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The map label for this gene is ksgA [H]

Identifier: 158312623

GI number: 158312623

Start: 892702

End: 893577

Strand: Direct

Name: ksgA [H]

Synonym: Franean1_0767

Alternate gene names: 158312623

Gene position: 892702-893577 (Clockwise)

Preceding gene: 158312622

Following gene: 158312627

Centisome position: 9.94

GC content: 78.2

Gene sequence:

>876_bases
CTGCTCTCGCCGGCCGACATCCGGGAGCTCGCCCACGCCCTTGACCTGCGGCCGACGAAGCGCAGGGGCCAGAACTTCCT
GGTGGATCCGAACACCGTCCGCCGGCTGGTGCGCCTGGCCGCGGTCGGCCCGGACGACGTCGCGCTCGAGGTGGGCCCCG
GGCTGGGCTCGCTCACCCTCGGCCTGGTCACCGAGGCGGCGGCGGTGGCCGCGGTCGAGGTCGATCCGGTGCTCGCCGCC
GCCCTGCCCGTCACCGCCGCGGCCCGGCTGCCGGCGGCGGTGGCCGCCCGGCTCCACGTCGTCGAGGCGGACGGCCTGCG
GGTCGAGCCGTCCGACCTGCCGCCGGCGGTCGCCGCGCCGACGGTGCTGGCGGCGAACCTGCCGTACAACGTGGCCGTCC
CGCTGCTGCTCGGCCTCCTCGAGCGGTTCCCGTCGATCCGGCGGGGCCTGGTGATGGTGCAGGCCGAGGTCGCCGACCGC
CTCACCTCGCCGCCCGGCGGGCGGATCTACGGCGTGCCGAGCGTGAAACTGGCCTGGTACGCGCAGGCCCGGCCGGCCGG
CGCGGTGCCCCGCCCGGTGTTCTGGCCGCAGCCCAACGTCGACTCCGGCCTCGTCGCCTTCACCCGGCGCGCCGCCCCAC
CGGCGGACGCCGGTCTGCGCCGCGAGGTCTTCGCGGCCGTCGACGCGGCCTTCGCCCAACGACGCAAGACGTTGCGGACG
GCGCTCGCCCCCTGGGCCGGCTCACCCGCGCGAGCCGAGCAGCTCGCCCGTGCGGCCGGGGTGGACCCGGGCGCCCGCGG
CGAGACCCTCGACGTCGAGGCGTTCGCCCGGCTGGCCCAGCAGGCCCGCATCCTCCCGGCCGACCAGCCCGCCTGA

Upstream 100 bases:

>100_bases
GGCTGCTGGCACAGACCCGCGGCGAGGCCGTCGACGAGCTCGCCGCCCAGGTCGCCGCCAACGCGGAACGGACGTTCGGG
CCCTGGTAGAGATCGAGGCG

Downstream 100 bases:

>100_bases
CCGCGCCGGTCAGGCGGGGCCGGTCAGCCGACGCCGATCGCGCGGCGGGCGCCGGCCAGGACGGGGCGGGCGCGGTCGCG
GGCCTTGTCCGCGCCGGCGG

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLSPADIRELAHALDLRPTKRRGQNFLVDPNTVRRLVRLAAVGPDDVALEVGPGLGSLTLGLVTEAAAVAAVEVDPVLAA
ALPVTAAARLPAAVAARLHVVEADGLRVEPSDLPPAVAAPTVLAANLPYNVAVPLLLGLLERFPSIRRGLVMVQAEVADR
LTSPPGGRIYGVPSVKLAWYAQARPAGAVPRPVFWPQPNVDSGLVAFTRRAAPPADAGLRREVFAAVDAAFAQRRKTLRT
ALAPWAGSPARAEQLARAAGVDPGARGETLDVEAFARLAQQARILPADQPA

Sequences:

