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The map label for this gene is hisB

Identifier: 158313753

GI number: 158313753

Start: 2299808

End: 2300395

Strand: Direct

Name: hisB

Synonym: Franean1_1918

Alternate gene names: 158313753

Gene position: 2299808-2300395 (Clockwise)

Preceding gene: 158313752

Following gene: 158313754

Centisome position: 25.6

GC content: 70.58

Gene sequence:

>588_bases
ATGGCACGTACCGCTCGCGTCGAGCGCAAGACCAAGGAGTCGCACGTCCTGATCGAGCTCGACCTCGACGGGACGGGCCT
GGCATCGGCGGAGACCGGCGTTCCGTTCTTCGACCACATGATGGAGCAGCTCGGCAAGCACGGGGGCTTCGACCTCACCG
TGCGCACCGAGGGCGACCTGCACATCGACGCGCACCACACCGTCGAGGACACGGCCATCGCGTTCGGCACCGCGCTGCGC
GAGGCGCTCGGCGACAAGGCGGGCATCCGCCGTTTCGGCGACGCGACCGTGCCGCTCGACGAGGCGCTGGTGCAGTCGGC
CGTCGACCTCTCCGGCCGGCCCTACTGCGTGCACGTCGAGCCGGAGCTGGTCGGCCTGATCGGCACCTACGACACCACGC
TCACCCGGCACATCTTCGAGTCGATCACCGCCTCGGCGCGGATCGCGCTGCATGTGCGGGTGCTGTCCGGGCGCAACGCC
CACCACGTCGTCGAGGCGCAGTTCAAGTCGGTGGCCCGGGCCATGCGCGACGCTGTGGCGCTCGACGCGCGGGTCGCCGG
CGTGCCGTCCACCAAGGGCGTGCTTTGA

Upstream 100 bases:

>100_bases
CGGACCGACCCGAACATCCGGACCGGTACGACCGCCCGGACCGACCAAACAGCCAGCCGGCCGGTCCAGCGCCGTACCAG
TGGAGAACCCGAGGGAAACG

Downstream 100 bases:

>100_bases
GCGGCCCGCGGCCGGACGTCGTCGTCCTCGACTACGGCTCGGGGAACCTGCGTTCGGCCGAGCGGGCGCTCGCCCGGGTC
GGTGCCGAGGTGACGGTGAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MARTARVERKTKESHVLIELDLDGTGLASAETGVPFFDHMMEQLGKHGGFDLTVRTEGDLHIDAHHTVEDTAIAFGTALR
EALGDKAGIRRFGDATVPLDEALVQSAVDLSGRPYCVHVEPELVGLIGTYDTTLTRHIFESITASARIALHVRVLSGRNA
HHVVEAQFKSVARAMRDAVALDARVAGVPSTKGVL

Sequences:

>Translated_195_residues
MARTARVERKTKESHVLIELDLDGTGLASAETGVPFFDHMMEQLGKHGGFDLTVRTEGDLHIDAHHTVEDTAIAFGTALR
EALGDKAGIRRFGDATVPLDEALVQSAVDLSGRPYCVHVEPELVGLIGTYDTTLTRHIFESITASARIALHVRVLSGRNA
HHVVEAQFKSVARAMRDAVALDARVAGVPSTKGVL
>Mature_194_residues
ARTARVERKTKESHVLIELDLDGTGLASAETGVPFFDHMMEQLGKHGGFDLTVRTEGDLHIDAHHTVEDTAIAFGTALRE
ALGDKAGIRRFGDATVPLDEALVQSAVDLSGRPYCVHVEPELVGLIGTYDTTLTRHIFESITASARIALHVRVLSGRNAH
HVVEAQFKSVARAMRDAVALDARVAGVPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=44.1025641025641, Blast_Score=162, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324776, Length=221, Percent_Identity=41.6289592760181, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_FRASN (A8LGQ5)

Other databases:

- EMBL:   CP000820
- RefSeq:   YP_001506261.1
- ProteinModelPortal:   A8LGQ5
- GeneID:   5670319
- GenomeReviews:   CP000820_GR
- KEGG:   fre:Franean1_1918
- HOGENOM:   HBG289010
- OMA:   RQAVEYD
- ProtClustDB:   PRK00951
- BioCyc:   FSP1855:FRANEAN1_1918-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21012; Mature: 20881

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTARVERKTKESHVLIELDLDGTGLASAETGVPFFDHMMEQLGKHGGFDLTVRTEGDL
CCCCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCE
HIDAHHTVEDTAIAFGTALREALGDKAGIRRFGDATVPLDEALVQSAVDLSGRPYCVHVE
EEECCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEC
PELVGLIGTYDTTLTRHIFESITASARIALHVRVLSGRNAHHVVEAQFKSVARAMRDAVA
HHHEEEEECHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LDARVAGVPSTKGVL
HHHHCCCCCCCCCCC
>Mature Secondary Structure 
ARTARVERKTKESHVLIELDLDGTGLASAETGVPFFDHMMEQLGKHGGFDLTVRTEGDL
CCCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCE
HIDAHHTVEDTAIAFGTALREALGDKAGIRRFGDATVPLDEALVQSAVDLSGRPYCVHVE
EEECCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEC
PELVGLIGTYDTTLTRHIFESITASARIALHVRVLSGRNAHHVVEAQFKSVARAMRDAVA
HHHEEEEECHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LDARVAGVPSTKGVL
HHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA