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The map label for this gene is acdA [H]

Identifier: 158316353

GI number: 158316353

Start: 5464314

End: 5465570

Strand: Reverse

Name: acdA [H]

Synonym: Franean1_4582

Alternate gene names: 158316353

Gene position: 5465570-5464314 (Counterclockwise)

Preceding gene: 158316354

Following gene: 158316352

Centisome position: 60.85

GC content: 72.87

Gene sequence:

>1257_bases
GTGACGATGACGCCAGCAGGCTCCGACCGGTCCGACCGGACCGCCGCCGAGACCACCAGCGAGACGACCACCGGCCCCGC
GGCCGAGACCCGCACCGGGCCGGACAGCGACGAGGAGTTCCGCGCCCAGCTGCGGGACTTCCTGGCGACCCGGCATCCCG
GGCGCCCGCCGAAGAAGCCGGACGAGCGGGTCGCCTGGACGAAGGCCTGGCTGGCGACCCTGTTCGACCACGGCTACGCC
GGCCCCAGCTGGCCGCGTGAGTTCGGCGGGATGGACCTGCCGTTCGGGCGGCAGGTGATCTACCAGGAGGAGCTGGCCCG
CGCGCGGGTGCCCGGCCCGCTCGGCACCGGCCTCAATATCGCCGCCCCGACGATCATCCGGTACGGCACGCAGGAACAGA
AGGAACGCTGGCTCGCGCCGATGCTGCGCGGCGACCGGATCTGGGTGCAGGGGTACTCCGAACCCGGCGCCGGCTCGGAC
CTGCCGAGCCTGCGCACCACCGCCCGCCGGCAGGGCGATGAGTACGTCGTCAACGGCCAGAAGGTCTGGACGTCGCACGC
GGCGAGCGCCGACATCATCTTCGCGCTGGTCCGGACCGGCACGCAGCAGAGCCGCCAGCGCGGCATCAGCTACCTGATCG
TGGACGCGCACGGGCCCGGCGTGCAGGTGCGGCCGCTGCGCGACCTGACCGGCGGCTACCTGTTCGCCGAGGTGTTCTTC
GACGACGTCCGGGTGCCGGTCGCCGACCGGATCGGTGCCGAGAACGAGGGCTGGGCGCTCGCCCGGACGAGCCTCGGGCA
CGAACGGGCCGCCGGGGCGATGAACCAGGCCGCGCTCTACCGGCGGGTGCTCACCGAGCTCGAGCAGCTCGCGCGGGAGC
GTGGCCTGCTGGCGGACGGCGTCGTCCGGGACCGGTTCGCGGACCTGGAGATCCGGGTGCGGGTCATGCGCTACAACGCC
CAGCGGGTCATCTCCGACATCCTGGCCAAGGGCGAGCCGGGCCCGACGTCGTCGGTGTCGCGGCTGCTGATCACGGAGTT
CGAACAGGAGATCCACGAGCTCGCGGTCGACCTGCTCGGGCCGGCCGGCCTGTTGCTCAAGACCGAGCCCGGGTCGGTGC
AGGGTGGGCGCTGGCTGCACGGATTCCTGCGGACCAGGGCGTCGACGATCGGTGCCGGCACCCGCGAGATCCAGCTCAAC
ACGCTCGCCGAGCAGGTGCTCGGACTTCCGTACGACCCGGCGATGCCGCCGCGCTGA

Upstream 100 bases:

>100_bases
CGCGCACCTCTTCCTGCGGCGGGCGAAGTCCTCCGAGCTGTTCTTCGGGGCACCGCGGGCGCAGCGCAATCGGCTCGCGG
ACCTGGTCGGGATCTGAGCG

Downstream 100 bases:

>100_bases
CCGACGTTTAGGGAGACTCCATGCGGTTGGAGACCAGTCCGGACCTGGTGGAGTTCCGGGCCGAGGTTCGCGCGTTCATC
GCCGAACACGGCCCGGGACC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTMTPAGSDRSDRTAAETTSETTTGPAAETRTGPDSDEEFRAQLRDFLATRHPGRPPKKPDERVAWTKAWLATLFDHGYA
GPSWPREFGGMDLPFGRQVIYQEELARARVPGPLGTGLNIAAPTIIRYGTQEQKERWLAPMLRGDRIWVQGYSEPGAGSD
LPSLRTTARRQGDEYVVNGQKVWTSHAASADIIFALVRTGTQQSRQRGISYLIVDAHGPGVQVRPLRDLTGGYLFAEVFF
DDVRVPVADRIGAENEGWALARTSLGHERAAGAMNQAALYRRVLTELEQLARERGLLADGVVRDRFADLEIRVRVMRYNA
QRVISDILAKGEPGPTSSVSRLLITEFEQEIHELAVDLLGPAGLLLKTEPGSVQGGRWLHGFLRTRASTIGAGTREIQLN
TLAEQVLGLPYDPAMPPR

Sequences:

>Translated_418_residues
MTMTPAGSDRSDRTAAETTSETTTGPAAETRTGPDSDEEFRAQLRDFLATRHPGRPPKKPDERVAWTKAWLATLFDHGYA
GPSWPREFGGMDLPFGRQVIYQEELARARVPGPLGTGLNIAAPTIIRYGTQEQKERWLAPMLRGDRIWVQGYSEPGAGSD
LPSLRTTARRQGDEYVVNGQKVWTSHAASADIIFALVRTGTQQSRQRGISYLIVDAHGPGVQVRPLRDLTGGYLFAEVFF
DDVRVPVADRIGAENEGWALARTSLGHERAAGAMNQAALYRRVLTELEQLARERGLLADGVVRDRFADLEIRVRVMRYNA
QRVISDILAKGEPGPTSSVSRLLITEFEQEIHELAVDLLGPAGLLLKTEPGSVQGGRWLHGFLRTRASTIGAGTREIQLN
TLAEQVLGLPYDPAMPPR
>Mature_417_residues
TMTPAGSDRSDRTAAETTSETTTGPAAETRTGPDSDEEFRAQLRDFLATRHPGRPPKKPDERVAWTKAWLATLFDHGYAG
PSWPREFGGMDLPFGRQVIYQEELARARVPGPLGTGLNIAAPTIIRYGTQEQKERWLAPMLRGDRIWVQGYSEPGAGSDL
PSLRTTARRQGDEYVVNGQKVWTSHAASADIIFALVRTGTQQSRQRGISYLIVDAHGPGVQVRPLRDLTGGYLFAEVFFD
DVRVPVADRIGAENEGWALARTSLGHERAAGAMNQAALYRRVLTELEQLARERGLLADGVVRDRFADLEIRVRVMRYNAQ
RVISDILAKGEPGPTSSVSRLLITEFEQEIHELAVDLLGPAGLLLKTEPGSVQGGRWLHGFLRTRASTIGAGTREIQLNT
LAEQVLGLPYDPAMPPR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=212, Percent_Identity=31.1320754716981, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226958414, Length=264, Percent_Identity=28.030303030303, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557233, Length=392, Percent_Identity=26.7857142857143, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI4501857, Length=381, Percent_Identity=23.8845144356955, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI187960098, Length=347, Percent_Identity=25.0720461095101, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4557231, Length=347, Percent_Identity=25.0720461095101, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4501859, Length=361, Percent_Identity=27.4238227146814, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI7656849, Length=259, Percent_Identity=28.1853281853282, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI38505218, Length=255, Percent_Identity=28.2352941176471, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4557235, Length=326, Percent_Identity=25.1533742331288, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI76496475, Length=326, Percent_Identity=25.1533742331288, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI21361497, Length=318, Percent_Identity=25.4716981132075, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI48976061, Length=269, Percent_Identity=26.0223048327138, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI211971008, Length=269, Percent_Identity=26.0223048327138, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786223, Length=385, Percent_Identity=24.9350649350649, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=22.8346456692913, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17538396, Length=242, Percent_Identity=29.7520661157025, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17508101, Length=364, Percent_Identity=28.021978021978, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17570075, Length=383, Percent_Identity=25.065274151436, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17505929, Length=339, Percent_Identity=25.3687315634218, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17506239, Length=349, Percent_Identity=27.7936962750716, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17534899, Length=258, Percent_Identity=28.2945736434109, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17551932, Length=335, Percent_Identity=23.5820895522388, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17569725, Length=298, Percent_Identity=25.1677852348993, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI32563615, Length=195, Percent_Identity=32.3076923076923, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=27.1428571428571, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71982178, Length=213, Percent_Identity=29.1079812206573, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=177, Percent_Identity=31.0734463276836, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71985184, Length=177, Percent_Identity=31.0734463276836, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562446, Length=173, Percent_Identity=31.7919075144509, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17533517, Length=162, Percent_Identity=30.8641975308642, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21355753, Length=355, Percent_Identity=30.1408450704225, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646207, Length=277, Percent_Identity=29.2418772563177, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24666513, Length=362, Percent_Identity=25.6906077348066, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24660351, Length=315, Percent_Identity=26.984126984127, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356377, Length=238, Percent_Identity=26.890756302521, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281363737, Length=324, Percent_Identity=25.6172839506173, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 46041; Mature: 45909

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTPAGSDRSDRTAAETTSETTTGPAAETRTGPDSDEEFRAQLRDFLATRHPGRPPKKP
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
DERVAWTKAWLATLFDHGYAGPSWPREFGGMDLPFGRQVIYQEELARARVPGPLGTGLNI
CHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
AAPTIIRYGTQEQKERWLAPMLRGDRIWVQGYSEPGAGSDLPSLRTTARRQGDEYVVNGQ
CCCHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEECCH
KVWTSHAASADIIFALVRTGTQQSRQRGISYLIVDAHGPGVQVRPLRDLTGGYLFAEVFF
HHHHHHCCHHHHHHHHHHCCCHHHHHCCCEEEEEECCCCCEEEEEHHHCCCCCEEHHHHH
DDVRVPVADRIGAENEGWALARTSLGHERAAGAMNQAALYRRVLTELEQLARERGLLADG
HHCCCCHHHHCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VVRDRFADLEIRVRVMRYNAQRVISDILAKGEPGPTSSVSRLLITEFEQEIHELAVDLLG
HHHHHHCCCEEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PAGLLLKTEPGSVQGGRWLHGFLRTRASTIGAGTREIQLNTLAEQVLGLPYDPAMPPR
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TMTPAGSDRSDRTAAETTSETTTGPAAETRTGPDSDEEFRAQLRDFLATRHPGRPPKKP
CCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
DERVAWTKAWLATLFDHGYAGPSWPREFGGMDLPFGRQVIYQEELARARVPGPLGTGLNI
CHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
AAPTIIRYGTQEQKERWLAPMLRGDRIWVQGYSEPGAGSDLPSLRTTARRQGDEYVVNGQ
CCCHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEECCH
KVWTSHAASADIIFALVRTGTQQSRQRGISYLIVDAHGPGVQVRPLRDLTGGYLFAEVFF
HHHHHHCCHHHHHHHHHHCCCHHHHHCCCEEEEEECCCCCEEEEEHHHCCCCCEEHHHHH
DDVRVPVADRIGAENEGWALARTSLGHERAAGAMNQAALYRRVLTELEQLARERGLLADG
HHCCCCHHHHCCCCCCCCEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VVRDRFADLEIRVRVMRYNAQRVISDILAKGEPGPTSSVSRLLITEFEQEIHELAVDLLG
HHHHHHCCCEEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PAGLLLKTEPGSVQGGRWLHGFLRTRASTIGAGTREIQLNTLAEQVLGLPYDPAMPPR
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]