGCCGATGTCGATCTCGTCGCGTTCACCGATGACCTGATGGCGCGGGTCGGCGCGCT
GGCGCCGCGGCGGTGGCGGCTGGCCGAGGCCGGCTCGGGCACGGCCATGATGGACCGGCACCGGATCACGCAGGCACTGG
TCCAGCTCGCGCAGAACGCCGTGCAGCACACGGGCGTGGGTGATGAGGTGCGCCTCGGCTGCCGGCCGCGCGCCGGCGTG
GTCCGCTTCTGGGTCGCTGACTCTGGTCCAGGGGTCGCCCCCGAGGACCGGGACCGGATCTTCGAGCGGTTCGCCCGTGG
CCGGCCGGGCCGCGGGACGTCCGAGGGTGCCGGGCTCGGCCTGGCGATCGTGCGGGCGATCGCGGTGGCGCACGGCGGTG
ACGTCCAGGTCCTCGGCGGGCCCGGCGAGGGCGCGACCTTCGAGCTGGCGGTGCCCCGCCGTGGCCCCTCCGGCACGGGA
CGGCCCGGTGCCGTGGTCGGTGTCGTGGTCGGAGGGCGGGACTGA

Upstream 100 bases:

>100_bases
CCGAGGTCTCGTCGGTACCCGCGCCGGCGCCGGCGAGATGAGGAGATTCTCATCCAGCGCACATGCGTGCCGGGGGATCC
GTCGACCAGGCTGGTAGGTC

Downstream 100 bases:

>100_bases
GATGGCCAACCGGGTGCTGATCGCCGAGGACGAGTACCGGATCGCCTCGTTCATCGAGAAGGGCCTGCGCGCGAACGGGT
TCCTGCCGGTCTGCGTCGGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MRLSRTRRVVRHVATSARLHILGWQVLLVGVALAGSVLVSREVLLARVDERVDRGLARQVAELRRLATASVDPRTSRPFT
DVRELLEAHLERTIPGSNETMLALVDGRPFRRSAEEPVYRLDNDPRAVAAFVVGPQPRYGTITTPAGEVRFATVPVQVAG
APERGVFAAAVFADRERAEVQEVVRVLAIAGFAALALAGAGGWLVAGRVLAPVRELRRTAQAISDTDFSRRIPVAGRDEI
AELARTFNSMLDRLEDAFATQRAFVDDAGHELRTPITIISGHLELLSDDPAERTETVALVTDELDRMSRMVDDLLTLAKA
RQPDFLRVADVDLVAFTDDLMARVGALAPRRWRLAEAGSGTAMMDRHRITQALVQLAQNAVQHTGVGDEVRLGCRPRAGV
VRFWVADSGPGVAPEDRDRIFERFARGRPGRGTSEGAGLGLAIVRAIAVAHGGDVQVLGGPGEGATFELAVPRRGPSGTG
RPGAVVGVVVGGRD

Sequences:

>Translated_494_residues
MRLSRTRRVVRHVATSARLHILGWQVLLVGVALAGSVLVSREVLLARVDERVDRGLARQVAELRRLATASVDPRTSRPFT
DVRELLEAHLERTIPGSNETMLALVDGRPFRRSAEEPVYRLDNDPRAVAAFVVGPQPRYGTITTPAGEVRFATVPVQVAG
APERGVFAAAVFADRERAEVQEVVRVLAIAGFAALALAGAGGWLVAGRVLAPVRELRRTAQAISDTDFSRRIPVAGRDEI
AELARTFNSMLDRLEDAFATQRAFVDDAGHELRTPITIISGHLELLSDDPAERTETVALVTDELDRMSRMVDDLLTLAKA
RQPDFLRVADVDLVAFTDDLMARVGALAPRRWRLAEAGSGTAMMDRHRITQALVQLAQNAVQHTGVGDEVRLGCRPRAGV
VRFWVADSGPGVAPEDRDRIFERFARGRPGRGTSEGAGLGLAIVRAIAVAHGGDVQVLGGPGEGATFELAVPRRGPSGTG
RPGAVVGVVVGGRD
>Mature_494_residues
MRLSRTRRVVRHVATSARLHILGWQVLLVGVALAGSVLVSREVLLARVDERVDRGLARQVAELRRLATASVDPRTSRPFT
DVRELLEAHLERTIPGSNETMLALVDGRPFRRSAEEPVYRLDNDPRAVAAFVVGPQPRYGTITTPAGEVRFATVPVQVAG
APERGVFAAAVFADRERAEVQEVVRVLAIAGFAALALAGAGGWLVAGRVLAPVRELRRTAQAISDTDFSRRIPVAGRDEI
AELARTFNSMLDRLEDAFATQRAFVDDAGHELRTPITIISGHLELLSDDPAERTETVALVTDELDRMSRMVDDLLTLAKA
RQPDFLRVADVDLVAFTDDLMARVGALAPRRWRLAEAGSGTAMMDRHRITQALVQLAQNAVQHTGVGDEVRLGCRPRAGV
VRFWVADSGPGVAPEDRDRIFERFARGRPGRGTSEGAGLGLAIVRAIAVAHGGDVQVLGGPGEGATFELAVPRRGPSGTG
RPGAVVGVVVGGRD

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=32.2344322344322, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1786783, Length=408, Percent_Identity=28.4313725490196, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1787894, Length=295, Percent_Identity=31.1864406779661, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1786600, Length=272, Percent_Identity=28.6764705882353, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789403, Length=308, Percent_Identity=31.8181818181818, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=32.2727272727273, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=29.0909090909091, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788713, Length=258, Percent_Identity=25.968992248062, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=322, Percent_Identity=24.8447204968944, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788549, Length=217, Percent_Identity=29.0322580645161, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789808, Length=273, Percent_Identity=26.007326007326, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=29.7413793103448, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=27.3684210526316, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87081816, Length=235, Percent_Identity=31.9148936170213, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=275, Percent_Identity=28.7272727272727, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI87082128, Length=275, Percent_Identity=20, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53192; Mature: 53192

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSRTRRVVRHVATSARLHILGWQVLLVGVALAGSVLVSREVLLARVDERVDRGLARQV
CCCHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELRRLATASVDPRTSRPFTDVRELLEAHLERTIPGSNETMLALVDGRPFRRSAEEPVYR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEE
LDNDPRAVAAFVVGPQPRYGTITTPAGEVRFATVPVQVAGAPERGVFAAAVFADRERAEV
CCCCCCEEEEEEECCCCCCCEEECCCCCEEEEEEEEEECCCCCCCCEEEHHHHCCHHHHH
QEVVRVLAIAGFAALALAGAGGWLVAGRVLAPVRELRRTAQAISDTDFSRRIPVAGRDEI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
AELARTFNSMLDRLEDAFATQRAFVDDAGHELRTPITIISGHLELLSDDPAERTETVALV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEECHHHHHCCCCCHHHHEEEEH
TDELDRMSRMVDDLLTLAKARQPDFLRVADVDLVAFTDDLMARVGALAPRRWRLAEAGSG
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCEEECCCCCC
TAMMDRHRITQALVQLAQNAVQHTGVGDEVRLGCRPRAGVVRFWVADSGPGVAPEDRDRI
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCHHHHH
FERFARGRPGRGTSEGAGLGLAIVRAIAVAHGGDVQVLGGPGEGATFELAVPRRGPSGTG
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCC
RPGAVVGVVVGGRD
CCCCEEEEEECCCC
>Mature Secondary Structure
MRLSRTRRVVRHVATSARLHILGWQVLLVGVALAGSVLVSREVLLARVDERVDRGLARQV
CCCHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELRRLATASVDPRTSRPFTDVRELLEAHLERTIPGSNETMLALVDGRPFRRSAEEPVYR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEE
LDNDPRAVAAFVVGPQPRYGTITTPAGEVRFATVPVQVAGAPERGVFAAAVFADRERAEV
CCCCCCEEEEEEECCCCCCCEEECCCCCEEEEEEEEEECCCCCCCCEEEHHHHCCHHHHH
QEVVRVLAIAGFAALALAGAGGWLVAGRVLAPVRELRRTAQAISDTDFSRRIPVAGRDEI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
AELARTFNSMLDRLEDAFATQRAFVDDAGHELRTPITIISGHLELLSDDPAERTETVALV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEECHHHHHCCCCCHHHHEEEEH
TDELDRMSRMVDDLLTLAKARQPDFLRVADVDLVAFTDDLMARVGALAPRRWRLAEAGSG
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCEEECCCCCC
TAMMDRHRITQALVQLAQNAVQHTGVGDEVRLGCRPRAGVVRFWVADSGPGVAPEDRDRI
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEEEECCCCCCCCCHHHHH
FERFARGRPGRGTSEGAGLGLAIVRAIAVAHGGDVQVLGGPGEGATFELAVPRRGPSGTG
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCC
RPGAVVGVVVGGRD
CCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA