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The map label for this gene is argE [C]

Identifier: 158316666

GI number: 158316666

Start: 5888510

End: 5889898

Strand: Reverse

Name: argE [C]

Synonym: Franean1_4903

Alternate gene names: 158316666

Gene position: 5889898-5888510 (Counterclockwise)

Preceding gene: 158316671

Following gene: 158316660

Centisome position: 65.57

GC content: 72.14

Gene sequence:

>1389_bases
ATGGCAAACGCGCCCCATGATCCCACTGACGCCCTCGCCGCCGCGGCCGCGGGGGACCCACTCGCGGCGAGGACAGGGCG
GCCGGCCGTCCCGTCCGCCGCCGAGTCCGAGGTCGTGGATCTGTGTCGGGACCTGCTGCGCTTCGAGTCGGTGAACCGCG
GGAACGGCGACGGCCACGAGCGGCCCATCGCCGAGTACGTGGCCACCAGGCTGGCCGAGGTCGGGCTGGAGCCGGTGCTG
CTCGAGTCCGCGCCCGGCCGCACGAGCGTGGTGACCAGGGTGGAGGGCACCGACCCGTCCCGCTCCCCGCTGCTCATCCA
CGGCCACCTGGACGTCGTGCCCGCCGACCCGTCCGAGTGGCGCGTGCACCCCTTCTCGGGCGAGGAGGCCGACGGCTGCC
TGTGGGGGCGCGGCGCCATTGACATGAAGGACATGGACGCGATGACGCTCGCCGTCGTGCGCGACATGGTCCGGTCGGGC
CGGCGTCCGCCCCGTGATCTCGTCGTCGCCTTCGTCGCGGACGAGGAGGCCGGCGGCACCCTCGGCGCGCGGTGGCTGGT
GGACAACCATCCCGACCACTTCGCCGACTGCACCGAGGCGATCAGCGAGGTCGGCGGGTTCTCCTACACCGTCTCGGACG
ACCTGCGGCTGTACCTGATCGAGACGGCGCAGAAGGGCATCGCCTGGATGAAGCTGACCGTCGCCGGCCGGGCCGGCCAC
GGGTCGATGATCAGCGAGGACAATGCGGTGACCAAGCTGTGCGAGGCGGTCGCCCGGCTCGGTCGGCACCAGTTCCCGAT
CGTGGTGACCCCGACCGTGCGCGTCTTTCTCGACTCGATCGGCGAGGCGCTGGGCATCGAGCTCCCCGCGGACGACCTGG
AGACCACGATCGCGAAGCTCGGCCCGATCGCGCGCATGATCGGGGCGACGATCCGCAACACGGCGAACCCCACGCAGCTC
GCCGCCGGACACAAGGTCAACGTGATCCCCGGCGAGGCTGTGGCCTACGTCGACGGGCGCTACCTGCCTGGGCAGGAGGA
GGAGTTCCTGCGCCAGGTCGACGAGCTGCTCGGGCCGGAGGTCCGGCGTGAGTGGGTGGTGAACGACCAGGCGCTGGAGA
CCGGGTTCGACGGCCCACTGGTGGACGCGATGGCCTCGGCGCTGCGCGCGGAGGACCCGGCCGCCCGGGCCGTCCCGTAC
ATGCTCTCGGGCGGTACCGACGCGAAGTCGTTCTCCCGGCTCGGCATCCGCTGCTTCGGGTTCTCCCCGCTGCTGCTCCC
GCCGGACCTCGACTTCGCCGGCATGTTCCACGGCGTGGACGAGCGGGTGCCCGTCGACGCCCTGCGGTTCGGGGTCCGCG
TCCTGGACCGTTTCCTCGCCGCCTCCTGA

Upstream 100 bases:

>100_bases
TGATCGGTCGTTGTTGGACCTGAAACCGGCCGGCAACACGCAGCTTCGACGCTACGTCCCCGCCCCGGCGACCGCATGCC
GCGCGGGGCAGACTGGAGAC

Downstream 100 bases:

>100_bases
TGGGAGCTGACCCGCGCCGGCGTGCGAACCGCTCTGCCAGGCGAACCAGCCCGGCTGGCGAACCGGCCTGGCCCACGAAC
CGGCCCGGACCTGATGGTCC

Product: hypothetical protein

Products: Acetate; Ornithine [C]

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MANAPHDPTDALAAAAAGDPLAARTGRPAVPSAAESEVVDLCRDLLRFESVNRGNGDGHERPIAEYVATRLAEVGLEPVL
LESAPGRTSVVTRVEGTDPSRSPLLIHGHLDVVPADPSEWRVHPFSGEEADGCLWGRGAIDMKDMDAMTLAVVRDMVRSG
RRPPRDLVVAFVADEEAGGTLGARWLVDNHPDHFADCTEAISEVGGFSYTVSDDLRLYLIETAQKGIAWMKLTVAGRAGH
GSMISEDNAVTKLCEAVARLGRHQFPIVVTPTVRVFLDSIGEALGIELPADDLETTIAKLGPIARMIGATIRNTANPTQL
AAGHKVNVIPGEAVAYVDGRYLPGQEEEFLRQVDELLGPEVRREWVVNDQALETGFDGPLVDAMASALRAEDPAARAVPY
MLSGGTDAKSFSRLGIRCFGFSPLLLPPDLDFAGMFHGVDERVPVDALRFGVRVLDRFLAAS

Sequences:

