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The map label for this gene is acoB [H]

Identifier: 158315118

GI number: 158315118

Start: 3929447

End: 3930442

Strand: Direct

Name: acoB [H]

Synonym: Franean1_3317

Alternate gene names: 158315118

Gene position: 3929447-3930442 (Clockwise)

Preceding gene: 158315117

Following gene: 158315119

Centisome position: 43.75

GC content: 69.48

Gene sequence:

>996_bases
ATGACGATGCGCGAGGCGTTGAACCTCGCCCTGGACCAGGCGCTGGAGCGTGACGAGCGCGTCTTCCTGATCGGCGAGGA
CATCGCCGACCCGGGGGCGTCCGGCCCGACCGCCGGGCTGTCGAGCAGGTACGGCACCGAGCGGGTGCTGGACACGCCGA
TCTCCGAGGCGGCGATCGTGGGCGCGGCCATCGGAGCCGCGATGGAGGGCTTCCGTCCGGTGGCCGAAATAATGATCATG
GACTTCATCGGGATAGCCGCCGACCAGATCATCAACCACGCGGCGAAGATGCGGTTCATGACCGGGGGGCGGACAACCGC
GCCCATCACCGTGCGCACACAGATCTACGGCGGACTCGGCACCGGCGCCACGCACTCGCAGTCGCTGGAGGCGTGGTTCA
TGCACATTCCCGGGCTGAAAGTCATCGTTCCCTCGACGCCGCGCGACGGCAAAGGCCTGCTCACGTCCGCGATCTTCGAC
GACGACCCGTGCATCTTCCTGGAGACGATCCGCCTGCAGGGCCAGCGTGGAATGGTGCCGGTCGACCCGGGATTCTCGAT
CCCGCTCGGCCAGGCGGACGTGAAGCGCGCCGGCACCGACGTCACGCTGATCAGCTACGGCCGGGGGGTCGTCGAGTCGC
TCGGCGCGGCGGACGCGCTCGCGCGCCAGGAGATCAGTGCCGAGGTACTCGATCTCCGTACCCTCGTCCCGCTCGACACG
GCGGCGATCGTCGAATCGGTGCGCCGGACGACGCGAGCGGTGGTGGTGCACGACGCCGTGCGGTTCGCCGGCCCCGGAGC
GGAGATCGTCGCCATTCTCCAGGGCGAGCTCTTCGACCAGCTCGCGGCGCCGGTGGAGCGGGTGGGCGCCCGGTTCGTGC
CGAACCCGGCCCCGCCGGCGCTGGAGTCGCAGGTGTACCCGGATTCCGAAAAGATCATCGCCGCCGTCCACCGGACGCTG
CGGTGGAAAACCACCAGGGAAGGTGCCCGTGGCTGA

Upstream 100 bases:

>100_bases
ACTGCCCCGCGTAGCGCGACTGCCCCCGTAACGCGCGCTTAGAACGTGCATTCCGTATCGAACGTGGCCTGGCAATGAGG
TGGACGTGGACGAACGACGG

Downstream 100 bases:

>100_bases
CTTCACGATCCGCATTCCACGCGTATCGGTCGCGATCTCGGAGGCGGAGCTGCTCGAGCTTCTCGTGGAGGAGGGGGCGC
GCGTGGAGGAGGGCGACCCG

Product: transketolase central region

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-beta; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit beta [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTMREALNLALDQALERDERVFLIGEDIADPGASGPTAGLSSRYGTERVLDTPISEAAIVGAAIGAAMEGFRPVAEIMIM
DFIGIAADQIINHAAKMRFMTGGRTTAPITVRTQIYGGLGTGATHSQSLEAWFMHIPGLKVIVPSTPRDGKGLLTSAIFD
DDPCIFLETIRLQGQRGMVPVDPGFSIPLGQADVKRAGTDVTLISYGRGVVESLGAADALARQEISAEVLDLRTLVPLDT
AAIVESVRRTTRAVVVHDAVRFAGPGAEIVAILQGELFDQLAAPVERVGARFVPNPAPPALESQVYPDSEKIIAAVHRTL
RWKTTREGARG

Sequences:

>Translated_331_residues
MTMREALNLALDQALERDERVFLIGEDIADPGASGPTAGLSSRYGTERVLDTPISEAAIVGAAIGAAMEGFRPVAEIMIM
DFIGIAADQIINHAAKMRFMTGGRTTAPITVRTQIYGGLGTGATHSQSLEAWFMHIPGLKVIVPSTPRDGKGLLTSAIFD
DDPCIFLETIRLQGQRGMVPVDPGFSIPLGQADVKRAGTDVTLISYGRGVVESLGAADALARQEISAEVLDLRTLVPLDT
AAIVESVRRTTRAVVVHDAVRFAGPGAEIVAILQGELFDQLAAPVERVGARFVPNPAPPALESQVYPDSEKIIAAVHRTL
RWKTTREGARG
>Mature_330_residues
TMREALNLALDQALERDERVFLIGEDIADPGASGPTAGLSSRYGTERVLDTPISEAAIVGAAIGAAMEGFRPVAEIMIMD
FIGIAADQIINHAAKMRFMTGGRTTAPITVRTQIYGGLGTGATHSQSLEAWFMHIPGLKVIVPSTPRDGKGLLTSAIFDD
DPCIFLETIRLQGQRGMVPVDPGFSIPLGQADVKRAGTDVTLISYGRGVVESLGAADALARQEISAEVLDLRTLVPLDTA
AIVESVRRTTRAVVVHDAVRFAGPGAEIVAILQGELFDQLAAPVERVGARFVPNPAPPALESQVYPDSEKIIAAVHRTLR
WKTTREGARG

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde [H]

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=41.4110429447853, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=39.8773006134969, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI4557353, Length=327, Percent_Identity=38.8379204892966, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI34101272, Length=327, Percent_Identity=38.8379204892966, Blast_Score=218, Evalue=5e-57,
Organism=Escherichia coli, GI1786622, Length=236, Percent_Identity=25.4237288135593, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=44.478527607362, Blast_Score=267, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17506935, Length=329, Percent_Identity=39.209726443769, Blast_Score=194, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=41.7177914110429, Blast_Score=253, Evalue=3e-68,
Organism=Drosophila melanogaster, GI21358145, Length=336, Percent_Identity=43.452380952381, Blast_Score=251, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24650940, Length=336, Percent_Identity=43.452380952381, Blast_Score=251, Evalue=3e-67,
Organism=Drosophila melanogaster, GI160714828, Length=322, Percent_Identity=38.1987577639752, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI160714832, Length=322, Percent_Identity=38.1987577639752, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24650943, Length=95, Percent_Identity=50.5263157894737, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24650945, Length=95, Percent_Identity=50.5263157894737, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 1.2.4.1

Molecular weight: Translated: 35228; Mature: 35097

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMREALNLALDQALERDERVFLIGEDIADPGASGPTAGLSSRYGTERVLDTPISEAAIV
CCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHH
GAAIGAAMEGFRPVAEIMIMDFIGIAADQIINHAAKMRFMTGGRTTAPITVRTQIYGGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEECCEEEEEEEECCCC
TGATHSQSLEAWFMHIPGLKVIVPSTPRDGKGLLTSAIFDDDPCIFLETIRLQGQRGMVP
CCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCEEHHEECCCCEEEEEEEEECCCCCCEE
VDPGFSIPLGQADVKRAGTDVTLISYGRGVVESLGAADALARQEISAEVLDLRTLVPLDT
CCCCCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AAIVESVRRTTRAVVVHDAVRFAGPGAEIVAILQGELFDQLAAPVERVGARFVPNPAPPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LESQVYPDSEKIIAAVHRTLRWKTTREGARG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TMREALNLALDQALERDERVFLIGEDIADPGASGPTAGLSSRYGTERVLDTPISEAAIV
CHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHH
GAAIGAAMEGFRPVAEIMIMDFIGIAADQIINHAAKMRFMTGGRTTAPITVRTQIYGGLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEECCEEEEEEEECCCC
TGATHSQSLEAWFMHIPGLKVIVPSTPRDGKGLLTSAIFDDDPCIFLETIRLQGQRGMVP
CCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCEEHHEECCCCEEEEEEEEECCCCCCEE
VDPGFSIPLGQADVKRAGTDVTLISYGRGVVESLGAADALARQEISAEVLDLRTLVPLDT
CCCCCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AAIVESVRRTTRAVVVHDAVRFAGPGAEIVAILQGELFDQLAAPVERVGARFVPNPAPPA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LESQVYPDSEKIIAAVHRTLRWKTTREGARG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10368162; 8969503; 9384377 [H]