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The map label for this gene is adk [H]

Identifier: 158313772

GI number: 158313772

Start: 2325657

End: 2326256

Strand: Direct

Name: adk [H]

Synonym: Franean1_1937

Alternate gene names: 158313772

Gene position: 2325657-2326256 (Clockwise)

Preceding gene: 158313771

Following gene: 158313773

Centisome position: 25.89

GC content: 73.67

Gene sequence:

>600_bases
ATGAGGCTCGTGCTGCTTGGCCCGCCCGGCGCCGGCAAGGGGACCCAGGCCGCGCGGATCAGCGCGCGCCACGGCGTGCC
GGCGATCTCGACCGGTCAGCTCTTCGACCAGCAGATCTCCGCCGGGTCGCCGCTGGGCCGGCGGGCCGAGCACTATGTCC
GGGCCGGTGAGCTCGTCCCGGACGAGATCGTCCTGGACATGGTCGCCGAGCGCCTCGCCACCGGCATCGACTGCGAGGTG
GGGTTCCTGCTCGACGGCTTCCCCCGGACGCTGCCGCAGGCCGAGGCGCTCGACCGCATGCTGACCGCCACCTGCGGGCC
ACTCCACCTGGTCCTCGACCTCGACGTCGACGAGACCGAGGTGCTCGCCCGGATCGGCCGGCGCTCGCTGTCCGAGGGCC
GCCTCGACGACAACCAGGAGACGGCGCGGCGGCGGCTGAAGGTGTTCGCCGAGGAGACGGCCCCGCTGCGCAGCCACTAT
GCCGAGCAGGGTCTCCTGCGCACCGTAGACGGCACCGGCATGCCGGACGAGGTCGCCGCCCGTATCGAGGAGATCCTCGC
GGCGGCGGCCCATCCCGAGTTGCGGGCGGCCCGTCCCTGA

Upstream 100 bases:

>100_bases
GTCGACCGTTGGGTGAGCTAGCTCGCGTCGCGTCCGGTCTGCCCCGGTTCACCGTCGCGGCGGCTCTACTGGAAGCCAAC
CAGCCGGTACCGTGCAGGCC

Downstream 100 bases:

>100_bases
CGTGACCTTCGGGTGTCCGGGCGGGTCGAGAGATCCCGTGGCGGGATAAATTGGACCTGTCAGTGACGGCATGCGGTGAC
AGGTCGGGGATGGCCGGATG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MRLVLLGPPGAGKGTQAARISARHGVPAISTGQLFDQQISAGSPLGRRAEHYVRAGELVPDEIVLDMVAERLATGIDCEV
GFLLDGFPRTLPQAEALDRMLTATCGPLHLVLDLDVDETEVLARIGRRSLSEGRLDDNQETARRRLKVFAEETAPLRSHY
AEQGLLRTVDGTGMPDEVAARIEEILAAAAHPELRAARP

Sequences:

>Translated_199_residues
MRLVLLGPPGAGKGTQAARISARHGVPAISTGQLFDQQISAGSPLGRRAEHYVRAGELVPDEIVLDMVAERLATGIDCEV
GFLLDGFPRTLPQAEALDRMLTATCGPLHLVLDLDVDETEVLARIGRRSLSEGRLDDNQETARRRLKVFAEETAPLRSHY
AEQGLLRTVDGTGMPDEVAARIEEILAAAAHPELRAARP
>Mature_199_residues
MRLVLLGPPGAGKGTQAARISARHGVPAISTGQLFDQQISAGSPLGRRAEHYVRAGELVPDEIVLDMVAERLATGIDCEV
GFLLDGFPRTLPQAEALDRMLTATCGPLHLVLDLDVDETEVLARIGRRSLSEGRLDDNQETARRRLKVFAEETAPLRSHY
AEQGLLRTVDGTGMPDEVAARIEEILAAAAHPELRAARP

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502011, Length=180, Percent_Identity=33.8888888888889, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4502013, Length=221, Percent_Identity=34.3891402714932, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI7524346, Length=209, Percent_Identity=35.4066985645933, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI7706497, Length=188, Percent_Identity=30.3191489361702, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI28144899, Length=197, Percent_Identity=32.48730964467, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI28144897, Length=197, Percent_Identity=32.48730964467, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=30.6532663316583, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=30.1507537688442, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=30.1507537688442, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=30.1507537688442, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=30.1507537688442, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=41.2844036697248, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=181, Percent_Identity=34.8066298342541, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17552384, Length=224, Percent_Identity=30.8035714285714, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17533833, Length=188, Percent_Identity=30.3191489361702, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=191, Percent_Identity=29.8429319371728, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147457, Length=187, Percent_Identity=24.0641711229947, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=34.9282296650718, Blast_Score=130, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=33.502538071066, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322828, Length=160, Percent_Identity=31.25, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=34.2857142857143, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI221459597, Length=191, Percent_Identity=30.3664921465969, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21356893, Length=191, Percent_Identity=30.3664921465969, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17737899, Length=201, Percent_Identity=31.8407960199005, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24645822, Length=201, Percent_Identity=31.8407960199005, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24663208, Length=160, Percent_Identity=31.875, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17647141, Length=160, Percent_Identity=31.875, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 21487; Mature: 21487

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLLGPPGAGKGTQAARISARHGVPAISTGQLFDQQISAGSPLGRRAEHYVRAGELVP
CEEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
DEIVLDMVAERLATGIDCEVGFLLDGFPRTLPQAEALDRMLTATCGPLHLVLDLDVDETE
HHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
VLARIGRRSLSEGRLDDNQETARRRLKVFAEETAPLRSHYAEQGLLRTVDGTGMPDEVAA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHH
RIEEILAAAAHPELRAARP
HHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRLVLLGPPGAGKGTQAARISARHGVPAISTGQLFDQQISAGSPLGRRAEHYVRAGELVP
CEEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
DEIVLDMVAERLATGIDCEVGFLLDGFPRTLPQAEALDRMLTATCGPLHLVLDLDVDETE
HHHHHHHHHHHHHCCCCCEEHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
VLARIGRRSLSEGRLDDNQETARRRLKVFAEETAPLRSHYAEQGLLRTVDGTGMPDEVAA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHH
RIEEILAAAAHPELRAARP
HHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA