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The map label for this gene is hemN [H]

Identifier: 158313942

GI number: 158313942

Start: 2534053

End: 2535282

Strand: Direct

Name: hemN [H]

Synonym: Franean1_2108

Alternate gene names: 158313942

Gene position: 2534053-2535282 (Clockwise)

Preceding gene: 158313940

Following gene: 158313943

Centisome position: 28.21

GC content: 74.39

Gene sequence:

>1230_bases
ATGCCATCCAAGCCTCTCGAGGGGGCGCCGGCACCCGTCGACGGCGCACTCCCCGACGCCGCGCTCACCGAGGTCGGGAC
CCGGCCGTTCGGTGTCTACGTGCACGTGCCGTACTGCGCGGCGCGCTGCGGGTACTGCGACTTCAACACCTATACCCCGG
CCGAGCTCGGCGCGGGCGGCCAGGGTGGGGCCGCCTCGTTCGTCGACTCGGTGGCCACCGAGGCCCGGCTGGCCCGCTCG
GTCCTGGGCGAGCGGGACCTGACGGTCTCGACAGTCTTCGTCGGCGGTGGCACCCCGACGCTGCTGCCGGCCGCCGACCT
GGCCAAGGTCCTGCGGGTCCTGGACGACACCTTCGGCCTGGCCGGCGACGCGGAGGTCACCACCGAGGCCAACCCGGAGT
CCGTCGACCGGGAGACTCTCGAACAGCTCCGGGCGAGTGGGTACACGCGGATCTCGTTCGGCATGCAGAGCGCCCGCCCG
CACGTGCTCGCGGCGCTGGACCGGCGGCACACCCCCGGCCGGGTGCCCGAGGTGGTCGGATGGGCGCGGTCCGCCGGGTT
CCGCCAGCTCAGCCTCGACCTCATCTACGGCGCGCCGGGGGAGTCCGAGAGCGACTGGGCGGCGAGCCTGGACACGGTGA
TCGAGCTCGCGCCCGACCACGTCAGCGCCTACGCCCTGACCGTGGAGGAGGGCACCAAGCTTTCCCGCCGGGTGCGCCGC
GGCGAGCTGCTGGAGCCGGACGACGACCTGCTCGCCGATCGCTACCTGCAGGCCGACGAGGCGCTCGCCGCCGCCGGCCT
GACCAACTACGAGGTCAGCAACTGGGCACGCGACCAGTCCTCCTGGTGCCGCCATAACATGGGCTACTGGCGGGGCGACG
ACTGGTGGGGGCTGGGGCCGGGCGCCCACAGCCACGTGGGTGGCGTCCGCTGGTGGAACGTCCGCCACCCGACCGAGTAC
GCCACCCGGGTCGGCGCCGGCCACAGCCCGGCCGCCGGCCGCGAGGTGCTCGATGCCCAGGCCCGCCGGGTCGAGCGGGT
CATGCTGGGGGTCCGCCTCGTCGAGGGGCTGGGCGTCGACGCGCTGGGCGAGCAGGCGCTGGACGTCGCCGCCGAGCTCG
CGGCGGACGGCCTCATCGTCGCGGACGTCCTCGCGCAGGGCCGGGTGGCCCTCACTCGCCGTGGCAGGCTGCTGACCGAT
ACGGTCGTCCGTGCCCTGTTGCCCGACTGA

Upstream 100 bases:

>100_bases
GGTCCCGATGTCGTCCGAGACCGGCAAAAATGACGGTCTCCGGGCACGTTGACAAACAGAGCGTTGCGGTCTCGGCACGC
GTTGGGGGCACACTGGGGAC

Downstream 100 bases:

>100_bases
GCGTCCCGCTACCCACTCGGGTGGTGACCCGCGGTCCCGGATCTCCGTGTGTCCTCGGACGCGGGTCTGCTCGCGATGGC
TGCCTCGACCTGGGTGGGAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MPSKPLEGAPAPVDGALPDAALTEVGTRPFGVYVHVPYCAARCGYCDFNTYTPAELGAGGQGGAASFVDSVATEARLARS
VLGERDLTVSTVFVGGGTPTLLPAADLAKVLRVLDDTFGLAGDAEVTTEANPESVDRETLEQLRASGYTRISFGMQSARP
HVLAALDRRHTPGRVPEVVGWARSAGFRQLSLDLIYGAPGESESDWAASLDTVIELAPDHVSAYALTVEEGTKLSRRVRR
GELLEPDDDLLADRYLQADEALAAAGLTNYEVSNWARDQSSWCRHNMGYWRGDDWWGLGPGAHSHVGGVRWWNVRHPTEY
ATRVGAGHSPAAGREVLDAQARRVERVMLGVRLVEGLGVDALGEQALDVAAELAADGLIVADVLAQGRVALTRRGRLLTD
TVVRALLPD

Sequences:

>Translated_409_residues
MPSKPLEGAPAPVDGALPDAALTEVGTRPFGVYVHVPYCAARCGYCDFNTYTPAELGAGGQGGAASFVDSVATEARLARS
VLGERDLTVSTVFVGGGTPTLLPAADLAKVLRVLDDTFGLAGDAEVTTEANPESVDRETLEQLRASGYTRISFGMQSARP
HVLAALDRRHTPGRVPEVVGWARSAGFRQLSLDLIYGAPGESESDWAASLDTVIELAPDHVSAYALTVEEGTKLSRRVRR
GELLEPDDDLLADRYLQADEALAAAGLTNYEVSNWARDQSSWCRHNMGYWRGDDWWGLGPGAHSHVGGVRWWNVRHPTEY
ATRVGAGHSPAAGREVLDAQARRVERVMLGVRLVEGLGVDALGEQALDVAAELAADGLIVADVLAQGRVALTRRGRLLTD
TVVRALLPD
>Mature_408_residues
PSKPLEGAPAPVDGALPDAALTEVGTRPFGVYVHVPYCAARCGYCDFNTYTPAELGAGGQGGAASFVDSVATEARLARSV
LGERDLTVSTVFVGGGTPTLLPAADLAKVLRVLDDTFGLAGDAEVTTEANPESVDRETLEQLRASGYTRISFGMQSARPH
VLAALDRRHTPGRVPEVVGWARSAGFRQLSLDLIYGAPGESESDWAASLDTVIELAPDHVSAYALTVEEGTKLSRRVRRG
ELLEPDDDLLADRYLQADEALAAAGLTNYEVSNWARDQSSWCRHNMGYWRGDDWWGLGPGAHSHVGGVRWWNVRHPTEYA
TRVGAGHSPAAGREVLDAQARRVERVMLGVRLVEGLGVDALGEQALDVAAELAADGLIVADVLAQGRVALTRRGRLLTDT
VVRALLPD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=272, Percent_Identity=37.1323529411765, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1789325, Length=336, Percent_Identity=33.6309523809524, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87082341, Length=402, Percent_Identity=26.865671641791, Blast_Score=131, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43697; Mature: 43566

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKPLEGAPAPVDGALPDAALTEVGTRPFGVYVHVPYCAARCGYCDFNTYTPAELGAGG
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECHHHHHHCCCCCCCCCCCHHHCCCC
QGGAASFVDSVATEARLARSVLGERDLTVSTVFVGGGTPTLLPAADLAKVLRVLDDTFGL
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
AGDAEVTTEANPESVDRETLEQLRASGYTRISFGMQSARPHVLAALDRRHTPGRVPEVVG
CCCCCEECCCCCHHCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHH
WARSAGFRQLSLDLIYGAPGESESDWAASLDTVIELAPDHVSAYALTVEEGTKLSRRVRR
HHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHCHHHHHHHHC
GELLEPDDDLLADRYLQADEALAAAGLTNYEVSNWARDQSSWCRHNMGYWRGDDWWGLGP
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GAHSHVGGVRWWNVRHPTEYATRVGAGHSPAAGREVLDAQARRVERVMLGVRLVEGLGVD
CCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ALGEQALDVAAELAADGLIVADVLAQGRVALTRRGRLLTDTVVRALLPD
HHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PSKPLEGAPAPVDGALPDAALTEVGTRPFGVYVHVPYCAARCGYCDFNTYTPAELGAGG
CCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECHHHHHHCCCCCCCCCCCHHHCCCC
QGGAASFVDSVATEARLARSVLGERDLTVSTVFVGGGTPTLLPAADLAKVLRVLDDTFGL
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
AGDAEVTTEANPESVDRETLEQLRASGYTRISFGMQSARPHVLAALDRRHTPGRVPEVVG
CCCCCEECCCCCHHCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHH
WARSAGFRQLSLDLIYGAPGESESDWAASLDTVIELAPDHVSAYALTVEEGTKLSRRVRR
HHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHCHHHHHHHHC
GELLEPDDDLLADRYLQADEALAAAGLTNYEVSNWARDQSSWCRHNMGYWRGDDWWGLGP
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GAHSHVGGVRWWNVRHPTEYATRVGAGHSPAAGREVLDAQARRVERVMLGVRLVEGLGVD
CCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ALGEQALDVAAELAADGLIVADVLAQGRVALTRRGRLLTDTVVRALLPD
HHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]