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The map label for this gene is hrcA

Identifier: 158313943

GI number: 158313943

Start: 2535542

End: 2536561

Strand: Direct

Name: hrcA

Synonym: Franean1_2109

Alternate gene names: 158313943

Gene position: 2535542-2536561 (Clockwise)

Preceding gene: 158313942

Following gene: 158313944

Centisome position: 28.23

GC content: 67.75

Gene sequence:

>1020_bases
GTGTTGGAGGAACGGCGGCTGGAGGTGCTGCGGGCGATCGTCGAGGATTTCGTGCTCAGCAACGAGCCGGTGGGATCCAA
GACGTTGGCCGAGCGGCATGCTCTGGGCGTGTCGCCCGCCACGGTGCGTAACGACATGTCGGCCCTTGAGGAAGAGGGCT
ACATCACCCAGCCGCACACCAGCGCGGGCCGTATCCCGACAGACAAAGGCTATCGCCTCTTCGTCGACCGGCTCTCCGGC
GTCAAGCCGCTGTCGCGCGCCGAGCGCCGGGCCATCCAGAGCTTCCTGGAGGGCGCGGTCGACCTCGACGACGTGGTGCG
GCGGTCGGTGCGTCTGCTCGCGCAACTCACACGTCAGGTGGCTGTGGTCCAGTACCCCTCACTCTCGTCCAGCAGCGTCC
GACACATCGAGATCGTCACGCTCAATCCGAACCGCCTGCTCCTGGTACTGATCACGGACACGGGCCGGGTTGAGCAGCGG
GTGGTGGACATTCCCACCCCGGTCGACGACGGCGTGGTCGGCGAGCTGCGCGGCCTGCTGAACGGCTCGCTGCGGGGCCG
TCGTGTGGTCGACGCCACAGAGGTCGCGGCGGACCTGCCCGAGACCGTCCGGCCGGATCTGCGTCCGCACCTGACGACGC
TCACCACCGTGGTGCTCGAGGCCCTCCTGGAGCGGCAGGAGGAGCGGGTCGCGCTGGCCGGTACCGCCAACCTCACACGC
TCCTCGGTCGACTTCGCCGACTCGCTGCGGTTCATTCTGGAGGCACTCGAGGAGCAGGTCGTGCTCCTCAAACTGATCGG
TTCAGCCCGGGAGACCGGTACTGTGACGGTGCGCATCGGGCGTGAGACGGATGTGGACGCCCTCCGCTCAACGTCGGTAA
TCGCCACCGGGTACGGTCTCGGCCCAGCGGTGCTGGGCGGAATGGGAGTCGTCGGCCCGATGCGGATGGACTATCCGGGA
ACGATGGCGGCCGTACGAGCCGTCGCCAAGTACGTGGGTGAACTCTTGGGTGCCGACTGA

Upstream 100 bases:

>100_bases
TACCAGCGGGACAGGGTGACCAGTAGCACAGGGTGACCGGTCCGGCGCGCGCCGCCAGCCCCGCCTGGCTTACCGAAACC
GGCGAAGGGGGTGTGGCCAC

Downstream 100 bases:

>100_bases
TGGCAGTGGATTATTACGCGACGCTCGGTGTGCGGCGTGACGCCACCGGTGACGAGATCAAGCGGGCCTACCGCAAGCTG
GCCCGGGAGCTGCATCCGGA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLEERRLEVLRAIVEDFVLSNEPVGSKTLAERHALGVSPATVRNDMSALEEEGYITQPHTSAGRIPTDKGYRLFVDRLSG
VKPLSRAERRAIQSFLEGAVDLDDVVRRSVRLLAQLTRQVAVVQYPSLSSSSVRHIEIVTLNPNRLLLVLITDTGRVEQR
VVDIPTPVDDGVVGELRGLLNGSLRGRRVVDATEVAADLPETVRPDLRPHLTTLTTVVLEALLERQEERVALAGTANLTR
SSVDFADSLRFILEALEEQVVLLKLIGSARETGTVTVRIGRETDVDALRSTSVIATGYGLGPAVLGGMGVVGPMRMDYPG
TMAAVRAVAKYVGELLGAD

Sequences:

>Translated_339_residues
MLEERRLEVLRAIVEDFVLSNEPVGSKTLAERHALGVSPATVRNDMSALEEEGYITQPHTSAGRIPTDKGYRLFVDRLSG
VKPLSRAERRAIQSFLEGAVDLDDVVRRSVRLLAQLTRQVAVVQYPSLSSSSVRHIEIVTLNPNRLLLVLITDTGRVEQR
VVDIPTPVDDGVVGELRGLLNGSLRGRRVVDATEVAADLPETVRPDLRPHLTTLTTVVLEALLERQEERVALAGTANLTR
SSVDFADSLRFILEALEEQVVLLKLIGSARETGTVTVRIGRETDVDALRSTSVIATGYGLGPAVLGGMGVVGPMRMDYPG
TMAAVRAVAKYVGELLGAD
>Mature_339_residues
MLEERRLEVLRAIVEDFVLSNEPVGSKTLAERHALGVSPATVRNDMSALEEEGYITQPHTSAGRIPTDKGYRLFVDRLSG
VKPLSRAERRAIQSFLEGAVDLDDVVRRSVRLLAQLTRQVAVVQYPSLSSSSVRHIEIVTLNPNRLLLVLITDTGRVEQR
VVDIPTPVDDGVVGELRGLLNGSLRGRRVVDATEVAADLPETVRPDLRPHLTTLTTVVLEALLERQEERVALAGTANLTR
SSVDFADSLRFILEALEEQVVLLKLIGSARETGTVTVRIGRETDVDALRSTSVIATGYGLGPAVLGGMGVVGPMRMDYPG
TMAAVRAVAKYVGELLGAD

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_FRASN (A8KYV9)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001506451.1
- ProteinModelPortal:   A8KYV9
- SMR:   A8KYV9
- GeneID:   5670509
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_2109
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   FSP1855:FRANEAN1_2109-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00081
- InterPro:   IPR001034
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA; PF08220 HTH_DeoR

EC number: NA

Molecular weight: Translated: 36772; Mature: 36772

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEERRLEVLRAIVEDFVLSNEPVGSKTLAERHALGVSPATVRNDMSALEEEGYITQPHT
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCC
SAGRIPTDKGYRLFVDRLSGVKPLSRAERRAIQSFLEGAVDLDDVVRRSVRLLAQLTRQV
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AVVQYPSLSSSSVRHIEIVTLNPNRLLLVLITDTGRVEQRVVDIPTPVDDGVVGELRGLL
HHEECCCCCCCCCEEEEEEEECCCEEEEEEEECCCCHHHHEEECCCCCCCCHHHHHHHHH
NGSLRGRRVVDATEVAADLPETVRPDLRPHLTTLTTVVLEALLERQEERVALAGTANLTR
CCCCCCCEECHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCH
SSVDFADSLRFILEALEEQVVLLKLIGSARETGTVTVRIGRETDVDALRSTSVIATGYGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHCCCEEEECCCC
GPAVLGGMGVVGPMRMDYPGTMAAVRAVAKYVGELLGAD
CHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLEERRLEVLRAIVEDFVLSNEPVGSKTLAERHALGVSPATVRNDMSALEEEGYITQPHT
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEECCCC
SAGRIPTDKGYRLFVDRLSGVKPLSRAERRAIQSFLEGAVDLDDVVRRSVRLLAQLTRQV
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AVVQYPSLSSSSVRHIEIVTLNPNRLLLVLITDTGRVEQRVVDIPTPVDDGVVGELRGLL
HHEECCCCCCCCCEEEEEEEECCCEEEEEEEECCCCHHHHEEECCCCCCCCHHHHHHHHH
NGSLRGRRVVDATEVAADLPETVRPDLRPHLTTLTTVVLEALLERQEERVALAGTANLTR
CCCCCCCEECHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCH
SSVDFADSLRFILEALEEQVVLLKLIGSARETGTVTVRIGRETDVDALRSTSVIATGYGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHCCCEEEECCCC
GPAVLGGMGVVGPMRMDYPGTMAAVRAVAKYVGELLGAD
CHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA