Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 158315644

GI number: 158315644

Start: 4576310

End: 4577947

Strand: Reverse

Name: groEL [H]

Synonym: Franean1_3854

Alternate gene names: 158315644

Gene position: 4577947-4576310 (Counterclockwise)

Preceding gene: 158315646

Following gene: 158315642

Centisome position: 50.97

GC content: 68.25

Gene sequence:

>1638_bases
ATGCCGAAGATCATTGCCTTCGATGAAGAGGCACGGCGCGGCCTGGAGCGCGGCATGAACCAGCTGGCCGACGCGGTCAA
GGTCACGCTCGGCCCCAAGGGTCGCAACGTCGTGCTGGAGAAGAAGTGGGGCGTCCCCACGATCACCAACGACGGCGTCA
GCATCGCCAAGGAGATCGAGCTCGAGGACCCGTACGAGAAGATCGGCGCGGAGCTCGTCAAGGAAGTCGCGAAGAAGACC
AACGACGTCGCGGGTGACGGCACCACCACCGCCACGATCCTCGCCCAGGCGCTCGTCCGCGAGGGCCTGCGCAACGTCGC
CGCCGGTGCGAACCCGATCGGCCTGAAGAAGGGCATCGAGGCCGCCGTCGAGCGTGTCTCCGAGGAGCTCTCCAGCGTCG
CCAAGGACGTGGAGACCAAGGAGCAGATCGCCTCGGCCGCCTCCATCTCCGCCGGTGACCCGGCCATCGGCGCCATGATC
GCCGAGGCGATGGACAAGGTCGGCAAGGAAGGCGTCATCACCGTCGAGGAGAGCAACACCTTCGGGCTCGAGCTCGAGCT
CACCGAGGGCATGCGCTTCGACAAGGGCTACATCTCGCCCTACTTCGTCACCGACACCGACCGCATGGAAGCCGTCCTCG
ACGACCCGTACATCCTGATCACCAACAGCAAGATCTCCGCGGTCAAGGACCTCCTCCCGATCCTGGAGAAGGTCATGCAG
GCCGGCAAGCAACTCGTGATCCTCTCCGAGGACGTCGAGGGCGAGGCCCTGGCCACCCTGGTCGTGAACAAGATCCGCGG
CACGTTCAAGAGCGCCGCGGTCAAGGCGCCCGGCTTCGGTGACCGCCGCAAGGCCATGCTGACCGACATCGCCGTCCTCA
CCGGCGGCCAGGTCATCTCCGAGGACATCGGCCTCAAGCTCGAGGGCACCACCGTCGACCTGCTCGGCCGGGCCCGCAAG
GTCGTCATCACCAAGGACGAGACCACCATCGTCGAGGGTGCCGGCGACGCGGACCAGATCGCGGGGCGGGTCAACCAGAT
CCGCAACGAGATCGAGAAGTCCGACTCCGACTACGACCGCGAGAAGCTCCAGGAGCGGCTGGCCAAGCTCGCCGGCGGCG
TCGCGGTCATCAAGGTCGGCGCGGCCACCGAGGTCGAGCTCAAGGAGAAGAAGCACCGCATCGAGGACGCCGTCTCGAAC
GCGAAGGCCGCGGTCGAGGAGGGCATCGTCGCCGGCGGTGGCGTCGCGCTCCTGCAGGCCTCCACCAGCGCCTTCGAGAA
GCTCGACCTCTCCGGCGACGAGGCCACCGGCGCCCTGATCGTCGAGCGCGCGCTCGCCGCACCGCTACGCCAGATCGCCA
CCAACGCCGGGCTCGAGGGCGGCGTCGTGGTCGAGAAGGTCCGCGGTCTCCCGACCGGGCACGGCCTGAACGCCGCCACC
GGCGAGTACGTCGACATGATCGCCGCCGGGATCATCGACCCGGTGAAGGTCACCCGCTCGGCGCTACAGAACGCCGCGTC
CATCACCGGCCTCTTCCTCACCATCGAGGTCGTCGTCGCGGACAAGCCGGAGCCCGCGGGCGCCGGCGGTGGTGCTGACG
CGGCCGCCATGGGCGGCATGGGCGGCATGGGCTTCTGA

Upstream 100 bases:

>100_bases
CGGGTGCCCGGGCCGACGGCCCGATCATCAGGTTCTTTTGGGCCCCGCCGGCGGCAGGCACTCCTCCGCATGGCCCAAGC
CCAGGAGGAAAGACTCCAAT

Downstream 100 bases:

>100_bases
TCCACTCGGCGAGCCGGGCCACCCGGTGAGCTGAGCTGAACCACCGGTGGGTGGGCCCGCGGTGCAACCTGCGGACCCAC
CCACCGTCGTGTCACCGGCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MPKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGVPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKT
NDVAGDGTTTATILAQALVREGLRNVAAGANPIGLKKGIEAAVERVSEELSSVAKDVETKEQIASAASISAGDPAIGAMI
AEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDTDRMEAVLDDPYILITNSKISAVKDLLPILEKVMQ
AGKQLVILSEDVEGEALATLVVNKIRGTFKSAAVKAPGFGDRRKAMLTDIAVLTGGQVISEDIGLKLEGTTVDLLGRARK
VVITKDETTIVEGAGDADQIAGRVNQIRNEIEKSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKEKKHRIEDAVSN
AKAAVEEGIVAGGGVALLQASTSAFEKLDLSGDEATGALIVERALAAPLRQIATNAGLEGGVVVEKVRGLPTGHGLNAAT
GEYVDMIAAGIIDPVKVTRSALQNAASITGLFLTIEVVVADKPEPAGAGGGADAAAMGGMGGMGF

Sequences:

>Translated_545_residues
MPKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGVPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKT
NDVAGDGTTTATILAQALVREGLRNVAAGANPIGLKKGIEAAVERVSEELSSVAKDVETKEQIASAASISAGDPAIGAMI
AEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDTDRMEAVLDDPYILITNSKISAVKDLLPILEKVMQ
AGKQLVILSEDVEGEALATLVVNKIRGTFKSAAVKAPGFGDRRKAMLTDIAVLTGGQVISEDIGLKLEGTTVDLLGRARK
VVITKDETTIVEGAGDADQIAGRVNQIRNEIEKSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKEKKHRIEDAVSN
AKAAVEEGIVAGGGVALLQASTSAFEKLDLSGDEATGALIVERALAAPLRQIATNAGLEGGVVVEKVRGLPTGHGLNAAT
GEYVDMIAAGIIDPVKVTRSALQNAASITGLFLTIEVVVADKPEPAGAGGGADAAAMGGMGGMGF
>Mature_544_residues
PKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGVPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTN
DVAGDGTTTATILAQALVREGLRNVAAGANPIGLKKGIEAAVERVSEELSSVAKDVETKEQIASAASISAGDPAIGAMIA
EAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDTDRMEAVLDDPYILITNSKISAVKDLLPILEKVMQA
GKQLVILSEDVEGEALATLVVNKIRGTFKSAAVKAPGFGDRRKAMLTDIAVLTGGQVISEDIGLKLEGTTVDLLGRARKV
VITKDETTIVEGAGDADQIAGRVNQIRNEIEKSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKEKKHRIEDAVSNA
KAAVEEGIVAGGGVALLQASTSAFEKLDLSGDEATGALIVERALAAPLRQIATNAGLEGGVVVEKVRGLPTGHGLNAATG
EYVDMIAAGIIDPVKVTRSALQNAASITGLFLTIEVVVADKPEPAGAGGGADAAAMGGMGGMGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=524, Percent_Identity=46.5648854961832, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI31542947, Length=524, Percent_Identity=46.5648854961832, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI38455427, Length=131, Percent_Identity=31.2977099236641, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790586, Length=523, Percent_Identity=59.0822179732314, Blast_Score=589, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17555558, Length=525, Percent_Identity=47.6190476190476, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI193210679, Length=208, Percent_Identity=48.5576923076923, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI25144674, Length=133, Percent_Identity=31.5789473684211, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=49.4274809160305, Blast_Score=490, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322524, Length=183, Percent_Identity=26.2295081967213, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=49.0530303030303, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=49.0530303030303, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=46.1100569259962, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=46.1100569259962, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=46.1100569259962, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17864606, Length=550, Percent_Identity=40.5454545454545, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24584129, Length=524, Percent_Identity=33.7786259541985, Blast_Score=270, Evalue=3e-72,
Organism=Drosophila melanogaster, GI19921262, Length=524, Percent_Identity=33.7786259541985, Blast_Score=270, Evalue=3e-72,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56902; Mature: 56771

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGVPTITNDGVSIAKEIE
CCCEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHCC
LEDPYEKIGAELVKEVAKKTNDVAGDGTTTATILAQALVREGLRNVAAGANPIGLKKGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AAVERVSEELSSVAKDVETKEQIASAASISAGDPAIGAMIAEAMDKVGKEGVITVEESNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
FGLELELTEGMRFDKGYISPYFVTDTDRMEAVLDDPYILITNSKISAVKDLLPILEKVMQ
EEEEEEECCCCEECCCCCCCEEECCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
AGKQLVILSEDVEGEALATLVVNKIRGTFKSAAVKAPGFGDRRKAMLTDIAVLTGGQVIS
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHH
EDIGLKLEGTTVDLLGRARKVVITKDETTIVEGAGDADQIAGRVNQIRNEIEKSDSDYDR
HCCCEEECCCCHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
EKLQERLAKLAGGVAVIKVGAATEVELKEKKHRIEDAVSNAKAAVEEGIVAGGGVALLQA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
STSAFEKLDLSGDEATGALIVERALAAPLRQIATNAGLEGGVVVEKVRGLPTGHGLNAAT
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCC
GEYVDMIAAGIIDPVKVTRSALQNAASITGLFLTIEVVVADKPEPAGAGGGADAAAMGGM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCCCHHHHCCC
GGMGF
CCCCC
>Mature Secondary Structure 
PKIIAFDEEARRGLERGMNQLADAVKVTLGPKGRNVVLEKKWGVPTITNDGVSIAKEIE
CCEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHCC
LEDPYEKIGAELVKEVAKKTNDVAGDGTTTATILAQALVREGLRNVAAGANPIGLKKGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
AAVERVSEELSSVAKDVETKEQIASAASISAGDPAIGAMIAEAMDKVGKEGVITVEESNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCC
FGLELELTEGMRFDKGYISPYFVTDTDRMEAVLDDPYILITNSKISAVKDLLPILEKVMQ
EEEEEEECCCCEECCCCCCCEEECCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
AGKQLVILSEDVEGEALATLVVNKIRGTFKSAAVKAPGFGDRRKAMLTDIAVLTGGQVIS
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHH
EDIGLKLEGTTVDLLGRARKVVITKDETTIVEGAGDADQIAGRVNQIRNEIEKSDSDYDR
HCCCEEECCCCHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCH
EKLQERLAKLAGGVAVIKVGAATEVELKEKKHRIEDAVSNAKAAVEEGIVAGGGVALLQA
HHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEH
STSAFEKLDLSGDEATGALIVERALAAPLRQIATNAGLEGGVVVEKVRGLPTGHGLNAAT
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCC
GEYVDMIAAGIIDPVKVTRSALQNAASITGLFLTIEVVVADKPEPAGAGGGADAAAMGGM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCCCHHHHCCC
GGMGF
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA