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The map label for this gene is devS [H]

Identifier: 158316742

GI number: 158316742

Start: 5975058

End: 5976953

Strand: Reverse

Name: devS [H]

Synonym: Franean1_4980

Alternate gene names: 158316742

Gene position: 5976953-5975058 (Counterclockwise)

Preceding gene: 158316747

Following gene: 158316738

Centisome position: 66.54

GC content: 75.42

Gene sequence:

>1896_bases
ATGGTCCAGACCGGCGCCGGCCCAGATGCGCCGGCGACCAGCAGCGCCGAGCCGCGGACGCTCGGCGGCGCCGGCCGTCG
CCTCAAGCCCGGGCCGAGGTCGGAGGTCTACGCGGTGCAGAGCCGGATGCGCGGCCTGCTCGACGCCGTGGTCGATGTCG
CGCGCGAGCTGAGCCTGCCAGTGACGCTACGCCGGATCGCGCAGGCGGCCCGCTCCCTGGTGGACTGCGAGCTCGGCGCG
CTCGGGGTCCTCGGCCAGGACGGCGCCATCACCGAGCTGATCGCGGTCGGCCCGGGGGAGGAGGTTCCCCGCGACATCGC
CCGGATGCCGCCCGGCCGCGGCCTGATCGGCGAGCCCGGGGGCGGCCCCCACCCGGGCGGGAACGCACCGCGGGTGGGCA
CCGCCGTCGTCGCGCCGGAGACGCTCGGCTTCCCGCCCGGCCGGCCTCGTTTCACCACGTTCCTCAACGTCCCGATCGCC
GTCCGCGGGGAGGCGTTCGGCAACCTGTACCTGGTGGGCAAGCGCGGCCCCGAGTTCACCCAGGAGGACGAGGACCTGGT
CGAGGCGCTCGCCGCGGCCGTCGGCTTCGCCATCGAGAACGCCCGCCTTTACGAGGCCACCCGGCGGCGCCAGGCCTGGC
TCACCGCGAGTGCCGAGATCACCACGGCGCTGCTGTCGGTGGCCGAGCCCGTCGACGCGTTACGGCTGGTCGCCCGGCGT
GCCAGGCAGATCACCTCGGCCCTGCTCGCCGCGATCGTGCTCCCGGTGAACAGCGCGGAGGCGGCCCGGCCCGGCCGCTT
CGGCGTCCGGCCCCGCCGGCCCGCCGCGCGGGCCGGCGGGGCCCCGAGGTCGCTGGAGGTGGCCGTCGTCGACGGTCCGC
TCGCCGAGCAGTTGCGGGGGCGGATGCTGCCCGAGCGGGTCGGGCTGTTCAAGATCATGAAGGCGGGCCGGGCGGTGCTC
GTCCCCGCCGAGCGCGCCGATCCCGCCGCGCACAGCCTGCTGGGCGAGGCCGTCGACGGCCTGGTGATCGGCACCGTGAT
GGTCATCCCGCTGTTGGCCGCCGGGCGGCCGCTGGGGGTGCTCATGCTCACCGCGGCCCCGGGCGCGGTCCCGTTCGGCC
AGCTCGACCTGGAGATGGCGGCGGCGTTCGCCGGTCAGGCCGCGCTCGCCCTGGAACTCGCCCGCGTGCAGTGGGACAGG
GAACGCCTCGCGGTGTTCGAGGAACGCGACCGCATCGCCCGCGACCTGCACGACGTCGTCATCCAGCGGCTGTTCGCCAC
CGGTCTGCAGATGCAGGGCCTCGCCCGGGTGATCGACGAGGGCGCCGCGGTGCGGCTCAACGACGCCGTCCGCGAGCTGG
ATCAGACGATCGCCGACATCCGCCATACGATTTTCTCGCTGACGGCGTCCGCCGGCGCCGTCGACCTGCGGGCCGAGATC
GCCGGAATCGTGTCACAGGCCGAGCAGGCGCTGGGCATCCGGCCCACGGCCCGCATCGACGGCCCGGTCGACCGCGGTAT
CCCGGAGGTGATCCATCCGCACCTGCTGGCGGCCATCCGTGAGGCGCTGTCGAACATCGCACGGCATGCCCGGGCGACCC
GCATCGAGGTGCTGGTGCGGGTCACCAACACCGACGTCTCGGTGCAGGTGCGCGACGACGGCTGCGGCCCGGGTGGCGCG
TCGCGCAGCAGCGGCCTGACGAACCTGCGCCGCCGGGCGCTCGACCTCGGCGGCCGGATGGAGTTCGGCCCAGGCGAAGA
CGGCATCGGCACGACGGTGACCTGGTACGTGCCGCTGGTTCAGCCCATCCCGCCACCGCGCGCGCTGCCGCGGGCCGGGG
ACACCCCCGCCCCGCGACTCGGCGTCGGGCCCGCGGAGGGGCCTGGTGGGCCCTGA

Upstream 100 bases:

>100_bases
CGCTCGTGGCAGGGAGGAGTCCGCCGGATACGCGGGGAGTCCCCCGGGGGGGTCATGTGCTCGTTATCGTCACGGGAGGC
GATCGGACGGGAGGCGTGGG

Downstream 100 bases:

>100_bases
ACCGGTCCGGCGGCGGTTGCCCCAGCGGTGCTTCCCCGTCAGGCGCCCCAGCGGCCAGTCAGGGCCGGGGCTCCCACGCC
GGCTGTCAGGACGACAGCTT

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MVQTGAGPDAPATSSAEPRTLGGAGRRLKPGPRSEVYAVQSRMRGLLDAVVDVARELSLPVTLRRIAQAARSLVDCELGA
LGVLGQDGAITELIAVGPGEEVPRDIARMPPGRGLIGEPGGGPHPGGNAPRVGTAVVAPETLGFPPGRPRFTTFLNVPIA
VRGEAFGNLYLVGKRGPEFTQEDEDLVEALAAAVGFAIENARLYEATRRRQAWLTASAEITTALLSVAEPVDALRLVARR
ARQITSALLAAIVLPVNSAEAARPGRFGVRPRRPAARAGGAPRSLEVAVVDGPLAEQLRGRMLPERVGLFKIMKAGRAVL
VPAERADPAAHSLLGEAVDGLVIGTVMVIPLLAAGRPLGVLMLTAAPGAVPFGQLDLEMAAAFAGQAALALELARVQWDR
ERLAVFEERDRIARDLHDVVIQRLFATGLQMQGLARVIDEGAAVRLNDAVRELDQTIADIRHTIFSLTASAGAVDLRAEI
AGIVSQAEQALGIRPTARIDGPVDRGIPEVIHPHLLAAIREALSNIARHARATRIEVLVRVTNTDVSVQVRDDGCGPGGA
SRSSGLTNLRRRALDLGGRMEFGPGEDGIGTTVTWYVPLVQPIPPPRALPRAGDTPAPRLGVGPAEGPGGP

Sequences:

>Translated_631_residues
MVQTGAGPDAPATSSAEPRTLGGAGRRLKPGPRSEVYAVQSRMRGLLDAVVDVARELSLPVTLRRIAQAARSLVDCELGA
LGVLGQDGAITELIAVGPGEEVPRDIARMPPGRGLIGEPGGGPHPGGNAPRVGTAVVAPETLGFPPGRPRFTTFLNVPIA
VRGEAFGNLYLVGKRGPEFTQEDEDLVEALAAAVGFAIENARLYEATRRRQAWLTASAEITTALLSVAEPVDALRLVARR
ARQITSALLAAIVLPVNSAEAARPGRFGVRPRRPAARAGGAPRSLEVAVVDGPLAEQLRGRMLPERVGLFKIMKAGRAVL
VPAERADPAAHSLLGEAVDGLVIGTVMVIPLLAAGRPLGVLMLTAAPGAVPFGQLDLEMAAAFAGQAALALELARVQWDR
ERLAVFEERDRIARDLHDVVIQRLFATGLQMQGLARVIDEGAAVRLNDAVRELDQTIADIRHTIFSLTASAGAVDLRAEI
AGIVSQAEQALGIRPTARIDGPVDRGIPEVIHPHLLAAIREALSNIARHARATRIEVLVRVTNTDVSVQVRDDGCGPGGA
SRSSGLTNLRRRALDLGGRMEFGPGEDGIGTTVTWYVPLVQPIPPPRALPRAGDTPAPRLGVGPAEGPGGP
>Mature_631_residues
MVQTGAGPDAPATSSAEPRTLGGAGRRLKPGPRSEVYAVQSRMRGLLDAVVDVARELSLPVTLRRIAQAARSLVDCELGA
LGVLGQDGAITELIAVGPGEEVPRDIARMPPGRGLIGEPGGGPHPGGNAPRVGTAVVAPETLGFPPGRPRFTTFLNVPIA
VRGEAFGNLYLVGKRGPEFTQEDEDLVEALAAAVGFAIENARLYEATRRRQAWLTASAEITTALLSVAEPVDALRLVARR
ARQITSALLAAIVLPVNSAEAARPGRFGVRPRRPAARAGGAPRSLEVAVVDGPLAEQLRGRMLPERVGLFKIMKAGRAVL
VPAERADPAAHSLLGEAVDGLVIGTVMVIPLLAAGRPLGVLMLTAAPGAVPFGQLDLEMAAAFAGQAALALELARVQWDR
ERLAVFEERDRIARDLHDVVIQRLFATGLQMQGLARVIDEGAAVRLNDAVRELDQTIADIRHTIFSLTASAGAVDLRAEI
AGIVSQAEQALGIRPTARIDGPVDRGIPEVIHPHLLAAIREALSNIARHARATRIEVLVRVTNTDVSVQVRDDGCGPGGA
SRSSGLTNLRRRALDLGGRMEFGPGEDGIGTTVTWYVPLVQPIPPPRALPRAGDTPAPRLGVGPAEGPGGP

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaer

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=264, Percent_Identity=28.7878787878788, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788812, Length=223, Percent_Identity=31.390134529148, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016030
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66165; Mature: 66165

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQTGAGPDAPATSSAEPRTLGGAGRRLKPGPRSEVYAVQSRMRGLLDAVVDVARELSLP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VTLRRIAQAARSLVDCELGALGVLGQDGAITELIAVGPGEEVPRDIARMPPGRGLIGEPG
HHHHHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCC
GGPHPGGNAPRVGTAVVAPETLGFPPGRPRFTTFLNVPIAVRGEAFGNLYLVGKRGPEFT
CCCCCCCCCCCCCEEEECCHHCCCCCCCCCEEEEEECCEEEECCCCCCEEEEECCCCCCC
QEDEDLVEALAAAVGFAIENARLYEATRRRQAWLTASAEITTALLSVAEPVDALRLVARR
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ARQITSALLAAIVLPVNSAEAARPGRFGVRPRRPAARAGGAPRSLEVAVVDGPLAEQLRG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEECCHHHHHHHH
RMLPERVGLFKIMKAGRAVLVPAERADPAAHSLLGEAVDGLVIGTVMVIPLLAAGRPLGV
CCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LMLTAAPGAVPFGQLDLEMAAAFAGQAALALELARVQWDRERLAVFEERDRIARDLHDVV
EEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQRLFATGLQMQGLARVIDEGAAVRLNDAVRELDQTIADIRHTIFSLTASAGAVDLRAEI
HHHHHHHCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AGIVSQAEQALGIRPTARIDGPVDRGIPEVIHPHLLAAIREALSNIARHARATRIEVLVR
HHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
VTNTDVSVQVRDDGCGPGGASRSSGLTNLRRRALDLGGRMEFGPGEDGIGTTVTWYVPLV
EECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEC
QPIPPPRALPRAGDTPAPRLGVGPAEGPGGP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVQTGAGPDAPATSSAEPRTLGGAGRRLKPGPRSEVYAVQSRMRGLLDAVVDVARELSLP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
VTLRRIAQAARSLVDCELGALGVLGQDGAITELIAVGPGEEVPRDIARMPPGRGLIGEPG
HHHHHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCC
GGPHPGGNAPRVGTAVVAPETLGFPPGRPRFTTFLNVPIAVRGEAFGNLYLVGKRGPEFT
CCCCCCCCCCCCCEEEECCHHCCCCCCCCCEEEEEECCEEEECCCCCCEEEEECCCCCCC
QEDEDLVEALAAAVGFAIENARLYEATRRRQAWLTASAEITTALLSVAEPVDALRLVARR
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ARQITSALLAAIVLPVNSAEAARPGRFGVRPRRPAARAGGAPRSLEVAVVDGPLAEQLRG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEECCHHHHHHHH
RMLPERVGLFKIMKAGRAVLVPAERADPAAHSLLGEAVDGLVIGTVMVIPLLAAGRPLGV
CCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LMLTAAPGAVPFGQLDLEMAAAFAGQAALALELARVQWDRERLAVFEERDRIARDLHDVV
EEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQRLFATGLQMQGLARVIDEGAAVRLNDAVRELDQTIADIRHTIFSLTASAGAVDLRAEI
HHHHHHHCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AGIVSQAEQALGIRPTARIDGPVDRGIPEVIHPHLLAAIREALSNIARHARATRIEVLVR
HHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
VTNTDVSVQVRDDGCGPGGASRSSGLTNLRRRALDLGGRMEFGPGEDGIGTTVTWYVPLV
EECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEC
QPIPPPRALPRAGDTPAPRLGVGPAEGPGGP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]