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The map label for this gene is thrB [H]

Identifier: 158312861

GI number: 158312861

Start: 1188091

End: 1189044

Strand: Direct

Name: thrB [H]

Synonym: Franean1_1007

Alternate gene names: 158312861

Gene position: 1188091-1189044 (Clockwise)

Preceding gene: 158312860

Following gene: 158312862

Centisome position: 13.23

GC content: 75.89

Gene sequence:

>954_bases
GTGAGCACCACCGGGCCGGGTGGAGGCCGTCCGCCGGGCGCGGTCCGCCTGCGGGTCCCGGCCACGAGCGCCAACCTGGG
TCCGGGCTTCGACGCGCTGGGCCTGGCACTCGGGCTGTACGACGAGGTGTCCGTGCGGCTGACGCCGTCCGGGCTCTCCA
TCGACGCGGTCGGCCCGGACGCTGTCCCCGCGGACGAGGCGCATCTGGTGGTCCGGGCGATCCGCGCCACCTTCGACGAG
CTGGAGTGGGCGCAACCCGGGCTCGCGCTGCGCTGCGTGAACCGGATCCCGCACGGGCGGGGTCTCGGTTCGTCCGCCGC
AGCGATTGTGGCCGGAGTCACAGCCGCCGACGCCCTCGCCGGCGGGCCGCTCGGTCCGGCCGGGCGGCTGCGGGTGGCCA
ACGCGATCGAAGGGCATCCGGACAACGTCGCGGCGGCCCTGCTCGGTGGCCTCACCGTCGCCTGGTACGAGGGCGATGTG
CCGCGGTCCCTCCGGGTGGCACCGCTCGGCGAGCTACGGCCCGTGGTGTTCGTCCCATCGCGACGCCAGTCGACCGAGCA
GGCCCGGGGCGCTCTCCCGAAGCAGGTCCCGCATGCCGACGCCGCGGTGAACATCGGCCGCGCGGCGCTGCTCGCGCTCG
CGCTGTCCGGCGCGGAACCGGCGGCCGGCGCTGGCGAGGAACGCTCGCGGCTGCTGCTGACCGCGACCGAGGACCGGATG
CACCAGCCGTACCGCCTTCCCGCCATGCCCGCCTCCGCGGATCTGGTCGGACGGCTGCGCGCCGCCGGCATACCGGCCGC
GCTGTCGGGTTCCGGGCCGTCCGTGGTGGCGCTCGGGGTCGGTGGCGGACAGGCCGCGGCGGCGATCGGCGTTGCCGCCC
CGGGCTTCTCGGTCGTCCCGCTGGCTGTCGACACCGAGGGTGTTCGAGTCGAGGCGGTCGACTCCTCGGAGTGA

Upstream 100 bases:

>100_bases
CGCCGGCAGCGCCTCGGGAAGCGGTACGGCCAGCGCGTCGGCGAATGCCTCCGTCAGCACACGGGTGAGCACGATCGTCA
GTGCGTCGGCGAGCGTGACG

Downstream 100 bases:

>100_bases
TTATGGTACTCCGCTGCGTTCCTGGATGCTGGCTCAGGGGTCGCGCGGACCCCCGCGGAGGGCTCCAAGCTGTCATCAGG
GAGTCCCTCGTGGTGTCATC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSTTGPGGGRPPGAVRLRVPATSANLGPGFDALGLALGLYDEVSVRLTPSGLSIDAVGPDAVPADEAHLVVRAIRATFDE
LEWAQPGLALRCVNRIPHGRGLGSSAAAIVAGVTAADALAGGPLGPAGRLRVANAIEGHPDNVAAALLGGLTVAWYEGDV
PRSLRVAPLGELRPVVFVPSRRQSTEQARGALPKQVPHADAAVNIGRAALLALALSGAEPAAGAGEERSRLLLTATEDRM
HQPYRLPAMPASADLVGRLRAAGIPAALSGSGPSVVALGVGGGQAAAAIGVAAPGFSVVPLAVDTEGVRVEAVDSSE

Sequences:

>Translated_317_residues
MSTTGPGGGRPPGAVRLRVPATSANLGPGFDALGLALGLYDEVSVRLTPSGLSIDAVGPDAVPADEAHLVVRAIRATFDE
LEWAQPGLALRCVNRIPHGRGLGSSAAAIVAGVTAADALAGGPLGPAGRLRVANAIEGHPDNVAAALLGGLTVAWYEGDV
PRSLRVAPLGELRPVVFVPSRRQSTEQARGALPKQVPHADAAVNIGRAALLALALSGAEPAAGAGEERSRLLLTATEDRM
HQPYRLPAMPASADLVGRLRAAGIPAALSGSGPSVVALGVGGGQAAAAIGVAAPGFSVVPLAVDTEGVRVEAVDSSE
>Mature_316_residues
STTGPGGGRPPGAVRLRVPATSANLGPGFDALGLALGLYDEVSVRLTPSGLSIDAVGPDAVPADEAHLVVRAIRATFDEL
EWAQPGLALRCVNRIPHGRGLGSSAAAIVAGVTAADALAGGPLGPAGRLRVANAIEGHPDNVAAALLGGLTVAWYEGDVP
RSLRVAPLGELRPVVFVPSRRQSTEQARGALPKQVPHADAAVNIGRAALLALALSGAEPAAGAGEERSRLLLTATEDRMH
QPYRLPAMPASADLVGRLRAAGIPAALSGSGPSVVALGVGGGQAAAAIGVAAPGFSVVPLAVDTEGVRVEAVDSSE

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=281, Percent_Identity=29.8932384341637, Blast_Score=85, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321814, Length=321, Percent_Identity=29.595015576324, Blast_Score=125, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 31644; Mature: 31513

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTGPGGGRPPGAVRLRVPATSANLGPGFDALGLALGLYDEVSVRLTPSGLSIDAVGPD
CCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEECCCCC
AVPADEAHLVVRAIRATFDELEWAQPGLALRCVNRIPHGRGLGSSAAAIVAGVTAADALA
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
GGPLGPAGRLRVANAIEGHPDNVAAALLGGLTVAWYEGDVPRSLRVAPLGELRPVVFVPS
CCCCCCCCCEEEEHHCCCCCCHHHHHHHCCEEEEEECCCCCCCEEECCCCCCCCEEEECC
RRQSTEQARGALPKQVPHADAAVNIGRAALLALALSGAEPAAGAGEERSRLLLTATEDRM
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHC
HQPYRLPAMPASADLVGRLRAAGIPAALSGSGPSVVALGVGGGQAAAAIGVAAPGFSVVP
CCCEECCCCCCCHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCHHHEEEECCCCCEEEE
LAVDTEGVRVEAVDSSE
EEECCCCCEEEEECCCC
>Mature Secondary Structure 
STTGPGGGRPPGAVRLRVPATSANLGPGFDALGLALGLYDEVSVRLTPSGLSIDAVGPD
CCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEECCCCC
AVPADEAHLVVRAIRATFDELEWAQPGLALRCVNRIPHGRGLGSSAAAIVAGVTAADALA
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
GGPLGPAGRLRVANAIEGHPDNVAAALLGGLTVAWYEGDVPRSLRVAPLGELRPVVFVPS
CCCCCCCCCEEEEHHCCCCCCHHHHHHHCCEEEEEECCCCCCCEEECCCCCCCCEEEECC
RRQSTEQARGALPKQVPHADAAVNIGRAALLALALSGAEPAAGAGEERSRLLLTATEDRM
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHC
HQPYRLPAMPASADLVGRLRAAGIPAALSGSGPSVVALGVGGGQAAAAIGVAAPGFSVVP
CCCEECCCCCCCHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCHHHEEEECCCCCEEEE
LAVDTEGVRVEAVDSSE
EEECCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]