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The map label for this gene is hyuA [H]

Identifier: 158316590

GI number: 158316590

Start: 5764096

End: 5766591

Strand: Reverse

Name: hyuA [H]

Synonym: Franean1_4826

Alternate gene names: 158316590

Gene position: 5766591-5764096 (Counterclockwise)

Preceding gene: 158316591

Following gene: 158316589

Centisome position: 64.2

GC content: 75.76

Gene sequence:

>2496_bases
GTGACCTCCGCCCCGCGGACTCCGCGGATCCCGACTGCGCGGGCCCTGAAGGCCCCGCGGGGCGGCGCGGTCGGGGGATA
CCGCGTCGCGGTGGACGTCGGCGGGACCTTCACCGACCTCGTCCTGCGCCGCCCGGACGGGACGGAGGCCGTCCACAAGA
CGAGCTCGACGCCGGGGGACCCGGCTCGGGCCGTCGTCGCCGGGCTCACCGGGCTGGCCGCCGCCGAGAGGCTGGCGCCG
CACGAACTGCTCGGCCGCACCGAAACCATCGTCCACGGCACGACGATCACCACCAACGCCCTGATCACCGGATCGGGCGC
GTGCACGGGGCTGGTCACGACCGCCGGTCTGCGCGATGTGCTCCCGGCCCGGCAGGGCAGCCGCGAGGACCAGTTCGCCT
CGAAGTCCGCCCCACCGCCGTCTCTGGTGCCCCGCCGTCTCGTCATCCCCGTCCGCGAGCGGGTGGACCGGACGGGCGCC
GTGGTGATGCCACTGGACGAGTCCGACGTGCGCCGCGCGGCCGGTCGGCTGCGCGCCGCCGGGGTGGAGGCCGTGGCGGT
GAGCTTCGTCTTCTCCTATCTGTTCGACGGGCATGAGCGGCAGGCCGCGGCGATCCTCGCGCAGGAGCTGCCGGGGGTGT
TCGTCACCACGGCATCCCGGCTCGTCCCGCAGGTGCGGATGTTCGAGCGGACCACGACCACCGCGCTCAACGCCTACGTG
GGTCCTGTCCTGCGCGACTACCTCGACGGGCTCGCCGACCGGCTGGCGGAGCTCGGATACGGCGGCCGGGTCCTGATCAT
GCAGTCGAACGGTGGTGTCGTCGGGCTGGAGCAGGCCGCCGACCGTGCCGTCGAGACACTGCTCTCCGGGCCGGCGGGAG
CGCCGGCGGCGGTCGCCGAGATCGTGCGTACCCTCGGCACGCGGGCGGCATGCGCCGGTGCGGGCGGCACCGGCGGCGCG
GGCGGCACCGGCGGCGCGGCCGGCGTCGACGGCGCGGGCCCGCCGACGCGACCGCCCGACACCATCACGATCGACATGGG
CGGGACGAGCTTCGAGGCCAGCCTGGCCCGCGGCGGGCGCACCGAGACCACCAGCAACGGCTCGCTGGCCGGGCATCCCG
TCTGCCTGCCCGCCCTGGACATCAGCACCATCGGCGCGGGCGGCGGGTCGGTGGCCTGGGTGACCGCGGGCGGGCTGCCG
AGGGTCGGCCCGCGCAGCGCCGGGGCGGTGCCGGGGCCCGCGGGCTACGGCCGTGGCGGCACCGAGCCGACCGTGACCGA
CGCCGACCTGCTCCTCGGCTACCTCGACCCGGACGGCTTCAGCGGCGGGATCGCGCTCTCGCGGGACGCGGCTGTCCGGG
CTGTCGGTGGGCTCGCCGAGCGACTCGGGATCAGGGGCTCCGCCGGCCGGCATCCTGACACCGCGGTGACTGACGCGGCA
GTGATCGACACGGGCGTGATCGACGATGCGGTGATCGAGGCGGCGGCCGGTGTGCACCGCGCGGTGAACGCGGCGATGGC
CGACAGCCTGCGCCTGCTGACCGGGCGCCGGGGCCTCGACCCGCGGCGGTTCGCCCTGGTGGCCGCCGGCGGCGCCGGGC
CGGTGCACGCCGTCGAGATCGCCCGTGAGCTCGGCATCCCGCTGGTGGTCGTCCCGGCCGGTGCCTCCGTCCTGTGTGCC
CGCGGGATGCTGCGGACAGACCTGGTGCGCTACTACGTGACGACCCTTCGCCCCGACCCGCGCGACCCGGGCGCCCTGCC
GGTCCCGTCGGACCTGGACGTGGCCTTCGACCGGATGGCCGCCGAGGCGCTGGACGACCTGCGTCCCCACCTGCCCGGGA
CGGGGCGGGTCGGGTTCACCCGGAGCGCGGATGTCCGCTACGCCGGTCAGGTCCACGAGATCCCCGTTCCCTTCGCGGAC
CCTGCTGTGCCCATGGACCCTGCCGTGCCCGCGGAGCCGGCCGGATCGGTGCTCCCGCGCACCGATGACGCCGGTCTGAA
GGATCTCCTTGAGCGGTTCCACGACGAGCACGAGCTGCGCTACGGGTACCGGCGCCCGGAACTCGCGGTGGAGATCGTCA
ACCTTCGCCTGGTGGCCCGCGTCCCGACCCTCCCGCCCGTCCCGGCTGATTCGCCCGCCCCACCTGACCCAGCTCATCCA
GCCGCCGTGGCCCCGCCGATCCGTGCGGCGGCACTCACCGCGCCCCTCGCGCCCCTCGCGGTGGCCCGCCGCCGCGAGGT
GTGGTTCGACGGCGGCTTCCGCGAGGTGAACGTCCACGACCCGGCGACGCTGAGCCCCGGCTGCCCCCACCAGGGACCGG
CGTTGGTGGCGCATCCCGCGAGCACCGTGGTCGTCCCGCCCGGATATGCCTTCGAGCTGGCCGAGGACGGAACCGTCCTG
GTCTTCGCGGCCACTGACACCGCGGACGCCGTCCTGCACCGGCTCGGGCTCGTCGGCGTCGCCGGCGCCGGCGACGCCGA
CGCGGCGGCCCGATGA

Upstream 100 bases:

>100_bases
CGCCGGGCCAGTTTCGAGCTGTTCGCCACCGACATCGCGCCCACGCTGCGGACCTCCGTCCCCGACCCGCCGTGGCCCGC
CCAGTGACCGCGGGCCCGCG

Downstream 100 bases:

>100_bases
CCGGCGCGGACCCGGTGCTGGCCGGGATCGTCGACAACCGGCTGCACGCGATCGCCGAGCAGATGGCGCAGGCCATGCTG
CGTTCCTGCCGGTCGATGGT

Product: 5-oxoprolinase

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 831; Mature: 830

Protein sequence:

>831_residues
MTSAPRTPRIPTARALKAPRGGAVGGYRVAVDVGGTFTDLVLRRPDGTEAVHKTSSTPGDPARAVVAGLTGLAAAERLAP
HELLGRTETIVHGTTITTNALITGSGACTGLVTTAGLRDVLPARQGSREDQFASKSAPPPSLVPRRLVIPVRERVDRTGA
VVMPLDESDVRRAAGRLRAAGVEAVAVSFVFSYLFDGHERQAAAILAQELPGVFVTTASRLVPQVRMFERTTTTALNAYV
GPVLRDYLDGLADRLAELGYGGRVLIMQSNGGVVGLEQAADRAVETLLSGPAGAPAAVAEIVRTLGTRAACAGAGGTGGA
GGTGGAAGVDGAGPPTRPPDTITIDMGGTSFEASLARGGRTETTSNGSLAGHPVCLPALDISTIGAGGGSVAWVTAGGLP
RVGPRSAGAVPGPAGYGRGGTEPTVTDADLLLGYLDPDGFSGGIALSRDAAVRAVGGLAERLGIRGSAGRHPDTAVTDAA
VIDTGVIDDAVIEAAAGVHRAVNAAMADSLRLLTGRRGLDPRRFALVAAGGAGPVHAVEIARELGIPLVVVPAGASVLCA
RGMLRTDLVRYYVTTLRPDPRDPGALPVPSDLDVAFDRMAAEALDDLRPHLPGTGRVGFTRSADVRYAGQVHEIPVPFAD
PAVPMDPAVPAEPAGSVLPRTDDAGLKDLLERFHDEHELRYGYRRPELAVEIVNLRLVARVPTLPPVPADSPAPPDPAHP
AAVAPPIRAAALTAPLAPLAVARRREVWFDGGFREVNVHDPATLSPGCPHQGPALVAHPASTVVVPPGYAFELAEDGTVL
VFAATDTADAVLHRLGLVGVAGAGDADAAAR

Sequences:

>Translated_831_residues
MTSAPRTPRIPTARALKAPRGGAVGGYRVAVDVGGTFTDLVLRRPDGTEAVHKTSSTPGDPARAVVAGLTGLAAAERLAP
HELLGRTETIVHGTTITTNALITGSGACTGLVTTAGLRDVLPARQGSREDQFASKSAPPPSLVPRRLVIPVRERVDRTGA
VVMPLDESDVRRAAGRLRAAGVEAVAVSFVFSYLFDGHERQAAAILAQELPGVFVTTASRLVPQVRMFERTTTTALNAYV
GPVLRDYLDGLADRLAELGYGGRVLIMQSNGGVVGLEQAADRAVETLLSGPAGAPAAVAEIVRTLGTRAACAGAGGTGGA
GGTGGAAGVDGAGPPTRPPDTITIDMGGTSFEASLARGGRTETTSNGSLAGHPVCLPALDISTIGAGGGSVAWVTAGGLP
RVGPRSAGAVPGPAGYGRGGTEPTVTDADLLLGYLDPDGFSGGIALSRDAAVRAVGGLAERLGIRGSAGRHPDTAVTDAA
VIDTGVIDDAVIEAAAGVHRAVNAAMADSLRLLTGRRGLDPRRFALVAAGGAGPVHAVEIARELGIPLVVVPAGASVLCA
RGMLRTDLVRYYVTTLRPDPRDPGALPVPSDLDVAFDRMAAEALDDLRPHLPGTGRVGFTRSADVRYAGQVHEIPVPFAD
PAVPMDPAVPAEPAGSVLPRTDDAGLKDLLERFHDEHELRYGYRRPELAVEIVNLRLVARVPTLPPVPADSPAPPDPAHP
AAVAPPIRAAALTAPLAPLAVARRREVWFDGGFREVNVHDPATLSPGCPHQGPALVAHPASTVVVPPGYAFELAEDGTVL
VFAATDTADAVLHRLGLVGVAGAGDADAAAR
>Mature_830_residues
TSAPRTPRIPTARALKAPRGGAVGGYRVAVDVGGTFTDLVLRRPDGTEAVHKTSSTPGDPARAVVAGLTGLAAAERLAPH
ELLGRTETIVHGTTITTNALITGSGACTGLVTTAGLRDVLPARQGSREDQFASKSAPPPSLVPRRLVIPVRERVDRTGAV
VMPLDESDVRRAAGRLRAAGVEAVAVSFVFSYLFDGHERQAAAILAQELPGVFVTTASRLVPQVRMFERTTTTALNAYVG
PVLRDYLDGLADRLAELGYGGRVLIMQSNGGVVGLEQAADRAVETLLSGPAGAPAAVAEIVRTLGTRAACAGAGGTGGAG
GTGGAAGVDGAGPPTRPPDTITIDMGGTSFEASLARGGRTETTSNGSLAGHPVCLPALDISTIGAGGGSVAWVTAGGLPR
VGPRSAGAVPGPAGYGRGGTEPTVTDADLLLGYLDPDGFSGGIALSRDAAVRAVGGLAERLGIRGSAGRHPDTAVTDAAV
IDTGVIDDAVIEAAAGVHRAVNAAMADSLRLLTGRRGLDPRRFALVAAGGAGPVHAVEIARELGIPLVVVPAGASVLCAR
GMLRTDLVRYYVTTLRPDPRDPGALPVPSDLDVAFDRMAAEALDDLRPHLPGTGRVGFTRSADVRYAGQVHEIPVPFADP
AVPMDPAVPAEPAGSVLPRTDDAGLKDLLERFHDEHELRYGYRRPELAVEIVNLRLVARVPTLPPVPADSPAPPDPAHPA
AVAPPIRAAALTAPLAPLAVARRREVWFDGGFREVNVHDPATLSPGCPHQGPALVAHPASTVVVPPGYAFELAEDGTVLV
FAATDTADAVLHRLGLVGVAGAGDADAAAR

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=812, Percent_Identity=28.8177339901478, Blast_Score=188, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI133901900, Length=420, Percent_Identity=29.0476190476191, Blast_Score=132, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322634, Length=704, Percent_Identity=26.5625, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI45550492, Length=811, Percent_Identity=27.7435265104809, Blast_Score=186, Evalue=6e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 84816; Mature: 84685

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAPRTPRIPTARALKAPRGGAVGGYRVAVDVGGTFTDLVLRRPDGTEAVHKTSSTPGD
CCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCEEHHEEECCCCCHHHHHCCCCCCC
PARAVVAGLTGLAAAERLAPHELLGRTETIVHGTTITTNALITGSGACTGLVTTAGLRDV
HHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCEEEECEEEECCCCHHHHHHHHHHHHH
LPARQGSREDQFASKSAPPPSLVPRRLVIPVRERVDRTGAVVMPLDESDVRRAAGRLRAA
HHCCCCCCHHHHHCCCCCCCCCCCCCEEEHHHHHCCCCCCEEEECCHHHHHHHHHHHHHC
GVEAVAVSFVFSYLFDGHERQAAAILAQELPGVFVTTASRLVPQVRMFERTTTTALNAYV
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
GPVLRDYLDGLADRLAELGYGGRVLIMQSNGGVVGLEQAADRAVETLLSGPAGAPAAVAE
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHH
IVRTLGTRAACAGAGGTGGAGGTGGAAGVDGAGPPTRPPDTITIDMGGTSFEASLARGGR
HHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCC
TETTSNGSLAGHPVCLPALDISTIGAGGGSVAWVTAGGLPRVGPRSAGAVPGPAGYGRGG
CCCCCCCCCCCCCEEEECCCCEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
TEPTVTDADLLLGYLDPDGFSGGIALSRDAAVRAVGGLAERLGIRGSAGRHPDTAVTDAA
CCCCCCCHHHEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHH
VIDTGVIDDAVIEAAAGVHRAVNAAMADSLRLLTGRRGLDPRRFALVAAGGAGPVHAVEI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHH
ARELGIPLVVVPAGASVLCARGMLRTDLVRYYVTTLRPDPRDPGALPVPSDLDVAFDRMA
HHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
AEALDDLRPHLPGTGRVGFTRSADVRYAGQVHEIPVPFADPAVPMDPAVPAEPAGSVLPR
HHHHHHHHCCCCCCCCCCCCCCCCCEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
TDDAGLKDLLERFHDEHELRYGYRRPELAVEIVNLRLVARVPTLPPVPADSPAPPDPAHP
CCCHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCC
AAVAPPIRAAALTAPLAPLAVARRREVWFDGGFREVNVHDPATLSPGCPHQGPALVAHPA
CCCCCCHHHHHHHCCHHHHHHHHHHHEEECCCEEEEECCCCCCCCCCCCCCCCEEEECCC
STVVVPPGYAFELAEDGTVLVFAATDTADAVLHRLGLVGVAGAGDADAAAR
CEEEECCCCEEEECCCCEEEEEEECCHHHHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure 
TSAPRTPRIPTARALKAPRGGAVGGYRVAVDVGGTFTDLVLRRPDGTEAVHKTSSTPGD
CCCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCEEHHEEECCCCCHHHHHCCCCCCC
PARAVVAGLTGLAAAERLAPHELLGRTETIVHGTTITTNALITGSGACTGLVTTAGLRDV
HHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCEEEECEEEECCCCHHHHHHHHHHHHH
LPARQGSREDQFASKSAPPPSLVPRRLVIPVRERVDRTGAVVMPLDESDVRRAAGRLRAA
HHCCCCCCHHHHHCCCCCCCCCCCCCEEEHHHHHCCCCCCEEEECCHHHHHHHHHHHHHC
GVEAVAVSFVFSYLFDGHERQAAAILAQELPGVFVTTASRLVPQVRMFERTTTTALNAYV
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
GPVLRDYLDGLADRLAELGYGGRVLIMQSNGGVVGLEQAADRAVETLLSGPAGAPAAVAE
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHH
IVRTLGTRAACAGAGGTGGAGGTGGAAGVDGAGPPTRPPDTITIDMGGTSFEASLARGGR
HHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHCCCC
TETTSNGSLAGHPVCLPALDISTIGAGGGSVAWVTAGGLPRVGPRSAGAVPGPAGYGRGG
CCCCCCCCCCCCCEEEECCCCEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
TEPTVTDADLLLGYLDPDGFSGGIALSRDAAVRAVGGLAERLGIRGSAGRHPDTAVTDAA
CCCCCCCHHHEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHH
VIDTGVIDDAVIEAAAGVHRAVNAAMADSLRLLTGRRGLDPRRFALVAAGGAGPVHAVEI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHH
ARELGIPLVVVPAGASVLCARGMLRTDLVRYYVTTLRPDPRDPGALPVPSDLDVAFDRMA
HHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
AEALDDLRPHLPGTGRVGFTRSADVRYAGQVHEIPVPFADPAVPMDPAVPAEPAGSVLPR
HHHHHHHHCCCCCCCCCCCCCCCCCEECCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
TDDAGLKDLLERFHDEHELRYGYRRPELAVEIVNLRLVARVPTLPPVPADSPAPPDPAHP
CCCHHHHHHHHHHCCHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCC
AAVAPPIRAAALTAPLAPLAVARRREVWFDGGFREVNVHDPATLSPGCPHQGPALVAHPA
CCCCCCHHHHHHHCCHHHHHHHHHHHEEECCCEEEEECCCCCCCCCCCCCCCCEEEECCC
STVVVPPGYAFELAEDGTVLVFAATDTADAVLHRLGLVGVAGAGDADAAAR
CEEEECCCCEEEECCCCEEEEEEECCHHHHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]