Click here to switch to the map view.

The map label for this gene is hutU

Identifier: 157963980

GI number: 157963980

Start: 5061037

End: 5062725

Strand: Reverse

Name: hutU

Synonym: Spea_4169

Alternate gene names: 157963980

Gene position: 5062725-5061037 (Counterclockwise)

Preceding gene: 157963981

Following gene: 157963979

Centisome position: 97.84

GC content: 51.39

Gene sequence:

>1689_bases
ATGGATAAGAGACACGATCCAAGCCGCCGCATTATCGCGCCGACAGGAACAGAGTTAAGTTGTAAGAGCTGGCTAACCGA
AGCCCCATTGCGCATGTTGATGAACAACCTGCACCCTGATGTGGCTGAGCGCCCTGAAGACTTGGTGGTTTATGGTGGTA
TTGGCCGTGCTGCCCGTGACTGGGAATGTTACGACAAAATCGTTGAGGTTCTGCAACGCCTTGAAGAGGACGAAACGCTA
TTAGTACAGTCTGGTAAGCCAGTTGGCGTGTTCAAGACTCACAACAATGCACCGCGGGTGATCATCGCTAACTCTAACCT
AGTGCCACATTGGGCTAACTGGGAGCACTTTAACGAGTTAGATAAGAAAGGTTTGGCCATGTATGGCCAGATGACGGCGG
GTTCTTGGATCTACATCGGCTCGCAAGGCATAGTTCAAGGGACTTACGAGACCTTCGTTGCTATGGCTAAACAGCACTTT
AATGGTTCATCTGCTGGCAAGTGGATCTTAACCGGCGGCCTTGGTGGTATGGGGGGCGCGCAGCCACTAGCTGGCACCAT
GGCGGGTTACTCGGTACTGACCTGTGAAGTGGATGAGACTCGTATCGATTTCCGCCTACGTACAAAATACGTCGACAAAA
AAGCCACCACCCTTGATGAAGCTTTGGCGATGATTGATGAAGCTAACAAGAGCGGCAAGCCTGTCTCTGTTGGCCTATTA
GCTAATGCTGCTGACGTATTTGCCGAGCTAGTAGAGCGCGGTATTACCCCTGATGTAGTAACCGACCAAACATCGGCGCA
TGATCCGCTCAATGGTTACCTGCCACAAGGCTGGACGTTAGAACAAGCTATCGAGATGCGTAAGACTGATGAAGCTGCAG
TAGTTAAAGCGGCTAAGCAGTCGATGGCGGTTCAAGTTAAGGCGATGCTAGCACTGCAAGCAGCTGGTGCGGCAACCACC
GATTACGGTAACAACATTCGCCAAATGGCATTTGAAGAAGGCGTAGAAAACGCATTCGATTTCCCAGGTTTCGTACCTGC
CTATGTGCGCCCTCTGTTCTGTGAAGGTATTGGACCATTCCGTTGGGTGGCGCTGTCTGGCGACCCTGAAGATATCTACA
AGACCGACGCTAAAGTTAAAGAGCTTATTCCTGATAATCCGCACTTACACAACTGGCTGGATATGGCGCGAGAGCGTATT
GCCTTCCAAGGTTTGCCATCACGCATCTGTTGGGTGGGTCTAAAAGACCGTGCTCGCTTAGCATTAGCCTTTAACGAGAT
GGTTAAAAATGGCGAACTTTCAGCGCCGGTTGTGATTGGTCGCGACCATTTAGACTCAGGCTCTGTTGCTAGCCCTAACC
GTGAAACCGAATCTATGCTCGACGGCTCTGATGCGGTATCGGACTGGCCATTAATGAATGCACTATTGAATACGGCTAGT
GGCGCCACTTGGGTGTCACTACACCACGGTGGTGGTGTGGGTATGGGCTTTAGCCAGCACTCAGGTGTGGTGATTGTGGC
AGACGGTACTGATGATGCGGCTGCGCGCTTAGGTCGCGTACTGTGGAATGACCCTGCAACCGGCGTAATGCGTCATGCTG
ACGCGGGTTACGATATCGCTAAAAATTGTGCAAAAGAGCAGGGTCTAGACCTGCCGATGCTAGAGAAAGCCACAACAGAG
GGTAAGTAG

Upstream 100 bases:

>100_bases
GATTTACCAAATGATTTACAAAATAAATAGACAGTAAATATAAAGCTTAAAAATAAGCGAATAAGAAAAACATAAAAACA
AATTGAACGAGGTAGTCCCC

Downstream 100 bases:

>100_bases
AACATGAGCCATTTAGTATTAACTCCGGGTACCTTAACCCTAGCGCAAATCCGTGAAATCAGCCGTGGCAAGGTCACTTT
AGAGCTGGCCGAAAGTGCTA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MDKRHDPSRRIIAPTGTELSCKSWLTEAPLRMLMNNLHPDVAERPEDLVVYGGIGRAARDWECYDKIVEVLQRLEEDETL
LVQSGKPVGVFKTHNNAPRVIIANSNLVPHWANWEHFNELDKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHF
NGSSAGKWILTGGLGGMGGAQPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATTLDEALAMIDEANKSGKPVSVGLL
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEQAIEMRKTDEAAVVKAAKQSMAVQVKAMLALQAAGAATT
DYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERI
AFQGLPSRICWVGLKDRARLALAFNEMVKNGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAARLGRVLWNDPATGVMRHADAGYDIAKNCAKEQGLDLPMLEKATTE
GK

Sequences:

>Translated_562_residues
MDKRHDPSRRIIAPTGTELSCKSWLTEAPLRMLMNNLHPDVAERPEDLVVYGGIGRAARDWECYDKIVEVLQRLEEDETL
LVQSGKPVGVFKTHNNAPRVIIANSNLVPHWANWEHFNELDKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHF
NGSSAGKWILTGGLGGMGGAQPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATTLDEALAMIDEANKSGKPVSVGLL
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEQAIEMRKTDEAAVVKAAKQSMAVQVKAMLALQAAGAATT
DYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERI
AFQGLPSRICWVGLKDRARLALAFNEMVKNGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAARLGRVLWNDPATGVMRHADAGYDIAKNCAKEQGLDLPMLEKATTE
GK
>Mature_562_residues
MDKRHDPSRRIIAPTGTELSCKSWLTEAPLRMLMNNLHPDVAERPEDLVVYGGIGRAARDWECYDKIVEVLQRLEEDETL
LVQSGKPVGVFKTHNNAPRVIIANSNLVPHWANWEHFNELDKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHF
NGSSAGKWILTGGLGGMGGAQPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATTLDEALAMIDEANKSGKPVSVGLL
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEQAIEMRKTDEAAVVKAAKQSMAVQVKAMLALQAAGAATT
DYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERI
AFQGLPSRICWVGLKDRARLALAFNEMVKNGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAARLGRVLWNDPATGVMRHADAGYDIAKNCAKEQGLDLPMLEKATTE
GK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=576, Percent_Identity=33.3333333333333, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI260306182, Length=352, Percent_Identity=32.1022727272727, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71997891, Length=560, Percent_Identity=34.2857142857143, Blast_Score=316, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_SHEPA (A8HA92)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001504014.1
- ProteinModelPortal:   A8HA92
- SMR:   A8HA92
- STRING:   A8HA92
- GeneID:   5664553
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_4169
- NMPDR:   fig|398579.3.peg.3620
- eggNOG:   COG2987
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- BioCyc:   SPEA398579:SPEA_4169-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 61076; Mature: 61076

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 410-410

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRHDPSRRIIAPTGTELSCKSWLTEAPLRMLMNNLHPDVAERPEDLVVYGGIGRAARD
CCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCCCCC
WECYDKIVEVLQRLEEDETLLVQSGKPVGVFKTHNNAPRVIIANSNLVPHWANWEHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHH
DKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHFNGSSAGKWILTGGLGGMGGA
HHCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
QPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATTLDEALAMIDEANKSGKPVSVGLL
CCHHHHHCCCEEEEEEECCCEEEEEEEEHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEHH
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEQAIEMRKTDEAAVVKAAKQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
SMAVQVKAMLALQAAGAATTDYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPF
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPSRICWVGLKDRARL
EEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
ALAFNEMVKNGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
HHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAARLGRVLWNDPATGVMRHADAGYDIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHH
KNCAKEQGLDLPMLEKATTEGK
HHHHHHHCCCCCHHHHHCCCCC
>Mature Secondary Structure
MDKRHDPSRRIIAPTGTELSCKSWLTEAPLRMLMNNLHPDVAERPEDLVVYGGIGRAARD
CCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCCCCC
WECYDKIVEVLQRLEEDETLLVQSGKPVGVFKTHNNAPRVIIANSNLVPHWANWEHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHH
DKKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVAMAKQHFNGSSAGKWILTGGLGGMGGA
HHCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCC
QPLAGTMAGYSVLTCEVDETRIDFRLRTKYVDKKATTLDEALAMIDEANKSGKPVSVGLL
CCHHHHHCCCEEEEEEECCCEEEEEEEEHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEHH
ANAADVFAELVERGITPDVVTDQTSAHDPLNGYLPQGWTLEQAIEMRKTDEAAVVKAAKQ
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
SMAVQVKAMLALQAAGAATTDYGNNIRQMAFEEGVENAFDFPGFVPAYVRPLFCEGIGPF
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPSRICWVGLKDRARL
EEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
ALAFNEMVKNGELSAPVVIGRDHLDSGSVASPNRETESMLDGSDAVSDWPLMNALLNTAS
HHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGVVIVADGTDDAAARLGRVLWNDPATGVMRHADAGYDIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHH
KNCAKEQGLDLPMLEKATTEGK
HHHHHHHCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA