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The map label for this gene is devS [H]

Identifier: 158313804

GI number: 158313804

Start: 2365089

End: 2366795

Strand: Direct

Name: devS [H]

Synonym: Franean1_1969

Alternate gene names: 158313804

Gene position: 2365089-2366795 (Clockwise)

Preceding gene: 158313798

Following gene: 158313805

Centisome position: 26.33

GC content: 76.22

Gene sequence:

>1707_bases
ATGGACGTCCCGGACGCGTTCGACGAGTTCGGCGCGGAGCGCCCCGGCCGGCTCGAGCTGGACGAGCTGATGGCGCAGCT
CGTCGAGCGCGCGCATGAGGTGATGACCACCCAGGGCCGGCTGCGCGGCCTGCTGCGGGCGCACCGCGCGGTCGCCGCCG
ACCTGAGCCTGGAGGTCGTCCTCCGGCGGATCGCGGAGGCCGCCTGCGAGCTGGTCGACGCCCGCTATGGCGCGCTCGGC
GTGATCGCCCGCGACGGCCGGCTCGAACAGTTCATCCACGTCGGGATGGACGCCGATCTGGTCGGCCGGATCGGCCACCT
GCCCCGCGGCGAGGGGGTGCTCGGGCTGCTGACCGCCGAGCCCCGGGCCGTCCGCCTCGATGACATCGCCGCGCACGAGC
ACGCGGTCGGCTTCCCGCCCGGCCACCCGCCGATGCGCACGTTCCTCGGCGTCCCGATCAAGGTCCGCAGCGAGGTCTTC
GGGAACCTCTACCTGACCGAGAAGCGCGGCGGGCGCCGTTTCACCGCGCAGGACGAGGAGCTCGTCCTGGCCCTCGCCGC
GAGCGCCGGCGTGGCGATCGAGAACGCCCGGCTGTTCGGTGCGGCGCAGCGCCGCCAGCAGTGGCTGCAGGCATCCGCGG
ACATCATGCGCCACCTGCTGGCGGACGGGCCGGAGCCGCTCACGCTGATCGTCGCGCGGGCCCGCGAGGTCGCCGACGCC
GATCTGGCGTGCGTCCTGCTCGCCGACGGAGCGACCGAGGAGCTGCTCGTCGACGCGGCCGACGGCCCGCAGGCCGACCG
CCTCCTGGGCGAGTCCGTTCCGATGGCCGGAACCCTCGCCGGCCGGGCGGTCGCGGCCGGGCGGCCCCTGCTGGTCGACG
ACGCCGCGGCCGAGCCGGGCGTCACCGGCTTCGGTGGCCTCGACATCGGCCCGCTGATGGTCATCCCCCTGGTCGGGGCG
CAGGTCGGGACGGGCGCGGTCGTGCTGGCCCGGGGGCCCGCGGGCCGGCCGTTCGCCGACGGCGATCTGGACATGGCGGC
GACGTTCGCCGGGCATGTGCAGGTCGCCCTCGGCCTGGCCGCGTCCCGGGCCACCCGTGACCGGCTGCTCGTCCTGGAGG
ACCGCGACCGGATCGCCCGCGACCTGCACGACCACGTCATGCAGCGGCTCTACGCCGTCGCGCTGGGTCTGCAGGGGATG
GCGGCCGCCGAGGAGCGCCCGCAGTCCGCCGGCCGGCTCACCACCTACGTCGACGACCTCGACGCGACCATCCGGGAGAT
CCGCTCGACGGTCTTCGAGCTGCGCGGGCGGCGCAGCACCGGCGGGCCGGGCGTGCGGGCCCGCCTCGGCGAGATCGTCG
AGGAGGTCGCCGAGGCGCTCGGCTTCAGCCCGCGCCTGCGGGTGGACGGCCCGCTCGACACCGCGCTGGAGGGGAACATC
GCCGACCATCTCCTCGCCGTCGCGCGGGAGAGCCTGTCGAACGTGGCGCGCCACGCCCGCGCCAGCCGGGTGGAGCTGTC
GGTCACCGTCGGCCAGGGCTGGCTGTGCGCCGAGGTCACCGATGACGGGGTCGGGCTGGGCGACACCGGCCGGCGCAGCG
GCCTGCGCAACCTGCGCAGCCGCGCCGAGGAGCTCGGCGGGACCTTCGACATCGCCCCCGGCCCGTCCGGCGGCACCCGG
CTGCGCTGGGCGGTCCCGCTGCCGTAG

Upstream 100 bases:

>100_bases
CCGGGAGATCCACGAAATTCAGCAGATCCGGGAAATACGCGAGATCCAGGAGATCCTGACGGCTCGGGACGTCGAGGAGA
CCACCGAGAGCCTCAAGATC

Downstream 100 bases:

>100_bases
CCCGCCGGCCGCCCGAACCGGGCCCCGCGGTGGACGTCCGGCGCCGGACGTCCGGGCTGTCGTCGATGGGTCCGAGGACC
ATCGCGGGGGGTGCGAAGGA

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MDVPDAFDEFGAERPGRLELDELMAQLVERAHEVMTTQGRLRGLLRAHRAVAADLSLEVVLRRIAEAACELVDARYGALG
VIARDGRLEQFIHVGMDADLVGRIGHLPRGEGVLGLLTAEPRAVRLDDIAAHEHAVGFPPGHPPMRTFLGVPIKVRSEVF
GNLYLTEKRGGRRFTAQDEELVLALAASAGVAIENARLFGAAQRRQQWLQASADIMRHLLADGPEPLTLIVARAREVADA
DLACVLLADGATEELLVDAADGPQADRLLGESVPMAGTLAGRAVAAGRPLLVDDAAAEPGVTGFGGLDIGPLMVIPLVGA
QVGTGAVVLARGPAGRPFADGDLDMAATFAGHVQVALGLAASRATRDRLLVLEDRDRIARDLHDHVMQRLYAVALGLQGM
AAAEERPQSAGRLTTYVDDLDATIREIRSTVFELRGRRSTGGPGVRARLGEIVEEVAEALGFSPRLRVDGPLDTALEGNI
ADHLLAVARESLSNVARHARASRVELSVTVGQGWLCAEVTDDGVGLGDTGRRSGLRNLRSRAEELGGTFDIAPGPSGGTR
LRWAVPLP

Sequences:

>Translated_568_residues
MDVPDAFDEFGAERPGRLELDELMAQLVERAHEVMTTQGRLRGLLRAHRAVAADLSLEVVLRRIAEAACELVDARYGALG
VIARDGRLEQFIHVGMDADLVGRIGHLPRGEGVLGLLTAEPRAVRLDDIAAHEHAVGFPPGHPPMRTFLGVPIKVRSEVF
GNLYLTEKRGGRRFTAQDEELVLALAASAGVAIENARLFGAAQRRQQWLQASADIMRHLLADGPEPLTLIVARAREVADA
DLACVLLADGATEELLVDAADGPQADRLLGESVPMAGTLAGRAVAAGRPLLVDDAAAEPGVTGFGGLDIGPLMVIPLVGA
QVGTGAVVLARGPAGRPFADGDLDMAATFAGHVQVALGLAASRATRDRLLVLEDRDRIARDLHDHVMQRLYAVALGLQGM
AAAEERPQSAGRLTTYVDDLDATIREIRSTVFELRGRRSTGGPGVRARLGEIVEEVAEALGFSPRLRVDGPLDTALEGNI
ADHLLAVARESLSNVARHARASRVELSVTVGQGWLCAEVTDDGVGLGDTGRRSGLRNLRSRAEELGGTFDIAPGPSGGTR
LRWAVPLP
>Mature_568_residues
MDVPDAFDEFGAERPGRLELDELMAQLVERAHEVMTTQGRLRGLLRAHRAVAADLSLEVVLRRIAEAACELVDARYGALG
VIARDGRLEQFIHVGMDADLVGRIGHLPRGEGVLGLLTAEPRAVRLDDIAAHEHAVGFPPGHPPMRTFLGVPIKVRSEVF
GNLYLTEKRGGRRFTAQDEELVLALAASAGVAIENARLFGAAQRRQQWLQASADIMRHLLADGPEPLTLIVARAREVADA
DLACVLLADGATEELLVDAADGPQADRLLGESVPMAGTLAGRAVAAGRPLLVDDAAAEPGVTGFGGLDIGPLMVIPLVGA
QVGTGAVVLARGPAGRPFADGDLDMAATFAGHVQVALGLAASRATRDRLLVLEDRDRIARDLHDHVMQRLYAVALGLQGM
AAAEERPQSAGRLTTYVDDLDATIREIRSTVFELRGRRSTGGPGVRARLGEIVEEVAEALGFSPRLRVDGPLDTALEGNI
ADHLLAVARESLSNVARHARASRVELSVTVGQGWLCAEVTDDGVGLGDTGRRSGLRNLRSRAEELGGTFDIAPGPSGGTR
LRWAVPLP

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaer

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=240, Percent_Identity=29.1666666666667, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788812, Length=213, Percent_Identity=30.0469483568075, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016030
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60262; Mature: 60262

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVPDAFDEFGAERPGRLELDELMAQLVERAHEVMTTQGRLRGLLRAHRAVAADLSLEVV
CCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRRIAEAACELVDARYGALGVIARDGRLEQFIHVGMDADLVGRIGHLPRGEGVLGLLTAE
HHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECC
PRAVRLDDIAAHEHAVGFPPGHPPMRTFLGVPIKVRSEVFGNLYLTEKRGGRRFTAQDEE
CCEEEEHHHHHHCCCCCCCCCCCHHHHHHCCCEEEHHHHHCCEEEEECCCCCCCCCCCCC
LVLALAASAGVAIENARLFGAAQRRQQWLQASADIMRHLLADGPEPLTLIVARAREVADA
EEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
DLACVLLADGATEELLVDAADGPQADRLLGESVPMAGTLAGRAVAAGRPLLVDDAAAEPG
CEEEEEEECCCCHHEEEECCCCCHHHHHHCCCCCCCHHHCCCHHHCCCCEEEECCCCCCC
VTGFGGLDIGPLMVIPLVGAQVGTGAVVLARGPAGRPFADGDLDMAATFAGHVQVALGLA
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASRATRDRLLVLEDRDRIARDLHDHVMQRLYAVALGLQGMAAAEERPQSAGRLTTYVDDL
HHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHH
DATIREIRSTVFELRGRRSTGGPGVRARLGEIVEEVAEALGFSPRLRVDGPLDTALEGNI
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHCCCH
ADHLLAVARESLSNVARHARASRVELSVTVGQGWLCAEVTDDGVGLGDTGRRSGLRNLRS
HHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHH
RAEELGGTFDIAPGPSGGTRLRWAVPLP
HHHHCCCEEECCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MDVPDAFDEFGAERPGRLELDELMAQLVERAHEVMTTQGRLRGLLRAHRAVAADLSLEVV
CCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRRIAEAACELVDARYGALGVIARDGRLEQFIHVGMDADLVGRIGHLPRGEGVLGLLTAE
HHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECC
PRAVRLDDIAAHEHAVGFPPGHPPMRTFLGVPIKVRSEVFGNLYLTEKRGGRRFTAQDEE
CCEEEEHHHHHHCCCCCCCCCCCHHHHHHCCCEEEHHHHHCCEEEEECCCCCCCCCCCCC
LVLALAASAGVAIENARLFGAAQRRQQWLQASADIMRHLLADGPEPLTLIVARAREVADA
EEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
DLACVLLADGATEELLVDAADGPQADRLLGESVPMAGTLAGRAVAAGRPLLVDDAAAEPG
CEEEEEEECCCCHHEEEECCCCCHHHHHHCCCCCCCHHHCCCHHHCCCCEEEECCCCCCC
VTGFGGLDIGPLMVIPLVGAQVGTGAVVLARGPAGRPFADGDLDMAATFAGHVQVALGLA
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ASRATRDRLLVLEDRDRIARDLHDHVMQRLYAVALGLQGMAAAEERPQSAGRLTTYVDDL
HHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHH
DATIREIRSTVFELRGRRSTGGPGVRARLGEIVEEVAEALGFSPRLRVDGPLDTALEGNI
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHCCCH
ADHLLAVARESLSNVARHARASRVELSVTVGQGWLCAEVTDDGVGLGDTGRRSGLRNLRS
HHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHH
RAEELGGTFDIAPGPSGGTRLRWAVPLP
HHHHCCCEEECCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]