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The map label for this gene is cysM [H]

Identifier: 158317401

GI number: 158317401

Start: 6864853

End: 6865800

Strand: Reverse

Name: cysM [H]

Synonym: Franean1_5652

Alternate gene names: 158317401

Gene position: 6865800-6864853 (Counterclockwise)

Preceding gene: 158317402

Following gene: 158317396

Centisome position: 76.44

GC content: 70.46

Gene sequence:

>948_bases
ATGCGTTACGACTCCCTGGTGGACTCGGTAGGCCGAACCCCGCTGGTCGGACTGCCTCGGTTGTCTCCCTCTGCGGAGGT
CCGACTCTGGGCGAAGCTGGAACAGGACAACCCCACCGGTTCGATCAAGGACCGGGCGGCACTGTGGATGATCGCGGACG
GGGAGAAGCGAGGCCTGCTCACCCCGGGCGCGACCGTCCTCGAGCCCACGTCCGGCAACACCGGGATCTCGCTGGCGATG
GTCTGCAGCCAGCGGGGATACCGGCTGATCTGCGTGATGCCGGAGAACACCTCCGTGGAGCGCCGCCAGCTGCTCCAGAT
GTGGGGGGCCGAGATCGTCTCGTCCCCGGCGGCCGGCGGCTCGAACGAGGCGGTCGCGGTGGCCAAGCGGCTCGCGGCGG
AGAACCCCGACTGGGTGATGCTCTACCAGTACGGCAACCCGGCGAACGCACAGGCGCACTACGAGACGACCGGCCCGGAG
ATCCTGGAGGACCTGCCGGGTATCACCCATTTCGTGGCGGGGCTCGGCACCACCGGGACGCTGATGGGTACCGGTCGCTA
CCTGCGGGAGCGCAAGCCCGACGTCGTGATCGTCGCGGCCGAGCCGCGGTACGGCGAGCTCGTCTACGGGCTGCGCAACA
TCGACGAGGGCTTCGTCCCGGAGCTCTACGATGCCTCGGTGCTGACCTCGCGGTACTCGGTCGGCCCTCGGGACGCGCTG
CGCCGCACGCGCGAGCTCGTCCAGCAGGAGGGGATCTTCGCCGGGATCTCGACGGGGGCGATCCTGCACGCCGCCCTCGC
GCAGGCCGACCGTGCGGTGCGGGAGGGGCGGCGGGCCGACATCGCCTTCATCGTCTGCGACGGTGGTTGGAAGTACCTGT
CGACCGGTGCGTACGCCGGCACGCTCGCCGAGGCCGAGGCCGCGCTCGAGGGGCAGCTCTGGGCCTGA

Upstream 100 bases:

>100_bases
GACTTTGCTGCCGACGACCTAGCCGGCGGCTGCGCTCGGGTGCCGATCTCGTCCGGCATGGCTACCCGGCTCTTCTGATC
AGGGCGGCAGGTCCCTACTC

Downstream 100 bases:

>100_bases
GCGCATAGCCGCGAGCCCCGCCCCGCCCCGCCCTGGCCCATCGGCGCGGGGCGGTGCCGGCGTGCGACCGCGGCGCCGGG
CCGCCCGGCGCGGCGGTCGC

Product: cysteine synthase

Products: NA

Alternate protein names: OPS sulfhydrylase; CysO-thiocarboxylate-dependent cysteine synthase; Cysteine synthase B; CSase B; O-phosphoserine-specific cysteine synthase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRYDSLVDSVGRTPLVGLPRLSPSAEVRLWAKLEQDNPTGSIKDRAALWMIADGEKRGLLTPGATVLEPTSGNTGISLAM
VCSQRGYRLICVMPENTSVERRQLLQMWGAEIVSSPAAGGSNEAVAVAKRLAAENPDWVMLYQYGNPANAQAHYETTGPE
ILEDLPGITHFVAGLGTTGTLMGTGRYLRERKPDVVIVAAEPRYGELVYGLRNIDEGFVPELYDASVLTSRYSVGPRDAL
RRTRELVQQEGIFAGISTGAILHAALAQADRAVREGRRADIAFIVCDGGWKYLSTGAYAGTLAEAEAALEGQLWA

Sequences:

>Translated_315_residues
MRYDSLVDSVGRTPLVGLPRLSPSAEVRLWAKLEQDNPTGSIKDRAALWMIADGEKRGLLTPGATVLEPTSGNTGISLAM
VCSQRGYRLICVMPENTSVERRQLLQMWGAEIVSSPAAGGSNEAVAVAKRLAAENPDWVMLYQYGNPANAQAHYETTGPE
ILEDLPGITHFVAGLGTTGTLMGTGRYLRERKPDVVIVAAEPRYGELVYGLRNIDEGFVPELYDASVLTSRYSVGPRDAL
RRTRELVQQEGIFAGISTGAILHAALAQADRAVREGRRADIAFIVCDGGWKYLSTGAYAGTLAEAEAALEGQLWA
>Mature_315_residues
MRYDSLVDSVGRTPLVGLPRLSPSAEVRLWAKLEQDNPTGSIKDRAALWMIADGEKRGLLTPGATVLEPTSGNTGISLAM
VCSQRGYRLICVMPENTSVERRQLLQMWGAEIVSSPAAGGSNEAVAVAKRLAAENPDWVMLYQYGNPANAQAHYETTGPE
ILEDLPGITHFVAGLGTTGTLMGTGRYLRERKPDVVIVAAEPRYGELVYGLRNIDEGFVPELYDASVLTSRYSVGPRDAL
RRTRELVQQEGIFAGISTGAILHAALAQADRAVREGRRADIAFIVCDGGWKYLSTGAYAGTLAEAEAALEGQLWA

Specific function: Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in v

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=307, Percent_Identity=36.8078175895765, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI295821200, Length=307, Percent_Identity=36.8078175895765, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4557415, Length=307, Percent_Identity=36.8078175895765, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI2367138, Length=295, Percent_Identity=42.3728813559322, Blast_Score=231, Evalue=3e-62,
Organism=Escherichia coli, GI1788754, Length=316, Percent_Identity=39.873417721519, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=39.4648829431438, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=39.5424836601307, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32566674, Length=279, Percent_Identity=40.8602150537634, Blast_Score=193, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17561720, Length=313, Percent_Identity=38.9776357827476, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI115535073, Length=317, Percent_Identity=36.9085173501577, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17534315, Length=312, Percent_Identity=37.5, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=312, Percent_Identity=33.974358974359, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI32566672, Length=220, Percent_Identity=36.3636363636364, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321594, Length=287, Percent_Identity=37.6306620209059, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=34.3653250773994, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=38.1877022653722, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=38.1877022653722, Blast_Score=177, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.65 [H]

Molecular weight: Translated: 33979; Mature: 33979

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00165 DEHYDRATASE_SER_THR ; PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDSLVDSVGRTPLVGLPRLSPSAEVRLWAKLEQDNPTGSIKDRAALWMIADGEKRGLL
CCHHHHHHHHCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCC
TPGATVLEPTSGNTGISLAMVCSQRGYRLICVMPENTSVERRQLLQMWGAEIVSSPAAGG
CCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
SNEAVAVAKRLAAENPDWVMLYQYGNPANAQAHYETTGPEILEDLPGITHFVAGLGTTGT
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHCCCHHHHHHHCCCCCE
LMGTGRYLRERKPDVVIVAAEPRYGELVYGLRNIDEGFVPELYDASVLTSRYSVGPRDAL
EEECCHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHH
RRTRELVQQEGIFAGISTGAILHAALAQADRAVREGRRADIAFIVCDGGWKYLSTGAYAG
HHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCHH
TLAEAEAALEGQLWA
HHHHHHHHHCCCCCC
>Mature Secondary Structure
MRYDSLVDSVGRTPLVGLPRLSPSAEVRLWAKLEQDNPTGSIKDRAALWMIADGEKRGLL
CCHHHHHHHHCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCCC
TPGATVLEPTSGNTGISLAMVCSQRGYRLICVMPENTSVERRQLLQMWGAEIVSSPAAGG
CCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
SNEAVAVAKRLAAENPDWVMLYQYGNPANAQAHYETTGPEILEDLPGITHFVAGLGTTGT
CCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHCCCHHHHHHHCCCCCE
LMGTGRYLRERKPDVVIVAAEPRYGELVYGLRNIDEGFVPELYDASVLTSRYSVGPRDAL
EEECCHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHH
RRTRELVQQEGIFAGISTGAILHAALAQADRAVREGRRADIAFIVCDGGWKYLSTGAYAG
HHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCHH
TLAEAEAALEGQLWA
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]