>Translated_462_residues
MANAPHDPTDALAAAAAGDPLAARTGRPAVPSAAESEVVDLCRDLLRFESVNRGNGDGHERPIAEYVATRLAEVGLEPVL
LESAPGRTSVVTRVEGTDPSRSPLLIHGHLDVVPADPSEWRVHPFSGEEADGCLWGRGAIDMKDMDAMTLAVVRDMVRSG
RRPPRDLVVAFVADEEAGGTLGARWLVDNHPDHFADCTEAISEVGGFSYTVSDDLRLYLIETAQKGIAWMKLTVAGRAGH
GSMISEDNAVTKLCEAVARLGRHQFPIVVTPTVRVFLDSIGEALGIELPADDLETTIAKLGPIARMIGATIRNTANPTQL
AAGHKVNVIPGEAVAYVDGRYLPGQEEEFLRQVDELLGPEVRREWVVNDQALETGFDGPLVDAMASALRAEDPAARAVPY
MLSGGTDAKSFSRLGIRCFGFSPLLLPPDLDFAGMFHGVDERVPVDALRFGVRVLDRFLAAS
>Mature_461_residues
ANAPHDPTDALAAAAAGDPLAARTGRPAVPSAAESEVVDLCRDLLRFESVNRGNGDGHERPIAEYVATRLAEVGLEPVLL
ESAPGRTSVVTRVEGTDPSRSPLLIHGHLDVVPADPSEWRVHPFSGEEADGCLWGRGAIDMKDMDAMTLAVVRDMVRSGR
RPPRDLVVAFVADEEAGGTLGARWLVDNHPDHFADCTEAISEVGGFSYTVSDDLRLYLIETAQKGIAWMKLTVAGRAGHG
SMISEDNAVTKLCEAVARLGRHQFPIVVTPTVRVFLDSIGEALGIELPADDLETTIAKLGPIARMIGATIRNTANPTQLA
AGHKVNVIPGEAVAYVDGRYLPGQEEEFLRQVDELLGPEVRREWVVNDQALETGFDGPLVDAMASALRAEDPAARAVPYM
LSGGTDAKSFSRLGIRCFGFSPLLLPPDLDFAGMFHGVDERVPVDALRFGVRVLDRFLAAS

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=390, Percent_Identity=27.6923076923077, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI4501901, Length=436, Percent_Identity=26.1467889908257, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71982082, Length=401, Percent_Identity=26.6832917705736, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17538642, Length=400, Percent_Identity=25.75, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71982085, Length=415, Percent_Identity=25.7831325301205, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17538640, Length=401, Percent_Identity=26.6832917705736, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71982710, Length=390, Percent_Identity=25.3846153846154, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322289, Length=178, Percent_Identity=30.8988764044944, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24649202, Length=379, Percent_Identity=27.1767810026385, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24649204, Length=379, Percent_Identity=27.1767810026385, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21356353, Length=432, Percent_Identity=25.2314814814815, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24649206, Length=386, Percent_Identity=24.0932642487047, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24649212, Length=444, Percent_Identity=25.9009009009009, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24649210, Length=435, Percent_Identity=25.2873563218391, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24649208, Length=436, Percent_Identity=24.0825688073394, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 49547; Mature: 49415

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANAPHDPTDALAAAAAGDPLAARTGRPAVPSAAESEVVDLCRDLLRFESVNRGNGDGHE
CCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
RPIAEYVATRLAEVGLEPVLLESAPGRTSVVTRVEGTDPSRSPLLIHGHLDVVPADPSEW
CHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEEECEEEECCCCCCC
RVHPFSGEEADGCLWGRGAIDMKDMDAMTLAVVRDMVRSGRRPPRDLVVAFVADEEAGGT
EEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCCCC
LGARWLVDNHPDHFADCTEAISEVGGFSYTVSDDLRLYLIETAQKGIAWMKLTVAGRAGH
EEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEEEHHHCCCEEEEEEEECCCCC
GSMISEDNAVTKLCEAVARLGRHQFPIVVTPTVRVFLDSIGEALGIELPADDLETTIAKL
CCCCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
GPIARMIGATIRNTANPTQLAAGHKVNVIPGEAVAYVDGRYLPGQEEEFLRQVDELLGPE
HHHHHHHHHHHHCCCCCHHHCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCHH
VRREWVVNDQALETGFDGPLVDAMASALRAEDPAARAVPYMLSGGTDAKSFSRLGIRCFG
HHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCCEECCCCCHHHHHHCCEEEEC
FSPLLLPPDLDFAGMFHGVDERVPVDALRFGVRVLDRFLAAS
CCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ANAPHDPTDALAAAAAGDPLAARTGRPAVPSAAESEVVDLCRDLLRFESVNRGNGDGHE
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
RPIAEYVATRLAEVGLEPVLLESAPGRTSVVTRVEGTDPSRSPLLIHGHLDVVPADPSEW
CHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEEECEEEECCCCCCC
RVHPFSGEEADGCLWGRGAIDMKDMDAMTLAVVRDMVRSGRRPPRDLVVAFVADEEAGGT
EEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCCCC
LGARWLVDNHPDHFADCTEAISEVGGFSYTVSDDLRLYLIETAQKGIAWMKLTVAGRAGH
EEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEEEHHHCCCEEEEEEEECCCCC
GSMISEDNAVTKLCEAVARLGRHQFPIVVTPTVRVFLDSIGEALGIELPADDLETTIAKL
CCCCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
GPIARMIGATIRNTANPTQLAAGHKVNVIPGEAVAYVDGRYLPGQEEEFLRQVDELLGPE
HHHHHHHHHHHHCCCCCHHHCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHCHH
VRREWVVNDQALETGFDGPLVDAMASALRAEDPAARAVPYMLSGGTDAKSFSRLGIRCFG
HHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCCEECCCCCHHHHHHCCEEEEC
FSPLLLPPDLDFAGMFHGVDERVPVDALRFGVRVLDRFLAAS
CCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]