>Translated_291_residues
MLSPADIRELAHALDLRPTKRRGQNFLVDPNTVRRLVRLAAVGPDDVALEVGPGLGSLTLGLVTEAAAVAAVEVDPVLAA
ALPVTAAARLPAAVAARLHVVEADGLRVEPSDLPPAVAAPTVLAANLPYNVAVPLLLGLLERFPSIRRGLVMVQAEVADR
LTSPPGGRIYGVPSVKLAWYAQARPAGAVPRPVFWPQPNVDSGLVAFTRRAAPPADAGLRREVFAAVDAAFAQRRKTLRT
ALAPWAGSPARAEQLARAAGVDPGARGETLDVEAFARLAQQARILPADQPA
>Mature_291_residues
MLSPADIRELAHALDLRPTKRRGQNFLVDPNTVRRLVRLAAVGPDDVALEVGPGLGSLTLGLVTEAAAVAAVEVDPVLAA
ALPVTAAARLPAAVAARLHVVEADGLRVEPSDLPPAVAAPTVLAANLPYNVAVPLLLGLLERFPSIRRGLVMVQAEVADR
LTSPPGGRIYGVPSVKLAWYAQARPAGAVPRPVFWPQPNVDSGLVAFTRRAAPPADAGLRREVFAAVDAAFAQRRKTLRT
ALAPWAGSPARAEQLARAAGVDPGARGETLDVEAFARLAQQARILPADQPA

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=224, Percent_Identity=33.0357142857143, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI156415992, Length=309, Percent_Identity=28.8025889967638, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1786236, Length=263, Percent_Identity=30.7984790874525, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25141369, Length=301, Percent_Identity=28.5714285714286, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25146882, Length=217, Percent_Identity=31.3364055299539, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324989, Length=207, Percent_Identity=32.8502415458937, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358017, Length=196, Percent_Identity=32.1428571428571, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21357273, Length=288, Percent_Identity=28.8194444444444, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 30415; Mature: 30415

Theoretical pI: Translated: 10.66; Mature: 10.66

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSPADIRELAHALDLRPTKRRGQNFLVDPNTVRRLVRLAAVGPDDVALEVGPGLGSLTL
CCCHHHHHHHHHHHCCCCCHHCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
GLVTEAAAVAAVEVDPVLAAALPVTAAARLPAAVAARLHVVEADGLRVEPSDLPPAVAAP
HHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEECCCCCCCCHHCC
TVLAANLPYNVAVPLLLGLLERFPSIRRGLVMVQAEVADRLTSPPGGRIYGVPSVKLAWY
HHEECCCCCHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHCCCCCCEEECCCCCEEEEE
AQARPAGAVPRPVFWPQPNVDSGLVAFTRRAAPPADAGLRREVFAAVDAAFAQRRKTLRT
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAPWAGSPARAEQLARAAGVDPGARGETLDVEAFARLAQQARILPADQPA
HHCCCCCCHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLSPADIRELAHALDLRPTKRRGQNFLVDPNTVRRLVRLAAVGPDDVALEVGPGLGSLTL
CCCHHHHHHHHHHHCCCCCHHCCCEEEECCHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
GLVTEAAAVAAVEVDPVLAAALPVTAAARLPAAVAARLHVVEADGLRVEPSDLPPAVAAP
HHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEECCCCCCCCHHCC
TVLAANLPYNVAVPLLLGLLERFPSIRRGLVMVQAEVADRLTSPPGGRIYGVPSVKLAWY
HHEECCCCCHHHHHHHHHHHHHHHHHHHCEEEEEHHHHHHHCCCCCCEEECCCCCEEEEE
AQARPAGAVPRPVFWPQPNVDSGLVAFTRRAAPPADAGLRREVFAAVDAAFAQRRKTLRT
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAPWAGSPARAEQLARAAGVDPGARGETLDVEAFARLAQQARILPADQPA
HHCCCCCCHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA