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The map label for this gene is glyA [H]

Identifier: 158312867

GI number: 158312867

Start: 1195305

End: 1196561

Strand: Direct

Name: glyA [H]

Synonym: Franean1_1013

Alternate gene names: 158312867

Gene position: 1195305-1196561 (Clockwise)

Preceding gene: 158312866

Following gene: 158312868

Centisome position: 13.31

GC content: 72.16

Gene sequence:

>1257_bases
GTGAGTACCCCGTTCTGGGGCCCGGACTTCGACCAGCTGCGGGCCACCGATCCGGACATCGCCGCGGTCGTGGTCGACGA
GTTGGAGCGGCTGCGCGGCGGCCTCCAGCTCATCGCGAGCGAGAACTTCACCTCGCCGGCGGTGCTCGCGGCGCTCGGCT
CAACGCTGTCGAACAAGTACGCCGAGGGCTACCCGGGGCGCCGCTACTACGGCGGGTGCCAGGTGGTCGACCGCGCCGAG
GAGATCGGCATCGCGCGGGCCCGGGAGCTGTTCGGTGCCGAGCACGCGAACCTGCAGCCGCACTCGGGCACGCAGGCGAA
CTTCGCCGTCTACGCCGCCCTGCTCACACCGGGGGACACTGTCCTGGCGATGTCGCTGCCGCACGGCGGGCACCTGACGC
ACGGCAGCCGTGTCAACTTCTCCGGGCGGTGGTTCGACGTCGTGGCCTACGGGGTCCGGGAGGACACCGAGCTCATCGAC
TACGACCAGGTCCGTGAGCTGGCCCTGCAACACCGGCCCAAGATGATCATTTGCGGGGCGACGGCCTACCCCCGCCGCAT
CGACTTCGCCGCGTTCCGCTCGATCGCCGACGAGGTCGGCGCCTGGCTGATGGTGGACGCGGCGCACTTCATCGGGCTGG
TCGCCGGCGGCGCGCTGCCGAGCCCGGTGCCGCACGCCGACGTCGTCAGCTTCACCACGCACAAGGTGCTGCGCGGCCCG
CGCGGCGGCATGATCCTCTGCCGGGAGGAGCTGGCCGCCCGCATCGACAAGGCGGTGTTCCCGTTCAGCCAGGGCGGGCC
GCTGATGCACGCCGTCGCGGCGAAGGCGGTGGCGCTCAAGGAGGCCGCGACCCCCGAGTACGCCACCTACGCCCACCAGG
TGATCGCGAACGCGCAGACCCTCGCCGAGGGGCTGGCGGCCGAGGGTGTCCGGCCGGTGGCGGGCGGCACCGACACCCAC
CTGACCCTGCTCGACCTGCGGGAGCTCGGCGTGACCGGCCGCGACGCCGAGGCACGCTGCGACGCGGCGGGCATCACGCT
CAACAAGAACGCCATCCCGTACGACCCGCAGCCGCCCGCGATCTCCTCCGGCATCCGGGTGGGCACTCCCGCGGTGACGA
CGCAGGGCATGCGGGAGGGCGAAATGAAGGAGATCGCCGGTCTGATCGCCCGTGCGGTGCGTGACCCGTCCGCGGCGGCT
GACGTCTCCGCCGCGGTGTCCGTGCTCGTCGACCGTCACCCGGCCTATCCGAGATAG

Upstream 100 bases:

>100_bases
CTGGGCCCCGCGCGAGCCGGCGGCTGAGCCTGCGGGCGACGCGCGGGCCCGGGGCGGCCGGTCATATCCTGGGCATCGAG
CCGGCGGGAGGTGGGTCATA

Downstream 100 bases:

>100_bases
CCGGGCGGCCGCGGGCGACCGCGCCGGCTGGCGCACGATGAGAGCCCGGGGCAGCGCAGGATGAAACGGCGGAACAGGTA
GGGATGCGCGAGTATCTGCT

Product: glycine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSTPFWGPDFDQLRATDPDIAAVVVDELERLRGGLQLIASENFTSPAVLAALGSTLSNKYAEGYPGRRYYGGCQVVDRAE
EIGIARARELFGAEHANLQPHSGTQANFAVYAALLTPGDTVLAMSLPHGGHLTHGSRVNFSGRWFDVVAYGVREDTELID
YDQVRELALQHRPKMIICGATAYPRRIDFAAFRSIADEVGAWLMVDAAHFIGLVAGGALPSPVPHADVVSFTTHKVLRGP
RGGMILCREELAARIDKAVFPFSQGGPLMHAVAAKAVALKEAATPEYATYAHQVIANAQTLAEGLAAEGVRPVAGGTDTH
LTLLDLRELGVTGRDAEARCDAAGITLNKNAIPYDPQPPAISSGIRVGTPAVTTQGMREGEMKEIAGLIARAVRDPSAAA
DVSAAVSVLVDRHPAYPR

Sequences:

>Translated_418_residues
MSTPFWGPDFDQLRATDPDIAAVVVDELERLRGGLQLIASENFTSPAVLAALGSTLSNKYAEGYPGRRYYGGCQVVDRAE
EIGIARARELFGAEHANLQPHSGTQANFAVYAALLTPGDTVLAMSLPHGGHLTHGSRVNFSGRWFDVVAYGVREDTELID
YDQVRELALQHRPKMIICGATAYPRRIDFAAFRSIADEVGAWLMVDAAHFIGLVAGGALPSPVPHADVVSFTTHKVLRGP
RGGMILCREELAARIDKAVFPFSQGGPLMHAVAAKAVALKEAATPEYATYAHQVIANAQTLAEGLAAEGVRPVAGGTDTH
LTLLDLRELGVTGRDAEARCDAAGITLNKNAIPYDPQPPAISSGIRVGTPAVTTQGMREGEMKEIAGLIARAVRDPSAAA
DVSAAVSVLVDRHPAYPR
>Mature_417_residues
STPFWGPDFDQLRATDPDIAAVVVDELERLRGGLQLIASENFTSPAVLAALGSTLSNKYAEGYPGRRYYGGCQVVDRAEE
IGIARARELFGAEHANLQPHSGTQANFAVYAALLTPGDTVLAMSLPHGGHLTHGSRVNFSGRWFDVVAYGVREDTELIDY
DQVRELALQHRPKMIICGATAYPRRIDFAAFRSIADEVGAWLMVDAAHFIGLVAGGALPSPVPHADVVSFTTHKVLRGPR
GGMILCREELAARIDKAVFPFSQGGPLMHAVAAKAVALKEAATPEYATYAHQVIANAQTLAEGLAAEGVRPVAGGTDTHL
TLLDLRELGVTGRDAEARCDAAGITLNKNAIPYDPQPPAISSGIRVGTPAVTTQGMREGEMKEIAGLIARAVRDPSAAAD
VSAAVSVLVDRHPAYPR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=407, Percent_Identity=44.963144963145, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI261862352, Length=407, Percent_Identity=44.963144963145, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI261862350, Length=407, Percent_Identity=44.963144963145, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI261862348, Length=407, Percent_Identity=44.963144963145, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI22547186, Length=405, Percent_Identity=44.9382716049383, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI261862346, Length=410, Percent_Identity=43.6585365853659, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI22547189, Length=390, Percent_Identity=43.3333333333333, Blast_Score=298, Evalue=5e-81,
Organism=Escherichia coli, GI1788902, Length=406, Percent_Identity=53.2019704433498, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI25144732, Length=407, Percent_Identity=44.2260442260442, Blast_Score=337, Evalue=6e-93,
Organism=Caenorhabditis elegans, GI25144729, Length=407, Percent_Identity=44.2260442260442, Blast_Score=336, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6323087, Length=406, Percent_Identity=43.8423645320197, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=402, Percent_Identity=43.2835820895522, Blast_Score=333, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24640005, Length=420, Percent_Identity=44.2857142857143, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI221329721, Length=420, Percent_Identity=44.2857142857143, Blast_Score=358, Evalue=6e-99,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44444; Mature: 44313

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPFWGPDFDQLRATDPDIAAVVVDELERLRGGLQLIASENFTSPAVLAALGSTLSNKY
CCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHH
AEGYPGRRYYGGCQVVDRAEEIGIARARELFGAEHANLQPHSGTQANFAVYAALLTPGDT
HCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCE
VLAMSLPHGGHLTHGSRVNFSGRWFDVVAYGVREDTELIDYDQVRELALQHRPKMIICGA
EEEEECCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECC
TAYPRRIDFAAFRSIADEVGAWLMVDAAHFIGLVAGGALPSPVPHADVVSFTTHKVLRGP
CCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
RGGMILCREELAARIDKAVFPFSQGGPLMHAVAAKAVALKEAATPEYATYAHQVIANAQT
CCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LAEGLAAEGVRPVAGGTDTHLTLLDLRELGVTGRDAEARCDAAGITLNKNAIPYDPQPPA
HHHHHHHCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
ISSGIRVGTPAVTTQGMREGEMKEIAGLIARAVRDPSAAADVSAAVSVLVDRHPAYPR
CCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
STPFWGPDFDQLRATDPDIAAVVVDELERLRGGLQLIASENFTSPAVLAALGSTLSNKY
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHH
AEGYPGRRYYGGCQVVDRAEEIGIARARELFGAEHANLQPHSGTQANFAVYAALLTPGDT
HCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCE
VLAMSLPHGGHLTHGSRVNFSGRWFDVVAYGVREDTELIDYDQVRELALQHRPKMIICGA
EEEEECCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECC
TAYPRRIDFAAFRSIADEVGAWLMVDAAHFIGLVAGGALPSPVPHADVVSFTTHKVLRGP
CCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
RGGMILCREELAARIDKAVFPFSQGGPLMHAVAAKAVALKEAATPEYATYAHQVIANAQT
CCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LAEGLAAEGVRPVAGGTDTHLTLLDLRELGVTGRDAEARCDAAGITLNKNAIPYDPQPPA
HHHHHHHCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC
ISSGIRVGTPAVTTQGMREGEMKEIAGLIARAVRDPSAAADVSAAVSVLVDRHPAYPR
CCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA